Detailed information for compound 1120920

Basic information

Technical information
  • TDR Targets ID: 1120920
  • Name: 4-amino-2-(2-oxo-2-piperidin-1-ylethyl)sulfan ylpyrimidine-5-carbonitrile
  • MW: 277.345 | Formula: C12H15N5OS
  • H donors: 1 H acceptors: 4 LogP: 1.34 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cnc(nc1N)SCC(=O)N1CCCCC1
  • InChi: 1S/C12H15N5OS/c13-6-9-7-15-12(16-11(9)14)19-8-10(18)17-4-2-1-3-5-17/h7H,1-5,8H2,(H2,14,15,16)
  • InChiKey: XXTKRPLVXDVTJR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-amino-2-[2-oxo-2-(1-piperidyl)ethyl]sulfanyl-pyrimidine-5-carbonitrile
  • 4-amino-2-[[2-oxo-2-(1-piperidyl)ethyl]thio]-5-pyrimidinecarbonitrile
  • 4-amino-2-[(2-keto-2-piperidino-ethyl)thio]pyrimidine-5-carbonitrile
  • 4-amino-2-(2-oxo-2-piperidin-1-yl-ethyl)sulfanyl-pyrimidine-5-carbonitrile
  • SMR000498801
  • ZINC00285470
  • Oprea1_542748
  • 4-amino-2-{[2-oxo-2-(1-piperidinyl)ethyl]thio}-5-pyrimidinecarbonitrile
  • MLS000999677

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0321 0.1394 0.2147
Loa Loa (eye worm) hypothetical protein 0.0968 0.4815 0.5143
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0845 0.4162 0.4152
Schistosoma mansoni jumonji domain containing protein 0.0192 0.0715 0.0907
Trypanosoma brucei ISWI complex protein 0.036 0.16 0.249
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0108 0.0268 0.0251
Brugia malayi hypothetical protein 0.0497 0.2325 0.2325
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0108 0.0268 0.0268
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.062 0.1665
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.062 0.1665
Echinococcus granulosus geminin 0.1052 0.5257 0.5248
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0153 0.0508 0.1489
Loa Loa (eye worm) hypothetical protein 0.0064 0.0036 0.0038
Leishmania major phosphatidylinositol 3-kinase, putative 0.0108 0.0268 0.0367
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0321 0.1394 0.1379
Trichomonas vaginalis bromodomain and PHD finger-containing protein, putative 0.0066 0.005 0.0083
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0301 0.1292 0.1292
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0217 0.0844 0.2548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0239 0.096 0.2606
Mycobacterium ulcerans hypothetical protein 0.0217 0.0844 0.2548
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Brugia malayi MH2 domain containing protein 0.0074 0.0091 0.0091
Echinococcus granulosus hexokinase 0.0079 0.0115 0.0098
Trypanosoma cruzi PAB1-binding protein , putative 0.0103 0.0243 0.0351
Schistosoma mansoni hypothetical protein 0.0595 0.2845 0.3609
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0217 0.0844 0.2548
Brugia malayi Calcitonin receptor-like protein seb-1 0.0301 0.1292 0.1292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0154 0.0372
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0061 0.002 0.0026
Echinococcus multilocularis jumonji domain containing 1A 0.0192 0.0715 0.0699
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0095 0.0204 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0216 0.0842 0.1295
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Plasmodium vivax bromodomain protein, putative 0.0066 0.005 0.005
Schistosoma mansoni hypothetical protein 0.1052 0.5257 0.6668
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Onchocerca volvulus Huntingtin homolog 0.0131 0.0391 0.0418
Loa Loa (eye worm) hypothetical protein 0.0131 0.0391 0.0418
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0095 0.0204 0.0187
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0266 0.1103 0.1103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192 0.0712 0.1919
Brugia malayi latrophilin 2 splice variant baaae 0.0206 0.0788 0.0788
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0064 0.0036 0.0025
Schistosoma mansoni hypothetical protein 0.036 0.16 0.2029
Loa Loa (eye worm) acetyltransferase 0.049 0.2289 0.2446
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0119 0.0327 0.046
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0064 0.0036 0.0114
Schistosoma mansoni smad1 5 8 and 0.0074 0.0091 0.0115
Schistosoma mansoni hypothetical protein 0.0066 0.005 0.0064
Loa Loa (eye worm) hexokinase 0.0079 0.0115 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0173 0.0613 0.1645
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0183 0.0669 0.2296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0255 0.1047 0.2849
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0064 0.0036 0.0025
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Trypanosoma cruzi Bromodomain, putative 0.0066 0.005 0.0047
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0064 0.0036 0.0055
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Loa Loa (eye worm) hypothetical protein 0.0301 0.1292 0.138
Trichomonas vaginalis bromodomain containing protein, putative 0.0066 0.005 0.0083
Entamoeba histolytica hexokinase 1 0.0079 0.0115 0.0687
Echinococcus multilocularis polycomb protein SCMH1 0.0095 0.02 0.0183
Echinococcus granulosus TGF beta signal transducer SmadC 0.0074 0.0091 0.0074
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0095 0.0204 0.0187
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1261 0.6362 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0217 0.0844 0.6
Schistosoma mansoni hypothetical protein 0.0066 0.005 0.0064
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Loa Loa (eye worm) RNA binding protein 0.02 0.0754 0.0806
Onchocerca volvulus 0.0064 0.0036 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0173 0.0615 0.1649
Schistosoma mansoni zinc finger protein 0.036 0.16 0.2029
Echinococcus multilocularis Smad4 0.0074 0.0091 0.0074
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0301 0.1292 0.138
Plasmodium vivax SET domain containing protein 0.0071 0.0075 0.0138
Trypanosoma brucei hexokinase 0.0079 0.0115 0.0149
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0192 0.0715 0.0907
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0061 0.002 0.0003
Toxoplasma gondii LsmAD domain-containing protein 0.0103 0.0243 0.0789
Leishmania major mitochondrial DNA polymerase beta 0.1261 0.6362 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Schistosoma mansoni hypothetical protein 0.0066 0.005 0.0064
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0147 0.0477 0.0461
Brugia malayi MH2 domain containing protein 0.0074 0.0091 0.0091
Onchocerca volvulus 0.0217 0.0844 0.0902
Loa Loa (eye worm) hypothetical protein 0.0061 0.002 0.0022
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0064 0.0036 0.0036
Treponema pallidum hexokinase (hxk) 0.0079 0.0115 0.5
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0192 0.0715 0.1095
Trypanosoma brucei hexokinase, putative 0.0079 0.0115 0.0149
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0152 0.0501 0.0758
Trypanosoma brucei AAA ATPase, putative 0.0066 0.005 0.0047
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0217 0.0844 0.2548
Plasmodium falciparum bromodomain protein 2, putative 0.0066 0.005 0.005
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Brugia malayi bromodomain containing protein 0.0066 0.005 0.005
Brugia malayi PHD-finger family protein 0.0595 0.2845 0.2845
Loa Loa (eye worm) hypothetical protein 0.0162 0.0555 0.0593
Schistosoma mansoni phd finger protein 0.0066 0.005 0.0064
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0064 0.0036 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0239 0.096 0.2606
Echinococcus multilocularis 0.0066 0.005 0.0033
Trypanosoma brucei Bromodomain factor 1 0.0066 0.005 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0268 0.0687
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.062 0.1665
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Echinococcus granulosus peregrin 0.0662 0.3195 0.3183
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0048
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0268 0.0687
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Loa Loa (eye worm) hypothetical protein 0.0108 0.0269 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Brugia malayi jmjC domain containing protein 0.0192 0.0715 0.0715
Brugia malayi AMP-binding enzyme family protein 0.0064 0.0036 0.0036
Echinococcus multilocularis SAM and MBT domain containing protein 0.0095 0.02 0.0183
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0068 0.0057 0.013
Plasmodium vivax hypothetical protein, conserved 0.0595 0.2845 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0095 0.02 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Echinococcus granulosus tumor protein p63 0.1705 0.8702 0.87
Brugia malayi MH1 domain containing protein 0.0074 0.0091 0.0091
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Brugia malayi PHD-finger family protein 0.06 0.2867 0.2867
Echinococcus multilocularis chromobox protein 1 0.0073 0.0086 0.0068
Loa Loa (eye worm) hypothetical protein 0.0066 0.005 0.0054
Echinococcus multilocularis chromobox protein 1 0.0073 0.0086 0.0068
Trypanosoma brucei mitochondrial DNA polymerase beta 0.1261 0.6362 1
Trypanosoma brucei Bromodomain, putative 0.0066 0.005 0.0047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0207 0.0263
Schistosoma mansoni bromodomain containing protein 0.0114 0.0304 0.0386
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0255 0.1049 0.1601
Leishmania major hypothetical protein, conserved 0.0103 0.0243 0.0328
Loa Loa (eye worm) jmjC domain-containing protein 0.0192 0.0715 0.0764
Entamoeba histolytica acyl-CoA synthetase, putative 0.0217 0.0844 0.6
Trichomonas vaginalis bromodomain containing protein, putative 0.0066 0.005 0.0083
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0064 0.0036 0.0038
Echinococcus granulosus Bromodomain containing protein 0.0066 0.005 0.0033
Trichomonas vaginalis bromodomain-containing protein 4, brd4, putative 0.0066 0.005 0.0083
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0066 0.005 0.005
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Schistosoma mansoni lozenge 0.0229 0.0912 0.1157
Brugia malayi Latrophilin receptor protein 2 0.0095 0.0204 0.0204
Trypanosoma brucei Bromodomain, putative 0.0066 0.005 0.0047
Trypanosoma cruzi Bromodomain, putative 0.0066 0.005 0.0047
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0217 0.0844 0.2548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0255 0.1047 0.2849
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Echinococcus granulosus bromodomain containing protein 8 0.0066 0.005 0.0033
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0207 0.0221
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Echinococcus granulosus Smad4 0.0074 0.0091 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0239 0.096 0.2606
Brugia malayi jmjC domain containing protein 0.0192 0.0715 0.0715
Loa Loa (eye worm) hypothetical protein 0.0217 0.0844 0.0902
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Echinococcus multilocularis hexokinase type 2 0.0079 0.0115 0.0098
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0074 0.0091 0.0115
Schistosoma mansoni jumonji/arid domain-containing protein 0.0769 0.3761 0.4771
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.1103 0.3003
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0192 0.0715 0.1095
Loa Loa (eye worm) hypothetical protein 0.0103 0.0243 0.026
Loa Loa (eye worm) hypothetical protein 0.0902 0.4465 0.4769
Brugia malayi mbt repeat family protein 0.0095 0.02 0.02
Brugia malayi Bromodomain containing protein 0.0066 0.005 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0401 0.1818 0.1803
Plasmodium falciparum histone acetyltransferase GCN5 0.0117 0.0319 0.1007
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0192 0.0715 0.1095
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0064 0.0036 0.0019
Schistosoma mansoni hexokinase 0.0079 0.0115 0.0146
Schistosoma mansoni chromobox protein 0.0073 0.0086 0.0109
Loa Loa (eye worm) hypothetical protein 0.0066 0.005 0.0054
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Plasmodium vivax bromodomain protein, putative 0.0066 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.1829 0.9361 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0101 0.0235 0.0235
Onchocerca volvulus Brd8 homolog 0.0066 0.005 0.0054
Echinococcus multilocularis geminin 0.1052 0.5257 0.5248
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0064 0.0036 0.0025
Loa Loa (eye worm) mbt repeat family protein 0.0095 0.02 0.0213
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0173 0.0615 0.1649
Echinococcus multilocularis peregrin 0.0662 0.3195 0.3183
Brugia malayi Bromodomain containing protein 0.0066 0.005 0.005
Brugia malayi Smad1 0.0074 0.0091 0.0091
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Schistosoma mansoni bromodomain containing protein 0.0066 0.005 0.0064
Echinococcus multilocularis Bromodomain containing protein 0.0066 0.005 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0239 0.096 0.2606
Brugia malayi jmjC domain containing protein 0.0769 0.3761 0.3761
Schistosoma mansoni transcription initiation factor tfiid 0.0066 0.005 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0208 0.08 0.2162
Onchocerca volvulus 0.1829 0.9361 1
Brugia malayi Bromodomain containing protein 0.0066 0.005 0.005
Trypanosoma cruzi bromodomain factor 2 protein 0.0066 0.005 0.0047
Entamoeba histolytica hypothetical protein 0.0147 0.0477 0.3328
Plasmodium vivax hypothetical protein, conserved 0.0198 0.0746 0.2528
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0207 0.019
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0183 0.0669 0.2296
Toxoplasma gondii PHD-finger domain-containing protein 0.0595 0.2845 1
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0057 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0321 0.1394 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.062 0.1665
Trypanosoma cruzi bromodomain-containing protein 3 0.0066 0.005 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.062 0.1665
Trichomonas vaginalis bromodomain containing protein, putative 0.0066 0.005 0.0083
Leishmania major DNA-binding protein, putative,predicted bromodomain protein 0.0066 0.005 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0597 0.2853 0.4453
Onchocerca volvulus 0.0107 0.0263 0.0281
Loa Loa (eye worm) hypothetical protein 0.0162 0.0555 0.0593
Onchocerca volvulus 0.0064 0.0036 0.0038
Toxoplasma gondii hypothetical protein 0.0066 0.005 0.0106
Trypanosoma cruzi hexokinase, putative 0.0079 0.0115 0.0149
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0212 0.0821 0.1041
Loa Loa (eye worm) transcription factor SMAD2 0.1086 0.5438 0.5809
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0373 0.1669 0.1654
Leishmania major hypothetical protein, conserved 0.0066 0.005 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0268 0.0687
Trypanosoma cruzi target of rapamycin kinase 3 0.0255 0.1049 0.1622
Toxoplasma gondii bromodomain-containing protein 0.0066 0.005 0.0106
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0108 0.0268 0.0251
Trichomonas vaginalis bromodomain containing protein, putative 0.0066 0.005 0.0083
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0653 0.3149 0.3364
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0198 0.0746 0.2528
Trypanosoma cruzi Bromodomain, putative 0.0066 0.005 0.0047
Trypanosoma cruzi Bromodomain, putative 0.0066 0.005 0.0047
Schistosoma mansoni myelin transcription factor 1 myt1 0.0108 0.0269 0.0341
Schistosoma mansoni Smad4 0.0074 0.0091 0.0115
Echinococcus multilocularis Protein lozenge 0.0229 0.0912 0.0896
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0183 0.0669 0.1799
Echinococcus granulosus PH interacting protein 0.0066 0.005 0.0033
Leishmania major 4-coumarate:coa ligase-like protein 0.0217 0.0844 0.1278
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0217 0.0844 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Loa Loa (eye worm) hypothetical protein 0.1017 0.5069 0.5415
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0355 0.045
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.024 0.0969 0.0954
Brugia malayi Bromodomain containing protein 0.0066 0.005 0.005
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0064 0.0036 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Loa Loa (eye worm) CBP-B 0.0066 0.005 0.0054
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0177 0.0637 0.0972
Loa Loa (eye worm) hypothetical protein 0.0192 0.0715 0.0764
Mycobacterium ulcerans hypothetical protein 0.0664 0.3209 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0095 0.02 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0321 0.1394 0.3811
Loa Loa (eye worm) phosphatidylinositol 3 0.0321 0.1394 0.1489
Loa Loa (eye worm) jmjC domain-containing protein 0.0192 0.0715 0.0764
Loa Loa (eye worm) CHromoDomain protein family member 0.006 0.0017 0.0019
Schistosoma mansoni hypothetical protein 0.0147 0.0477 0.0606
Echinococcus granulosus jumonji domain containing 1A 0.0192 0.0715 0.0699
Schistosoma mansoni methyl-cpg binding protein mbd 0.0401 0.1818 0.2306
Entamoeba histolytica bromodomain-containing protein 0.0066 0.005 0.0217
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0162 0.0555 0.5
Brugia malayi TAZ zinc finger family protein 0.0066 0.005 0.005
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0108 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0131 0.0391 0.0418
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0207 0.0263
Echinococcus granulosus lysine specific demethylase 6a 0.0192 0.0715 0.0699
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0108 0.0268 0.0391
Entamoeba histolytica bromodomain-containing protein 0.0066 0.005 0.0217
Onchocerca volvulus 0.0079 0.0115 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.1146 0.3123
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.1103 0.3003
Plasmodium vivax bromodomain protein, putative 0.0066 0.005 0.005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0207 0.0207
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0108 0.0268 0.0367
Echinococcus granulosus JmjC domain containing protein 4 0.0192 0.0715 0.0699
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Loa Loa (eye worm) MH2 domain-containing protein 0.1086 0.5438 0.5809
Giardia lamblia Histone acetyltransferase GCN5 0.0117 0.0319 0.0961
Onchocerca volvulus 0.025 0.1018 0.1087
Brugia malayi jmjC domain containing protein 0.0192 0.0715 0.0715
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0177 0.0637 0.0972
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.02 0.0754 0.0806
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0162 0.0555 0.1636
Echinococcus granulosus chromobox protein 1 0.0073 0.0086 0.0068
Echinococcus multilocularis hexokinase 0.0079 0.0115 0.0098
Trypanosoma cruzi ISWI complex protein 0.036 0.16 0.249
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.1103 0.3003
Schistosoma mansoni hypothetical protein 0.0095 0.0204 0.0258
Schistosoma mansoni bromodomain containing protein 0.1502 0.7631 0.9681
Trichomonas vaginalis lymphoid specific helicase, putative 0.0066 0.005 0.0083
Echinococcus granulosus jumonji domain containing protein 0.0829 0.4076 0.4066
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Schistosoma mansoni smad1 5 8 and 0.0074 0.0091 0.0115
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0119 0.0327 0.031
Brugia malayi BRM protein 0.0066 0.005 0.005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0153 0.0508 0.1489
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0036 0.0036
Brugia malayi MH1 domain containing protein 0.0074 0.0091 0.0091
Trypanosoma cruzi PAB1-binding protein , putative 0.0103 0.0243 0.0351
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0597 0.2853 0.4467
Toxoplasma gondii PHD-finger domain-containing protein 0.0195 0.0728 0.2505
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0095 0.0204 0.0187
Brugia malayi F/Y-rich N-terminus family protein 0.026 0.1075 0.1075
Schistosoma mansoni tar DNA-binding protein 0.02 0.0754 0.0957
Loa Loa (eye worm) hypothetical protein 0.0068 0.0057 0.0061
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Brugia malayi AMP-binding enzyme family protein 0.0217 0.0844 0.0844
Trypanosoma cruzi Bromodomain factor 1 0.0066 0.005 0.0047
Echinococcus multilocularis JmjC domain containing protein 4 0.0192 0.0715 0.0699
Trichomonas vaginalis antibiotic synthetase, putative 0.0064 0.0036 0.0043
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0064 0.0036 0.0025
Brugia malayi hypothetical protein 0.0147 0.0477 0.0477
Schistosoma mansoni hypothetical protein 0.0101 0.0235 0.0299
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Entamoeba histolytica bromodomain-containing protein 0.0066 0.005 0.0217
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.1103 0.3003
Schistosoma mansoni methyl-cpg binding protein mbd 0.0401 0.1818 0.2306
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0327 0.0916
Echinococcus multilocularis hexokinase 0.0079 0.0115 0.0098
Plasmodium falciparum JmjC domain-containing protein, putative 0.0192 0.0715 0.2417
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0107 0.0263 0.0334
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Echinococcus granulosus hexokinase 0.0079 0.0115 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Echinococcus multilocularis bromodomain containing protein 8 0.0066 0.005 0.0033
Trypanosoma brucei Bromodomain, putative 0.0066 0.005 0.0047
Echinococcus multilocularis smad 0.0074 0.0091 0.0074
Plasmodium falciparum hexokinase 0.0079 0.0115 0.028
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0597 0.2853 0.4467
Schistosoma mansoni eyes absent homolog 0.0545 0.2581 0.3274
Loa Loa (eye worm) bromodomain containing protein 0.0426 0.195 0.2083
Schistosoma mansoni cpg binding protein 0.0105 0.0254 0.0323
Echinococcus granulosus lysine specific demethylase 5A 0.0769 0.3761 0.375
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192 0.0712 0.1919
Brugia malayi jmjC domain containing protein 0.0192 0.0715 0.0715
Schistosoma mansoni protein phosphatase 2C 0.0192 0.0715 0.0907
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0177 0.0637 0.0972
Onchocerca volvulus Glucosylceramidase homolog 0.0174 0.062 0.0663
Trichomonas vaginalis set domain proteins, putative 0.0743 0.3625 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Echinococcus multilocularis tumor protein p63 0.1705 0.8702 0.87
Echinococcus multilocularis bromodomain containing 2 0.0066 0.005 0.0033
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0108 0.0268 0.0391
Loa Loa (eye worm) PHD-finger family protein 0.0485 0.2262 0.2416
Echinococcus granulosus CREB binding protein 0.0066 0.005 0.0033
Entamoeba histolytica acetyltransferase, GNAT family 0.0117 0.0319 0.2172
Loa Loa (eye worm) hypothetical protein 0.0243 0.0982 0.1049
Loa Loa (eye worm) hypothetical protein 0.025 0.1018 0.1087
Trypanosoma brucei bromodomain factor 2 protein, putative 0.0066 0.005 0.0047
Loa Loa (eye worm) MH1 domain-containing protein 0.0074 0.0091 0.0097
Onchocerca volvulus Huntingtin homolog 0.0131 0.0391 0.0418
Schistosoma mansoni hypothetical protein 0.0095 0.0204 0.0258
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0147 0.0477 0.0461
Brugia malayi AMP-binding enzyme family protein 0.0217 0.0844 0.0844
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0064 0.0036 0.0055
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0255 0.1049 0.1622
Loa Loa (eye worm) hypothetical protein 0.0066 0.005 0.0054
Schistosoma mansoni sex comb on midleg homolog 0.0095 0.02 0.0253
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0195 0.0728 0.2505
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0321 0.1394 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Loa Loa (eye worm) hypothetical protein 0.0497 0.2325 0.2484
Loa Loa (eye worm) PHD-finger family protein 0.0595 0.2845 0.3039
Toxoplasma gondii histone lysine methyltransferase SET1 0.0177 0.0637 0.2183
Echinococcus granulosus survival motor neuron protein 1 0.0497 0.2325 0.2312
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.0066 0.005 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0217 0.0844 0.2548
Plasmodium falciparum acyl-CoA synthetase 0.0162 0.0555 0.1848
Loa Loa (eye worm) latrophilin receptor protein 2 0.0095 0.0204 0.0218
Schistosoma mansoni hypothetical protein 0.0095 0.0204 0.0258
Echinococcus granulosus bromodomain containing 2 0.0066 0.005 0.0033
Schistosoma mansoni hypothetical protein 0.0485 0.2262 0.287
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0068 0.0058 0.0105
Mycobacterium ulcerans acyl-CoA synthetase 0.0217 0.0844 0.2548
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0086 0.0181
Leishmania major 4-coumarate:coa ligase-like protein 0.0217 0.0844 0.1278
Brugia malayi hypothetical protein 0.1829 0.9361 0.9361
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0068 0.0058 0.0105
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.0327 0.0414
Trichomonas vaginalis PIKK family atypical protein kinase 0.0239 0.096 0.2606
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Loa Loa (eye worm) jmjC domain-containing protein 0.123 0.6193 0.6616
Schistosoma mansoni chromobox protein 0.0073 0.0086 0.0109
Loa Loa (eye worm) hypothetical protein 0.0545 0.2581 0.2757
Trichomonas vaginalis PIKK family atypical protein kinase 0.0239 0.096 0.2606
Brugia malayi Bromodomain containing protein 0.0066 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.1663 0.8482 0.9061
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Leishmania major hexokinase, putative 0.0079 0.0115 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.1418 0.7187 0.7182
Brugia malayi AMP-binding enzyme family protein 0.0217 0.0844 0.0844
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0061 0.002 0.002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0217 0.0844 0.6
Brugia malayi hypothetical protein 0.0545 0.2581 0.2581
Loa Loa (eye worm) hypothetical protein 0.1829 0.9361 1
Brugia malayi Bromodomain containing protein 0.0662 0.3195 0.3195
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0061 0.002 0.002
Schistosoma mansoni zinc finger protein 0.0474 0.2204 0.2796
Brugia malayi CHD4 protein 0.006 0.0017 0.0017
Entamoeba histolytica bromodomain-containing protein 0.0066 0.005 0.0217
Onchocerca volvulus 0.0079 0.0115 0.0123
Trichomonas vaginalis bromodomain containing protein, putative 0.0066 0.005 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0239 0.096 0.2606
Entamoeba histolytica hexokinase 2 0.0079 0.0115 0.0687
Toxoplasma gondii histone acetyltransferase TAF1/250 0.0066 0.005 0.0106
Loa Loa (eye worm) oxidoreductase 0.0064 0.0036 0.0038
Schistosoma mansoni chromodomain helicase DNA binding protein 0.006 0.0017 0.0022
Schistosoma mansoni CREB-binding protein 2 0.0066 0.005 0.0064
Leishmania major hypothetical protein, conserved 0.036 0.16 0.2472
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0321 0.1394 0.2166
Echinococcus granulosus mothers against decapentaplegic 5 0.0074 0.0091 0.0074
Echinococcus granulosus hexokinase type 2 0.0079 0.0115 0.0098
Loa Loa (eye worm) hypothetical protein 0.1021 0.5092 0.5439
Loa Loa (eye worm) hypothetical protein 0.0162 0.0555 0.0593
Entamoeba histolytica bromodomain-containing protein 0.0066 0.005 0.0217
Echinococcus granulosus transcription initiation factor TFIID subunit 1 0.0066 0.005 0.0033
Schistosoma mansoni phd/f-box containing protein 0.0192 0.0715 0.0907
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0108 0.0269 0.0252
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0217 0.0844 0.2548
Loa Loa (eye worm) hypothetical protein 0.0064 0.0036 0.0038
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0133 0.0404 0.0604
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Loa Loa (eye worm) hypothetical protein 0.0162 0.0555 0.0593
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.1103 0.3003
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0192 0.0715 0.246
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Plasmodium vivax acyl-CoA synthetase, putative 0.0162 0.0555 0.1848
Toxoplasma gondii hypothetical protein 0.0203 0.0774 0.267
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.195 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0321 0.1394 0.1394
Echinococcus multilocularis phd:f box containing protein 0.0192 0.0715 0.0699
Toxoplasma gondii aldehyde dehydrogenase 0.0119 0.0327 0.1085
Leishmania major hypothetical protein, conserved,predicted bromodomain protein 0.0066 0.005 0.0022
Schistosoma mansoni sex comb on midleg homolog 0.0095 0.02 0.0253
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Brugia malayi AMP-binding enzyme family protein 0.0064 0.0036 0.0036
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0327 0.0916
Loa Loa (eye worm) jmjC domain-containing protein 0.0192 0.0715 0.0764
Echinococcus granulosus histone acetyltransferase KAT2B 0.0183 0.0669 0.0653
Schistosoma mansoni hypothetical protein 0.0195 0.0728 0.0923
Loa Loa (eye worm) hypothetical protein 0.0217 0.0844 0.0902
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0702 0.1891
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0207 0.019
Schistosoma mansoni hypothetical protein 0.1052 0.5257 0.6668
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0086 0.0181
Brugia malayi Heterochromatin protein 1 0.0073 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0066 0.005 0.0054
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0321 0.1394 0.1768
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0064 0.0036 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0217 0.0844 0.2548
Brugia malayi Bromodomain containing protein 0.0911 0.4512 0.4512
Schistosoma mansoni smad1 5 8 and 0.0074 0.0091 0.0115
Trypanosoma cruzi ISWI complex protein 0.036 0.16 0.249
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Echinococcus multilocularis hexokinase 0.0079 0.0115 0.0098
Echinococcus granulosus protein kinase C binding protein 1 0.0066 0.005 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.1103 0.3003
Plasmodium vivax ataxin-2 like protein, putative 0.0103 0.0243 0.0738
Schistosoma mansoni hypothetical protein 0.0575 0.2737 0.3472
Brugia malayi mbt repeat family protein 0.0095 0.02 0.02
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0108 0.0268 0.0391
Brugia malayi polybromodomain protein 0.0066 0.005 0.005
Brugia malayi MH2 domain containing protein 0.1086 0.5438 0.5438
Trichomonas vaginalis bromodomain-containing protein 3, brd3, putative 0.0066 0.005 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0195 0.0728 0.1116
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Giardia lamblia GTOR 0.0321 0.1394 0.4808
Onchocerca volvulus 0.0743 0.3625 0.3872
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.067 0.1803
Loa Loa (eye worm) Smad1 0.0074 0.0091 0.0097
Schistosoma mansoni tar DNA-binding protein 0.02 0.0754 0.0957
Echinococcus multilocularis survival motor neuron protein 1 0.0497 0.2325 0.2312
Schistosoma mansoni helicase 0.0066 0.005 0.0064
Loa Loa (eye worm) phosphatidylinositol 3 0.0108 0.0268 0.0286
Brugia malayi PHD-finger family protein 0.0243 0.0982 0.0982
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Loa Loa (eye worm) hypothetical protein 0.0095 0.0204 0.0218
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Brugia malayi TAR-binding protein 0.02 0.0754 0.0754
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0217 0.0844 0.2548
Loa Loa (eye worm) hypothetical protein 0.0066 0.005 0.0054
Loa Loa (eye worm) hypothetical protein 0.0545 0.2581 0.2757
Onchocerca volvulus 0.0066 0.005 0.0054
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0177 0.0637 0.0972
Schistosoma mansoni hypothetical protein 0.0066 0.005 0.0064
Schistosoma mansoni polybromo-1 0.0066 0.005 0.0064
Brugia malayi Bromodomain containing protein 0.1777 0.9086 0.9086
Loa Loa (eye worm) hexokinase 0.0079 0.0115 0.0123
Toxoplasma gondii bromodomain-containing protein 0.0066 0.005 0.0106
Schistosoma mansoni tar DNA-binding protein 0.02 0.0754 0.0957
Trichomonas vaginalis PIKK family atypical protein kinase 0.0255 0.1047 0.2849
Mycobacterium tuberculosis Conserved hypothetical protein 0.0664 0.3209 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0173 0.0613 0.1645
Toxoplasma gondii target of rapamycin (TOR), putative 0.0239 0.096 0.3326
Echinococcus granulosus chromobox protein 1 0.0073 0.0086 0.0068
Plasmodium falciparum ataxin-2 like protein, putative 0.0103 0.0243 0.0738
Echinococcus granulosus histone acetyltransferase KAT2B 0.0422 0.1931 0.1917
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.1418 0.7187 0.7182
Schistosoma mansoni smad 0.0074 0.0091 0.0115
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0266 0.1103 0.1178
Entamoeba histolytica bromodomain-containing protein 0.0066 0.005 0.0217
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0066 0.005 0.0064
Brugia malayi RNA binding protein 0.02 0.0754 0.0754
Toxoplasma gondii hexokinase 0.0079 0.0115 0.0334
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.062 0.1665
Plasmodium vivax SET domain protein, putative 0.0095 0.02 0.0585
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.049 0.2289 0.2904
Trichomonas vaginalis hypothetical protein 0.0066 0.005 0.0083
Loa Loa (eye worm) hypothetical protein 0.0066 0.005 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0207 0.019
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0533 0.2516 0.2503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0173 0.0615 0.1649
Giardia lamblia PHD finger protein 15 0.0595 0.2845 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0327 0.0916
Brugia malayi hypothetical protein 0.0066 0.0051 0.0051
Schistosoma mansoni bromodomain containing 0.0066 0.005 0.0064
Echinococcus multilocularis zinc finger protein 0.0474 0.2204 0.2191
Brugia malayi Bromodomain containing protein 0.0066 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0162 0.0555 0.0593
Onchocerca volvulus 0.0095 0.02 0.0213
Toxoplasma gondii propionate-CoA ligase 0.0064 0.0036 0.0055
Brugia malayi AF-10 protein 0.0195 0.0728 0.0728
Brugia malayi polybromodomain protein 0.0066 0.005 0.005
Schistosoma mansoni cellular tumor antigen P53 0.025 0.1018 0.1291
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0496 0.2318 0.2305
Schistosoma mansoni hypothetical protein 0.0206 0.0788 0.1
Echinococcus granulosus histone lysine methyltransferase setb 0.0496 0.2318 0.2305
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0064 0.0036 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.067 0.1803
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Trichomonas vaginalis bromodomain-containing protein, putative 0.0183 0.0669 0.1799
Echinococcus granulosus zinc finger protein 0.0474 0.2204 0.2191
Loa Loa (eye worm) hypothetical protein 0.0595 0.2845 0.3039
Schistosoma mansoni jumonji/arid domain-containing protein 0.0769 0.3761 0.4771
Trypanosoma brucei PAB1-binding protein , putative 0.0103 0.0243 0.0351
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.02 0.0254
Schistosoma mansoni hypothetical protein 0.0095 0.0204 0.0258
Echinococcus granulosus tar DNA binding protein 0.02 0.0754 0.0738
Entamoeba histolytica hypothetical protein 0.0147 0.0477 0.3328
Brugia malayi acetyltransferase, GNAT family protein 0.049 0.2289 0.2289
Plasmodium vivax JmjC domain containing protein 0.0192 0.0715 0.2417
Echinococcus granulosus Bromodomain containing protein 0.0066 0.005 0.0033
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.0327 0.0414
Schistosoma mansoni cpg binding protein 0.0105 0.0254 0.0323
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0321 0.1394 0.2166
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0066 0.005 0.0083
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0066 0.005 0.0064
Echinococcus granulosus GPCR family 2 0.0095 0.0204 0.0187
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0119 0.0327 0.0916
Echinococcus multilocularis CREB binding protein 0.0066 0.005 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0702 0.1891
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Echinococcus granulosus hexokinase 0.0079 0.0115 0.0098
Schistosoma mansoni jumonji domain containing protein 0.1549 0.7883 1
Schistosoma mansoni microtubule-associated protein tau 0.1372 0.6948 0.8813
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.005 0.0047
Echinococcus multilocularis tar DNA binding protein 0.02 0.0754 0.0738
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0108 0.0268 0.034
Onchocerca volvulus 0.0079 0.0115 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Brugia malayi Hexokinase family protein 0.0079 0.0115 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0255 0.1047 0.2849
Entamoeba histolytica hypothetical protein 0.0066 0.005 0.0217
Echinococcus multilocularis GPCR, family 2 0.0095 0.0204 0.0187
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Loa Loa (eye worm) jmjC domain-containing protein 0.0769 0.3761 0.4017
Entamoeba histolytica ankyrin repeat protein, putative 0.0066 0.005 0.0217
Loa Loa (eye worm) runx1 0.0229 0.0912 0.0974
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Echinococcus multilocularis microtubule associated protein 2 0.1372 0.6948 0.6942
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Loa Loa (eye worm) BRM protein 0.0066 0.005 0.0054
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.009 0.0176 0.0158
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0373 0.1669 0.1654
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.0066 0.005 0.0033
Loa Loa (eye worm) hypothetical protein 0.0192 0.0715 0.0764
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.024 0.0969 0.0954
Toxoplasma gondii PHD-finger domain-containing protein 0.0595 0.2845 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0119 0.0327 0.031
Echinococcus granulosus phd:f box containing protein 0.0192 0.0715 0.0699
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Trichomonas vaginalis antibiotic synthetase, putative 0.0064 0.0036 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Echinococcus granulosus histone acetyltransferase MYST2 0.0108 0.0269 0.0252
Brugia malayi AMP-binding enzyme family protein 0.0064 0.0036 0.0036
Schistosoma mansoni transcription factor LCR-F1 0.0147 0.0477 0.0606
Plasmodium vivax hypothetical protein, conserved 0.0066 0.005 0.005
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0066 0.005 0.0106
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0496 0.2318 0.294
Leishmania major hypothetical protein, conserved 0.0192 0.0715 0.1073
Echinococcus granulosus SAM and MBT domain containing protein 0.0095 0.02 0.0183
Schistosoma mansoni phosphatidylserine receptor 0.0192 0.0715 0.0907
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Trypanosoma cruzi Bromodomain, putative 0.0066 0.005 0.0047
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0183 0.0669 0.2253
Loa Loa (eye worm) MBCTL1 0.0108 0.0269 0.0287
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Onchocerca volvulus 0.0066 0.005 0.0054
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192 0.0712 0.1919
Loa Loa (eye worm) hypothetical protein 0.0217 0.0844 0.0902
Echinococcus multilocularis jumonji domain containing protein 0.0829 0.4076 0.4066
Brugia malayi hypothetical protein 0.0131 0.0391 0.0391
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Echinococcus granulosus polybromo 1 0.0066 0.005 0.0033
Echinococcus granulosus smad 0.0074 0.0091 0.0074
Loa Loa (eye worm) hypothetical protein 0.0066 0.005 0.0054
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0321 0.1394 0.1379
Loa Loa (eye worm) hypothetical protein 0.0114 0.0304 0.0325
Echinococcus multilocularis serine protein kinase ATM 0.0061 0.002 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0207 0.019
Entamoeba histolytica hypothetical protein 0.0147 0.0477 0.3328
Echinococcus granulosus cpg binding protein 0.0105 0.0254 0.0237
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0108 0.0269 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0845 0.4162 0.4152
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0108 0.0268 0.0391
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0496 0.2318 0.294
Plasmodium falciparum phd finger protein, putative 0.0595 0.2845 1
Echinococcus multilocularis polybromo 1 0.0066 0.005 0.0033
Brugia malayi ATPase, AAA family protein 0.0066 0.005 0.005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0153 0.0508 0.1489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0268 0.0687
Loa Loa (eye worm) MH2 domain-containing protein 0.0074 0.0091 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Echinococcus multilocularis global transcription activator snf2l2 0.0066 0.005 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0215 0.0836 0.2263
Onchocerca volvulus 0.0064 0.0036 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0255 0.1047 0.2849
Trichomonas vaginalis PIKK family atypical protein kinase 0.0321 0.1394 0.3811
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0192 0.0715 0.246
Schistosoma mansoni survival motor neuron protein 0.0101 0.0235 0.0299
Echinococcus multilocularis mothers against decapentaplegic 5 0.0074 0.0091 0.0074
Echinococcus granulosus serine protein kinase ATM 0.0061 0.002 0.0003
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Loa Loa (eye worm) TAR-binding protein 0.02 0.0754 0.0806
Loa Loa (eye worm) bromodomain containing protein 0.0066 0.005 0.0054
Onchocerca volvulus Alhambra homolog 0.0595 0.2845 0.3039
Leishmania major hypothetical protein, conserved 0.0066 0.005 0.0022
Brugia malayi AMP-binding enzyme family protein 0.0064 0.0036 0.0036
Echinococcus multilocularis histone acetyltransferase MYST2 0.0108 0.0269 0.0252
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0066 0.005 0.0083
Echinococcus multilocularis protein kinase C binding protein 1 0.0066 0.005 0.0033
Loa Loa (eye worm) hypothetical protein 0.0095 0.02 0.0213
Trichomonas vaginalis bromodomain containing protein, putative 0.0066 0.005 0.0083
Schistosoma mansoni acetyl-CoA synthetase 0.0064 0.0036 0.0046
Echinococcus multilocularis lysine specific demethylase 6a 0.0192 0.0715 0.0699
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0095 0.02 0.0637
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0095 0.02 0.0183
Brugia malayi Bromodomain containing protein 0.0066 0.005 0.005
Plasmodium falciparum bromodomain protein, putative 0.0066 0.005 0.005
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Entamoeba histolytica hypothetical protein 0.0147 0.0477 0.3328
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0321 0.1394 0.2147
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1261 0.6362 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Onchocerca volvulus 0.0066 0.005 0.0054
Loa Loa (eye worm) hypothetical protein 0.0206 0.0788 0.0842
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0595 0.2845 0.3609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0153 0.0508 0.1489
Echinococcus granulosus polycomb protein SCMH1 0.0095 0.02 0.0183
Plasmodium falciparum bromodomain protein 1 0.0066 0.005 0.005
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0074 0.0091 0.0074
Brugia malayi hypothetical protein 0.0103 0.0243 0.0243
Brugia malayi Pre-SET motif family protein 0.0095 0.02 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Echinococcus multilocularis PH interacting protein 0.0066 0.005 0.0033
Plasmodium vivax hexokinase, putative 0.0079 0.0115 0.028
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Brugia malayi hexokinase 0.0079 0.0115 0.0115
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.195 1 1
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0086 0.0091
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.049 0.2289 0.2276
Schistosoma mansoni tar DNA-binding protein 0.02 0.0754 0.0957
Onchocerca volvulus 0.0101 0.0235 0.0251
Echinococcus granulosus PHD finger protein rhinoceros 0.0595 0.2845 0.2832
Echinococcus multilocularis lysine specific demethylase 5A 0.0721 0.3506 0.3495
Echinococcus granulosus CREB binding protein 0.0066 0.005 0.0033
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Echinococcus granulosus microtubule associated protein 2 0.1372 0.6948 0.6942
Plasmodium falciparum ataxin-2 like protein, putative 0.0103 0.0243 0.0738
Echinococcus granulosus fetal alzheimer antigen falz 0.0533 0.2516 0.2503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0268 0.0687
Toxoplasma gondii bromodomain-containing protein 0.0066 0.005 0.0106
Echinococcus granulosus global transcription activator snf2l2 0.0066 0.005 0.0033
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0321 0.1394 0.2166
Echinococcus granulosus methyl CpG binding domain protein 2 0.0401 0.1818 0.1803
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0066 0.005 0.0083
Brugia malayi RNA recognition motif domain containing protein 0.02 0.0754 0.0754
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0195 0.0728 0.1116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0321 0.1394 0.3811
Trichomonas vaginalis hypothetical protein 0.0066 0.005 0.0083
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0066 0.005 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.062 0.1665
Loa Loa (eye worm) hexokinase type II 0.0079 0.0115 0.0123
Onchocerca volvulus 0.0064 0.0036 0.0038
Loa Loa (eye worm) hypothetical protein 0.0496 0.2318 0.2476
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0321 0.1394 0.2166
Echinococcus multilocularis Bromodomain containing protein 0.0066 0.005 0.0033
Leishmania major hexokinase, putative 0.0079 0.0115 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0173 0.0615 0.1649
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0533 0.2516 0.3192
Onchocerca volvulus Bromodomain adjacent to zinc finger domain protein 1A homolog 0.0066 0.005 0.0054
Brugia malayi Pre-SET motif family protein 0.0653 0.3149 0.3149
Toxoplasma gondii bromodomain-containing protein 0.0066 0.005 0.0106
Leishmania major 4-coumarate:coa ligase-like protein 0.0217 0.0844 0.1278
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Echinococcus multilocularis cpg binding protein 0.0105 0.0254 0.0237
Echinococcus multilocularis PHD finger protein rhinoceros 0.0595 0.2845 0.2832
Schistosoma mansoni fkbp-rapamycin associated protein 0.0061 0.002 0.0026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0207 0.0263
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0095 0.0204 0.0187
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0061 0.002 0.0003
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.168 0.8574 0.8572
Loa Loa (eye worm) hypothetical protein 0.0066 0.005 0.0054
Toxoplasma gondii bromodomain-containing protein 0.0066 0.005 0.0106
Schistosoma mansoni tar DNA-binding protein 0.02 0.0754 0.0957
Trypanosoma brucei hexokinase 0.0079 0.0115 0.0149
Trypanosoma cruzi hexokinase, putative 0.0079 0.0115 0.0149
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.005 0.0083
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0162 0.0555 0.1636
Trichomonas vaginalis PIKK family atypical protein kinase 0.0173 0.0613 0.1645
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0217 0.0844 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0066 0.005 0.0083

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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