Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0066 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.9233 | 0.9233 |
Trypanosoma brucei | cytochrome P450, putative | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.9233 | 0.1972 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0066 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0024 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.9045 | 0.9045 |
Brugia malayi | RNA binding protein | 0.0062 | 0.9045 | 0.9045 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.9233 | 0.9233 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.9045 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0053 | 0.7046 | 0.7046 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.9233 | 0.1972 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.9233 | 0.9233 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.9233 | 0.9233 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0062 | 0.8953 | 0.9898 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.9233 | 0.1972 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.9045 | 0.9045 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0066 | 1 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0066 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.9233 | 0.5 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0066 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.9233 | 0.1972 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.9045 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0053 | 0.7046 | 0.779 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.9045 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0066 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.