Detailed information for compound 1122303

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 489.556 | Formula: C29H29F2N3O2
  • H donors: 0 H acceptors: 2 LogP: 3.36 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(CC1)C(c1ccc(cc1)F)c1ccc(cc1)F)CCC(=O)N1Cc2c(C1)cccc2
  • InChi: 1S/C29H29F2N3O2/c30-25-9-5-21(6-10-25)29(22-7-11-26(31)12-8-22)33-17-15-32(16-18-33)27(35)13-14-28(36)34-19-23-3-1-2-4-24(23)20-34/h1-12,29H,13-20H2
  • InChiKey: PHLGWVXKGPRXHA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0187 0.1913
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1773 0.6365
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0975 0.3432
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0109 0.0109
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0975 0.0975
Schistosoma mansoni hypothetical protein 0.0149 0.427 0.427
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.2818 0.6994
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0109 0.0271
Echinococcus multilocularis cysteine protease 0.0018 0.0187 0.0127
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0817 0.2851
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0061 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1773 0.6365
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0817 0.5322
Echinococcus multilocularis snurportin 1 0.0332 1 1
Leishmania major hypothetical protein, conserved 0.0038 0.0817 0.2851
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0975 0.3432
Echinococcus granulosus lamin dm0 0.0029 0.0531 0.0531
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0975 0.3432
Loa Loa (eye worm) hypothetical protein 0.0031 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0038 0.0817 0.0817
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0338 0.1654
Loa Loa (eye worm) hypothetical protein 0.0019 0.0201 0.0201
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0338 0.5351
Brugia malayi beta-lactamase 0.0038 0.0817 0.2029
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0975 0.3432
Schistosoma mansoni hypothetical protein 0.0332 1 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0975 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0975 0.3432
Onchocerca volvulus 0.0018 0.0187 0.2283
Echinococcus multilocularis dna polymerase eta 0.01 0.2761 0.2717
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0594 0.3091
Brugia malayi MH2 domain containing protein 0.0141 0.403 1
Schistosoma mansoni intermediate filament proteins 0.0029 0.0531 0.0531
Echinococcus granulosus dna polymerase eta 0.01 0.2761 0.2761
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0817 0.8381
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0338 0.0338
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.041 0.4208
Trichomonas vaginalis importin beta-1, putative 0.0025 0.041 0.4208
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0201 0.0201
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0338 0.3166
Entamoeba histolytica Ran family GTPase 0.0023 0.0338 0.3461
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0187 0.1913
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0149 0.427 0.427
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0042
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.2818 0.2818
Leishmania major GTP-binding protein, putative 0.0023 0.0338 0.1087
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0531 0.0531
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.1586 0.5678
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0975 0.3432
Onchocerca volvulus 0.0029 0.0531 0.6499
Mycobacterium ulcerans lipase LipD 0.0038 0.0817 0.5322
Loa Loa (eye worm) hypothetical protein 0.0032 0.0633 0.0633
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0975 0.3432
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0975 0.0245
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0187 0.1913
Echinococcus multilocularis cysteine protease 0.0018 0.0187 0.0127
Onchocerca volvulus 0.0038 0.0817 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1773 0.6365
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0633 0.0633
Brugia malayi jmjC domain containing protein 0.0019 0.0201 0.0499
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0187 0.1913
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0633 0.0633
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.2725 0.2725
Trypanosoma brucei unspecified product 0.0043 0.0975 0.3432
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0201 0.089
Loa Loa (eye worm) hypothetical protein 0.0029 0.0531 0.0531
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0187 0.0531
Plasmodium vivax vivapain-2 0.0018 0.0187 0.1864
Trypanosoma brucei unspecified product 0.003 0.0555 0.1887
Loa Loa (eye worm) hypothetical protein 0.0038 0.0817 0.0817
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0187 0.1913
Echinococcus granulosus phd:f box containing protein 0.0019 0.0201 0.0201
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0201 0.0201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0187 0.1913
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0975 0.0975
Echinococcus granulosus cathepsin l1 0.0018 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0019 0.0201 0.0201
Entamoeba histolytica cysteine protease, putative 0.0018 0.0187 0.1913
Onchocerca volvulus 0.0018 0.0187 0.2283
Brugia malayi jmjC domain containing protein 0.007 0.1793 0.4451
Schistosoma mansoni thyroid hormone receptor 0.0161 0.4643 0.4643
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0594 0.203
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.041 0.1354
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0975 1
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0594 0.0537
Schistosoma mansoni hypothetical protein 0.0032 0.0633 0.0633
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0201 0.0585
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.1807 0.4484
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0555 0.1887
Schistosoma mansoni ran 0.0023 0.0338 0.0338
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0338 0.3811
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0975 0.3432
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0975 0.3432
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0187 0.1913
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0975 0.3432
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0817 0.8381
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0975 0.6405
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0044
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0338 0.1087
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0338 0.1087
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0201 0.089
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.2725 0.2725
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0201 0.0201
Schistosoma mansoni hypothetical protein 0.0032 0.0633 0.0633
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0817 0.0817
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1499 0.1499
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.2725 0.2725
Schistosoma mansoni jumonji domain containing protein 0.007 0.1793 0.1793
Brugia malayi jmjC domain containing protein 0.007 0.1793 0.4451
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0817 0.0817
Brugia malayi intermediate filament protein 0.0029 0.0531 0.1318
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0633 0.0576
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0817 0.2851
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0187 0.2283
Giardia lamblia DINP protein human, muc B family 0.0043 0.0975 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0975 0.3432
Brugia malayi ImpB/MucB/SamB family protein 0.01 0.2761 0.6853
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.1499 0.8157
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0817 0.2029
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.1793 0.1793
Echinococcus granulosus intermediate filament protein 0.0029 0.0531 0.0531
Echinococcus multilocularis GPCR, family 2 0.0032 0.0633 0.0576
Leishmania major cathepsin L-like protease 0.0069 0.1773 0.6365
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0187 0.2283
Leishmania major DNA polymerase eta, putative 0.0071 0.1828 0.6568
Loa Loa (eye worm) MH2 domain-containing protein 0.0141 0.403 0.403
Toxoplasma gondii ABC1 family protein 0.0038 0.0817 0.4341
Echinococcus granulosus lamin 0.0029 0.0531 0.0531
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0817 0.0817
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0187 0.1913
Leishmania major cathepsin L-like protease 0.0069 0.1773 0.6365
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0817 0.0761
Loa Loa (eye worm) hypothetical protein 0.0018 0.0187 0.0187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0187 0.1913
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0071 0.1828 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0187 0.1913
Trichomonas vaginalis esterase, putative 0.0038 0.0817 0.8381
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1499 0.1499
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0633 0.0633
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0244 0.7259 1
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0817 1
Echinococcus multilocularis lamin 0.0029 0.0531 0.0473
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0201 0.0141
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0555 0.1887
Brugia malayi Cathepsin L-like precursor 0.0018 0.0187 0.0463
Brugia malayi jmjC domain containing protein 0.0019 0.0201 0.0499
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0187 0.2617
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0042 0.0042
Leishmania major cathepsin L-like protease 0.0018 0.0187 0.0531
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0817 0.8381
Echinococcus multilocularis lamin dm0 0.0029 0.0531 0.0473
Onchocerca volvulus 0.0018 0.0187 0.2283
Trypanosoma cruzi DNA polymerase eta, putative 0.01 0.2761 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1773 0.6365
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0187 0.0187
Loa Loa (eye worm) ctsf protein 0.0018 0.0187 0.0187
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0817 0.8381
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0975 0.242
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.007 0.1793 0.1793
Echinococcus granulosus lysine specific demethylase 5A 0.007 0.1793 0.1793
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0975 0.0245
Onchocerca volvulus 0.0038 0.0817 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0187 0.1913
Mycobacterium ulcerans beta-lactamase 0.0038 0.0817 0.5322
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0531 0.1318
Leishmania major importin beta-1 subunit, putative 0.0025 0.041 0.1354
Leishmania major hypothetical protein, conserved 0.0019 0.0201 0.0585
Brugia malayi beta-lactamase family protein 0.0038 0.0817 0.2029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0187 0.1913
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0187 0.1913
Trypanosoma brucei DNA polymerase eta, putative 0.01 0.2761 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0071 0.1828 0.6568
Brugia malayi Cathepsin L-like precursor 0.0018 0.0187 0.0463
Onchocerca volvulus 0.0018 0.0187 0.2283
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0201 0.0141
Loa Loa (eye worm) hypothetical protein 0.0029 0.0515 0.0515
Schistosoma mansoni hypothetical protein 0.0032 0.0633 0.0633
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0975 0.6405
Loa Loa (eye worm) hypothetical protein 0.0019 0.0201 0.0201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0187 0.1913
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0817 0.8381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0187 0.1913
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0044
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.1773 0.6365
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0187 0.1913
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0187 0.0187
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0201 0.0201
Mycobacterium ulcerans hypothetical protein 0.0038 0.0817 0.5322
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0201 0.0201
Leishmania major cathepsin L-like protease 0.0018 0.0187 0.0531
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0332 1 1
Schistosoma mansoni DNA polymerase eta 0.01 0.2761 0.2761
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0187 0.1913
Leishmania major DNA polymerase kappa, putative 0.0043 0.0975 0.3432
Plasmodium vivax importin-beta 2, putative 0.0031 0.0594 0.7121
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0633 0.1572
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0201 0.0201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1773 0.6365
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0531 0.0531
Brugia malayi jmjC domain containing protein 0.0019 0.0201 0.0499
Loa Loa (eye worm) hypothetical protein 0.0038 0.0817 0.0817
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0975 0.0975
Onchocerca volvulus 0.0018 0.0187 0.2283
Loa Loa (eye worm) hypothetical protein 0.0038 0.0817 0.0817
Loa Loa (eye worm) hypothetical protein 0.007 0.1807 0.1807
Onchocerca volvulus 0.0029 0.0531 0.6499
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.041 0.4208
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0975 0.3432
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0187 0.1913
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0187 0.1913
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.2725 0.268
Leishmania major cathepsin L-like protease 0.0018 0.0187 0.0531
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0201 0.0141
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0633 0.1572
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1773 0.6365
Schistosoma mansoni ran 0.0023 0.0338 0.0338
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0187 0.0127
Brugia malayi Cathepsin L-like precursor 0.0018 0.0187 0.0463
Loa Loa (eye worm) fibroinase 0.0018 0.0187 0.0187
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0201 0.0201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0187 0.1913
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0975 0.3432
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.1773 0.6365
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.2725 0.268
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1773 0.6365
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.1793 0.1793
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0187 0.0531
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1499 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.1499 0.1058
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0061
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0817 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1499 1
Trypanosoma brucei unspecified product 0.003 0.0555 0.1887
Loa Loa (eye worm) hypothetical protein 0.01 0.2761 0.2761
Schistosoma mansoni lamin 0.0029 0.0531 0.0531
Leishmania major cathepsin L-like protease 0.0018 0.0187 0.0531
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0594 0.203
Onchocerca volvulus 0.0018 0.0187 0.2283
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0201 0.0141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0187 0.1913
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0187 0.0187
Brugia malayi beta-lactamase family protein 0.0038 0.0817 0.2029
Schistosoma mansoni hypothetical protein 0.0032 0.0633 0.0633
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.1499 0.1499
Brugia malayi RNA, U transporter 1 0.0088 0.2387 0.5922
Plasmodium vivax vivapain-2 0.0018 0.0187 0.1864
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1773 0.6365
Loa Loa (eye worm) transcription factor SMAD2 0.0141 0.403 0.403
Leishmania major cathepsin L-like protease 0.0069 0.1773 0.6365
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0817 0.5322
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0338 0.0338
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0975 0.3432
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0187 0.1913
Brugia malayi polk-prov protein 0.0013 0.0042 0.0104
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0201 0.288
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0201 0.0585
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0201 0.0201
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.1793 0.1793
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0187 0.1913
Onchocerca volvulus 0.0038 0.0817 1
Entamoeba histolytica hypothetical protein 0.0025 0.041 0.4208
Leishmania major cathepsin L-like protease 0.0018 0.0187 0.0531
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.007 0.1793 0.1743
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0975 0.3432
Loa Loa (eye worm) hypothetical protein 0.0038 0.0817 0.0817
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0201 0.0585
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0201 0.0201
Toxoplasma gondii cathepsin CPL 0.0018 0.0187 0.0809
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0187 0.0127
Echinococcus granulosus GPCR family 2 0.0032 0.0633 0.0633
Echinococcus multilocularis thyroid hormone receptor alpha 0.0161 0.4643 0.461
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0338 0.1087
Plasmodium vivax JmjC domain containing protein 0.0019 0.0201 0.2051
Loa Loa (eye worm) hypothetical protein 0.0038 0.0817 0.0817
Brugia malayi Cathepsin L-like precursor 0.0018 0.0187 0.0463
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1773 0.6365
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0975 0.3432
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0338 0.0838
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.2725 0.2725
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0187 0.0187
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0201 0.0201
Schistosoma mansoni thyroid hormone receptor 0.0161 0.4643 0.4643
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0975 0.092
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.2725 0.6762
Loa Loa (eye worm) hypothetical protein 0.0102 0.2818 0.2818
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0201 0.0201
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.1773 0.6365
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0187 0.2617
Echinococcus granulosus importin subunit beta 1 0.0031 0.0594 0.0594
Brugia malayi jmjC domain containing protein 0.0019 0.0201 0.0499
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0187 0.1913
Onchocerca volvulus 0.0018 0.0187 0.2283
Plasmodium falciparum importin beta, putative 0.0031 0.0594 1
Echinococcus granulosus dna polymerase kappa 0.0043 0.0975 0.0975
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0187 0.0187
Echinococcus multilocularis lysine specific demethylase 5A 0.007 0.1793 0.1743
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0187 0.2283
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0201 0.0201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0187 0.1913
Brugia malayi Cathepsin L-like precursor 0.0018 0.0187 0.0463
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0975 0.3432
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0633 0.0576
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.1773 0.6365
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0201 0.0141
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.1499 0.1447
Schistosoma mansoni lamin 0.0029 0.0531 0.0531
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0187 0.1913
Leishmania major DNA polymerase eta, putative 0.01 0.2761 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.1499 0.5358
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.2725 0.2725
Brugia malayi Importin beta-1 subunit 0.0031 0.0594 0.1475
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1499 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0817 0.0817
Echinococcus multilocularis musashi 0.0029 0.0531 0.0473
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0149 0.427 0.4235
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0187 0.0187
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.2818 0.6994
Loa Loa (eye worm) beta-lactamase 0.0038 0.0817 0.0817
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0187 0.0463
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0975 0.0975
Schistosoma mansoni hypothetical protein 0.007 0.1807 0.1807
Brugia malayi Cathepsin L-like precursor 0.0018 0.0187 0.0463
Trichomonas vaginalis ran, putative 0.0023 0.0338 0.3461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0187 0.1913
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0555 0.1887
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0187 0.2617
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0975 1
Loa Loa (eye worm) cysteine protease 0.0018 0.0187 0.0187
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1773 0.6365
Schistosoma mansoni importin beta-1 0.0031 0.0594 0.0594
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0975 0.3432
Mycobacterium leprae Probable lipase LipE 0.0038 0.0817 0.5
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0338 0.0278
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.2725 0.2725
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.1313 0.4672
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1773 0.6365
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0187 0.0127
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0817 0.2851
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0187 0.0127
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0975 0.092

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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