Detailed information for compound 112061

Basic information

Technical information
  • TDR Targets ID: 112061
  • Name: 5-methyl-2-thiophen-2-yl-1,3-thiazol-4-ol
  • MW: 197.277 | Formula: C8H7NOS2
  • H donors: 1 H acceptors: 2 LogP: 2.71 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1nc(sc1C)c1cccs1
  • InChi: 1S/C8H7NOS2/c1-5-7(10)9-8(12-5)6-3-2-4-11-6/h2-4,10H,1H3
  • InChiKey: FZOJPSGILYRFTG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-methyl-2-(2-thienyl)thiazol-4-ol
  • 5-methyl-2-(2-thienyl)-4-thiazolol
  • 2H-473S
  • ZINC03116629
  • Bionet2_000125

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Arachidonate 5-lipoxygenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Diacylglycerol kinase theta 0.0169 0.1531 0.1521
Trichomonas vaginalis taga, putative 0.0032 0.0088 0.0238
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0222 0.0285
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0209 0.0198
Loa Loa (eye worm) hypothetical protein 0.0443 0.4424 0.5408
Loa Loa (eye worm) hypoxia-induced factor 1 0.0159 0.1427 0.1745
Brugia malayi hypoxia-induced factor 1 0.0159 0.1427 0.1836
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0216 0.2027 0.2478
Toxoplasma gondii ABC1 family protein 0.0041 0.0183 0.0848
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Loa Loa (eye worm) acetyltransferase 0.015 0.1327 0.1622
Echinococcus granulosus protein kinase c epsilon type 0.0562 0.5677 0.5672
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0088 0.0238
Loa Loa (eye worm) hypothetical protein 0.0041 0.0183 0.0223
Treponema pallidum nitrogen fixation protein (rnfC) 0.0074 0.0524 0.5
Brugia malayi C2 domain containing protein 0.0025 0.0012 0.0015
Brugia malayi C2 domain containing protein 0.0025 0.0012 0.0015
Brugia malayi C1-like domain containing protein 0.0308 0.2999 0.3857
Echinococcus granulosus raf serine:threonine protein kinase 0.0169 0.1531 0.1521
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0045 0.0222 0.0285
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Brugia malayi NEDD4.2 0.0025 0.0012 0.0015
Brugia malayi photoreceptor-specific nuclear receptor 0.0045 0.0222 0.0285
Brugia malayi C2 domain containing protein 0.0025 0.0012 0.0015
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0045 0.0222 0.021
Onchocerca volvulus 0.0307 0.2992 0.5062
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0183 0.0171
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0222 0.0285
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0183 0.0116
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0527 0.0516
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0804 0.8233 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.1282 0.1272
Brugia malayi RhoGEF domain containing protein 0.0169 0.1531 0.1969
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.033 0.3231 1
Brugia malayi Protein kinase domain containing protein 0.0026 0.0025 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0039 0.0086
Loa Loa (eye worm) hypothetical protein 0.0173 0.1579 0.193
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0045 0.0222 0.021
Loa Loa (eye worm) hypothetical protein 0.0303 0.2945 0.36
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0045 0.0222 0.0271
Loa Loa (eye worm) hypothetical protein 0.0041 0.0183 0.0223
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0369 0.0357
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0183 0.0531
Schistosoma mansoni thyroid hormone receptor 0.0172 0.1564 0.1554
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0032 0.0088 0.0238
Schistosoma mansoni thyroid hormone receptor 0.0172 0.1564 0.1554
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0216 0.2027 0.2478
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0369 0.0357
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0045 0.0222 0.021
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0045 0.0222 0.021
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0212 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0032 0.0088 0.0077
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0198 0.184 0.183
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.033 0.3231 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0369 0.0357
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0369 0.0357
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0174 0.1585 0.1576
Onchocerca volvulus 0.0044 0.0209 0.0336
Loa Loa (eye worm) hypothetical protein 0.0169 0.1531 0.1872
Loa Loa (eye worm) hypothetical protein 0.0045 0.0222 0.0271
Brugia malayi Synaptotagmin I 0.0025 0.0012 0.0015
Echinococcus granulosus single minded 2 0.0038 0.0149 0.0138
Echinococcus granulosus geminin 0.0164 0.1476 0.1466
Brugia malayi Synaptotagmin protein 3 0.0025 0.0012 0.0015
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.109 0.108
Brugia malayi Variant SH3 domain containing protein 0.003 0.0059 0.0076
Loa Loa (eye worm) hypothetical protein 0.017 0.1538 0.188
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0222 0.0285
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0369 0.0357
Entamoeba histolytica P-glyco protein 6, putative 0.0032 0.0088 0.0372
Loa Loa (eye worm) hypothetical protein 0.0041 0.0183 0.0223
Onchocerca volvulus 0.0303 0.2945 0.4981
Echinococcus granulosus chromobox protein 1 0.007 0.0483 0.0472
Schistosoma mansoni atypical protein kinase C 0.0693 0.7067 0.7064
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0088 0.0238
Echinococcus multilocularis thyroid hormone receptor alpha 0.0172 0.1564 0.1554
Echinococcus granulosus multidrug resistance protein 1 0.0032 0.0088 0.0077
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0032 0.0088 0.0077
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0045 0.0222 0.021
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0012 0.0015
Trichomonas vaginalis AGC family protein kinase 0.0216 0.2027 0.626
Loa Loa (eye worm) hypothetical protein 0.0045 0.0222 0.0271
Schistosoma mansoni multidrug resistance protein 0.0032 0.0088 0.0077
Leishmania major NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.033 0.3231 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0209 0.0256
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0369 0.0451
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0562 0.5677 0.694
Echinococcus granulosus intermediate filament protein 0.0026 0.0023 0.0011
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0209 0.0198
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0183 0.0531
Entamoeba histolytica hypothetical protein 0.0074 0.0527 0.25
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0169 0.1531 0.1521
Onchocerca volvulus Bile acid receptor homolog 0.0045 0.0222 0.0356
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0045 0.0222 0.0285
Schistosoma mansoni polycystin 1-related 0.0044 0.0209 0.0198
Onchocerca volvulus 0.0026 0.0023 0.0019
Schistosoma mansoni steroid hormone receptor ad4bp 0.0045 0.0222 0.021
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0032 0.0085 0.0073
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0216 0.2027 0.2018
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Echinococcus multilocularis serine threonine protein kinase 0.0802 0.8217 0.8215
Plasmodium falciparum LCCL domain-containing protein 0.0044 0.0209 1
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0169 0.1531 0.1872
Loa Loa (eye worm) RasGEF domain-containing protein 0.0169 0.1531 0.1872
Schistosoma mansoni rab6-interacting 0.0044 0.0209 0.0198
Loa Loa (eye worm) hypothetical protein 0.0169 0.1531 0.1872
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0045 0.0222 0.021
Toxoplasma gondii diacylglycerol kinase, putative 0.0169 0.1531 0.7538
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0032 0.0088 0.0381
Onchocerca volvulus 0.0055 0.033 0.0541
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0369 0.0357
Echinococcus granulosus serine:threonine protein kinase N2 0.0216 0.2027 0.2018
Entamoeba histolytica protein kinase, putative 0.022 0.2075 1
Mycobacterium ulcerans NADH dehydrogenase I subunit F 0.033 0.3231 0.3813
Echinococcus multilocularis chromobox protein 1 0.007 0.0483 0.0472
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0183 0.0223
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 51 kDa subunit 0.033 0.3231 0.395
Loa Loa (eye worm) hypothetical protein 0.0045 0.0222 0.0271
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0045 0.0222 0.0271
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0088 0.0238
Loa Loa (eye worm) hypothetical protein 0.0307 0.2992 0.3658
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0088 0.0238
Brugia malayi C2 domain containing protein 0.0025 0.0012 0.0015
Brugia malayi Copine VIII 0.0025 0.0012 0.0015
Trichomonas vaginalis abcb9, putative 0.0032 0.0088 0.0238
Loa Loa (eye worm) hypothetical protein 0.017 0.1538 0.188
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0209 0.0198
Schistosoma mansoni serine/threonine protein kinase 0.0216 0.2027 0.2018
Brugia malayi C2 domain containing protein 0.0025 0.0012 0.0015
Onchocerca volvulus 0.0041 0.0183 0.029
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0183 0.0171
Echinococcus multilocularis FTZ F1 alpha 0.0045 0.0222 0.021
Plasmodium vivax multidrug resistance protein 1, putative 0.0032 0.0088 0.3831
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0032 0.0088 0.0238
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0088 0.0238
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0045 0.0222 0.021
Schistosoma mansoni lipoxygenase 0.0198 0.184 0.183
Brugia malayi Protein kinase domain containing protein 0.0216 0.2027 0.2607
Echinococcus multilocularis RUN 0.0044 0.0209 0.0198
Echinococcus multilocularis Rac GTPase activating protein 1 0.0169 0.1531 0.1521
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0222 0.021
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.1327 0.1317
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0561 0.5673 0.5668
Echinococcus multilocularis chromobox protein 1 0.007 0.0483 0.0472
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0088 0.0238
Brugia malayi beta-lactamase family protein 0.0041 0.0183 0.0235
Echinococcus granulosus chromobox protein 1 0.007 0.0483 0.0472
Toxoplasma gondii hypothetical protein 0.017 0.1538 0.7571
Loa Loa (eye worm) hypothetical protein 0.0134 0.1161 0.142
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0222 0.021
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0183 0.0531
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0222 0.021
Loa Loa (eye worm) hypothetical protein 0.0169 0.1531 0.1872
Entamoeba histolytica diacylglycerol kinase, putative 0.0169 0.1531 0.7364
Schistosoma mansoni hypothetical protein 0.0164 0.1476 0.1466
Schistosoma mansoni diacylglycerol kinase theta 0.0169 0.1531 0.1521
Trichomonas vaginalis AGC family protein kinase 0.022 0.2075 0.6408
Brugia malayi beta-lactamase family protein 0.0041 0.0183 0.0235
Schistosoma mansoni vav2 0.0173 0.1579 0.1569
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0032 0.0088 0.5
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0088 0.0238
Schistosoma mansoni rab6-interacting 0.0044 0.0209 0.0198
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0216 0.2027 0.2478
Loa Loa (eye worm) steroid hormone receptor 0.0045 0.0222 0.0271
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0212 0.0994
Echinococcus multilocularis serine:threonine protein kinase N2 0.0368 0.363 0.3622
Brugia malayi hypothetical protein 0.0443 0.4424 0.569
Brugia malayi Protein kinase domain containing protein 0.0174 0.1585 0.2039
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0211 0.1973 0.6091
Brugia malayi jmjC domain containing protein 0.0059 0.0369 0.0474
Brugia malayi Doublecortin family protein 0.0044 0.0209 0.0269
Loa Loa (eye worm) hypothetical protein 0.0045 0.0222 0.0271
Echinococcus granulosus RNA directed DNA polymerase 0.0561 0.5673 0.5668
Echinococcus granulosus myotubularin protein 13 0.0173 0.1579 0.1569
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0194 0.1795 0.1785
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0045 0.0222 0.0271
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0088 0.0238
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Schistosoma mansoni protein kinase C mu 0.0169 0.1531 0.1521
Brugia malayi steroid hormone receptor 0.0045 0.0222 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0045 0.0222 0.0271
Plasmodium falciparum multidrug resistance protein 1 0.0032 0.0088 0.3885
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0045 0.0222 0.021
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0263 0.2526 0.2993
Echinococcus multilocularis lamin dm0 0.0026 0.0023 0.0011
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Trichomonas vaginalis ABC transporter, putative 0.0032 0.0088 0.0238
Schistosoma mansoni hypothetical protein 0.0169 0.1531 0.1521
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0045 0.0222 0.0285
Echinococcus multilocularis musashi 0.0026 0.0023 0.0011
Loa Loa (eye worm) variant SH3 domain-containing protein 0.003 0.0059 0.0073
Trichomonas vaginalis abcb9, putative 0.0032 0.0088 0.0238
Brugia malayi p70 ribosomal S6 kinase beta 0.0216 0.2027 0.2607
Echinococcus multilocularis myotubularin protein 13 0.0173 0.1579 0.1569
Leishmania major p-glycoprotein 0.0032 0.0088 0.0238
Loa Loa (eye worm) hypothetical protein 0.0583 0.59 0.7213
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0045 0.0222 0.0285
Brugia malayi Synapse defective protein 1 0.0025 0.0012 0.0015
Mycobacterium tuberculosis Conserved protein 0.0041 0.0183 0.0116
Brugia malayi multidrug resistance protein 3 0.0032 0.0088 0.0114
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0183 0.0116
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0032 0.0088 0.0077
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0088 0.0238
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.1327 0.1317
Onchocerca volvulus 0.0583 0.59 1
Loa Loa (eye worm) synaptotagmin-1 0.0025 0.0012 0.0014
Onchocerca volvulus 0.0026 0.0025 0.0022
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0025 0.0012 0.0015
Brugia malayi Pleckstrin Homology Domain 0.0173 0.1579 0.203
Schistosoma mansoni retinoic acid receptor RXR 0.0045 0.0222 0.021
Entamoeba histolytica hypothetical protein 0.0074 0.0527 0.25
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0169 0.1531 0.1521
Entamoeba histolytica diacylglycerol kinase, putative 0.0169 0.1531 0.7364
Schistosoma mansoni lozenge 0.0056 0.0334 0.0323
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0183 0.0116
Brugia malayi C2 domain containing protein 0.0025 0.0012 0.0015
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Brugia malayi C2 domain containing protein 0.0025 0.0012 0.0015
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0183 0.0235
Brugia malayi RhoGAP domain containing protein 0.0169 0.1531 0.1969
Schistosoma mansoni serine/threonine protein kinase 0.0562 0.5677 0.5672
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0032 0.0088 0.0077
Brugia malayi C2 domain containing protein 0.0025 0.0012 0.0015
Brugia malayi beta-lactamase 0.0041 0.0183 0.0235
Entamoeba histolytica protein kinase, putative 0.003 0.0066 0.0264
Brugia malayi C2 domain containing protein 0.0025 0.0012 0.0015
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0308 0.2999 0.3666
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0104
Plasmodium vivax multidomain scavenger receptor, putative 0.0044 0.0209 0.9862
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0173 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0023 0.0029
Schistosoma mansoni single-minded 0.0051 0.029 0.0279
Loa Loa (eye worm) hypothetical protein 0.0799 0.818 1
Echinococcus granulosus survival motor neuron protein 1 0.0271 0.2604 0.2595
Brugia malayi ABC transporter family protein 0.0032 0.0088 0.0114
Brugia malayi ecdysteroid receptor 0.0045 0.0222 0.0285
Mycobacterium ulcerans beta-lactamase 0.0041 0.0183 0.0041
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Loa Loa (eye worm) Nedd4-PD 0.0025 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0169 0.1531 0.1872
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0212 0.0622
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0308 0.2999 0.3857
Loa Loa (eye worm) hypothetical protein 0.0041 0.0183 0.0223
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0045 0.0222 0.0271
Schistosoma mansoni multidrug resistance protein 0.0032 0.0088 0.0077
Brugia malayi NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor 0.033 0.3231 0.4156
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0183 0.0531
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0483 0.4842 0.5919
Loa Loa (eye worm) C2 domain-containing protein 0.0025 0.0012 0.0014
Onchocerca volvulus 0.0026 0.0023 0.0019
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0804 0.8233 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0183 0.0116
Onchocerca volvulus 0.0443 0.4424 0.7493
Loa Loa (eye worm) hypothetical protein 0.017 0.1538 0.188
Echinococcus granulosus NADH dehydrogenase ubiquinone flavoprotein 1 0.033 0.3231 0.3223
Brugia malayi PAS domain containing protein 0.0051 0.029 0.0373
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0183 0.0531
Trichomonas vaginalis ABC transporter, putative 0.0032 0.0088 0.0238
Brugia malayi nuclear receptor NHR-88 0.0045 0.0222 0.0285
Loa Loa (eye worm) hypothetical protein 0.0031 0.0071 0.0086
Echinococcus multilocularis ATP binding cassette sub family B 0.0032 0.0085 0.0073
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0212 0.0201
Loa Loa (eye worm) AGC/NDR protein kinase 0.0216 0.2027 0.2478
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0023 0.0028
Echinococcus multilocularis N chimaerin 0.0169 0.1531 0.1521
Echinococcus granulosus lamin 0.0026 0.0023 0.0011
Echinococcus granulosus Diacylglycerol kinase theta 0.0169 0.1531 0.1521
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0088 0.0238
Loa Loa (eye worm) hypothetical protein 0.0032 0.0088 0.0108
Schistosoma mansoni rac gtpase activating protein 0.0169 0.1531 0.1521
Onchocerca volvulus 0.0041 0.0183 0.029
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0032 0.0088 0.0108
Loa Loa (eye worm) hypothetical protein 0.0169 0.1531 0.1872
Echinococcus multilocularis ecdysone induced protein 78C 0.0045 0.0222 0.021
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0045 0.0222 0.0271
Loa Loa (eye worm) C2 domain-containing protein 0.0025 0.0012 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0222 0.0285
Brugia malayi WW domain containing protein 0.0025 0.0012 0.0015
Loa Loa (eye worm) hypothetical protein 0.0041 0.0183 0.0223
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0369 0.0357
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0209 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.016 0.046
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0222 0.0285
Schistosoma mansoni serine/threonine protein kinase 0.0216 0.2027 0.2018
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0191 0.0557
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0045 0.0222 0.0285
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0591 0.5992 0.7325
Brugia malayi RhoGAP domain containing protein 0.0169 0.1531 0.1969
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Brugia malayi chromobox protein homolog 3 0.0039 0.016 0.0205
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.033 0.3231 1
Echinococcus granulosus N chimaerin 0.0169 0.1531 0.1521
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.033 0.0425
Loa Loa (eye worm) AGC/AKT protein kinase 0.022 0.2075 0.2537
Schistosoma mansoni lamin 0.0026 0.0023 0.0011
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0216 0.2027 0.2478
Schistosoma mansoni multidrug resistance protein 0.0032 0.0088 0.0077
Brugia malayi hypothetical protein 0.0044 0.0209 0.0269
Onchocerca volvulus 0.0032 0.0088 0.013
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0583 0.59 0.7213
Loa Loa (eye worm) hypothetical protein 0.073 0.7457 0.9116
Schistosoma mansoni hypothetical protein 0.0127 0.109 0.108
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0088 0.0238
Brugia malayi Variant SH3 domain containing protein 0.0169 0.1531 0.1969
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.1327 0.1706
Echinococcus multilocularis unc 13 (munc13) 0.0194 0.1795 0.1785
Echinococcus multilocularis raf serine:threonine protein kinase 0.0169 0.1531 0.1521
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0025 0.0012 0.0014
Mycobacterium tuberculosis Conserved hypothetical protein 0.0074 0.0524 0.0535
Brugia malayi C2 domain containing protein 0.0025 0.0012 0.0015
Loa Loa (eye worm) copine family protein 0.0025 0.0012 0.0014
Brugia malayi hypothetical protein 0.0271 0.2604 0.3349
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0183 0.0116
Schistosoma mansoni hypothetical protein 0.0055 0.033 0.0319
Entamoeba histolytica P-glycoprotein 5, putative 0.0032 0.0088 0.0372
Echinococcus granulosus lamin dm0 0.0026 0.0023 0.0011
Brugia malayi hypothetical protein 0.0044 0.0209 0.0269
Brugia malayi C2 domain containing protein 0.0025 0.0012 0.0015
Trichomonas vaginalis AGC family protein kinase 0.022 0.2075 0.6408
Echinococcus multilocularis serine:threonine protein kinase 38 0.0216 0.2027 0.2018
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0045 0.0222 0.021
Mycobacterium ulcerans hypothetical protein 0.0041 0.0183 0.0041
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0032 0.0088 0.0077
Echinococcus granulosus Polycystic kidney disease protein 0.0044 0.0209 0.0198
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0183 0.0531
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0194 0.1795 0.2195
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0191 0.0305
Loa Loa (eye worm) hypothetical protein 0.0026 0.0023 0.0028
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0183 0.0171
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.033 0.3231 0.3223
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0045 0.0222 0.0285
Brugia malayi Heterochromatin protein 1 0.007 0.0483 0.0621
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase I subunit F 0.033 0.3231 0.5
Brugia malayi diacylglycerol kinase 0.0169 0.1531 0.1969
Brugia malayi intermediate filament protein 0.0026 0.0023 0.0029
Echinococcus granulosus multidrug resistance protein 1 0.0032 0.0088 0.0077
Loa Loa (eye worm) hypothetical protein 0.0045 0.0222 0.0271
Loa Loa (eye worm) C2 domain-containing protein 0.0025 0.0012 0.0014
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) flavoprotein 1 0.033 0.3231 0.3223
Entamoeba histolytica protein kinase, putative 0.022 0.2075 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0183 0.0116
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0191 0.0557
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0216 0.2027 0.2018
Mycobacterium ulcerans lipase LipD 0.0041 0.0183 0.0041
Loa Loa (eye worm) hypothetical protein 0.0583 0.59 0.7213
Schistosoma mansoni smdr2 0.0032 0.0088 0.0077
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0088 0.0238
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0183 0.8527
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0088 0.0238
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Brugia malayi C2 domain containing protein 0.0025 0.0012 0.0015
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0173 0.8182
Schistosoma mansoni lipoxygenase 0.0119 0.1009 0.0999
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0216 0.2027 0.2018
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0032 0.0088 0.0077
Schistosoma mansoni serine/threonine protein kinase 0.0971 1 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.1161 0.142
Echinococcus multilocularis protein kinase c epsilon type 0.0562 0.5677 0.5672
Schistosoma mansoni protein kinase C 0.0194 0.1795 0.1785
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0045 0.0222 0.021
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0088 0.0238
Trichomonas vaginalis AGC family protein kinase 0.022 0.2075 0.6408
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0183 0.0041
Brugia malayi LD23056p 0.0025 0.0012 0.0015
Mycobacterium tuberculosis Conserved protein 0.0041 0.0183 0.0116
Brugia malayi calpain 5 0.0025 0.0012 0.0015
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0025 0.0012 0.0014
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0222 0.021
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0149 0.0192
Trichomonas vaginalis chromobox protein, putative 0.007 0.0483 0.1463
Loa Loa (eye worm) C2 domain-containing protein 0.0025 0.0012 0.0014
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.016 0.0251
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.109 0.108
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0032 0.0088 0.0238
Entamoeba histolytica PH domain containing protein kinase, putative 0.0161 0.1452 0.6982
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0045 0.0222 0.021
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0088 0.0238
Schistosoma mansoni coup transcription factor 0.0045 0.0222 0.021
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0183 0.0531
Brugia malayi C2 domain containing protein 0.0025 0.0012 0.0015
Brugia malayi Protein kinase domain containing protein 0.022 0.2075 0.2669
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0183 0.0041
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Brugia malayi Protein kinase c protein 2 0.076 0.7775 1
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0149 0.0138
Brugia malayi Copine family protein 0.0025 0.0012 0.0015
Schistosoma mansoni serine/threonine protein kinase 0.0174 0.1585 0.1576
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0045 0.0222 0.021
Toxoplasma gondii AGC kinase 0.0216 0.2027 1
Schistosoma mansoni lamin 0.0026 0.0023 0.0011
Trichomonas vaginalis ABC transporter, putative 0.0032 0.0088 0.0238
Schistosoma mansoni protein kinase C mu 0.0308 0.2999 0.2991
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0169 0.1531 0.1521
Trichomonas vaginalis chromobox protein, putative 0.007 0.0483 0.1463
Onchocerca volvulus NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog 0.0177 0.1615 0.2723
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0527 0.0516
Brugia malayi Hr1 repeat family protein 0.0216 0.2027 0.2607
Brugia malayi Synapse defective protein 1 0.0025 0.0012 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0045 0.0222 0.0271
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0088 0.0238
Echinococcus granulosus NDR protein kinase 0.0216 0.2027 0.2018
Schistosoma mansoni unc-13 (munc13) 0.0194 0.1795 0.1785
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0032 0.0088 0.0077
Trichomonas vaginalis AGC family protein kinase 0.0216 0.2027 0.626
Trichomonas vaginalis abcb9, putative 0.0032 0.0088 0.0238
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0169 0.1531 0.1872
Brugia malayi Ras association domain family 1 isoform A 0.0169 0.1531 0.1969
Trichomonas vaginalis AGC family protein kinase 0.022 0.2075 0.6408
Loa Loa (eye worm) hypothetical protein 0.0752 0.7684 0.9393
Echinococcus multilocularis multidrug resistance protein 1 0.0032 0.0088 0.0077
Brugia malayi protein kinase C II. 0.0562 0.5677 0.7301
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0026 0.0025 0.003
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0169 0.1531 0.1872
Loa Loa (eye worm) hypothetical protein 0.0032 0.0088 0.0108
Trichomonas vaginalis AGC family protein kinase 0.022 0.2075 0.6408
Mycobacterium ulcerans proteasome PrcA 0.0804 0.8233 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0157 0.1404 0.1394
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) 0.033 0.3231 0.3859
Echinococcus multilocularis protein kinase c iota type 0.0672 0.6844 0.6841
Schistosoma mansoni hypothetical protein 0.0164 0.1476 0.1466
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0169 0.1531 0.1521
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0045 0.0222 0.021
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0183 0.0116
Onchocerca volvulus 0.0031 0.0071 0.01
Entamoeba histolytica protein kinase, putative 0.003 0.0066 0.0264
Echinococcus multilocularis protein kinase c eta type 0.0169 0.1531 0.1521
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0039 0.0086
Schistosoma mansoni hypothetical protein 0.0044 0.0209 0.0198
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0971 1 1
Schistosoma mansoni diacylglycerol kinase theta 0.0169 0.1531 0.1521
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0173 0.0784
Brugia malayi Protein kinase domain containing protein 0.0216 0.2027 0.2607
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0483 0.059
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0032 0.0088 0.0077
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0174 0.1585 0.1576
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0045 0.0222 0.0285
Echinococcus multilocularis survival motor neuron protein 1 0.0271 0.2604 0.2595
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0216 0.2027 0.2018
Entamoeba histolytica protein kinase, putative 0.0216 0.2027 0.9769
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0088 0.0238
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0198 0.184 0.183
Leishmania major hypothetical protein, conserved 0.0041 0.0183 0.0531
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0183 0.0171
Trichomonas vaginalis AGC family protein kinase 0.022 0.2075 0.6408
Loa Loa (eye worm) hypothetical protein 0.0172 0.1568 0.1917
Entamoeba histolytica hypothetical protein 0.0169 0.1531 0.7364
Entamoeba histolytica P-glycoprotein-2, putative 0.0032 0.0088 0.0372
Entamoeba histolytica P-glycoprotein-5 0.0032 0.0088 0.0372
Loa Loa (eye worm) hypothetical protein 0.0561 0.5673 0.6936
Onchocerca volvulus 0.0045 0.0222 0.0356
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0183 0.0531
Schistosoma mansoni chromobox protein 0.007 0.0483 0.0472
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0222 0.0285
Loa Loa (eye worm) hypothetical protein 0.0443 0.4424 0.5408
Entamoeba histolytica P-glycoprotein-1 0.0032 0.0088 0.0372
Schistosoma mansoni serine/threonine protein kinase 0.0169 0.1531 0.1521
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0194 0.1795 0.1785
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.017 0.1538 0.188
Loa Loa (eye worm) hypothetical protein 0.0045 0.0222 0.0271
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.029 0.0279
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0222 0.021
Echinococcus multilocularis geminin 0.0164 0.1476 0.1466
Schistosoma mansoni RAR-like nuclear receptor 0.0045 0.0222 0.021
Schistosoma mansoni survival motor neuron protein 0.0055 0.033 0.0319
Onchocerca volvulus 0.0044 0.0209 0.0336
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0212 0.0994
Loa Loa (eye worm) runx1 0.0056 0.0334 0.0409
Onchocerca volvulus 0.0134 0.1161 0.1952
Schistosoma mansoni serine/threonine protein kinase 0.0971 1 1
Schistosoma mansoni unc-13 (munc13) 0.0194 0.1795 0.1785
Loa Loa (eye worm) hypothetical protein 0.0039 0.016 0.0195
Echinococcus granulosus FTZ F1 alpha 0.0045 0.0222 0.021
Onchocerca volvulus 0.0194 0.1795 0.3029
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0216 0.2027 0.2018
Brugia malayi protein kinase C3,putative 0.0461 0.4619 0.5941
Loa Loa (eye worm) multidrug resistance protein 3 0.0032 0.0088 0.0108
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0088 0.0238
Echinococcus granulosus RUN 0.0044 0.0209 0.0198
Echinococcus multilocularis Protein lozenge 0.0056 0.0334 0.0323
Echinococcus granulosus protein kinase c iota type 0.0672 0.6844 0.6841
Entamoeba histolytica P-glycoprotein-2 0.0032 0.0088 0.0372
Trichomonas vaginalis AGC family protein kinase 0.0216 0.2027 0.626
Brugia malayi hypothetical protein 0.0172 0.1568 0.2017
Entamoeba histolytica P-glycoprotein-2 0.0032 0.0088 0.0372
Trichomonas vaginalis esterase, putative 0.0041 0.0183 0.0531
Onchocerca volvulus 0.0038 0.0149 0.0234
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0216 0.2027 0.2018
Loa Loa (eye worm) hypothetical protein 0.0045 0.0222 0.0271
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0088 0.0238
Entamoeba histolytica hypothetical protein 0.0074 0.0527 0.25
Echinococcus granulosus protein kinase C gamma type 0.0802 0.8217 0.8215
Trichomonas vaginalis ABC transporter, putative 0.0032 0.0088 0.0238
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0045 0.0222 0.021
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0.033 0.3231 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.1531 0.1872
Echinococcus granulosus protein kinase c eta type 0.0169 0.1531 0.1521
Echinococcus granulosus ecdysone induced protein 78C 0.0045 0.0222 0.021
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0527 0.0516
Brugia malayi C2 domain containing protein 0.0025 0.0012 0.0015
Echinococcus granulosus Rac GTPase activating protein 1 0.0169 0.1531 0.1521
Schistosoma mansoni serine/threonine kinase 0.0216 0.2027 0.2018
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0212 0.0622
Loa Loa (eye worm) raf kinase 0.0169 0.1531 0.1872
Loa Loa (eye worm) C2 domain-containing protein 0.0025 0.0012 0.0014
Loa Loa (eye worm) C2 domain-containing protein 0.0025 0.0012 0.0014
Trichomonas vaginalis AGC family protein kinase 0.022 0.2075 0.6408
Loa Loa (eye worm) beta-lactamase 0.0041 0.0183 0.0223
Schistosoma mansoni hypothetical protein 0.0074 0.0527 0.0516
Echinococcus multilocularis RNA directed DNA polymerase 0.0561 0.5673 0.5668
Schistosoma mansoni loxhd1 0.0044 0.0209 0.0198
Onchocerca volvulus Protein ultraspiracle homolog 0.0045 0.0222 0.0356
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative 0.033 0.3231 1
Echinococcus granulosus unc 13 munc13 0.0194 0.1795 0.1785
Entamoeba histolytica hypothetical protein 0.0074 0.0527 0.25
Echinococcus granulosus multidrug resistance protein 1 0.0032 0.0088 0.0077
Mycobacterium ulcerans membrane protein ComEA 0.0074 0.0524 0.0464
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.016 0.046
Loa Loa (eye worm) doublecortin family protein 0.0044 0.0209 0.0256
Loa Loa (eye worm) hypothetical protein 0.0041 0.0183 0.0223
Loa Loa (eye worm) hypothetical protein 0.0044 0.0209 0.0256
Schistosoma mansoni serine/threonine protein kinase 0.0174 0.1585 0.1576
Brugia malayi phospholipase C homolog 0.0025 0.0012 0.0015
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0088 0.0238
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0045 0.0222 0.0356
Echinococcus multilocularis serine:threonine protein kinase N2 0.0216 0.2027 0.2018
Brugia malayi nuclear hormone receptor 0.0045 0.0222 0.0285
Mycobacterium tuberculosis Conserved protein 0.0041 0.0183 0.0116
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.033 0.3231 1
Trichomonas vaginalis AGC family protein kinase 0.022 0.2075 0.6408
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0222 0.0285
Schistosoma mansoni serine/threonine protein kinase 0.0216 0.2027 0.2018
Brugia malayi hypothetical protein 0.0074 0.0527 0.0678
Brugia malayi jmjC domain containing protein 0.0059 0.0369 0.0474
Schistosoma mansoni serine/threonine protein kinase 0.0216 0.2027 0.2018
Brugia malayi Steroid receptor seven-up type 2 0.0045 0.0222 0.0285
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0032 0.0088 0.0381
Echinococcus multilocularis multidrug resistance protein 1 0.0032 0.0088 0.0077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0222 0.021
Loa Loa (eye worm) AGC/PKN protein kinase 0.0216 0.2027 0.2478
Schistosoma mansoni intermediate filament proteins 0.0026 0.0023 0.0011
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0023 0.0028
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0032 0.0088 0.0077
Schistosoma mansoni chromobox protein 0.007 0.0483 0.0472
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0139 0.1216 0.1486
Brugia malayi diacylglycerol kinase 0.0169 0.1531 0.1969
Entamoeba histolytica protein kinase, putative 0.0216 0.2027 0.9769
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0014
Onchocerca volvulus 0.0041 0.0183 0.029
Trypanosoma brucei rac serine-threonine kinase, putative 0.022 0.2075 0.6408
Echinococcus multilocularis Polycystic kidney disease protein 0.0044 0.0209 0.0198
Loa Loa (eye worm) hypothetical protein 0.0271 0.2604 0.3183
Echinococcus multilocularis lamin 0.0026 0.0023 0.0011
Loa Loa (eye worm) hypothetical protein 0.0045 0.0222 0.0271

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.4 uM In vitro inhibition of 5-lipoxygenase (5-lo) from the 20000 g supernatant of RBI-1 cells ChEMBL. 2066989
IC50 (binding) = 1.4 uM In vitro inhibition of 5-lipoxygenase (5-lo) from the 20000 g supernatant of RBI-1 cells ChEMBL. 2066989

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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