Detailed information for compound 1120074

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 403.82 | Formula: C18H18ClN5O4
  • H donors: 2 H acceptors: 5 LogP: 0.83 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H](C[C@@H]1n1nnc(c1)c1ccc(cc1)Cl)n1cc(C)c(=O)[nH]c1=O
  • InChi: 1S/C18H18ClN5O4/c1-10-7-23(18(27)20-17(10)26)16-6-14(15(9-25)28-16)24-8-13(21-22-24)11-2-4-12(19)5-3-11/h2-5,7-8,14-16,25H,6,9H2,1H3,(H,20,26,27)/t14-,15+,16+/m0/s1
  • InChiKey: WWMWBLWTLDFTOG-ARFHVFGLSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Drosophila melanogaster deoxyribonucleoside kinase Starlite/ChEMBL References
Homo sapiens thymidine kinase 2, mitochondrial Starlite/ChEMBL References
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi thymidylate kinase Get druggable targets OG5_126920 All targets in OG5_126920
Echinococcus multilocularis transfer RNA-Ile Get druggable targets OG5_133103 All targets in OG5_133103
Wolbachia endosymbiont of Brugia malayi thymidylate kinase Get druggable targets OG5_126920 All targets in OG5_126920
Trypanosoma congolense thymidylate kinase, putative Get druggable targets OG5_126920 All targets in OG5_126920
Schistosoma japonicum similar to Centrosomal protein of 97 kDa, putative Get druggable targets OG5_133103 All targets in OG5_133103
Trichomonas vaginalis thymidylate kinase, putative Get druggable targets OG5_126920 All targets in OG5_126920
Candida albicans Thymidylate kinase Get druggable targets OG5_126920 All targets in OG5_126920
Cryptosporidium hominis thymidylate kinase Get druggable targets OG5_126920 All targets in OG5_126920
Trypanosoma brucei gambiense thymidylate kinase, putative Get druggable targets OG5_126920 All targets in OG5_126920
Echinococcus granulosus Thymidine kinase 2 mitochondrial Get druggable targets OG5_133103 All targets in OG5_133103
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) Get druggable targets OG5_126920 All targets in OG5_126920
Treponema pallidum thymidylate kinase (tmk) Get druggable targets OG5_126920 All targets in OG5_126920
Loa Loa (eye worm) thymidylate kinase Get druggable targets OG5_126920 All targets in OG5_126920
Echinococcus granulosus thymidine kinase Get druggable targets OG5_133103 All targets in OG5_133103
Neospora caninum Thymidylate kinase, related Get druggable targets OG5_126920 All targets in OG5_126920
Toxoplasma gondii thymidylate kinase Get druggable targets OG5_126920 All targets in OG5_126920
Onchocerca volvulus Putative thymidylate kinase Get druggable targets OG5_126920 All targets in OG5_126920
Cryptosporidium parvum thymidylate kinase Get druggable targets OG5_126920 All targets in OG5_126920
Leishmania major thymidylate kinase-like protein Get druggable targets OG5_126920 All targets in OG5_126920
Giardia lamblia CDC8 Get druggable targets OG5_126920 All targets in OG5_126920
Plasmodium vivax thymidylate kinase, putative Get druggable targets OG5_126920 All targets in OG5_126920
Plasmodium falciparum thymidylate kinase Get druggable targets OG5_126920 All targets in OG5_126920
Echinococcus granulosus thymidine kinase Get druggable targets OG5_133103 All targets in OG5_133103
Trypanosoma brucei thymidylate kinase, putative Get druggable targets OG5_126920 All targets in OG5_126920
Trypanosoma congolense thymidylate kinase, putative Get druggable targets OG5_126920 All targets in OG5_126920
Echinococcus multilocularis thymidine kinase Get druggable targets OG5_133103 All targets in OG5_133103
Trypanosoma cruzi thymidylate kinase, putative Get druggable targets OG5_126920 All targets in OG5_126920
Plasmodium berghei thymidylate kinase, putative Get druggable targets OG5_126920 All targets in OG5_126920
Trichomonas vaginalis thymidylate kinase, putative Get druggable targets OG5_126920 All targets in OG5_126920
Schistosoma mansoni thymidylate kinase Get druggable targets OG5_126920 All targets in OG5_126920
Plasmodium knowlesi thymidylate kinase, putative Get druggable targets OG5_126920 All targets in OG5_126920
Plasmodium yoelii Thymidylate kinase Get druggable targets OG5_126920 All targets in OG5_126920
Echinococcus multilocularis thymidylate kinase Get druggable targets OG5_126920 All targets in OG5_126920
Theileria parva thymidylate kinase, putative Get druggable targets OG5_126920 All targets in OG5_126920
Chlamydia trachomatis thymidylate kinase Get druggable targets OG5_126920 All targets in OG5_126920
Schistosoma japonicum ko:K00943 dTMP kinase [EC2.7.4.9], putative Get druggable targets OG5_126920 All targets in OG5_126920
Leishmania braziliensis thymidylate kinase-like protein Get druggable targets OG5_126920 All targets in OG5_126920
Leishmania infantum thymidylate kinase-like protein Get druggable targets OG5_126920 All targets in OG5_126920
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) Get druggable targets OG5_126920 All targets in OG5_126920
Mycobacterium ulcerans thymidylate kinase Get druggable targets OG5_126920 All targets in OG5_126920
Babesia bovis thymidylate kinase, putative Get druggable targets OG5_126920 All targets in OG5_126920
Schistosoma mansoni thymidylate kinase Get druggable targets OG5_126920 All targets in OG5_126920
Echinococcus granulosus thymidylate kinase Get druggable targets OG5_126920 All targets in OG5_126920
Candida albicans Thymidylate kinase Get druggable targets OG5_126920 All targets in OG5_126920
Schistosoma japonicum ko:K00857 thymidine kinase [EC2.7.1.21], putative Get druggable targets OG5_133103 All targets in OG5_133103
Trypanosoma cruzi thymidylate kinase, putative Get druggable targets OG5_126920 All targets in OG5_126920
Leishmania donovani thymidylate kinase-like protein Get druggable targets OG5_126920 All targets in OG5_126920
Schistosoma mansoni thymidine kinase Get druggable targets OG5_133103 All targets in OG5_133103
Leishmania mexicana thymidylate kinase-like protein Get druggable targets OG5_126920 All targets in OG5_126920
Trypanosoma brucei thymidylate kinase, putative Get druggable targets OG5_126920 All targets in OG5_126920
Schistosoma mansoni hypothetical protein Get druggable targets OG5_126920 All targets in OG5_126920
Schistosoma japonicum Thymidylate kinase, putative Get druggable targets OG5_126920 All targets in OG5_126920
Entamoeba histolytica Thymidylate kinase, putative Get druggable targets OG5_126920 All targets in OG5_126920
Echinococcus multilocularis thymidine kinase Get druggable targets OG5_133103 All targets in OG5_133103
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major mitochondrial DNA polymerase I protein A, putative thymidine kinase 2, mitochondrial 234 aa 232 aa 22.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 10 0.0016 0.0032 0.0025
Trichomonas vaginalis multiple ankyrin repeats single kh domain protein, putative 0.0016 0.0032 0.0032
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0077 0.0571 0.8241
Trichomonas vaginalis ankyrin, putative 0.0016 0.0032 0.0032
Loa Loa (eye worm) potassium channel tetramerisation domain containing 3 0.0017 0.0036 0.0021
Echinococcus multilocularis General substrate transporter 0.01 0.0771 0.1144
Schistosoma mansoni glutamate receptor AMPA 0.003 0.0153 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Trypanosoma brucei btb/poz domain containing protein, putative 0.0017 0.0036 0.0069
Toxoplasma gondii transporter, major facilitator family protein 0.0016 0.0031 0.0335
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Brugia malayi glutaminase DH11.1 0.0016 0.0032 0.0016
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.017 0.1395 0.1395
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0107 0.0838 0.1245
Entamoeba histolytica hypothetical protein 0.017 0.1395 0.1375
Echinococcus multilocularis voltage gated potassium channel 0.0032 0.0166 0.0228
Brugia malayi Ribonuclease 2-5A family protein 0.035 0.2994 0.2983
Plasmodium vivax kelch protein K13, putative 0.0017 0.0036 0.0063
Toxoplasma gondii methionine aminopeptidase 0.0031 0.0162 0.1766
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0166 0.0228
Echinococcus granulosus glutamate NMDA receptor subunit 0.003 0.0153 0.0208
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0121 0.0353
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.035 0.2994 0.4509
Plasmodium vivax hexose transporter 0.0116 0.0916 1
Trichomonas vaginalis unc-44 ankyrins, putative 0.0016 0.0032 0.0032
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.1138 1 1
Echinococcus multilocularis BTB:POZ domain containing protein KCTD16 0.0017 0.0036 0.0031
Trichomonas vaginalis ion channel nompc, putative 0.0016 0.0032 0.0032
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0049 0.0321 0.0463
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0049 0.0321 0.1023
Brugia malayi Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog 0.0017 0.0036 0.0021
Trichomonas vaginalis ankyrin repeat-cotaining protein, putative 0.0016 0.0032 0.0032
Echinococcus multilocularis BTB:POZ domain containing protein 0.0017 0.0036 0.0031
Trypanosoma cruzi Ankyrin repeats (many copies), putative 0.0016 0.0032 0.0055
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0204 0.0188
Brugia malayi mKIAA0176 protein 0.0017 0.0036 0.0021
Trichomonas vaginalis nf kappa B inhibitor I-kappa-B, putative 0.0016 0.0032 0.0032
Brugia malayi BRM protein 0.0071 0.0513 0.0498
Onchocerca volvulus 0.0017 0.0036 0.0021
Trichomonas vaginalis inversin, putative 0.0016 0.0032 0.0032
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0166 0.0228
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0388 0.3329 0.3319
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0121 0.1021
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0049 0.0321 0.1023
Echinococcus multilocularis glutamate receptor 2 0.003 0.0153 0.0208
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0021
Echinococcus multilocularis transfer RNA-Gly 0.0032 0.0166 0.0228
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 10 0.0016 0.0032 0.0025
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0015
Giardia lamblia Kinase, NEK 0.0019 0.0051 0.002
Brugia malayi hypothetical protein 0.0016 0.0031 0.0015
Schistosoma mansoni sugar transporter 0.0016 0.0031 0.0023
Entamoeba histolytica Thymidylate kinase, putative 0.0087 0.0658 0.0637
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0787 0.6882 1
Onchocerca volvulus 0.0016 0.0031 0.0015
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0077 0.0571 0.8241
Trichomonas vaginalis ion channel nompc, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0351 0.3004 0.3004
Echinococcus multilocularis ankyrin repeat domain containing protein 6 0.0016 0.0032 0.0025
Trichomonas vaginalis hypothetical protein 0.0016 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0021
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Echinococcus multilocularis transient receptor potential cation channel 0.0015 0.0016 0.00000015602
Brugia malayi K+ channel tetramerisation domain containing protein 0.0017 0.0036 0.0021
Trypanosoma brucei palmitoyl acyltransferase 1, putative 0.0016 0.0032 0.0055
Trypanosoma brucei potassium voltage-gated channel, putative 0.0017 0.0036 0.0069
Echinococcus multilocularis shaker cognate 0.0032 0.0166 0.0228
Entamoeba histolytica hypothetical protein 0.017 0.1395 0.1375
Schistosoma mansoni phospholipase 0.0016 0.0032 0.0025
Trichomonas vaginalis serine/threonine-protein kinase ripk4, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0205 0.0635
Trypanosoma cruzi palmitoyl acyltransferase 1, putative 0.0016 0.0032 0.0055
Schistosoma mansoni helicase 0.0071 0.0513 0.0752
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0205 0.0635
Brugia malayi metabotropic glutamate receptor type 2 0.0015 0.0023 0.0007
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0031 0.0162 0.0131
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0015 0.0016 0.017
Echinococcus multilocularis calcium activated potassium channel 0.0017 0.0035 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0036 0.0069
Loa Loa (eye worm) methionine aminopeptidase type I 0.0049 0.0321 0.0306
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Echinococcus granulosus nmda type glutamate receptor 0.0015 0.0023 0.0011
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0007
Giardia lamblia Hypothetical protein 0.0016 0.0032 0.0001
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0015 0.0016 0.0016
Giardia lamblia Protein 21.1 0.0016 0.0032 0.0001
Echinococcus multilocularis glutamate receptor subunit protein glur 0.003 0.0153 0.0208
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0192 0.1594 0.2389
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0166 0.0228
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Treponema pallidum thymidylate kinase (tmk) 0.0087 0.0658 1
Trypanosoma cruzi thymidylate kinase, putative 0.0087 0.0658 0.215
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0166 0.0228
Brugia malayi K+ channel tetramerisation domain containing protein 0.0017 0.0036 0.0021
Entamoeba histolytica hypothetical protein 0.0104 0.0809 0.0788
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0032 0.0166 0.0151
Giardia lamblia Kinase, NEK 0.0019 0.0051 0.002
Echinococcus granulosus transient receptor potential cation channel 0.0015 0.0016 0.00000015602
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Loa Loa (eye worm) Kv4.2 voltage-gated potassium channel 0.0017 0.0036 0.0021
Giardia lamblia Ankyrin repeat protein 0.0016 0.0032 0.0001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0033 0.0017
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0036 0.0031
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Schistosoma mansoni vesicular amine transporter 0.0032 0.0166 0.0228
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0077 0.0571 0.0788
Trichomonas vaginalis protein phosphatase 1 regulatory subunit 12C, putative 0.0016 0.0032 0.0032
Brugia malayi Cache domain containing protein 0.0085 0.0642 0.0627
Trichomonas vaginalis unc-44 ankyrins, putative 0.0016 0.0032 0.0032
Entamoeba histolytica protein tyrosine phosphatase, putative 0.1138 1 1
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0205 0.0205
Toxoplasma gondii methionine aminopeptidase 0.0049 0.0321 0.3507
Echinococcus granulosus serine:threonine protein kinase:endoribonuclease 0.035 0.2994 0.4509
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0017 0.0036 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0032 0.0166 0.0228
Schistosoma mansoni glutamate receptor NMDA 0.003 0.0153 0.0208
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.017 0.1395 0.1375
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0023 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.0016
Giardia lamblia Protein 21.1 0.0016 0.0032 0.0001
Leishmania major thymidylate kinase-like protein 0.0087 0.0658 0.215
Schistosoma mansoni glucose transporter 0.0016 0.0031 0.0023
Trichomonas vaginalis homeobox-containing protein wariai, putative 0.0016 0.0032 0.0032
Schistosoma mansoni tankyrase 0.0016 0.0032 0.0025
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.0106
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0016 0.0032 0.0032
Brugia malayi hypothetical protein 0.0026 0.0121 0.0106
Echinococcus granulosus atrial natriuretic peptide receptor 0.0015 0.0023 0.0011
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0015 0.0023 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.017 0.1395 0.1395
Echinococcus granulosus GPCR family 2 0.0017 0.0033 0.0026
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0045 0.0165
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0015 0.0016 0.017
Echinococcus granulosus potassium voltage gated channel protein 0.0388 0.3329 0.5017
Leishmania major glucose transporter, lmgt2 0.0036 0.0205 0.0635
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0093 0.0712 0.1054
Onchocerca volvulus 0.0017 0.0036 0.0021
Trichomonas vaginalis ankyrin, putative 0.0016 0.0032 0.0032
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0049 0.0321 0.1023
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0036 0.0031
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0032 0.0166 0.0228
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0016 0.0032 0.0025
Trichomonas vaginalis ion channel nompc, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.017 0.1395 0.1395
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Onchocerca volvulus 0.0017 0.0036 0.0021
Leishmania major huntingtin interacting protein (HIP), putative 0.0016 0.0032 0.0055
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0045 0.029 0.0415
Schistosoma mansoni glutamate receptor kainate 0.003 0.0153 0.0208
Trichomonas vaginalis ankyrin, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0205 0.0205
Trypanosoma brucei glucose transporter, putative 0.0036 0.0205 0.0635
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0031 0.0015
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0365 0.313 0.3114
Trypanosoma brucei glucose transporter, putative 0.0036 0.0205 0.0635
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0351 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0015
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Onchocerca volvulus 0.0016 0.0031 0.0015
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0045 0.029 0.0415
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Brugia malayi Glutamate receptor 1 precursor 0.003 0.0153 0.0138
Echinococcus multilocularis solute carrier family 22 0.0016 0.0031 0.0023
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0007
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0016 0.0032 0.0016
Echinococcus multilocularis glutamate receptor 2 0.0045 0.029 0.0415
Echinococcus granulosus global transcription activator snf2l2 0.0071 0.0513 0.0752
Brugia malayi Glutamate receptor 2 precursor 0.003 0.0153 0.0138
Echinococcus multilocularis serine:threonine protein kinase:endoribonuclease 0.035 0.2994 0.4509
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0017 0.0036 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0351 0.3004 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0017 0.0036 0.0069
Onchocerca volvulus 0.0016 0.0031 0.0015
Echinococcus granulosus General substrate transporter 0.01 0.0771 0.1144
Trichomonas vaginalis ankyrin repeat domain-containing protein, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.003 0.0153 0.0208
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0015
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Entamoeba histolytica ARF GTPase activating protein, putative 0.0016 0.0032 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Echinococcus multilocularis tyrosine kinase 0.0015 0.0023 0.0011
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.1138 1 1
Brugia malayi Leucine Rich Repeat family protein 0.0016 0.0032 0.0016
Trichomonas vaginalis ankyrin repeat-rich membrane-spanning protein, putative 0.0016 0.0032 0.0032
Onchocerca volvulus 0.0016 0.0031 0.0015
Toxoplasma gondii hypothetical protein 0.0015 0.0016 0.017
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0371 0.3179 0.4789
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0021 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0007
Echinococcus granulosus transient receptor potential cation channel 0.0015 0.0016 0.00000015602
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0031 0.0023
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0184 0.1524 0.2283
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Brugia malayi Sugar transporter family protein 0.0016 0.0031 0.0015
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0016 0.0032 0.0032
Brugia malayi hypothetical protein 0.0016 0.0031 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0031 0.0031
Echinococcus granulosus glutamate receptor 2 0.0045 0.029 0.0415
Leishmania major hypothetical protein, conserved 0.0026 0.0121 0.0353
Onchocerca volvulus 0.0017 0.0036 0.0021
Trichomonas vaginalis ankyrin, putative 0.0016 0.0032 0.0032
Brugia malayi Deoxynucleoside kinase family protein 0.017 0.1395 0.1381
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0007
Schistosoma mansoni hypothetical protein 0.0017 0.0033 0.0026
Toxoplasma gondii sugar transporter ST1 0.0016 0.0031 0.0335
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0031 0.0015
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0033 0.0026
Echinococcus granulosus receptor type guanylyl cyclase 0.0015 0.0023 0.0011
Onchocerca volvulus 0.0015 0.0023 0.0007
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0015 0.0023 0.0011
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0031 0.0162 0.0221
Onchocerca volvulus 0.0016 0.0031 0.0015
Onchocerca volvulus 0.0016 0.0032 0.0016
Giardia lamblia Deoxynucleoside kinase 0.017 0.1395 0.1368
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Schistosoma mansoni metabotropic glutamate receptor 0.0015 0.0023 0.0011
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1138 1 1
Schistosoma mansoni ga binding protein beta chain (transcription factor e4tf1-47) 0.0016 0.0032 0.0025
Onchocerca volvulus 0.0016 0.0031 0.0015
Entamoeba histolytica hypothetical protein 0.017 0.1395 0.1375
Onchocerca volvulus 0.0016 0.0031 0.0015
Onchocerca volvulus 0.0016 0.0031 0.0015
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0423 0.3641 0.5488
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0015
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0015
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0017 0.0036 0.0069
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0351 0.0336
Leishmania major hypothetical protein, conserved 0.0017 0.0036 0.0069
Mycobacterium ulcerans methionine aminopeptidase 0.0031 0.0162 0.0131
Trypanosoma brucei glucose transporter, putative 0.0036 0.0205 0.0635
Leishmania major extracellular receptor, putative 0.0015 0.0023 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Echinococcus granulosus Ankyrin 0.0016 0.0032 0.0025
Onchocerca volvulus 0.0016 0.0031 0.0015
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0045 0.029 0.0415
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Trichomonas vaginalis multiple ankyrin repeats single kh domain protein, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0015 0.0016 0.0016
Loa Loa (eye worm) sugar transporter 0.0016 0.0031 0.0015
Schistosoma mansoni tyrosine kinase 0.0015 0.0023 0.0011
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0025
Plasmodium falciparum thymidylate kinase 0.0087 0.0658 0.7088
Trichomonas vaginalis fetal globin-inducing factor, putative 0.0016 0.0032 0.0032
Toxoplasma gondii ankyrin repeat-containing protein 0.0016 0.0032 0.035
Trypanosoma cruzi sugar transporter, putative 0.0016 0.0031 0.005
Trichomonas vaginalis rolling pebbles, putative 0.0016 0.0032 0.0032
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0016 0.0032 0.0055
Brugia malayi Patatin-like phospholipase family protein 0.0016 0.0032 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Echinococcus granulosus thymidine kinase 0.0758 0.6621 1
Trypanosoma brucei glucose transporter, putative 0.0036 0.0205 0.0635
Echinococcus multilocularis potassium voltage gated channel protein 0.0032 0.0166 0.0228
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0015 0.0023 0.0007
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0021 0.0076 0.0076
Brugia malayi thymidylate kinase 0.0087 0.0658 0.0644
Loa Loa (eye worm) hypothetical protein 0.0085 0.0642 0.0627
Echinococcus multilocularis Ankyrin 0.0016 0.0032 0.0025
Onchocerca volvulus 0.0016 0.0031 0.0015
Loa Loa (eye worm) tnks protein 0.0016 0.0032 0.0016
Echinococcus granulosus glutamate receptor subunit protein glur 0.003 0.0153 0.0208
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0031 0.0023
Echinococcus multilocularis GPCR, family 2 0.0017 0.0033 0.0026
Schistosoma mansoni thymidine kinase 0.0758 0.6621 1
Toxoplasma gondii transporter, cation channel family protein 0.0015 0.0016 0.017
Trichomonas vaginalis fetal globin-inducing factor, putative 0.0016 0.0032 0.0032
Loa Loa (eye worm) Notch2 0.0016 0.0032 0.0016
Brugia malayi hypothetical protein 0.0017 0.0038 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0015
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0205 0.0205
Toxoplasma gondii transporter, cation channel family protein 0.0015 0.0016 0.017
Schistosoma mansoni glutamate receptor AMPA 0.003 0.0153 0.0208
Echinococcus multilocularis solute carrier family 22 0.0016 0.0031 0.0023
Trypanosoma cruzi ankyrin repeat protein, putative 0.0016 0.0032 0.0055
Loa Loa (eye worm) BRM protein 0.0045 0.0286 0.0271
Trichomonas vaginalis E3 ubiquitin protein ligase, putative 0.0016 0.0032 0.0032
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0033 0.0017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0015
Echinococcus granulosus glutamate receptor 2 0.0015 0.0023 0.0011
Brugia malayi Sugar transporter family protein 0.0016 0.0031 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0045 0.0099
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.017 0.1395 0.1375
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0015 0.0023 0.0011
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0351 0.3004 0.3004
Trypanosoma brucei thymidylate kinase, putative 0.0087 0.0658 0.215
Leishmania major hypothetical protein, conserved 0.0351 0.3004 1
Echinococcus granulosus thymidylate kinase 0.0087 0.0658 0.0973
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0031 0.0162 0.0221
Brugia malayi Sugar transporter family protein 0.0116 0.0916 0.0902
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0033 0.0026
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0121 0.1021
Schistosoma mansoni edp1-related 0.0017 0.0036 0.0031
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0121 0.1021
Schistosoma mansoni hypothetical protein 0.0017 0.0033 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0021
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0388 0.3329 0.5017
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0015 0.0023 0.0007
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0087 0.0658 1
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0031 0.0023
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Loa Loa (eye worm) thymidylate kinase 0.0087 0.0658 0.0644
Trypanosoma brucei glucose transporter 1E 0.0036 0.0205 0.0635
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0045 0.029 0.0415
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0205 0.0635
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0031 0.0023
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0015 0.0023 0.0007
Trypanosoma cruzi Ankyrin repeats (many copies), putative 0.0016 0.0032 0.0055
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.017 0.1395 0.1375
Trypanosoma brucei glucose transporter 2A 0.0036 0.0205 0.0635
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0007
Toxoplasma gondii kelch repeat and K+ channel tetramerisation domain containing protein 0.0017 0.0036 0.0396
Echinococcus multilocularis thymidylate kinase 0.0087 0.0658 0.0973
Echinococcus granulosus shaker cognate 0.0032 0.0166 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0031 0.0015
Brugia malayi Guanylyl cyclase protein 23 0.0015 0.0023 0.0007
Trypanosoma cruzi hexose transporter 0.0036 0.0205 0.0635
Schistosoma mansoni voltage-gated potassium channel 0.0388 0.3329 0.5017
Entamoeba histolytica ankyrin repeat protein, putative 0.0016 0.0032 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Brugia malayi K+ channel tetramerisation domain containing protein 0.0017 0.0036 0.0021
Entamoeba histolytica hypothetical protein 0.0016 0.0032 0.0009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0015
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0017 0.0036 0.0021
Echinococcus granulosus voltage gated potassium channel 0.0032 0.0166 0.0228
Echinococcus multilocularis global transcription activator snf2l2 0.0071 0.0513 0.0752
Brugia malayi hypothetical protein 0.0015 0.0023 0.0007
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0205 0.0635
Schistosoma mansoni thymidylate kinase 0.0087 0.0658 0.0973
Plasmodium falciparum hexose transporter 0.0116 0.0916 1
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0017 0.0036 0.0069
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0016 0.0031 0.005
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Trypanosoma cruzi hexose transporter, putative 0.002 0.006 0.015
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0049 0.0321 0.3282
Schistosoma mansoni glutamate receptor kainate 0.003 0.0153 0.0208
Echinococcus granulosus tyrosine kinase 0.0015 0.0023 0.0011
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0087 0.0658 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0032 0.0166 0.0228
Schistosoma mansoni serine-rich repeat protein 0.0099 0.0768 0.1139
Echinococcus granulosus Ankyrin 0.0016 0.0032 0.0025
Toxoplasma gondii rhoptry neck protein RON9 0.0016 0.0032 0.035
Echinococcus granulosus potassium voltage gated channel protein 0.0032 0.0166 0.0228
Toxoplasma gondii thymidylate kinase 0.0087 0.0658 0.7186
Echinococcus granulosus metabotropic glutamate receptor 5 0.0015 0.0023 0.0011
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0121 0.0353
Trichomonas vaginalis tankyrase, putative 0.0016 0.0032 0.0032
Schistosoma mansoni glucose transport protein 0.0116 0.0916 0.1363
Brugia malayi Receptor family ligand binding region containing protein 0.0015 0.0023 0.0007
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Onchocerca volvulus Putative thymidylate kinase 0.0087 0.0658 0.0644
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Giardia lamblia Kinase, NEK 0.0019 0.0051 0.002
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0116 0.0916 0.1363
Leishmania major myo-inositol/proton symporter (MIT) 0.0016 0.0031 0.005
Trichomonas vaginalis ion channel nompc, putative 0.0016 0.0032 0.0032
Entamoeba histolytica hypothetical protein 0.017 0.1395 0.1375
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0205 0.0205
Schistosoma mansoni sugar transporter 0.0016 0.0031 0.0023
Entamoeba histolytica hypothetical protein 0.017 0.1395 0.1375
Trypanosoma brucei btb/poz domain containing protein, putative 0.0017 0.0036 0.0069
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0031 0.0031
Entamoeba histolytica protein tyrosine phosphatase, putative 0.1138 1 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Leishmania major glucose transporter, lmgt3 0.0036 0.0205 0.0635
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.0016
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.00000010322
Trichomonas vaginalis 2-5A-dependent ribonuclease, putative 0.0016 0.0032 0.0032
Giardia lamblia Kinase, NEK-frag 0.0019 0.0051 0.002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0007
Trypanosoma brucei glucose transporter, putative 0.0036 0.0205 0.0635
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0021 0.0076 0.0076
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Echinococcus granulosus BTB:POZ domain containing protein KCTD16 0.0017 0.0036 0.0031
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0007
Toxoplasma gondii hypothetical protein 0.0015 0.0016 0.017
Echinococcus granulosus solute carrier family 22 0.0016 0.0031 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0166 0.0228
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Schistosoma mansoni transient receptor potential channel 0.0015 0.0016 0.00000015602
Trichomonas vaginalis sugar transport protein, putative 0.0016 0.0031 0.0031
Onchocerca volvulus 0.0016 0.0031 0.0015
Schistosoma mansoni sugar transporter 0.0016 0.0031 0.0023
Leishmania major potassium voltage-gated channel, putative 0.0017 0.0036 0.0069
Echinococcus granulosus voltage dependent calcium channel subunit 0.0423 0.3641 0.5488
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Schistosoma mansoni metabotropic glutamate receptor 0.0015 0.0023 0.0011
Chlamydia trachomatis thymidylate kinase 0.0087 0.0658 1
Trichomonas vaginalis 2-5A-dependent ribonuclease, putative 0.0016 0.0032 0.0032
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0205 0.0635
Entamoeba histolytica hypothetical protein 0.017 0.1395 0.1375
Toxoplasma gondii hypothetical protein 0.0018 0.0045 0.0494
Brugia malayi major facilitator superfamily protein 0.0016 0.0031 0.0015
Toxoplasma gondii K+ channel tetramerisation domain-containing protein 0.0017 0.0036 0.0396
Leishmania major hypothetical protein, conserved 0.0016 0.0032 0.0055
Trichomonas vaginalis ankyrin repeat and sam domain-containing protein, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Toxoplasma gondii sugar transporter ST3 0.0016 0.0031 0.0335
Brugia malayi Patatin-like phospholipase family protein 0.0016 0.0032 0.0016
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0023 0.0007
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.1138 1 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0116 0.0916 0.1363
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0034 0.0189 0.058
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0348 0.2975 0.2975
Giardia lamblia Hypothetical protein 0.017 0.1395 0.1368
Trichomonas vaginalis 2-5A-dependent ribonuclease, putative 0.0016 0.0032 0.0032
Echinococcus granulosus solute carrier family 22 0.0016 0.0031 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Leishmania major hypothetical protein, conserved 0.0017 0.0036 0.0069
Echinococcus multilocularis transfer RNA-Ile 0.0758 0.6621 1
Echinococcus granulosus calcium activated potassium channel 0.0017 0.0035 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0116 0.0916 0.1363
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0032 0.0166 0.0151
Trichomonas vaginalis mind bomb, putative 0.0016 0.0032 0.0032
Entamoeba histolytica protein kinase, putative 0.035 0.2994 0.2978
Loa Loa (eye worm) hypothetical protein 0.0036 0.0204 0.0188
Trypanosoma cruzi potassium voltage-gated channel, putative 0.0017 0.0036 0.0069
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0015
Onchocerca volvulus Putative transporter 0.0016 0.0031 0.0015
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Schistosoma mansoni ankyrin repeat domain protein 0.0016 0.0032 0.0025
Echinococcus multilocularis transient receptor potential cation channel 0.0015 0.0016 0.00000015602
Mycobacterium ulcerans thymidylate kinase 0.0087 0.0658 0.0629
Trypanosoma cruzi potassium voltage-gated channel 0.0017 0.0036 0.0069
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Trypanosoma brucei potassium voltage-gated channel, putative 0.0017 0.0036 0.0069
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0015
Trypanosoma brucei btb/poz domain containing protein, putative 0.0017 0.0036 0.0069
Schistosoma mansoni potassium channel tetramerization domain-containing 0.0017 0.0036 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0351 0.3004 1
Plasmodium falciparum kelch protein K13 0.0017 0.0036 0.0063
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.017 0.1395 0.1395
Schistosoma mansoni glucose transport protein 0.0116 0.0916 0.1363
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0016 0.0032 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0045 0.0099
Echinococcus multilocularis Ankyrin 0.0016 0.0032 0.0025
Schistosoma mansoni hypothetical protein 0.0017 0.0033 0.0026
Schistosoma mansoni protein kinase 0.0015 0.0023 0.0011
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Leishmania major glucose transporter/membrane transporter D2, putative 0.0036 0.0205 0.0635
Schistosoma mansoni thymidylate kinase 0.0087 0.0658 0.0973
Echinococcus granulosus transient receptor potential cation channel 0.0015 0.0016 0.00000015602
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0351 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0031 0.0162 0.1481
Echinococcus multilocularis solute carrier family 22 0.0016 0.0031 0.0023
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0031 0.0023
Echinococcus multilocularis potassium voltage gated channel protein 0.0032 0.0166 0.0228
Trichomonas vaginalis serine/threonine-protein kinase ripk4, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Giardia lamblia Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative 0.017 0.1395 0.1368
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Echinococcus multilocularis thymidine kinase 0.0758 0.6621 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1138 1 1
Trypanosoma brucei glucose transporter, putative 0.0036 0.0205 0.0635
Trypanosoma brucei BTB/POZ domain/Regulator of chromosome condensation (RCC1) repeat, putative 0.0017 0.0036 0.0069
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0016 0.0032 0.0032
Brugia malayi olfactory channel protein osm-9 0.0015 0.0016 0.00000010322
Echinococcus multilocularis solute carrier family 22 0.0016 0.0031 0.0023
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0052 0.0351 0.0336
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0032 0.0025
Trypanosoma brucei sugar transporter, putative 0.0016 0.0031 0.005
Entamoeba histolytica protein kinase, putative 0.035 0.2994 0.2978
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Echinococcus granulosus thymidine kinase 0.0758 0.6621 1
Loa Loa (eye worm) glutamate receptor 0.0015 0.0023 0.0007
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0045 0.029 0.0415
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.0016
Trichomonas vaginalis cortactin-binding protein, putative 0.0016 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0099 0.0768 0.1139
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0049 0.0321 0.1023
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0031 0.0162 0.0191
Entamoeba histolytica hypothetical protein 0.017 0.1395 0.1375
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0031 0.0162 0.0221
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0017 0.0036 0.0021
Trichomonas vaginalis glucose transporter, putative 0.0016 0.0031 0.0031
Schistosoma mansoni tyrosine kinase 0.0015 0.0023 0.0011
Schistosoma mansoni hypothetical protein 0.0017 0.0033 0.0026
Toxoplasma gondii transporter, cation channel family protein 0.0015 0.0016 0.017
Brugia malayi K+ channel tetramerisation domain containing protein 0.0017 0.0036 0.0021
Echinococcus multilocularis transient receptor potential cation channel 0.0015 0.0016 0.00000015602
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.003 0.0153 0.0208
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0916 0.0916
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Trichomonas vaginalis protein phosphatase 1 regulatory subunit 12B, putative 0.0016 0.0032 0.0032
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.003 0.0153 0.0208
Onchocerca volvulus 0.0015 0.0023 0.0007
Loa Loa (eye worm) glutamate receptor 1 0.003 0.0153 0.0138
Schistosoma mansoni 26S proteasome subunit 0.0016 0.0032 0.0025
Echinococcus granulosus Ankyrin 0.0016 0.0032 0.0025
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0033 0.0026
Trichomonas vaginalis centaurin beta, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Echinococcus multilocularis NADH ubiquinone oxidoreductase 42 kDa subunit 0.017 0.1395 0.2087
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0121 0.0353
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0017
Giardia lamblia Hypothetical protein 0.017 0.1395 0.1368
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.0016
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Plasmodium falciparum HP12 protein homolog, putative 0.0018 0.0045 0.0165
Loa Loa (eye worm) sugar transporter 0.0116 0.0916 0.0902
Onchocerca volvulus 0.0016 0.0031 0.0015
Onchocerca volvulus 0.0016 0.0031 0.0015
Brugia malayi Receptor family ligand binding region containing protein 0.0015 0.0023 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0032 0.0166 0.0151
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0049 0.0321 0.3282
Schistosoma mansoni hypothetical protein 0.0116 0.0916 0.1363
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0205 0.0205
Schistosoma mansoni hypothetical protein 0.003 0.0153 0.0208
Brugia malayi Metabotropic glutamate receptor precursor. 0.0015 0.0023 0.0007
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0116 0.0916 0.1363
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Echinococcus multilocularis nmda type glutamate receptor 0.0107 0.0838 0.1245
Echinococcus granulosus glutamate receptor ionotropic kainate 0.003 0.0153 0.0208
Loa Loa (eye worm) IRE protein kinase 0.035 0.2994 0.2983
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Entamoeba histolytica hypothetical protein 0.017 0.1395 0.1375
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0032 0.0166 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0166 0.0228
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0017 0.0036 0.0069
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0116 0.0916 0.1363
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0033 0.0026
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0036 0.0031
Trichomonas vaginalis thymidylate kinase, putative 0.0087 0.0658 0.0658
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0033 0.0017
Brugia malayi Uncoordinated protein 44 0.0016 0.0032 0.0016
Trypanosoma cruzi palmitoyl acyltransferase 1, putative 0.0016 0.0032 0.0055
Giardia lamblia Ankyrin 1 0.0016 0.0032 0.0001
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.003 0.0153 0.0208
Echinococcus granulosus BTB:POZ domain containing protein 0.0017 0.0036 0.0031
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0015 0.0023 0.0011
Schistosoma mansoni voltage-gated potassium channel 0.0388 0.3329 0.5017
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Echinococcus granulosus metabotropic glutamate receptor 2 0.0015 0.0023 0.0011
Echinococcus granulosus solute carrier family 22 0.0016 0.0031 0.0023
Loa Loa (eye worm) voltage-gated potassium channel 0.0032 0.0166 0.0151
Schistosoma mansoni glutamate receptor kainate 0.003 0.0153 0.0208
Trichomonas vaginalis serine threonine-protein kinase, putative 0.0348 0.2975 0.2975
Trypanosoma cruzi thymidylate kinase, putative 0.0087 0.0658 0.215
Leishmania major hypothetical protein, conserved 0.0034 0.0189 0.058
Leishmania major hypothetical protein, conserved 0.0016 0.0031 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0116 0.0916 0.1363
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0017 0.0036 0.0069
Echinococcus granulosus tankyrase 0.0016 0.0032 0.0025
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0049 0.0321 0.1023
Toxoplasma gondii sugar transporter ST2 0.0016 0.0031 0.0335
Onchocerca volvulus 0.0016 0.0031 0.0015
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0032 0.0166 0.0228
Trypanosoma brucei glucose transporter, putative 0.0036 0.0205 0.0635
Trichomonas vaginalis ankyrin, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Entamoeba histolytica hypothetical protein 0.017 0.1395 0.1375
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.003 0.0153 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0031 0.0031
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1138 1 1
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0016 0.0032 0.0032
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0034 0.0189 0.058
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Echinococcus granulosus voltage dependent calcium channel subunit 0.0192 0.1594 0.2389
Brugia malayi Methionine aminopeptidase protein type I 0.0049 0.0321 0.0306
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0045 0.029 0.0415
Loa Loa (eye worm) hypothetical protein 0.002 0.0059 0.0044
Plasmodium vivax K+ channel tetramerisation domain containing protein 0.0017 0.0036 0.0063
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.0016
Leishmania major ankyrin/TPR repeat protein 0.0016 0.0032 0.0055
Echinococcus multilocularis thymidine kinase 0.0758 0.6621 1
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0104 0.0809 0.0788
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Chlamydia trachomatis glutamine binding protein 0.0077 0.0571 0.8241
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0032 0.0166 0.0228
Schistosoma mansoni glucose transport protein 0.0116 0.0916 0.1363
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Onchocerca volvulus 0.0016 0.0031 0.0015
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0121 0.1321
Trypanosoma brucei thymidylate kinase, putative 0.0087 0.0658 0.215
Schistosoma mansoni hypothetical protein 0.0087 0.0658 0.0973
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Giardia lamblia DNA repair protein RAD52 0.0365 0.313 0.3108
Echinococcus multilocularis Ankyrin 0.0016 0.0032 0.0025
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Leishmania major hypothetical protein, conserved 0.0018 0.0045 0.0099
Trichomonas vaginalis protein phosphatase 1 regulatory subunit 12B, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis ankyrin repeat-rich membrane-spanning protein, putative 0.0016 0.0032 0.0032
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0031 0.0162 0.1481
Onchocerca volvulus 0.0017 0.0036 0.0021
Leishmania major hypothetical protein, conserved 0.0017 0.0036 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0205 0.0205
Echinococcus multilocularis glutamate receptor 2 0.0015 0.0023 0.0011
Trichomonas vaginalis TKL family protein kinase 0.0019 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0007
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0077 0.0571 0.8241
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0045 0.0099
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0031 0.0162 0.1766
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.00000010322
Loa Loa (eye worm) potassium channel tetramerisation domain containing 5 0.0017 0.0036 0.0021
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0031 0.0162 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0031 0.0031
Leishmania major glucose transporter, lmgt1 0.0036 0.0205 0.0635
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1138 1 1
Trichomonas vaginalis thymidylate kinase, putative 0.0087 0.0658 0.0658
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0031 0.0031
Echinococcus granulosus solute carrier family 22 0.0016 0.0031 0.0023
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0017 0.0036 0.0021
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0031 0.0162 0.2089
Echinococcus granulosus potassium voltage gated channel protein 0.0032 0.0166 0.0228
Schistosoma mansoni ATP-binding cassette transporter 0.003 0.0153 0.0208
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0205 0.0635
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0015
Onchocerca volvulus 0.0016 0.0031 0.0015
Trichomonas vaginalis cask-interacting protein (caskin) 1,2, putative 0.0016 0.0032 0.0032
Echinococcus multilocularis potassium voltage gated channel protein 0.0388 0.3329 0.5017
Echinococcus multilocularis NMDA receptor 0.003 0.0153 0.0208
Giardia lamblia CDC8 0.0087 0.0658 0.0629
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0031 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0032 0.0032
Echinococcus multilocularis receptor type guanylyl cyclase 0.0015 0.0023 0.0011
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0031 0.005
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0351 0.3004 1
Trypanosoma brucei glucose transporter, putative 0.0036 0.0205 0.0635
Plasmodium vivax thymidylate kinase, putative 0.0087 0.0658 0.7088
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0031 0.0015
Trypanosoma brucei Ankyrin repeats (many copies), putative 0.0016 0.0032 0.0055
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0077 0.0571 0.0542
Trichomonas vaginalis ankyrin, putative 0.0016 0.0032 0.0032
Trypanosoma brucei btb/poz domain containing protein, putative 0.0017 0.0036 0.0069
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0015
Echinococcus granulosus NADH ubiquinone oxidoreductase 42 kDa subunit 0.017 0.1395 0.2087
Trichomonas vaginalis unc-44 ankyrins, putative 0.0016 0.0032 0.0032
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0032 0.0166 0.0228
Trichomonas vaginalis hypothetical protein 0.0016 0.0032 0.0032
Schistosoma mansoni sugar transporter 0.0016 0.0031 0.0023
Echinococcus multilocularis nmda type glutamate receptor 0.0015 0.0023 0.0011
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0087 0.0658 0.0916
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0116 0.0916 0.1363
Loa Loa (eye worm) glutamate receptor 2 0.003 0.0153 0.0138
Loa Loa (eye worm) deoxynucleoside kinase 0.017 0.1395 0.1381
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0116 0.0916 0.1363
Loa Loa (eye worm) BRM protein 0.0036 0.021 0.0195
Giardia lamblia Kinase, NEK 0.0019 0.0051 0.002
Trichomonas vaginalis fibronectin type 3 and ankyrin repeat domains, putative 0.0016 0.0032 0.0032
Brugia malayi major facilitator superfamily protein 0.0016 0.0031 0.0015
Trichomonas vaginalis ion channel nompc, putative 0.0016 0.0032 0.0032
Brugia malayi hypothetical protein 0.0016 0.0031 0.0015
Toxoplasma gondii facilitative glucose transporter GT1 0.0116 0.0916 1
Trypanosoma cruzi glucose transporter, putative 0.0016 0.0031 0.005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0015
Schistosoma mansoni glutamate receptor NMDA 0.0045 0.029 0.0415
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0017 0.0036 0.0069
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.0016
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0045 0.029 0.0415
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1138 1 1
Loa Loa (eye worm) hypothetical protein 0.0388 0.3329 0.3319
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0049 0.0321 0.0463
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0015
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0031 0.0015
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0015 0.0023 0.0007
Trypanosoma brucei methionine aminopeptidase, putative 0.0049 0.0321 0.1023
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.017 0.1395 0.1375
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0016 0.0032 0.0025
Onchocerca volvulus 0.1138 1 1
Trichomonas vaginalis serine/threonine-protein kinase ripk4, putative 0.0016 0.0032 0.0032
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0023 0.0007
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.0758 0.6621 1
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0205 0.0205
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.017 0.1395 0.2087
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1138 1 1
Schistosoma mansoni hypothetical protein 0.0036 0.0204 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.017 0.1395 0.1395
Echinococcus granulosus nmda type glutamate receptor 0.0107 0.0838 0.1245
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0016 0.0032 0.0032
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0032 0.0032
Schistosoma mansoni transient receptor potential channel 0.0015 0.0016 0.00000015602
Echinococcus multilocularis tankyrase 0.0016 0.0032 0.0025
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0045 0.029 0.0415
Trichomonas vaginalis myo-inositol transporter, putative 0.0016 0.0031 0.0031
Trypanosoma cruzi extracellular receptor, putative 0.0015 0.0023 0.0024

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = 100 % Cytotoxicity against human CEM-SS cells assessed as cell viability at 10 uM after 6 days by MTS assay relative to control ChEMBL. 24102161
IC50 (binding) = 0.046 uM Inhibition of human recombinant mitochondrial thymidine kinase 2 assessed as inhibition of [methyl-3H]dThd phosphorylation after 30 mins by scintillation counting ChEMBL. 20218622
IC50 (binding) = 1.8 uM Inhibition of Drosophila melanogaster multifunctional deoxynucleoside kinase assessed as inhibition of [methyl-3H]dThd phosphorylation after 30 mins by scintillation counting ChEMBL. 20218622
IC50 (binding) = 27 uM Inhibition of HSV1 thymidine kinase assessed as inhibition of [methyl-3H]dThd phosphorylation after 30 mins by scintillation counting ChEMBL. 20218622
IC50 (binding) = 71 uM Inhibition of human recombinant cytosolic thymidine kinase 1 assessed as inhibition of [methyl-3H]dThd phosphorylation after 30 mins by scintillation counting ChEMBL. 20218622
Ki (binding) = 2.1 uM Competitive inhibition of Mycobacterium tuberculosis TMPK by Lineweaver-Burk analysis ChEMBL. 22061826

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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