Detailed information for compound 1121008

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 564.116 | Formula: C26H30ClN3O5S2
  • H donors: 1 H acceptors: 4 LogP: 4.78 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(ccc1OCCc1scnc1C)CN(S(=O)(=O)c1ccc(cc1)Cl)[C@@H]1CCCCNC1=O
  • InChi: 1S/C26H30ClN3O5S2/c1-18-25(36-17-29-18)12-14-35-23-11-6-19(15-24(23)34-2)16-30(22-5-3-4-13-28-26(22)31)37(32,33)21-9-7-20(27)8-10-21/h6-11,15,17,22H,3-5,12-14,16H2,1-2H3,(H,28,31)/t22-/m1/s1
  • InChiKey: ARHFHGURVXFXEN-JOCHJYFZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0228 0.2784 0.2783
Trichomonas vaginalis aldo-keto reductase, putative 0.0228 0.2784 0.2783
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0787 1 1
Brugia malayi hypothetical protein 0.0044 0.0407 0.0405
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0113 0.0111
Schistosoma mansoni nuclear hormone receptor 0.0083 0.0911 0.0911
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Schistosoma mansoni aldo-keto reductase 0.0787 1 1
Loa Loa (eye worm) oxidoreductase 0.0787 1 1
Brugia malayi nuclear receptor NHR-88 0.0039 0.0346 0.0344
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0118 0.1365 0.1365
Trichomonas vaginalis conserved hypothetical protein 0.0228 0.2784 0.2783
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0428 0.0428
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0787 1 1
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.1709 0.1708
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0228 0.2784 0.2783
Brugia malayi NADH-dependent xylose reductase 0.0228 0.2784 0.2783
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Onchocerca volvulus 0.0083 0.0911 0.0657
Schistosoma mansoni nuclear receptor 0.0039 0.0346 0.0346
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Brugia malayi hypothetical protein 0.0039 0.0346 0.0344
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0113 0.0111
Brugia malayi nuclear hormone receptor family member nhr-6 0.0039 0.0346 0.0344
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0428 0.0426
Echinococcus multilocularis aldo keto reductase 0.0787 1 1
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0392 0.039
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0787 1 1
Brugia malayi nuclear hormone receptor 0.0083 0.0911 0.0909
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0083 0.0911 0.0911
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0113 0.0113
Loa Loa (eye worm) oxidoreductase 0.0787 1 1
Schistosoma mansoni aldo-keto reductase 0.0787 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0272 0.0272
Brugia malayi tailless protein 0.0039 0.0346 0.0344
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0624 0.0622
Loa Loa (eye worm) hypothetical protein 0.0297 0.3678 0.3678
Brugia malayi nuclear receptor NHR-67 0.0039 0.0346 0.0344
Brugia malayi nuclear hormone receptor 0.0039 0.0346 0.0344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0083 0.0911 0.0911
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0792 0.0791
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0272 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0083 0.0911 0.0909
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0787 1 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0297 0.3678 0.3678
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0083 0.0911 0.0911
Echinococcus multilocularis muscleblind protein 1 0.0297 0.3678 0.3677
Echinococcus multilocularis voltage gated potassium channel subunit 0.0228 0.2784 0.2783
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0214 0.2603 0.2601
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.0792 0.0791
Onchocerca volvulus 0.0787 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0787 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0039 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Schistosoma mansoni pol-related 0.0787 1 1
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0045
Brugia malayi ecdysteroid receptor 0.0083 0.0911 0.0909
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.2838 0.2838
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0113 0.5
Leishmania major prostaglandin f synthase, putative 0.0787 1 1
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0002 0.0002
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0039 0.0346 0.0346
Onchocerca volvulus 0.0264 0.3252 0.3063
Brugia malayi Pre-SET motif family protein 0.0033 0.0272 0.027
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.0792 0.0791
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0083 0.0911 0.0909
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0074 0.0792 0.0791
Brugia malayi Muscleblind-like protein 0.0297 0.3678 0.3677
Brugia malayi nuclear receptor RXR 0.0039 0.0346 0.0344
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0044 0.0407 0.0407
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0787 1 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0391 0.0389
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0045 0.0043
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0624 0.0624
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0045 0.0043
Echinococcus granulosus nuclear receptor nhr 48 0.0039 0.0346 0.0344
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0391 0.0389
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0272 0.0272
Loa Loa (eye worm) DR-78 0.0039 0.0346 0.0346
Echinococcus granulosus hypothetical protein 0.0787 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0083 0.0911 0.0909
Toxoplasma gondii aldose reductase, putative 0.0787 1 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0391 0.0389
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0392 0.039
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0045 0.0043
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0792 0.0791
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0272 0.027
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.1709 0.1708
Schistosoma mansoni steroid hormone receptor ad4bp 0.0083 0.0911 0.0911
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0346 0.0344
Trypanosoma cruzi aldo/keto reductase, putative 0.0228 0.2784 0.2783
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0391 0.0389
Brugia malayi mbt repeat family protein 0.0053 0.0529 0.0527
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0083 0.0911 0.0909
Loa Loa (eye worm) nuclear hormone receptor 0.0039 0.0346 0.0346
Brugia malayi hypothetical protein 0.0044 0.0407 0.0405
Brugia malayi nuclear receptor RXR 0.0044 0.0407 0.0405
Entamoeba histolytica aldose reductase, putative 0.0787 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0792 0.0791
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Schistosoma mansoni hypothetical protein 0.0328 0.4071 0.4071
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0118 0.1365 0.1365
Schistosoma mansoni zinc finger protein 0.0039 0.0346 0.0346
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.0346 0.0344
Trypanosoma cruzi aldo/keto reductase, putative 0.0787 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0083 0.0911 0.0909
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0228 0.2784 0.2783
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0083 0.0911 0.0909
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.1709 0.1709
Trichomonas vaginalis aldo/keto reductase, putative 0.0787 1 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0911 0.0911
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.0792 0.0792
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.0792 0.0792
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0113 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Echinococcus granulosus voltage gated potassium channel subunit 0.0228 0.2784 0.2783
Loa Loa (eye worm) acetyltransferase 0.0145 0.1709 0.1709
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0407 0.0405
Loa Loa (eye worm) hypothetical protein 0.0787 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0391 0.0389
Entamoeba histolytica alcohol dehydrogenase, putative 0.0228 0.2784 0.2783
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0428 0.0426
Brugia malayi photoreceptor-specific nuclear receptor 0.0083 0.0911 0.0909
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.0346 0.0344
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0529 0.0529
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0045 0.0045
Onchocerca volvulus Bile acid receptor homolog 0.0083 0.0911 0.0657
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0118 0.1365 0.1363
Echinococcus granulosus GPCR family 2 0.0016 0.0045 0.0043
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0624 0.0622
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0428 0.0426
Echinococcus granulosus muscleblind protein 0.0297 0.3678 0.3677
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Echinococcus granulosus aldehyde reductase 0.0559 0.7058 0.7057
Schistosoma mansoni RAR-like nuclear receptor 0.0083 0.0911 0.0911
Echinococcus granulosus ecdysone induced protein 78C 0.0083 0.0911 0.0909
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0228 0.2784 0.2783
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0083 0.0911 0.0909
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0045
Trypanosoma brucei aldo-keto reductase, putative 0.0787 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0787 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0083 0.0911 0.0909
Echinococcus multilocularis nuclear receptor nhr 48 0.0039 0.0346 0.0344
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0529 0.0264
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0039 0.0346 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0083 0.0911 0.0909
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Schistosoma mansoni retinoic acid receptor RXR 0.0083 0.0911 0.0911
Mycobacterium tuberculosis Conserved protein 0.0228 0.2784 0.2702
Schistosoma mansoni coup transcription factor 0.0083 0.0911 0.0911
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Trichomonas vaginalis aldo-keto reductase, putative 0.0228 0.2784 0.2783
Echinococcus multilocularis aldo keto reductase 0.0787 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0787 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0118 0.1365 0.1363
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0113 0.0111
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0113 0.0398
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0045
Schistosoma mansoni ap endonuclease 0.0021 0.0113 0.0113
Echinococcus multilocularis ecdysone induced protein 78C 0.0083 0.0911 0.0909
Loa Loa (eye worm) hypothetical protein 0.0083 0.0911 0.0911
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0529 0.0529
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0529 0.0527
Onchocerca volvulus 0.0228 0.2784 0.2583
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0083 0.0911 0.0909
Brugia malayi mbt repeat family protein 0.0053 0.0529 0.0527
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0787 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0083 0.0911 0.0909
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0911 0.0911
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0113 0.0111
Mycobacterium ulcerans oxidoreductase 0.0787 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0484 0.0482
Brugia malayi nuclear receptor NHR-88 0.0083 0.0911 0.0909
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0083 0.0911 0.0909
Schistosoma mansoni thyroid hormone receptor 0.0083 0.0911 0.0911
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0529 0.0527
Loa Loa (eye worm) hypothetical protein 0.005 0.0484 0.0484
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0346 0.0346
Trichomonas vaginalis set domain proteins, putative 0.0264 0.3252 0.3251
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0039 0.0346 0.0344
Loa Loa (eye worm) hypothetical protein 0.0083 0.0911 0.0911
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0083 0.0911 0.0911
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0083 0.0911 0.0909
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.0346 0.0344
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0083 0.0911 0.0911
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0039 0.0346 0.0346
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0529 0.0527
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0113 0.0111
Onchocerca volvulus 0.0053 0.0529 0.0264
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0407 0.0407
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Toxoplasma gondii aldo-keto reductase 0.0228 0.2784 0.2783
Onchocerca volvulus 0.0169 0.2017 0.1794
Echinococcus granulosus thyroid hormone receptor alpha 0.0039 0.0346 0.0344
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0484 0.0482
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0272 0.027
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0083 0.0911 0.0911
Onchocerca volvulus 0.0787 1 1
Mycobacterium ulcerans hypothetical protein 0.0228 0.2784 0.2702
Brugia malayi steroid hormone receptor 0.0083 0.0911 0.0909
Loa Loa (eye worm) hypothetical protein 0.0044 0.0407 0.0407
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0529 0.0529
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0083 0.0911 0.0911
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0083 0.0911 0.0909
Loa Loa (eye worm) hypothetical protein 0.0044 0.0407 0.0407
Schistosoma mansoni hypothetical protein 0.0034 0.0281 0.0281
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0787 1 1
Entamoeba histolytica aldose reductase, putative 0.0787 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Schistosoma mansoni potassium channel beta 0.0228 0.2784 0.2784
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0044 0.0407 0.0405
Plasmodium vivax SET domain protein, putative 0.0033 0.0272 0.097
Onchocerca volvulus 0.0787 1 1
Echinococcus multilocularis aldo keto reductase 0.0787 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0787 1 1
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0228 0.2784 0.2783
Trypanosoma cruzi aldo-keto reductase 0.0787 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0039 0.0346 0.0077
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0624 0.0622
Plasmodium vivax aldehyde reductase, putative 0.0228 0.2784 1
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0579 0.7311 0.731
Loa Loa (eye worm) oxidoreductase 0.0787 1 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.2017 0.2017
Mycobacterium leprae Conserved hypothetical protein 0.0559 0.7058 0.5922
Onchocerca volvulus 0.0039 0.0346 0.0077
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0579 0.7311 0.731
Trichomonas vaginalis aldo/keto reductase, putative 0.0787 1 1
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0529 0.0527
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0039 0.0346 0.0344
Brugia malayi Nuclear hormone receptor E75 0.0039 0.0346 0.0344
Trypanosoma brucei aldo/keto reductase, putative 0.0228 0.2784 0.2783
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0113 0.0111
Brugia malayi Nuclear hormone receptor-like 1 0.0083 0.0911 0.0909
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0228 0.2784 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0428 0.0428
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0039 0.0346 0.0077
Giardia lamblia Aldose reductase 0.0787 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0484 0.0484
Echinococcus multilocularis aldehyde reductase 0.0559 0.7058 0.7057
Onchocerca volvulus Protein ultraspiracle homolog 0.0083 0.0911 0.0657
Loa Loa (eye worm) hypothetical protein 0.0083 0.0911 0.0911
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0345 0.1235
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0045 0.0043
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0113 0.0111
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0002 0.0002
Schistosoma mansoni thyroid hormone receptor 0.0083 0.0911 0.0911
Plasmodium falciparum aldo-keto reductase, putative 0.0228 0.2784 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0787 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0083 0.0911 0.0909
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0787 1 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0214 0.2603 0.2601
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0083 0.0911 0.0909
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0345 0.0344
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0083 0.0911 0.0911
Brugia malayi Pre-SET motif family protein 0.0232 0.2838 0.2837
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0113 0.0111
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0045
Schistosoma mansoni nuclear receptor 0.0039 0.0346 0.0346
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0083 0.0911 0.0909
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0083 0.0911 0.0909
Echinococcus multilocularis FTZ F1 alpha 0.0083 0.0911 0.0909
Loa Loa (eye worm) MBCTL1 0.0061 0.0624 0.0624
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0083 0.0911 0.0657
Loa Loa (eye worm) steroid hormone receptor 0.0083 0.0911 0.0911
Schistosoma mansoni ap endonuclease 0.0021 0.0113 0.0113
Echinococcus granulosus aldo keto reductase 0.0787 1 1
Onchocerca volvulus 0.0787 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.0039 0.0346 0.0344
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0787 1 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0407 0.0407
Plasmodium falciparum aldehyde reductase, putative 0.0228 0.2784 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0428 0.0426
Brugia malayi Steroid receptor seven-up type 2 0.0083 0.0911 0.0909
Schistosoma mansoni nuclear receptor nhr-48 0.0039 0.0346 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0083 0.0911 0.0909
Loa Loa (eye worm) hypothetical protein 0.0053 0.0529 0.0529
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0083 0.0911 0.0909
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0118 0.1365 0.1363
Brugia malayi Nuclear hormone receptor E75 0.0039 0.0346 0.0344
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0039 0.0346 0.0344
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0228 0.2784 0.2783
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0045 0.0043
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0428 0.0428
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0256 0.0254
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0083 0.0911 0.0909
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0118 0.1365 0.1363
Loa Loa (eye worm) hypothetical protein 0.0083 0.0911 0.0911
Onchocerca volvulus 0.0787 1 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0787 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0228 0.2784 0.2783
Loa Loa (eye worm) oxidoreductase 0.0787 1 1
Brugia malayi conserved hypotetical protein 0.0039 0.0346 0.0344
Entamoeba histolytica alcohol dehydrogenase, putative 0.0228 0.2784 0.2783
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0083 0.0911 0.0909
Loa Loa (eye worm) hypothetical protein 0.0034 0.0281 0.0281
Echinococcus multilocularis GPCR, family 2 0.0016 0.0045 0.0043
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0039 0.0346 0.0344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0083 0.0911 0.0911
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0083 0.0911 0.0911
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0428 0.0426
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0272 0.027
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0281 0.0279
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0346 0.0344
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0787 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0272 0.027
Brugia malayi nuclear hormone receptor family member odr-7 0.0039 0.0346 0.0344
Brugia malayi hypothetical protein 0.0169 0.2017 0.2016
Trichomonas vaginalis aldo/keto reductase, putative 0.0787 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0272 0.0272
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0345 0.0344
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.1657 0.1655
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.0792 0.0791
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0272 0.0272
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0624 0.0622
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0113 0.0111
Onchocerca volvulus 0.0039 0.0346 0.0077
Echinococcus granulosus aldo keto reductase 0.0787 1 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0391 0.1399
Echinococcus multilocularis thyroid hormone receptor alpha 0.0083 0.0911 0.0909
Echinococcus multilocularis aldo keto reductase 0.0787 1 1
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0228 0.2784 0.2784
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0113 0.0398
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0083 0.0911 0.0911
Loa Loa (eye worm) hypothetical protein 0.0044 0.0407 0.0407
Giardia lamblia Aldose reductase 0.0787 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0113 0.0111
Entamoeba histolytica aldose reductase, putative 0.0787 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0787 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.0346 0.0344
Loa Loa (eye worm) hypothetical protein 0.0044 0.0407 0.0407
Echinococcus granulosus aldo keto reductase 0.0787 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0083 0.0911 0.0909
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0624 0.0622
Loa Loa (eye worm) hypothetical protein 0.0083 0.0911 0.0911
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0044 0.0407 0.0405
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.0792 0.0791
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0083 0.0911 0.0911
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0113 0.0111
Brugia malayi hypothetical protein 0.0039 0.0346 0.0344
Trypanosoma brucei prostaglandin f synthase 0.0787 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0407 0.0405
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0083 0.0911 0.0909
Toxoplasma gondii exonuclease III APE 0.0021 0.0113 0.0111
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0083 0.0911 0.0909
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0083 0.0911 0.0909
Echinococcus multilocularis muscleblind protein 0.0297 0.3678 0.3677
Onchocerca volvulus 0.0787 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0911 0.0911
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0428 0.0428
Echinococcus granulosus FTZ F1 alpha 0.0083 0.0911 0.0909
Brugia malayi ecdysone receptor 0.0039 0.0346 0.0344
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0787 1 1
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0346 0.0346
Mycobacterium tuberculosis Probable oxidoreductase 0.0787 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0044 0.0407 0.0407
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0529 0.0529
Loa Loa (eye worm) oxidoreductase 0.0787 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0083 0.0911 0.0911
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0118 0.1365 0.1363
Leishmania major aldo-keto reductase-like protein 0.0787 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.