Detailed information for compound 112132

Basic information

Technical information
  • TDR Targets ID: 112132
  • Name: 4-[5-(4-hydroxyphenyl)pyridin-3-yl]phenol
  • MW: 263.291 | Formula: C17H13NO2
  • H donors: 2 H acceptors: 3 LogP: 3.39 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)c1cncc(c1)c1ccc(cc1)O
  • InChi: 1S/C17H13NO2/c19-16-5-1-12(2-6-16)14-9-15(11-18-10-14)13-3-7-17(20)8-4-13/h1-11,19-20H
  • InChiKey: LVQSMYWNOMFDGX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[5-(4-hydroxyphenyl)-3-pyridyl]phenol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0096 0.0044
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0096 0.0044
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0096 0.0044
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0022 0.0096 0.0044
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0096 0.0044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0096 0.0055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Onchocerca volvulus 0.0022 0.0096 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0022 0.0096 0.0044
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0022 0.0096 0.0079
Echinococcus multilocularis neuropeptide s receptor 0.0022 0.0096 0.0055
Echinococcus granulosus somatostatin receptor 0.0022 0.0096 0.0052
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0022 0.0096 0.0055
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0096 0.0052
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Loa Loa (eye worm) hypothetical protein 0.0318 0.5151 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0022 0.0096 0.0079
Echinococcus multilocularis neuropeptide receptor A26 0.0022 0.0096 0.0055
Echinococcus granulosus allatostatin A receptor 0.0022 0.0096 0.0052
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Schistosoma mansoni neuropeptide receptor 0.0022 0.0096 0.0044
Schistosoma mansoni amine GPCR 0.0022 0.0096 0.0044
Echinococcus multilocularis sex peptide receptor 0.0022 0.0096 0.0055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Schistosoma mansoni opsin-like receptor 0.0022 0.0096 0.0044
Echinococcus multilocularis sterol regulatory element binding protein 0.0131 0.1953 0.1994
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0096 0.0055
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0019 0.0043 0.0084
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0022 0.0096 0.0044
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0096 0.0186
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0096 0.0055
Schistosoma mansoni hypothetical protein 0.0022 0.0096 0.0044
Brugia malayi Tachykinin-like peptides receptor 99D 0.0022 0.0096 0.0079
Brugia malayi Serotonin receptor 0.0022 0.0096 0.0079
Schistosoma mansoni patched 1 0.0131 0.1953 0.3702
Echinococcus granulosus neuropeptide s receptor 0.0022 0.0096 0.0052
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Brugia malayi neuropeptide F receptor 0.0022 0.0096 0.0079
Brugia malayi hypothetical protein 0.0022 0.0096 0.0079
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0318 0.5151 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0096 0.0186
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Echinococcus granulosus neuropeptide FF receptor 2 0.0022 0.0096 0.0052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0096 0.0044
Brugia malayi Dopamine receptor 0.0022 0.0096 0.0079
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0022 0.0096 0.0055
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0022 0.0096 0.0186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0096 0.0044
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0096 0.0052
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0318 0.5151 1
Brugia malayi CHE-14 protein 0.0131 0.1953 0.2869
Brugia malayi putative neuropeptide receptor NPR1 0.0022 0.0096 0.0079
Brugia malayi Dopamine receptor protein 2 0.0022 0.0096 0.0079
Echinococcus granulosus 7tm_1 domain containing protein 0.0022 0.0096 0.0052
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0096 0.0055
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0096 0.0055
Echinococcus granulosus neuropeptide receptor A26 0.0022 0.0096 0.0052
Echinococcus multilocularis g-protein coupled receptor 0.0022 0.0096 0.0055
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0149 0.2265 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0022 0.0096 0.0044
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0096 0.0055
Brugia malayi hypothetical protein 0.0022 0.0096 0.0079
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0096 0.0052
Schistosoma mansoni histamine h1 receptor 0.0022 0.0096 0.0044
Onchocerca volvulus 0.0022 0.0096 0.5
Echinococcus multilocularis serotonin receptor 0.0022 0.0096 0.0055
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0096 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0131 0.1953 0.8608
Echinococcus multilocularis protein patched 0.0131 0.1953 0.1994
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0022 0.0096 0.0079
Echinococcus multilocularis conserved hypothetical protein 0.0579 0.962 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0096 0.0052
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0022 0.0096 0.0079
Onchocerca volvulus 0.0022 0.0096 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0022 0.0096 0.0052
Echinococcus granulosus Protein patched homolog 1 0.0131 0.1953 0.1918
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0022 0.0096 0.0052
Brugia malayi AKH receptor 0.0022 0.0096 0.0079
Onchocerca volvulus 0.0022 0.0096 0.5
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0096 0.0055
Echinococcus multilocularis G-protein coupled receptor, putative 0.0022 0.0096 0.0055
Echinococcus granulosus neuropeptide receptor 0.0022 0.0096 0.0052
Onchocerca volvulus 0.0022 0.0096 0.5
Schistosoma mansoni biogenic amine receptor 0.0022 0.0096 0.0044
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0022 0.0096 0.0044
Echinococcus granulosus orexin receptor type 2 0.0022 0.0096 0.0052
Schistosoma mansoni myosin xvIII 0.0022 0.0096 0.0044
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0096 0.0044
Echinococcus granulosus sterol regulatory element binding protein 0.0131 0.1953 0.1918
Brugia malayi Melatonin receptor type 1A 0.0022 0.0096 0.0079
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0096 0.0055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Onchocerca volvulus 0.0022 0.0096 0.5
Schistosoma mansoni adenoreceptor 0.0022 0.0096 0.0044
Schistosoma mansoni neuropeptide receptor 0.0022 0.0096 0.0044
Echinococcus multilocularis serotonin receptor 0.0022 0.0096 0.0055
Echinococcus granulosus sex peptide receptor 0.0022 0.0096 0.0052
Loa Loa (eye worm) melatonin receptor type 1A 0.0022 0.0096 0.0186
Onchocerca volvulus 0.0022 0.0096 0.5
Echinococcus granulosus neuropeptide receptor 0.0022 0.0096 0.0052
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Echinococcus multilocularis Niemann Pick C1 protein 0.0131 0.1953 0.1994
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0096 0.0055
Echinococcus multilocularis allatostatin A receptor 0.0022 0.0096 0.0055
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0096 0.0055
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0022 0.0096 0.0186
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Echinococcus granulosus alpha 1A adrenergic receptor 0.0022 0.0096 0.0052
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0096 0.0052
Onchocerca volvulus 0.0022 0.0096 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0096 0.0044
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0096 0.0055
Schistosoma mansoni neuropeptide receptor 0.0022 0.0096 0.0044
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0096 0.0044
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0318 0.5151 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0022 0.0096 0.0044
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0096 0.0055
Brugia malayi hypothetical protein 0.0022 0.0096 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0096 0.0044
Schistosoma mansoni amine GPCR 0.0022 0.0096 0.0044
Schistosoma mansoni biogenic amine receptor 0.0022 0.0096 0.0044
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0273 0.4378 0.4527
Brugia malayi RE15519p 0.0022 0.0096 0.0079
Brugia malayi hypothetical protein 0.0022 0.0096 0.0079
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0022 0.0096 0.0055
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0096 0.0052
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0022 0.0096 0.0186
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0318 0.5151 0.513
Brugia malayi G protein-coupled receptor F59B2.13 0.0022 0.0096 0.0079
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0022 0.0096 0.0186
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0096 0.0052
Echinococcus granulosus Niemann Pick C1 protein 0.0131 0.1953 0.1918
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0096 0.0044
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Brugia malayi hypothetical protein 0.0022 0.0096 0.0079
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0096 0.0044
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0318 0.5151 0.5
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0131 0.1953 0.3792
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0096 0.0044
Schistosoma mansoni opsin-like receptor 0.0022 0.0096 0.0044
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0096 0.0055
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0096 0.0055
Onchocerca volvulus 0.0022 0.0096 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0096 0.0055
Onchocerca volvulus 0.0022 0.0096 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0096 0.0052
Echinococcus granulosus g-protein coupled receptor 0.0022 0.0096 0.0052
Onchocerca volvulus 0.0022 0.0096 0.5
Echinococcus multilocularis somatostatin receptor 0.0022 0.0096 0.0055
Onchocerca volvulus 0.0022 0.0096 0.5
Brugia malayi hypothetical protein 0.0022 0.0096 0.0079
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0022 0.0096 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0096 0.0052
Onchocerca volvulus 0.0022 0.0096 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0096 0.0186
Schistosoma mansoni hypothetical protein 0.0022 0.0096 0.0044
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0096 0.0055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Schistosoma mansoni opsin-like receptor 0.0022 0.0096 0.0044
Echinococcus granulosus g protein coupled receptor 0.0022 0.0096 0.0052
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0318 0.5151 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0096 0.0055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Echinococcus granulosus peptide allatostatin:somatostatin 0.0022 0.0096 0.0052
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0096 0.0052
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0096 0.0052
Schistosoma mansoni hypothetical protein 0.0022 0.0096 0.0044
Brugia malayi putative neuropeptide receptor 0.0022 0.0096 0.0079
Schistosoma mansoni hypothetical protein 0.0022 0.0096 0.0044
Echinococcus multilocularis G protein coupled receptor 139 0.0022 0.0096 0.0055
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0318 0.5151 0.5333
Echinococcus multilocularis orexin receptor type 2 0.0022 0.0096 0.0055
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0022 0.0096 0.0044
Schistosoma mansoni biogenic amine receptor 0.0022 0.0096 0.0044
Brugia malayi hypothetical protein 0.0022 0.0096 0.0079
Echinococcus granulosus serotonin receptor 0.0022 0.0096 0.0052
Echinococcus granulosus 7TM GPCR rhodopsin 0.0022 0.0096 0.0052
Schistosoma mansoni amine GPCR 0.0022 0.0096 0.0044
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0022 0.0096 0.0044
Brugia malayi larval opioid receptor 0.0022 0.0096 0.0079
Echinococcus granulosus fmrfamide receptor 0.0022 0.0096 0.0052
Loa Loa (eye worm) hypothetical protein 0.0131 0.1953 0.3792
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Echinococcus multilocularis dro:myosuppressin receptor 0.0022 0.0096 0.0055
Echinococcus multilocularis protein dispatched 1 0.0131 0.1953 0.1994
Onchocerca volvulus 0.0022 0.0096 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0096 0.0055
Brugia malayi G-protein coupled receptor 0.0022 0.0096 0.0079
Echinococcus granulosus tm gpcr rhodopsin 0.0273 0.4378 0.4354
Brugia malayi Serotonin receptor 0.0408 0.6699 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Echinococcus granulosus dro:myosuppressin receptor 0.0022 0.0096 0.0052
Brugia malayi GnHR receptor homolog 0.0022 0.0096 0.0079
Echinococcus multilocularis neuropeptide FF receptor 2 0.0022 0.0096 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0096 0.0052
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0149 0.2265 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0096 0.0055
Brugia malayi G protein-coupled receptor 0.0022 0.0096 0.0079
Brugia malayi follicle stimulating hormone receptor 0.0022 0.0096 0.0079
Schistosoma mansoni amine GPCR 0.0022 0.0096 0.0044
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0096 0.0052
Schistosoma mansoni neuropeptide f receptor 76f 0.0022 0.0096 0.0044
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0096 0.0044
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0022 0.0096 0.0055
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0022 0.0096 0.0052
Loa Loa (eye worm) TYRA-2 protein 0.0022 0.0096 0.0186
Echinococcus granulosus tachykinin peptides receptor 99D 0.0022 0.0096 0.0052
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0096 0.0055
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0022 0.0096 0.5
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0096 0.0055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0096 0.0052
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0022 0.0096 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0096 0.0052
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0096 0.0186
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0096 0.0055
Brugia malayi hypothetical protein 0.0022 0.0096 0.0079
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Echinococcus granulosus g protein coupled receptor 0.0022 0.0096 0.0052
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0022 0.0096 0.0079
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0022 0.0096 0.0055
Onchocerca volvulus 0.0022 0.0096 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0096 0.0044
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0022 0.0096 0.0055
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0096 0.0055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Brugia malayi ORL1-like opioid receptor 0.0022 0.0096 0.0079
Schistosoma mansoni growth hormone secretagogue receptor 0.0022 0.0096 0.0044
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0318 0.5151 0.5
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0149 0.2265 1
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0318 0.5151 0.7674
Brugia malayi Dopamine receptor protein 1 0.0022 0.0096 0.0079
Brugia malayi hypothetical protein 0.0022 0.0096 0.0079
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Onchocerca volvulus 0.0022 0.0096 0.5
Echinococcus granulosus g protein coupled receptor 0.0022 0.0096 0.0052
Schistosoma mansoni neuropeptide receptor 0.0022 0.0096 0.0044
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0096 0.0052
Schistosoma mansoni amine GPCR 0.0022 0.0096 0.0044
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0096 0.0052
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0149 0.2265 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Onchocerca volvulus Neuropeptide F receptor homolog 0.0022 0.0096 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0096 0.0052
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0186
Brugia malayi sulfakinin receptor protein 0.0022 0.0096 0.0079
Brugia malayi G-protein coupled receptor 0.0022 0.0096 0.0079
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0131 0.1953 0.3702
Echinococcus granulosus G protein coupled receptor 139 0.0022 0.0096 0.0052
Onchocerca volvulus 0.0022 0.0096 0.5
Brugia malayi hypothetical protein 0.0022 0.0096 0.0079
Brugia malayi neuropeptide F receptor 0.0022 0.0096 0.0079
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0022 0.0096 0.0186
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0096 0.0044
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0022 0.0096 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0096 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0096 0.0044

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) In vivo inhibition of TNF- alpha after intraperitoneal administration of 25 mpk dose; showed no inhibition ChEMBL. No reference
Activity (functional) In vivo inhibition of serum IL-1 after i.p. administration of 25 mpk dose; showed no inhibition ChEMBL. No reference
Activity (functional) In vivo inhibition of serum IL-5 after i.p. administration of 25 mpk dose; showed no inhibition ChEMBL. No reference
Activity (functional) 0 In vivo inhibition of TNF- alpha after intraperitoneal administration of 25 mpk dose; showed no inhibition ChEMBL. No reference
Activity (functional) 0 In vivo inhibition of serum IL-1 after i.p. administration of 25 mpk dose; showed no inhibition ChEMBL. No reference
Activity (functional) 0 In vivo inhibition of serum IL-5 after i.p. administration of 25 mpk dose; showed no inhibition ChEMBL. No reference
ED50 (functional) = 2.8 MPK Effective dose required for in vivo inhibition of serum IL-6 . ChEMBL. No reference
ED50 (functional) = 2.8 MPK Effective dose required for in vivo inhibition of serum IL-6 . ChEMBL. No reference
IC50 (functional) = 0.4 uM Inhibitory activity of the compound against serum IL-6 . ChEMBL. No reference
IC50 (functional) = 0.4 uM Inhibitory activity of the compound against serum IL-6 . ChEMBL. No reference
Inhibition (functional) = 63 % In vivo inhibition of serum IL-6 after intraperitoneal administration of 25 mpk dose. ChEMBL. No reference
Inhibition (functional) = 63 % In vivo inhibition of serum IL-6 after intraperitoneal administration of 25 mpk dose. ChEMBL. No reference
Inhibition (functional) = 71 % In vivo inhibition of serum IL-6 after peroral administration of 25 mpk dose. ChEMBL. No reference
Inhibition (functional) = 71 % In vivo inhibition of serum IL-6 after peroral administration of 25 mpk dose. ChEMBL. No reference
Inhibition (functional) = 73 % In vitro inhibitory activity against lipopolysaccharide (LPS)-induced IL-6 production in murine myelomonocytic microM. ChEMBL. No reference
Inhibition (functional) = 73 % In vitro inhibitory activity against lipopolysaccharide (LPS)-induced IL-6 production in murine myelomonocytic microM. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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