Detailed information for compound 112091

Basic information

Technical information
  • TDR Targets ID: 112091
  • Name: (2S)-2-amino-5-(diaminomethylideneamino)-N-(4 -nitrophenyl)pentanamide
  • MW: 294.31 | Formula: C12H18N6O3
  • H donors: 4 H acceptors: 3 LogP: -0.78 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@H](C(=O)Nc1ccc(cc1)[N+](=O)[O-])CCCN=C(N)N
  • InChi: 1S/C12H18N6O3/c13-10(2-1-7-16-12(14)15)11(19)17-8-3-5-9(6-4-8)18(20)21/h3-6,10H,1-2,7,13H2,(H,17,19)(H4,14,15,16)/t10-/m0/s1
  • InChiKey: TWYRZWVFWYSNBU-JTQLQIEISA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-amino-5-guanidino-N-(4-nitrophenyl)pentanamide
  • (2S)-2-azanyl-5-[bis(azanyl)methylideneamino]-N-(4-nitrophenyl)pentanamide
  • (2S)-2-amino-5-guanidino-N-(4-nitrophenyl)valeramide
  • arginine-4-nitroanilide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0028 0.003 0.003
Brugia malayi RNase H family protein 0.0023 0.0022 0.0022
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.0137 0.316
Schistosoma mansoni rotamase 0.0034 0.0039 0.0166
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0001
Echinococcus multilocularis ryanodine receptor 44f 0.0018 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0013
Plasmodium vivax vivapain-2 0.0017 0.0013 0.005
Echinococcus granulosus potassium voltage gated channel protein 0.0018 0.0014 0.0061
Echinococcus granulosus hypothetical protein 0.0018 0.0014 0.0061
Toxoplasma gondii cathepsin CPL 0.0017 0.0013 0.0041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0131 0.0561
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0013
Trichomonas vaginalis esterase, putative 0.0072 0.0098 0.2295
Plasmodium falciparum glutathione reductase 0.0017 0.0013 0.005
Plasmodium vivax SET domain protein, putative 0.0036 0.0043 0.0167
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0142 0.0142
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0013 0.0302
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0001
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0052 0.0203
Brugia malayi ecdysteroid receptor 0.001 0.0003 0.0003
Brugia malayi Smad1 0.001 0.0001 0.0001
Trichomonas vaginalis ribonuclease H1, putative 0.0023 0.0022 0.0508
Chlamydia trachomatis pyruvate kinase 0.0034 0.0039 0.3038
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.003 0.0029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0013 0.0302
Echinococcus granulosus microtubule associated protein 2 0.1502 0.2342 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.003 0.0254
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.003 0.0709
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.003 0.0254
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0018 0.0014 0.0061
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0424 0.0651 0.278
Leishmania major fatty acid elongase, putative 0.1651 0.2576 1
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0014 0.0061
Leishmania major DNA polymerase eta, putative 0.0013 0.0007 0.0017
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0038 0.0138
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0424 0.0651 0.278
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.003 0.0254
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0039 0.0151
Brugia malayi beta-lactamase family protein 0.0072 0.0098 0.0098
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0014 0.0061
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0014 0.0061
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0018 0.0014 0.0014
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0013 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0007 0.0026
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0052 0.1218
Echinococcus multilocularis two pore calcium channel protein 1 0.0018 0.0014 0.0061
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0000017 0.0000072577
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0018 0.0014 0.0061
Leishmania major hypothetical protein, unknown function 0.0018 0.0014 0.0046
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0052 0.0223
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0424 0.0651 0.278
Brugia malayi olfactory channel protein osm-9 0.0018 0.0014 0.0014
Schistosoma mansoni coup transcription factor 0.001 0.0003 0.0011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0052 0.0203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0088 0.0341
Loa Loa (eye worm) hypothetical protein 0.0096 0.0137 0.0135
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0025 0.0096
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0024 0.0165
Trypanosoma brucei ingi protein (ORF1) 0.0025 0.0025 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0007 0.0026
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0018 0.0014 0.0061
Echinococcus granulosus sodium leak channel non selective protein 0.0018 0.0014 0.0061
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0003 0.0011
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0003 0.0011
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0424 0.0651 0.278
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0014 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.003 0.0576
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0018 0.0014 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0088 0.0341
Brugia malayi hypothetical protein 0.0446 0.0685 0.0685
Echinococcus granulosus short transient receptor potential channel 6 0.0018 0.0014 0.0061
Leishmania major pyruvate kinase 0.0034 0.0039 0.0142
Brugia malayi Pre-SET motif family protein 0.0036 0.0043 0.0043
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0023 0.0022
Trypanosoma cruzi fatty acid elongase, putative 0.1651 0.2576 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0018 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0013
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0013
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.003 0.013
Loa Loa (eye worm) oxidoreductase 0.0028 0.003 0.0029
Mycobacterium ulcerans lipase LipD 0.0072 0.0098 0.2231
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0013 0.015
Schistosoma mansoni hypothetical protein 0.0031 0.0035 0.0151
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0013 0.0302
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.003 0.0109
Schistosoma mansoni two-pore calcium channel 0.0018 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.03 0.0456 0.0455
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0052 0.0203
Schistosoma mansoni thyroid hormone receptor 0.001 0.0003 0.0011
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0039 0.0531
Schistosoma mansoni fatty acid acyl transferase-related 0.0429 0.0659 0.2815
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0043 0.0183
Trypanosoma brucei elongation of very long chain fatty acids protein, putative 0.0429 0.0659 0.2559
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0098 0.0382
Mycobacterium tuberculosis Probable reductase 0.0112 0.0161 0.2152
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0096 0.0137 0.7056
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.003 0.0118
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0028 0.003 0.0576
Schistosoma mansoni hypothetical protein 0.0018 0.0014 0.0061
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0013 0.005
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0099 0.2235
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0018 0.0014 0.0061
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0039 0.0039
Echinococcus granulosus two pore calcium channel protein 1 0.0018 0.0014 0.0061
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.003 0.013
Brugia malayi AMP-binding enzyme family protein 0.0096 0.0137 0.0137
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0007 0.0026
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.003 0.0254
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0014 0.0061
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0018 0.0014 0.0331
Loa Loa (eye worm) hypothetical protein 0.0099 0.0142 0.014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0131 0.0561
Leishmania major DNA polymerase kappa, putative 0.0013 0.0007 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0004 0.0096
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0013 0.0055
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0018 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0072 0.0099 0.0097
Entamoeba histolytica acyl-CoA synthetase, putative 0.0096 0.0137 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0035 0.0151
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0088 0.0377
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0013
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.003 0.0254
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0052 0.0203
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0013 0.0052
Onchocerca volvulus Elongation of very long chain fatty acids protein homolog 0.0411 0.0631 0.9208
Trichomonas vaginalis glutaminase, putative 0.0275 0.0418 0.9741
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.0113 0.0439
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0013 0.0149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0003 0.0001
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.0161 0.2152
Plasmodium falciparum thioredoxin reductase 0.0017 0.0013 0.005
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0098 0.124
Echinococcus granulosus expressed protein 0.0034 0.0039 0.0166
Echinococcus granulosus pyruvate kinase 0.0017 0.0013 0.0057
Leishmania major trypanothione reductase 0.0049 0.0063 0.0236
Brugia malayi Thioredoxin reductase 0.0049 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0013
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0018 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.0446 0.0685 0.0684
Schistosoma mansoni inositol monophosphatase 0.0081 0.0113 0.0483
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0018 0.0014 0.0046
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0039 0.0907
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0038 0.2762
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0013 0.015
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0003 0.0012
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0098 0.0382
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0124 0.0181 0.018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0043 0.0183
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0131 0.0561
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0018 0.0014 0.0046
Leishmania major fatty acid elongase, putative 0.0411 0.0631 0.2444
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0035 0.0035
Brugia malayi MH2 domain containing protein 0.001 0.0001 0.0001
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0014 0.0061
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0028 0.003 0.0576
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0003 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0131 0.0561
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.0137 0.0522
Onchocerca volvulus 0.0011 0.0004 0.0021
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.0113 0.0439
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0018 0.0014 0.0061
Toxoplasma gondii transporter, cation channel family protein 0.0148 0.0218 0.0837
Schistosoma mansoni transient receptor potential channel 0.0018 0.0014 0.0061
Onchocerca volvulus Huntingtin homolog 0.0124 0.0181 0.2619
Onchocerca volvulus 0.0446 0.0685 1
Echinococcus multilocularis Protein lozenge 0.0056 0.0074 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0003 0.0003
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0013 0.0041
Echinococcus multilocularis dna polymerase eta 0.0042 0.0052 0.0223
Echinococcus granulosus FTZ F1 alpha 0.001 0.0003 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0088 0.0341
Entamoeba histolytica deoxycytidyl transferase, putative 0.0042 0.0052 0.3823
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0088 0.0341
Loa Loa (eye worm) fatty acid elongation protein 3 0.0411 0.0631 0.063
Schistosoma mansoni terminal deoxycytidyl transferase 0.0042 0.0052 0.0223
Loa Loa (eye worm) hypothetical protein 0.0072 0.0098 0.0097
Brugia malayi glutaminase DH11.1 0.0275 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.013 0.019 0.0189
Leishmania major fatty acid elongase, putative 0.0429 0.0659 0.2552
Trypanosoma brucei Long chain fatty acyl elongase 0.0429 0.0659 0.2559
Echinococcus granulosus potassium voltage gated channel protein 0.0018 0.0014 0.0061
Schistosoma mansoni Smad4 0.001 0.0001 0.0006
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0013 0.0041
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0424 0.0651 0.278
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0082 0.0351
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.0022 0.0085
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0018 0.0014 0.0061
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0013 0.03
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.003 0.2226
Schistosoma mansoni lozenge 0.0056 0.0074 0.0316
Loa Loa (eye worm) hypothetical protein 0.0096 0.0137 0.0135
Echinococcus multilocularis pyruvate kinase 0.0026 0.0028 0.0119
Brugia malayi Cathepsin L-like precursor 0.0017 0.0013 0.0013
Schistosoma mansoni cpg binding protein 0.003 0.0033 0.0143
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0072 0.0098 0.0097
Onchocerca volvulus 0.003 0.0033 0.045
Brugia malayi Cathepsin L-like precursor 0.0017 0.0013 0.0013
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0018 0.0014 0.0061
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0013 0.005
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0081 0.0113 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0000017 0.0000072577
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.003 0.0576
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0003 0.0003
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0063 0.0245
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0003 0.0001
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0028 0.003 0.0576
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0013
Schistosoma mansoni smad1 5 8 and 0.001 0.0001 0.0006
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0018 0.0014 0.0061
Echinococcus multilocularis microtubule associated protein 2 0.1502 0.2342 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0043 0.0183
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0013 0.015
Loa Loa (eye worm) hypothetical protein 0.0072 0.0099 0.0097
Echinococcus multilocularis cysteine protease 0.0017 0.0013 0.0055
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0018 0.0014 0.0061
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0028 0.003 0.0576
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0013 0.005
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.003 0.0576
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0013 0.0302
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.003 0.0109
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.0181 1
Onchocerca volvulus 0.0282 0.0429 0.6242
Echinococcus multilocularis pyruvate kinase 0.0017 0.0013 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0088 0.0341
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0098 0.0382
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0018 0.0014 0.0061
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0007 0.0026
Echinococcus granulosus inositol monophosphatase 1 0.0081 0.0113 0.0483
Schistosoma mansoni microtubule-associated protein tau 0.1502 0.2342 1
Brugia malayi voltage-dependent calcium channel 0.0018 0.0014 0.0014
Brugia malayi nuclear receptor NHR-88 0.001 0.0003 0.0003
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0018 0.0014 0.0013
Trypanosoma brucei unspecified product 0.0029 0.0032 0.0123
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0038
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0039 0.0151
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.003 0.0118
Loa Loa (eye worm) hypothetical protein 0.0124 0.0181 0.018
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0018 0.0014 0.0061
Onchocerca volvulus 0.0028 0.003 0.0406
Echinococcus granulosus transient receptor potential cation channel 0.0018 0.0014 0.0061
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0018 0.0014 0.0061
Toxoplasma gondii ribonuclease HI protein 0.0023 0.0022 0.0076
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0066 0.0257
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0013 0.0302
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0098 0.2295
Leishmania major cathepsin L-like protease 0.0017 0.0013 0.0041
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0013 0.005
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0001 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0013 0.0302
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0003 0.0003
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.003 0.0254
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0098 0.452
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.0161 0.2152
Echinococcus multilocularis inositol monophosphatase 1 0.0081 0.0113 0.0483
Echinococcus multilocularis potassium large conductance calcium activated 0.0018 0.0014 0.0061
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0018 0.0014 0.0014
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0039 0.0907
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0003 0.0003
Echinococcus multilocularis transient receptor potential cation channel 0.0018 0.0014 0.0061
Brugia malayi Cathepsin L-like precursor 0.0017 0.0013 0.0013
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0007 0.0026
Loa Loa (eye worm) cysteine protease 0.0017 0.0013 0.0012
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0424 0.0651 0.0651
Mycobacterium tuberculosis Conserved protein 0.0072 0.0098 0.124
Brugia malayi MH1 domain containing protein 0.001 0.0001 0.0001
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0003 0.0011
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0043 0.0183
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.003 0.0109
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0078 0.0293
Onchocerca volvulus 0.0017 0.0013 0.015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0013 0.0302
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.0052 0.0223
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0018 0.0014 0.0061
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0018 0.0014 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.003 0.0576
Trypanosoma cruzi fatty acid elongase, putative 0.0429 0.0659 0.2559
Schistosoma mansoni voltage-dependent calcium channel 0.0018 0.0014 0.0061
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0003 0.0003
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.0181 0.2435
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0038 0.0146
Trypanosoma cruzi fatty acid elongase, putative 0.1651 0.2576 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0001 0.0006
Trichomonas vaginalis set domain proteins, putative 0.0282 0.0429 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0082 0.0351
Echinococcus multilocularis two pore calcium channel protein 2 0.0018 0.0014 0.0061
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0018 0.0014 0.0061
Brugia malayi AMP-binding enzyme family protein 0.0028 0.003 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0032 0.0123
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0013 0.0302
Leishmania major cathepsin L-like protease 0.0017 0.0013 0.0041
Mycobacterium leprae Probable lipase LipE 0.0072 0.0098 0.452
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0052 0.1218
Leishmania major cathepsin L-like protease 0.0065 0.0088 0.0333
Loa Loa (eye worm) hypothetical protein 0.0072 0.0098 0.0097
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.0137 0.316
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.003 0.003
Echinococcus granulosus neuropeptide s receptor 0.0465 0.0716 0.3058
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0098 0.2295
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0039 0.0038
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0052 0.0203
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.0161 0.2152
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0003 0.0003
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0013 0.0149
Brugia malayi Cathepsin L-like precursor 0.0017 0.0013 0.0013
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0038 0.0138
Trypanosoma brucei RNA helicase, putative 0.0085 0.012 0.0464
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0063 0.0269
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.003 0.013
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0013 0.0055
Plasmodium falciparum thioredoxin reductase 0.0049 0.0063 0.0245
Onchocerca volvulus 0.0028 0.003 0.0406
Trypanosoma brucei unspecified product 0.0042 0.0052 0.0203
Brugia malayi AMP-binding enzyme family protein 0.0096 0.0137 0.0137
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0096 0.0137 0.316
Loa Loa (eye worm) GNS1/SUR4 family protein 0.1651 0.2576 0.2575
Leishmania major ribonuclease H1, putative 0.0023 0.0022 0.0076
Echinococcus granulosus dna polymerase kappa 0.0042 0.0052 0.0223
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0018 0.0014 0.0014
Schistosoma mansoni elongation of fatty acids protein 1 0.0411 0.0631 0.2695
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0013 0.0954
Brugia malayi steroid hormone receptor 0.001 0.0003 0.0003
Schistosoma mansoni elongation of fatty acids protein 1 0.0429 0.0659 0.2815
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0003 0.0003
Echinococcus granulosus transient receptor potential cation channel 0.0018 0.0014 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0013 0.0302
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0088 0.0341
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0092 0.0092
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0003 0.0011
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0007 0.0029
Brugia malayi beta-lactamase family protein 0.0072 0.0098 0.0098
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0098 0.0382
Leishmania major DNA damage repair protein, putative 0.0013 0.0007 0.0017
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0052 0.1107
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0013 0.1347
Plasmodium vivax long chain polyunsaturated fatty acid elongation enzyme, putative 0.0429 0.0659 0.2559
Plasmodium vivax acyl-CoA synthetase, putative 0.0072 0.0099 0.0383
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0003 0.0011
Leishmania major fatty acid elongase, putative 0.0411 0.0631 0.2444
Brugia malayi fatty acid elongation protein 3 0.0411 0.0631 0.0631
Schistosoma mansoni nuclear hormone receptor 0.001 0.0003 0.0011
Echinococcus multilocularis cpg binding protein 0.0032 0.0036 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0003 0.0001
Echinococcus granulosus voltage dependent calcium channel 0.0424 0.0651 0.278
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0003 0.0011
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.003 0.0118
Mycobacterium ulcerans acetyl-CoA synthetase 0.0028 0.003 0.0576
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0013 0.0012
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0023 0.0022 0.176
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0018 0.0014 0.0061
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0013 0.0041
Schistosoma mansoni smad 0.001 0.0001 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0004 0.0096
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0038 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0052 0.0203
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0013
Trypanosoma cruzi DNA polymerase eta, putative 0.0013 0.0007 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0013 0.0302
Schistosoma mansoni cpg binding protein 0.0032 0.0036 0.0154
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0000017 0.0000072577
Mycobacterium ulcerans beta-lactamase 0.0072 0.0098 0.2231
Brugia malayi MH2 domain containing protein 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.03 0.0456 0.0455
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0052 0.0203
Schistosoma mansoni pyruvate kinase 0.0017 0.0013 0.0057
Schistosoma mansoni transient receptor potential channel 4 0.0018 0.0014 0.0061
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.0161 0.8702
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0039 0.0039
Echinococcus multilocularis cysteine protease 0.0017 0.0013 0.0055
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0018 0.0014 0.0169
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0003 0.0011
Schistosoma mansoni elongation of fatty acids protein 1 0.0429 0.0659 0.2815
Giardia lamblia Pyruvate kinase 0.0017 0.0013 0.144
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0013 0.0055
Loa Loa (eye worm) ryanodine receptor 0.0018 0.0014 0.0013
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0081 0.0113 0.8282
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0013 0.0302
Brugia malayi Inositol-1 0.0081 0.0113 0.0113
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0018 0.0014 0.0014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0092 0.1154
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0028 0.003 0.0576
Entamoeba histolytica acyl-CoA synthetase, putative 0.0096 0.0137 1
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0052 0.0052
Echinococcus granulosus hyperpolarization activated cyclic 0.0018 0.0014 0.0061
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0424 0.0651 0.278
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0006 0.0006
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0098 0.124
Schistosoma mansoni phosphoglucomutase 0.0023 0.0022 0.0093
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0018 0.0014 0.0061
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0052 0.0052
Echinococcus granulosus voltage gated potassium channel 0.0018 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.0096 0.0137 0.0135
Echinococcus multilocularis short transient receptor potential channel 6 0.0018 0.0014 0.0061
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0052 0.0203
Echinococcus multilocularis muscleblind protein 0.03 0.0456 0.1947
Schistosoma mansoni hypothetical protein 0.0031 0.0035 0.0151
Echinococcus multilocularis neuropeptide receptor A26 0.0465 0.0716 0.3058
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.0113 0.0439
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0003 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0013 0.0302
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0018 0.0014 0.0014
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0018 0.0014 0.0061
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0082 0.1834
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0042 0.0052 0.0223
Echinococcus multilocularis voltage dependent calcium channel 0.0424 0.0651 0.278
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0018 0.0014 0.0014
Echinococcus granulosus transient receptor potential cation channel 0.0018 0.0014 0.0061
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0000017 0.0000072577
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0018 0.0014 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0088 0.0341
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0013
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0088 0.0341
Trypanosoma brucei ribonuclease H1 0.0023 0.0022 0.0085
Echinococcus multilocularis potassium voltage gated channel protein 0.0018 0.0014 0.0061
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0018 0.0014 0.0061
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0018 0.0014 0.0061
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.0181 0.2435
Onchocerca volvulus 0.0017 0.0013 0.015
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0007 0.0026
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.003 0.0709
Leishmania major hypothetical protein, conserved 0.0018 0.0014 0.0046
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0007 0.0017
Brugia malayi cation channel family protein 0.0018 0.0014 0.0014
Schistosoma mansoni voltage-gated cation channel 0.0424 0.0651 0.278
Schistosoma mansoni hypothetical protein 0.0068 0.0092 0.0395
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0001
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0098 0.124
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0013 0.0302
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0039 0.0151
Echinococcus multilocularis transient receptor potential cation channel 0.0018 0.0014 0.0061
Loa Loa (eye worm) runx1 0.0056 0.0074 0.0073
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.003 0.0109
Echinococcus granulosus elongation of very long chain fatty acids 0.0429 0.0659 0.2815
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0013
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.0113 0.0431
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0096 0.0137 0.316
Brugia malayi Fatty acid elongation protein 3 0.1651 0.2576 0.2576
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0000017 0.0000072577
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0003 0.0003
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0018 0.0014 0.0055
Schistosoma mansoni hypothetical protein 0.0031 0.0035 0.0151
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.0181 0.2435
Brugia malayi hypothetical protein 0.0124 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0013 0.005
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0018 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.0072 0.0098 0.0097
Leishmania major pyruvate kinase 0.0034 0.0039 0.0142
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0052 0.0203
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0013 0.005
Echinococcus multilocularis transient receptor potential cation channel 0.0018 0.0014 0.0061
Trypanosoma brucei trypanothione reductase 0.0049 0.0063 0.0245
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0013 0.0954
Loa Loa (eye worm) fibroinase 0.0017 0.0013 0.0012
Echinococcus multilocularis smad 0.001 0.0001 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0013 0.0302
Trypanosoma brucei DNA polymerase eta, putative 0.0042 0.0052 0.0203
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0014 0.0061
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0082 0.031
Toxoplasma gondii hypothetical protein 0.0018 0.0014 0.0046
Loa Loa (eye worm) hypothetical protein 0.0072 0.0099 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0013 0.0302
Echinococcus granulosus muscleblind protein 0.03 0.0456 0.1947
Plasmodium vivax glutathione reductase, putative 0.0049 0.0063 0.0245
Onchocerca volvulus 0.0017 0.0013 0.015
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0013 0.0041
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0013 0.0012
Brugia malayi beta-lactamase 0.0072 0.0098 0.0098
Loa Loa (eye worm) MH2 domain-containing protein 0.0142 0.0209 0.0207
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0013 0.005
Brugia malayi Cathepsin L-like precursor 0.0011 0.0004 0.0004
Schistosoma mansoni glutaminase 0.0275 0.0418 0.1784
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0039 0.0909
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0013
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0098 0.124
Echinococcus multilocularis dnaJ subfamily B 0.0428 0.0658 0.2808
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0013 0.0055
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0092 0.1154
Schistosoma mansoni phosphoglucomutase 0.0023 0.0022 0.0093
Loa Loa (eye worm) voltage-gated potassium channel 0.0018 0.0014 0.0013
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0018 0.0014 0.0169
Toxoplasma gondii transporter, cation channel family protein 0.0018 0.0014 0.0046
Schistosoma mansoni voltage-gated ion channel 0.0018 0.0014 0.0061
Echinococcus granulosus potassium voltage gated channel protein 0.0018 0.0014 0.0061
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0018 0.0014 0.0013
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.0137 0.0522
Brugia malayi glutathione reductase 0.0049 0.0063 0.0063
Echinococcus multilocularis GPCR, family 2 0.0031 0.0035 0.0151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0088 0.0341
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0003 0.0011
Trypanosoma brucei Fatty acid elongase 0.0411 0.0631 0.2451
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0003 0.0003
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0039 0.0378
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0098 0.0098
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0013 0.005
Schistosoma mansoni smad1 5 8 and 0.001 0.0001 0.0006
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.0161 0.2152
Echinococcus multilocularis voltage gated potassium channel 0.0018 0.0014 0.0061
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0018 0.0014 0.0061
Trypanosoma brucei Fatty acid elongase 0.1651 0.2576 1
Echinococcus granulosus elongation of very long chain fatty acids 0.0411 0.0631 0.2695
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.003 0.0254
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.003 0.0254
Onchocerca volvulus 0.0036 0.0043 0.059
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0088 0.0341
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0096 0.0137 0.316
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0096 0.0137 0.1793
Echinococcus multilocularis voltage dependent calcium channel 0.0424 0.0651 0.278
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0014 0.0061
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0098 0.042
Toxoplasma gondii GNS1/SUR4 family protein 0.1651 0.2576 1
Echinococcus granulosus GPCR family 2 0.0031 0.0035 0.0151
Echinococcus multilocularis sodium channel protein 0.0018 0.0014 0.0061
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0018 0.0014 0.0061
Echinococcus multilocularis pyruvate kinase 0.0017 0.0013 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0088 0.0341
Brugia malayi RNase H family protein 0.0023 0.0022 0.0022
Trypanosoma cruzi fatty acid elongase, putative 0.0411 0.0631 0.2451
Schistosoma mansoni hypothetical protein 0.0085 0.012 0.051
Echinococcus multilocularis transient receptor potential cation channel 0.0018 0.0014 0.0061
Onchocerca volvulus 0.0072 0.0098 0.1403
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0018 0.0014 0.0046
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0013 0.0149
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0039 0.0039
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.0137 0.316
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0007 0.0026
Echinococcus multilocularis potassium voltage gated channel protein 0.0018 0.0014 0.0061
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0003 0.0011
Giardia lamblia DINP protein human, muc B family 0.0042 0.0052 1
Echinococcus granulosus transient receptor potential cation channel 0.0018 0.0014 0.0061
Leishmania major fatty acid elongase, putative 0.0411 0.0631 0.2444
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0013 0.0302
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.003 0.0576
Plasmodium falciparum acyl-CoA synthetase 0.0072 0.0099 0.0383
Onchocerca volvulus 0.0017 0.0013 0.015
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0148 0.0218 0.0846
Echinococcus granulosus dnaJ subfamily B 0.0428 0.0658 0.2808
Loa Loa (eye worm) hypothetical protein 0.0072 0.0098 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0003 0.0003
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0098 0.124
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.0002 0.0009
Echinococcus multilocularis conserved hypothetical protein 0.0018 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0001
Echinococcus granulosus transient receptor potential cation channel 0.0018 0.0014 0.0061
Echinococcus granulosus voltage gated potassium channel 0.0018 0.0014 0.0061
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0004 0.0301
Plasmodium vivax vivapain-2 0.0017 0.0013 0.005
Echinococcus granulosus neuropeptide receptor A26 0.0465 0.0716 0.3058
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0003 0.0001
Echinococcus granulosus two pore calcium channel protein 2 0.0018 0.0014 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0052 0.0203
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0013 0.0055
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0018 0.0014 0.0061
Leishmania major hypothetical protein, conserved 0.0072 0.0098 0.0374
Schistosoma mansoni hypothetical protein 0.0031 0.0035 0.0151
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.003 0.0576
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0042 0.0052 0.0051
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0001 0.0006
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0039 0.0038
Loa Loa (eye worm) voltage-gated calcium channel 0.0018 0.0014 0.0013
Brugia malayi MH2 domain containing protein 0.0142 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0013
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0052 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0052 0.0203
Loa Loa (eye worm) glutathione reductase 0.0049 0.0063 0.0062
Brugia malayi fatty acid elongation protein 3 0.0411 0.0631 0.0631
Echinococcus multilocularis voltage gated potassium channel 0.0018 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.0072 0.0099 0.0097
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0098 0.042
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0003 0.0011
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0013 0.005
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0039 0.0531
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0038 0.0146
Leishmania major fatty acid elongase, putative 0.0411 0.0631 0.2444
Echinococcus multilocularis elongation of very long chain fatty acids 0.0429 0.0659 0.2815
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0043 0.0158
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0013 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0092 0.1154
Echinococcus granulosus cathepsin l1 0.0017 0.0013 0.0055
Onchocerca volvulus Elongation of very long chain fatty acids protein 5 homolog 0.0411 0.0631 0.9208
Echinococcus granulosus cathepsin l1 0.0011 0.0004 0.0018
Echinococcus granulosus calcium activated potassium channel 0.0018 0.0014 0.0061
Loa Loa (eye worm) ELO-9 protein 0.0411 0.0631 0.063
Schistosoma mansoni transient receptor potential channel 0.0018 0.0014 0.0061
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0098 0.2231
Brugia malayi Cathepsin L-like precursor 0.0017 0.0013 0.0013
Loa Loa (eye worm) inositol-1 0.0081 0.0113 0.0112
Schistosoma mansoni elongation of fatty acids protein 1 0.0411 0.0631 0.2695
Onchocerca volvulus 0.0096 0.0137 0.1962
Mycobacterium tuberculosis Conserved protein 0.0072 0.0098 0.124
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0039 0.0038
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0018 0.0014 0.0061
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.003 0.0118
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0082 0.1003
Onchocerca volvulus Elongation of very long chain fatty acids protein homolog 0.0411 0.0631 0.9208
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.003 0.0118
Echinococcus multilocularis hyperpolarization activated cyclic 0.0018 0.0014 0.0061
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0007 0.0026
Echinococcus multilocularis Smad4 0.001 0.0001 0.0006
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0007 0.0017
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0028 0.003 0.0576
Loa Loa (eye worm) calcium channel 0.0424 0.0651 0.065
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0052 0.0203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0088 0.0341
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0003 0.0003
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0003 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0007 0.0026
Leishmania major fatty acid elongase, putative 0.0411 0.0631 0.2444
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0018 0.0014 0.0061
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0039 0.0783
Brugia malayi RNase H family protein 0.0023 0.0022 0.0022
Echinococcus granulosus shaker cognate 0.0018 0.0014 0.0061
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0018 0.0014 0.0061
Trypanosoma brucei unspecified product 0.0029 0.0032 0.0123
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0096 0.0137 0.316
Brugia malayi cation channel family protein 0.0018 0.0014 0.0014
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0035 0.0151
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0003 0.0011
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0013 0.005
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0018 0.0014 0.0061
Plasmodium vivax elongation of very long chain fatty acids protein 3, putative 0.0411 0.0631 0.2451
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0013 0.005
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0424 0.0651 0.278
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0013 0.005
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0081 0.0113 0.2589
Leishmania major cathepsin L-like protease 0.0017 0.0013 0.0041
Plasmodium falciparum long chain fatty acid elongation enzyme, putative 0.1651 0.2576 1
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0013 0.0043
Leishmania major fatty acid elongase, putative 0.0411 0.0631 0.2444
Schistosoma mansoni inositol monophosphatase 0.0081 0.0113 0.0483
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0018 0.0014 0.0014
Plasmodium vivax GNS1/SUR4 domain containing protein 0.1651 0.2576 1
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0018 0.0014 0.0014
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0001 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0032 0.0123
Leishmania major fatty acid elongase, putative 0.1651 0.2576 1
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0013 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0013 0.0302
Trypanosoma cruzi fatty acid elongase, putative 0.0411 0.0631 0.2451
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0018 0.0014 0.0014
Mycobacterium ulcerans hypothetical protein 0.0096 0.0137 0.316
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.003 0.0118
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.0137 0.0522
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.003 0.0254
Echinococcus multilocularis neuropeptide s receptor 0.0465 0.0716 0.3058
Brugia malayi AMP-binding enzyme family protein 0.0096 0.0137 0.0137
Brugia malayi GNS1/SUR4 family protein 0.1651 0.2576 0.2576
Toxoplasma gondii propionate-CoA ligase 0.0028 0.003 0.0109
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0052 0.1107
Entamoeba histolytica acyl-coA synthetase, putative 0.0096 0.0137 1
Echinococcus granulosus smad 0.001 0.0001 0.0006
Brugia malayi AMP-binding enzyme family protein 0.0028 0.003 0.003
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0013 0.0055
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.003 0.0576
Onchocerca volvulus 0.0411 0.0631 0.9208
Echinococcus multilocularis pyruvate kinase 0.0034 0.0039 0.0166
Echinococcus multilocularis short transient receptor potential channel 6 0.0018 0.0014 0.0061
Echinococcus multilocularis expressed protein 0.0034 0.0039 0.0166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0003 0.0001
Treponema pallidum ribonuclease H (rnhA) 0.0023 0.0022 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0131 0.0561
Leishmania major cathepsin L-like protease 0.0065 0.0088 0.0333
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0003 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0013 0.0302
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0013 0.005
Leishmania major fatty acid elongase, putative 0.0411 0.0631 0.2444
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0003 0.0011
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0424 0.0651 0.278
Leishmania major fatty acid elongase, putative 0.0411 0.0631 0.2444
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0088 0.0341
Loa Loa (eye worm) hypothetical protein 0.013 0.019 0.0189
Echinococcus granulosus potassium voltage gated channel protein 0.0018 0.0014 0.0061
Leishmania major cathepsin L-like protease 0.0017 0.0013 0.0041
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0013 0.0302
Schistosoma mansoni pyruvate kinase 0.0034 0.0039 0.0166
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0098 0.042
Echinococcus multilocularis transient receptor potential cation channel 0.0018 0.0014 0.0061
Trypanosoma cruzi fatty acid elongase, putative 0.0411 0.0631 0.2451
Echinococcus multilocularis pyruvate kinase 0.0034 0.0039 0.0166
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0043 0.0183
Echinococcus granulosus TRP transient receptor potential channel 0.0018 0.0014 0.0061
Onchocerca volvulus Huntingtin homolog 0.0124 0.0181 0.2619
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0001
Brugia malayi CXXC zinc finger family protein 0.003 0.0033 0.0033
Loa Loa (eye worm) ion channel NompC 0.0018 0.0014 0.0013
Loa Loa (eye worm) glutaminase 0.0275 0.0418 0.0416
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0131 0.0561
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.003 0.0118
Toxoplasma gondii fatty acid elongase 0.0429 0.0659 0.2552
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0018 0.0014 0.0061
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0248 0.0375 0.0374
Echinococcus multilocularis ribonuclease H1 0.0023 0.0022 0.0093
Echinococcus granulosus voltage gated hydrogen channel 1 0.0018 0.0014 0.0061
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0457 0.0703 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0098 0.2295
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0039 0.0142
Onchocerca volvulus 0.0028 0.003 0.0406
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.003 0.0118
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0131 0.0561
Loa Loa (eye worm) hypothetical protein 0.0068 0.0092 0.0091
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0098 0.124
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0006 0.0006
Mycobacterium ulcerans hypothetical protein 0.0072 0.0098 0.2231
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0013 0.005
Plasmodium falciparum glutathione reductase 0.0049 0.0063 0.0245
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0003 0.0011
Echinococcus multilocularis transient receptor potential cation channel 0.0018 0.0014 0.0061
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0039 0.0565
Loa Loa (eye worm) GNS1/SUR4 family protein 0.6383 1 1
Loa Loa (eye worm) voltage-dependent calcium channel 0.0148 0.0218 0.0216
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0098 0.042
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0052 0.0203
Loa Loa (eye worm) beta-lactamase 0.0072 0.0098 0.0097
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0018 0.0014 0.0061
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0018 0.0014 0.0061
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0098 0.2231
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0082 0.0351
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.0161 0.2152
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0082 0.031
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0014 0.0061
Trichomonas vaginalis inositol monophosphatase, putative 0.0081 0.0113 0.2638
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0014 0.0061
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0063 0.0245
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0052 0.0203
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0013 0.0055
Brugia malayi polk-prov protein 0.0013 0.0007 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0098 0.2295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0003 0.0001
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0014 0.0061
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0013 0.0055
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0018 0.0014 0.0061
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0082 0.0351
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0013 0.005
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0035 0.0034
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0446 0.0685 0.0684
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0013 0.0041
Loa Loa (eye worm) glutaminase 2 0.0275 0.0418 0.0416
Echinococcus granulosus transient receptor potential gamma protein 0.0018 0.0014 0.0061
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0148 0.0218 0.0846
Loa Loa (eye worm) hypothetical protein 0.0411 0.0631 0.063
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0052 0.0203
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0018 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.0036 0.0043 0.0042
Plasmodium falciparum fatty acid elongation protein, GNS1/SUR4 family, putative 0.1651 0.2576 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0003 0.0003
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0013 0.005
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0014 0.0061
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0018 0.0014 0.0055
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0013 0.005
Echinococcus granulosus pyruvate kinase 0.0017 0.0013 0.0057
Leishmania major fatty acid elongase, putative 0.0411 0.0631 0.2444
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0043 0.0183
Schistosoma mansoni hypothetical protein 0.0428 0.0658 0.2808
Brugia malayi Cathepsin L-like precursor 0.0011 0.0004 0.0004
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.003 0.0254
Onchocerca volvulus 0.0072 0.0098 0.1403
Brugia malayi fatty acid elongation protein 3 0.0411 0.0631 0.0631
Leishmania major fatty acid elongase, putative 0.1651 0.2576 1
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0035 0.0035
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0014 0.0061
Schistosoma mansoni cpg binding protein 0.0032 0.0036 0.0154
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.004 0.017
Echinococcus granulosus ribonuclease H1 0.0023 0.0022 0.0093
Loa Loa (eye worm) voltage-gated potassium channel 0.0018 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0022
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0043 0.0183
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.0029
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0082 0.1834
Giardia lamblia Pyruvate kinase 0.0034 0.0039 0.7074
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0003 0.0003
Trypanosoma cruzi fatty acid elongase, putative 0.0411 0.0631 0.2451
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0013 0.005
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0081 0.0113 0.2638
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0013 0.0055
Giardia lamblia Ribonuclease H 0.0023 0.0022 0.3311
Schistosoma mansoni thyroid hormone receptor 0.001 0.0003 0.0011
Echinococcus granulosus voltage dependent calcium channel 0.0148 0.0218 0.093
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0018 0.0014 0.0061
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0787 0.1221 0.5212
Echinococcus granulosus transient receptor potential cation channel 0.0018 0.0014 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0013 0.0302
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0013 0.005
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0063 0.0062
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0013
Echinococcus granulosus short transient receptor potential channel 6 0.0018 0.0014 0.0061
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0039 0.0038
Brugia malayi Cyclic-nucleotide gated cation channel 0.0018 0.0014 0.0014
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0023 0.1682
Mycobacterium tuberculosis Conserved protein 0.0072 0.0098 0.124
Entamoeba histolytica cysteine protease, putative 0.0017 0.0013 0.0947
Echinococcus granulosus pyruvate kinase 0.0034 0.0039 0.0166
Onchocerca volvulus 0.0017 0.0013 0.015
Trypanosoma brucei unspecified product 0.0025 0.0025 0.0096
Echinococcus multilocularis potassium voltage gated channel protein 0.0018 0.0014 0.0061
Schistosoma mansoni pyruvate kinase 0.0034 0.0039 0.0166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0013 0.0302
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0003 0.0011
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0014 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0013 0.0302
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0052 0.0203
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0018 0.0014 0.0331
Echinococcus multilocularis transfer RNA-Gly 0.0018 0.0014 0.0061
Onchocerca volvulus 0.0017 0.0013 0.015
Leishmania major cathepsin L-like protease 0.0065 0.0088 0.0333
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0081 0.0113 0.2638
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0014 0.0061
Loa Loa (eye worm) ctsf protein 0.0017 0.0013 0.0012
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0003 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0082 0.1834
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0035 0.0151
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0018 0.0014 0.0061
Schistosoma mansoni ryanodine receptor related 0.0018 0.0014 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0032 0.0123
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0072 0.01 0.4613
Brugia malayi Transient-receptor-potential like protein 0.0018 0.0014 0.0014
Echinococcus multilocularis sodium leak channel non selective protein 0.0018 0.0014 0.0061
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0003 0.0011
Trypanosoma cruzi fatty acid elongase, putative 0.1651 0.2576 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0013 0.005
Trichomonas vaginalis rotamase, putative 0.0034 0.0039 0.0909
Onchocerca volvulus 0.0017 0.0013 0.015
Echinococcus granulosus pyruvate kinase 0.0034 0.0039 0.0166
Brugia malayi Cathepsin L-like precursor 0.0017 0.0013 0.0013
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0004 0.0004
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0042 0.0052 0.0223
Loa Loa (eye worm) fatty acid elongation protein 3 0.0411 0.0631 0.063
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0013 0.03
Schistosoma mansoni smad1 5 8 and 0.001 0.0001 0.0006
Brugia malayi hypothetical protein 0.0018 0.0014 0.0014
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0131 0.013
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0424 0.0651 0.278
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0014 0.0061
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0003 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0003 0.0001
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0013 0.0055
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0035 0.0151
Loa Loa (eye worm) fatty acid elongation protein 3 0.0411 0.0631 0.063
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0088 0.0341
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.0029
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0025 0.0025 0.0096
Toxoplasma gondii hypothetical protein 0.013 0.019 0.0729
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0018 0.0014 0.0014
Trypanosoma brucei Fatty acid elongase 0.0411 0.0631 0.2451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0088 0.0341
Echinococcus granulosus ryanodine receptor 44f 0.0018 0.0014 0.0061
Echinococcus granulosus cpg binding protein 0.0032 0.0036 0.0154
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0005
Echinococcus granulosus potassium large conductance calcium activated 0.0018 0.0014 0.0061
Mycobacterium ulcerans glutaminase 0.0275 0.0418 1
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0007 0.0026
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0072 0.0099 0.1242
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0013
Brugia malayi Muscleblind-like protein 0.03 0.0456 0.0456
Onchocerca volvulus 0.0018 0.0014 0.0169
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0072 0.01 0.126
Echinococcus multilocularis calcium activated potassium channel 0.0018 0.0014 0.0061
Loa Loa (eye worm) transcription factor SMAD2 0.0142 0.0209 0.0207
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.0022 0.0085
Leishmania major DNA polymerase eta, putative 0.0042 0.0052 0.0194
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0018 0.0014 0.0061
Echinococcus multilocularis hyperpolarization activated cyclic 0.0018 0.0014 0.0061
Brugia malayi cathepsin L-like precursor 0.0011 0.0004 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0092 0.1154
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0018 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.0072 0.0099 0.0097
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0013 0.0947
Echinococcus granulosus sodium channel protein 0.0018 0.0014 0.0061
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0098 0.0097
Onchocerca volvulus 0.0411 0.0631 0.9208
Plasmodium falciparum pyruvate kinase 0.0034 0.0039 0.0151
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0018 0.0014 0.0061
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0014 0.0061
Toxoplasma gondii thioredoxin reductase 0.0049 0.0063 0.0236
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0018 0.0014 0.0014
Leishmania major DNA polymerase kappa, putative 0.0042 0.0052 0.0194
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0018 0.0014 0.0061
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0018 0.0014 0.0061
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0013 0.0947
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0052 0.057
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0098 0.2295
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0013 0.0302
Brugia malayi fatty acid elongation protein 3 0.0411 0.0631 0.0631
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0072 0.0098 0.0097
Echinococcus multilocularis potassium voltage gated channel protein 0.0018 0.0014 0.0061
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0001 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0096 0.0137 0.1793
Trichomonas vaginalis rotamase, putative 0.0033 0.0038 0.088
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0013
Brugia malayi nuclear hormone receptor 0.001 0.0003 0.0003
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0007 0.0026
Echinococcus multilocularis muscleblind protein 1 0.03 0.0456 0.1947
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0014 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.003 0.0576
Echinococcus granulosus pyruvate kinase 0.0017 0.0013 0.0057
Schistosoma mansoni calcium-activated potassium channel 0.0018 0.0014 0.0061
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0096 0.0137 0.7056
Brugia malayi MH1 domain containing protein 0.001 0.0001 0.0001
Toxoplasma gondii integral membrane protein, GNS1/SUR4 family protein, putative 0.1651 0.2576 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0001
Echinococcus granulosus potassium voltage gated channel protein 0.0018 0.0014 0.0061
Leishmania major long chain polyunsaturated fatty acid elongation enzyme-like protein 0.0429 0.0659 0.2552
Brugia malayi ion channel NompC 0.0018 0.0014 0.0014
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0039 0.0531
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0142 0.0142
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0018 0.0014 0.0014
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0033 0.0032
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0002 0.0009
Toxoplasma gondii transporter, cation channel family protein 0.0018 0.0014 0.0046
Echinococcus granulosus Smad4 0.001 0.0001 0.0006
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0003 0.0011
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0013 0.0041
Loa Loa (eye worm) hypothetical protein 0.0031 0.0035 0.0034
Echinococcus granulosus dna polymerase eta 0.0042 0.0052 0.0223
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0003 0.0011
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0098 0.124
Trypanosoma cruzi fatty acid elongase, putative 0.1651 0.2576 1
Loa Loa (eye worm) fatty acid elongation protein 3 0.1651 0.2576 0.2575
Schistosoma mansoni phosphoglucomutase 0.0023 0.0022 0.0093
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0424 0.0651 0.065
Onchocerca volvulus Ribonuclease H1 homolog 0.0023 0.0022 0.028
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0013 0.005
Schistosoma mansoni 60S ribosomal protein L21 0.0018 0.0014 0.0061
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0004 0.0018
Echinococcus multilocularis transient receptor potential gamma protein 0.0018 0.0014 0.0061
Onchocerca volvulus 0.0072 0.0098 0.1403
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0028 0.003 0.0576
Leishmania major cathepsin L-like protease 0.0017 0.0013 0.0041
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0039 0.0151
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0072 0.0099 1
Schistosoma mansoni vesicular amine transporter 0.0018 0.0014 0.0061
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0142 0.014
Brugia malayi Pre-SET motif family protein 0.0248 0.0375 0.0375
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0081 0.0113 0.0431
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.003 0.0109
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0003 0.0011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0052 0.0203
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.003 0.0576
Schistosoma mansoni transient receptor potential channel 0.0018 0.0014 0.0061
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0079 0.0307
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0003 0.0011
Onchocerca volvulus 0.0028 0.003 0.0406
Brugia malayi Hypothetical 34.1 kDa protein C40H1.4 in chromosome III 0.0411 0.0631 0.0631
Trypanosoma brucei ingi protein (ORF1) 0.0025 0.0025 0.0096
Echinococcus multilocularis elongation of very long chain fatty acids 0.0411 0.0631 0.2695
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0052 0.0203
Trypanosoma cruzi fatty acid elongase, putative 0.0429 0.0659 0.2559
Loa Loa (eye worm) hypothetical protein 0.0042 0.0052 0.0051
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.003 0.0254
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0052 0.057
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0063 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0013 0.0302
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0039 0.0151
Schistosoma mansoni DNA polymerase eta 0.0042 0.0052 0.0223
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0002 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0013 0.0302
Loa Loa (eye worm) hypothetical protein 0.0148 0.0218 0.0216
Echinococcus multilocularis shaker cognate 0.0018 0.0014 0.0061
Toxoplasma gondii hypothetical protein 0.0018 0.0014 0.0046
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0013 0.0055
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0013
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.003 0.003
Brugia malayi AMP-binding enzyme family protein 0.0028 0.003 0.003
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0063 0.0727
Echinococcus multilocularis pyruvate kinase 0.0017 0.0013 0.0057
Plasmodium falciparum long chain polyunsaturated fatty acid elongation enzyme, putative 0.0429 0.0659 0.2559
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0131 0.0131
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0007 0.0017
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0018 0.0014 0.0013
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0007 0.0026
Toxoplasma gondii ABC1 family protein 0.0072 0.0098 0.0374

Activities

Activity type Activity value Assay description Source Reference
k cat (binding) = 1.5 s-1 Kinetic parameter kcat against LTA4 hydrolase purified from human leukocytes ChEMBL. 8423594
k cat (binding) = 1.5 s-1 Kinetic parameter kcat against LTA4 hydrolase purified from human leukocytes ChEMBL. 8423594
Km (binding) = 200 uM Kinetic parameter (Km) for hydrolysis of LTA4 hydrolase purified from human leukocytes ChEMBL. 8423594
Km (binding) = 200 uM Kinetic parameter (Km) for hydrolysis of LTA4 hydrolase purified from human leukocytes ChEMBL. 8423594
Ratio (binding) = 0.075 Ratio of the compound was determined kcat /Km (1/M 1/s) ChEMBL. 8423594
Vmax (binding) = 135 nM min-1 mg-1 Kinetic parameter Vmax against LTA4 hydrolase purified from human leukocytes was determined ChEMBL. 8423594
Vmax (binding) = 135 nM min-1 mg-1 Kinetic parameter Vmax against LTA4 hydrolase purified from human leukocytes was determined ChEMBL. 8423594

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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