Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0128 | 0.2886 | 0.7701 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0323 | 0.9395 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.2886 | 0.2886 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.026 | 0.026 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0158 | 0.3894 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0323 | 0.9395 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0128 | 0.2886 | 0.2886 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0092 | 0.1699 | 0.4533 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.0256 | 0.0256 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.026 | 0.0695 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.0256 | 0.0256 |
Brugia malayi | RNA binding protein | 0.0128 | 0.2886 | 0.7701 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0323 | 0.9395 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0256 | 0.0256 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.1699 | 0.4533 |
Schistosoma mansoni | hypothetical protein | 0.0341 | 1 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0323 | 0.9395 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0128 | 0.2886 | 0.7701 |
Echinococcus multilocularis | GPCR, family 2 | 0.0049 | 0.0256 | 0.0256 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.2886 | 0.2886 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.026 | 0.026 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0049 | 0.0256 | 0.0683 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0158 | 0.3894 | 1 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0092 | 0.1699 | 0.1699 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.2132 | 0.2132 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0323 | 0.9395 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.2886 | 0.2886 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0153 | 0.3748 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0256 | 0.0256 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.2132 | 0.5688 |
Echinococcus granulosus | GPCR family 2 | 0.0049 | 0.0256 | 0.0256 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0049 | 0.0256 | 0.0683 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0323 | 0.9395 | 1 |
Echinococcus multilocularis | geminin | 0.0341 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.026 | 0.026 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0256 | 0.0256 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0041 | 0 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0323 | 0.9395 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.0256 | 0.0256 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0092 | 0.1699 | 0.1699 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0041 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0128 | 0.2886 | 0.2886 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0323 | 0.9395 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0105 | 0.2132 | 0.5688 |
Brugia malayi | TAR-binding protein | 0.0128 | 0.2886 | 0.7701 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0049 | 0.0256 | 0.0683 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0256 | 0.0256 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.0256 | 0.0256 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.026 | 0.026 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0323 | 0.9395 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0153 | 0.3748 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0128 | 0.2886 | 0.7701 |
Schistosoma mansoni | hypothetical protein | 0.0341 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.2886 | 0.2886 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0256 | 0.0683 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.026 | 0.0695 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0323 | 0.9395 | 1 |
Onchocerca volvulus | 0.0092 | 0.1699 | 0.5 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.026 | 0.026 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0158 | 0.3894 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.2886 | 0.2886 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.3748 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0041 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0153 | 0.3748 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0128 | 0.2886 | 0.7701 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.026 | 0.026 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0323 | 0.9395 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.026 | 0.026 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0041 | 0 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0323 | 0.9395 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0092 | 0.1699 | 0.1699 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | > 23.1 uM | Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay | ChEMBL. | 21885166 |
GI50 (functional) | > 23.1 uM | Cytotoxicity against human A549 cells after 72 hrs by SRB assay | ChEMBL. | 21885166 |
GI50 (functional) | > 23.1 uM | Cytotoxicity against human HT-29 cells after 72 hrs by SRB assay | ChEMBL. | 21885166 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.