Detailed information for compound 1122334

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 438.473 | Formula: C24H26N2O6
  • H donors: 0 H acceptors: 4 LogP: 4.27 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C([C@H]1[C@H](C[C@@H]2N(C1CC2)C)OC(=O)c1ccccc1)OCCc1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C24H26N2O6/c1-25-19-11-12-20(25)22(21(15-19)32-23(27)17-5-3-2-4-6-17)24(28)31-14-13-16-7-9-18(10-8-16)26(29)30/h2-10,19-22H,11-15H2,1H3/t19-,20?,21+,22-/m1/s1
  • InChiKey: XFDVAPZJHKZTNE-JGVPYUGNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine transporter Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Transmembrane protein 120 homolog Dopamine transporter   619 aa 578 aa 32.9 %
Schistosoma japonicum ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative Dopamine transporter   619 aa 551 aa 39.9 %
Schistosoma mansoni sodium/chloride dependent transporter Dopamine transporter   619 aa 558 aa 41.8 %
Brugia malayi Sodium:neurotransmitter symporter family protein Dopamine transporter   619 aa 578 aa 33.4 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Dopamine transporter   619 aa 578 aa 32.9 %
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter Dopamine transporter   619 aa 604 aa 37.9 %
Schistosoma mansoni sodium/chloride dependent transporter Dopamine transporter   619 aa 588 aa 40.3 %
Neospora caninum sodium-dependent transporter, putative Dopamine transporter   619 aa 498 aa 32.3 %
Echinococcus multilocularis sodium and chloride dependent glycine Dopamine transporter   619 aa 599 aa 41.9 %
Drosophila melanogaster CG13796 gene product from transcript CG13796-RD Dopamine transporter   619 aa 557 aa 23.9 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Dopamine transporter   619 aa 636 aa 31.8 %
Onchocerca volvulus Dopamine transporter   619 aa 612 aa 23.5 %
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Dopamine transporter   619 aa 509 aa 40.1 %
Echinococcus granulosus sodium and chloride dependent glycine Dopamine transporter   619 aa 594 aa 41.4 %
Drosophila melanogaster CG1698 gene product from transcript CG1698-RA Dopamine transporter   619 aa 522 aa 36.0 %
Plasmodium vivax hypothetical protein, conserved Dopamine transporter   619 aa 657 aa 20.1 %
Onchocerca volvulus High affinity copper uptake protein 1 homolog Dopamine transporter   619 aa 599 aa 44.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0029 0.0096 0.0116
Echinococcus granulosus acetylcholinesterase 0.0764 0.8275 0.9238
Loa Loa (eye worm) beta-lactamase 0.0072 0.0577 0.0698
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0195 0.0236
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0276 0.0334
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0486 0.0947
Loa Loa (eye worm) carboxylesterase 0.0129 0.1213 0.1466
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.0452 0.0478
Echinococcus multilocularis zinc finger protein 0.004 0.0219 0.0203
Loa Loa (eye worm) hypothetical protein 0.0109 0.0985 0.1191
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0294 0.305 0.6222
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0577 0.0669
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.1359 0.1494
Trypanosoma brucei glucosidase, putative 0.0038 0.0199 0.345
Schistosoma mansoni zinc finger protein 0.0031 0.0123 0.0118
Loa Loa (eye worm) hypothetical protein 0.0061 0.0452 0.0546
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0243 0.0294
Brugia malayi Steroid receptor seven-up type 2 0.0061 0.0452 0.0546
Echinococcus multilocularis thyroid hormone receptor alpha 0.0061 0.0452 0.0446
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0061 0.0452 0.0446
Echinococcus granulosus expressed conserved protein 0.0093 0.0817 0.0887
Brugia malayi nuclear receptor NHR-88 0.0029 0.0096 0.0116
Mycobacterium ulcerans lipase LipD 0.0072 0.0577 0.121
Trichomonas vaginalis esterase, putative 0.0072 0.0577 0.0386
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0195 0.0177
Echinococcus granulosus hypothetical protein 0.074 0.8013 0.8945
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0577 1
Echinococcus multilocularis muscleblind protein 1 0.047 0.5005 0.521
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0881 0.9583 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0898 0.1086
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0577 0.1135
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0919 1 1
Loa Loa (eye worm) hypothetical protein 0.0764 0.8275 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0096 0.0116
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0577 0.1135
Loa Loa (eye worm) hypothetical protein 0.0032 0.0134 0.0162
Schistosoma mansoni zinc finger protein 0.004 0.0219 0.0235
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0061 0.0452 0.0517
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.0452 0.0446
Entamoeba histolytica hypothetical protein 0.0257 0.264 0.2491
Echinococcus multilocularis transcription factor eb 0.0109 0.0991 0.101
Onchocerca volvulus 0.0129 0.1213 0.4724
Brugia malayi conserved hypotetical protein 0.0029 0.0096 0.0116
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.0031
Loa Loa (eye worm) hypothetical protein 0.047 0.5005 0.6049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0126 0.0121
Loa Loa (eye worm) hypothetical protein 0.0086 0.074 0.0894
Loa Loa (eye worm) hypothetical protein 0.0061 0.0452 0.0546
Brugia malayi Carboxylesterase family protein 0.0764 0.8275 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0061 0.0452 0.0546
Brugia malayi nuclear receptor NHR-67 0.0029 0.0096 0.0116
Brugia malayi hypothetical protein 0.0257 0.264 0.3191
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0199 0.0241
Echinococcus granulosus neuroligin 0.0129 0.1213 0.133
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.0031
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.1677 0.1728
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0061 0.0452 0.0546
Schistosoma mansoni retinoic acid receptor RXR 0.0061 0.0452 0.0517
Loa Loa (eye worm) hypothetical protein 0.0101 0.0898 0.1086
Loa Loa (eye worm) hypothetical protein 0.0133 0.1259 0.1522
Schistosoma mansoni coup transcription factor 0.0061 0.0452 0.0517
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.1677 0.185
Echinococcus multilocularis protein patched 0.0043 0.0253 0.0238
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0061 0.0452 0.0546
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0486 0.0515
Plasmodium falciparum protoporphyrinogen oxidase 0.0022 0.0025 0.5
Echinococcus granulosus para nitrobenzyl esterase 0.0129 0.1213 0.133
Brugia malayi hypothetical protein 0.0029 0.0096 0.0116
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0199 0.345
Loa Loa (eye worm) hypothetical protein 0.0043 0.0253 0.0305
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0061 0.0452 0.0478
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0486 0.1018
Loa Loa (eye worm) hypothetical protein 0.0032 0.0134 0.0162
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0199 0.345
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0347 0.039
Loa Loa (eye worm) hypothetical protein 0.0109 0.0996 0.1203
Loa Loa (eye worm) hypothetical protein 0.0129 0.1213 0.1466
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0577 0.1135
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.0096 0.0085
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0132 0.0112
Loa Loa (eye worm) hypothetical protein 0.0061 0.0452 0.0546
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.112 0.1353
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0096 0.028
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0121 0.1125 0.115
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0257 0.264 0.2736
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0577 0.1163
Loa Loa (eye worm) hypothetical protein 0.047 0.5005 0.6049
Onchocerca volvulus 0.0072 0.0577 0.2194
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0898 0.1086
Echinococcus multilocularis protein dispatched 1 0.0049 0.032 0.0308
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.051 0.0588
Echinococcus multilocularis FTZ F1 alpha 0.0061 0.0452 0.0446
Brugia malayi PAS domain containing protein 0.0051 0.0341 0.0413
Onchocerca volvulus 0.0028 0.0092 0.0265
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0022 0.0025 0.5
Brugia malayi Carboxylesterase family protein 0.0129 0.1213 0.1466
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.051 0.0588
Loa Loa (eye worm) zinc finger protein 0.0324 0.3384 0.4089
Brugia malayi Carboxylesterase family protein 0.0129 0.1213 0.1466
Schistosoma mansoni hypothetical protein 0.0032 0.0132 0.0129
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0113 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0253 0.0054
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0061 0.0452 0.0478
Onchocerca volvulus 0.0129 0.1213 0.4724
Echinococcus granulosus geminin 0.0525 0.5621 0.6266
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0199 0.0241
Echinococcus granulosus zinc finger protein 0.004 0.0219 0.0217
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.0031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0486 0.1018
Schistosoma mansoni hypothetical protein 0.0032 0.0132 0.0129
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0162 0.0143
Loa Loa (eye worm) hypothetical protein 0.0029 0.0096 0.0116
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0176 0.0213
Brugia malayi tailless protein 0.0029 0.0096 0.0116
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0096 0.0074
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.0096 0.0116
Entamoeba histolytica hypothetical protein 0.0257 0.264 0.2491
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0919 1 1
Mycobacterium tuberculosis Conserved protein 0.0072 0.0577 0.1135
Brugia malayi intermediate filament protein 0.0028 0.0092 0.0111
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0577 0.0698
Onchocerca volvulus Huntingtin homolog 0.0133 0.1259 0.4906
Echinococcus granulosus transcription factor eb 0.0109 0.0991 0.1081
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0577 1
Brugia malayi SWIRM domain containing protein 0.0022 0.0025 0.0031
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0577 0.0386
Loa Loa (eye worm) hypothetical protein 0.0032 0.0132 0.016
Brugia malayi Pre-SET motif family protein 0.0218 0.2204 0.2664
Leishmania major hypothetical protein, conserved 0.0031 0.0123 0.2126
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0449 0.4771 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0764 0.8275 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0162 0.0153
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0486 0.8413
Onchocerca volvulus 0.0152 0.1465 0.5727
Schistosoma mansoni alpha glucosidase 0.0038 0.0199 0.0211
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0061 0.0452 0.0478
Brugia malayi nuclear receptor RXR 0.0032 0.0134 0.0162
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0253 0.0254
Leishmania major UDP-galactopyranose mutase 0.0022 0.0025 0.0442
Loa Loa (eye worm) hypothetical protein 0.0764 0.8275 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0032 0.0134 0.0113
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0486 0.1018
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0199 0.345
Trypanosoma cruzi ISWI complex protein 0.0031 0.0123 0.2126
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0253 0.0254
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.051 0.0543
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0061 0.0452 0.1697
Loa Loa (eye worm) hypothetical protein 0.0061 0.0452 0.0546
Trypanosoma brucei ISWI complex protein 0.0031 0.0123 0.2126
Loa Loa (eye worm) hypothetical protein 0.0109 0.0996 0.1203
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0061 0.0452 0.0517
Brugia malayi beta-lactamase family protein 0.0072 0.0577 0.0698
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0129 0.1213 0.144
Brugia malayi Carboxylesterase family protein 0.0129 0.1213 0.1466
Schistosoma mansoni thyroid hormone receptor 0.0061 0.0452 0.0517
Echinococcus multilocularis carboxylesterase 5A 0.0764 0.8275 0.8631
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.0096 0.0116
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0092 0.0111
Onchocerca volvulus 0.0029 0.0096 0.028
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.112 0.1353
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0577 0.0577
Echinococcus granulosus tm gpcr rhodopsin 0.0825 0.8955 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0276 0.0281
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.1677 0.2027
Echinococcus granulosus muscleblind protein 0.047 0.5005 0.5576
Loa Loa (eye worm) hypothetical protein 0.0029 0.0096 0.0116
Schistosoma mansoni steroid hormone receptor ad4bp 0.0061 0.0452 0.0517
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0061 0.0452 0.0517
Schistosoma mansoni hypothetical protein 0.0031 0.0123 0.0118
Echinococcus granulosus single minded 2 0.0038 0.0195 0.019
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0195 0.0409
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.2204 0.2664
Schistosoma mansoni hypothetical protein 0.0069 0.0544 0.0628
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0459 0.4886 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0157 0.1523 0.184
Schistosoma mansoni gliotactin 0.0129 0.1213 0.144
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0032 0.0134 0.0121
Loa Loa (eye worm) hypothetical protein 0.0066 0.051 0.0617
Brugia malayi Nuclear hormone receptor-like 1 0.0061 0.0452 0.0546
Echinococcus multilocularis ecdysone induced protein 78C 0.0061 0.0452 0.0446
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0061 0.0452 0.0446
Onchocerca volvulus 0.0031 0.0126 0.0399
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0449 0.4771 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0919 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0276 0.0334
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0109 0.0985 0.1191
Loa Loa (eye worm) serotonin transporter b 0.0109 0.0996 0.1203
Schistosoma mansoni hypothetical protein 0.0041 0.0235 0.0255
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0919 1 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0129 0.1213 0.133
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0096 0.0079
Loa Loa (eye worm) hypothetical protein 0.0029 0.0096 0.0116
Brugia malayi PHD-finger family protein 0.0051 0.034 0.041
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0577 0.1135
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.0452 0.0478
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0096 0.0116
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0096 0.0085
Echinococcus granulosus FTZ F1 alpha 0.0061 0.0452 0.0478
Onchocerca volvulus 0.0072 0.0577 0.2194
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0577 0.121
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0061 0.0452 0.0546
Onchocerca volvulus 0.0109 0.0996 0.3859
Echinococcus granulosus BC026374 protein S09 family 0.0129 0.1213 0.133
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0132 0.012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0577 0.0669
Mycobacterium tuberculosis Carboxylesterase LipT 0.0129 0.1213 0.2444
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0577 0.1135
Loa Loa (eye worm) hypothetical protein 0.0129 0.1213 0.1466
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0276 0.0304
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0109 0.0991 0.1198
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0096 0.0085
Loa Loa (eye worm) hypothetical protein 0.0061 0.0452 0.0546
Echinococcus multilocularis neuroligin 0.0129 0.1213 0.1243
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0199 0.0182
Onchocerca volvulus Huntingtin homolog 0.0133 0.1259 0.4906
Schistosoma mansoni zinc finger protein 0.0029 0.0096 0.0085
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0061 0.0452 0.0546
Loa Loa (eye worm) hypothetical protein 0.0029 0.0096 0.0116
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0061 0.0452 0.0446
Brugia malayi Bromodomain containing protein 0.0152 0.147 0.1776
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.0096 0.0116
Schistosoma mansoni acetylcholinesterase 0.0129 0.1213 0.144
Echinococcus granulosus lamin 0.0028 0.0092 0.0075
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0588 0.063
Loa Loa (eye worm) hypothetical protein 0.0029 0.0096 0.0116
Entamoeba histolytica hypothetical protein 0.0257 0.264 0.2491
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0316 0.3298 0.6912
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0134 0.0162
Schistosoma mansoni intermediate filament proteins 0.0028 0.0092 0.0081
Onchocerca volvulus 0.0029 0.0096 0.028
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0898 0.1086
Brugia malayi amine oxidase, flavin-containing family protein 0.0022 0.0025 0.0031
Echinococcus multilocularis acetylcholinesterase 0.0764 0.8275 0.8631
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.051 0.0507
Brugia malayi hypothetical protein 0.0029 0.0096 0.0116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0919 1 1
Brugia malayi hypothetical protein 0.0744 0.8053 0.9732
Loa Loa (eye worm) hypothetical protein 0.0072 0.0577 0.0698
Brugia malayi hypoxia-induced factor 1 0.0157 0.1523 0.184
Onchocerca volvulus 0.0099 0.0876 0.3384
Loa Loa (eye worm) hypothetical protein 0.0052 0.0359 0.0434
Brugia malayi hypothetical protein 0.0032 0.0134 0.0162
Mycobacterium ulcerans beta-lactamase 0.0072 0.0577 0.121
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0825 0.8955 0.9343
Schistosoma mansoni single-minded 0.0051 0.0341 0.0383
Loa Loa (eye worm) hypothetical protein 0.0072 0.0577 0.0698
Echinococcus granulosus zinc finger transcription factor gli2 0.0324 0.3384 0.3761
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0577 0.0386
Echinococcus granulosus serotonin transporter 0.0109 0.0996 0.1087
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0544 0.0657
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0919 1 1
Brugia malayi hypothetical protein 0.017 0.1669 0.2018
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0046 0.0286 0.0273
Schistosoma mansoni BC026374 protein (S09 family) 0.0129 0.1213 0.144
Loa Loa (eye worm) hypothetical protein 0.0129 0.1213 0.1466
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0129 0.1213 0.144
Brugia malayi nuclear hormone receptor 0.0061 0.0452 0.0546
Loa Loa (eye worm) hypothetical protein 0.0029 0.0096 0.0116
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.0096 0.0085
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.0096 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0061 0.0452 0.0546
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.0096 0.0079
Loa Loa (eye worm) solute carrier family 6 member 4 0.0109 0.0996 0.1203
Loa Loa (eye worm) hypothetical protein 0.0099 0.0884 0.1069
Brugia malayi ecdysone receptor 0.0029 0.0096 0.0116
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0486 0.0558
Loa Loa (eye worm) carboxylesterase 0.0129 0.1213 0.1466
Mycobacterium tuberculosis Conserved protein 0.0072 0.0577 0.1135
Echinococcus multilocularis conserved hypothetical protein 0.0735 0.7958 0.83
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0129 0.1213 0.2444
Echinococcus multilocularis geminin 0.0525 0.5621 0.5854
Schistosoma mansoni hypothetical protein 0.0041 0.0235 0.0255
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0061 0.0452 0.0546
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0152 0.1465 0.1771
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0253 0.0238
Schistosoma mansoni alpha-glucosidase 0.0147 0.1413 0.1682
Schistosoma mansoni hypothetical protein 0.0257 0.264 0.317
Schistosoma mansoni survival motor neuron protein 0.0152 0.1465 0.1746
Onchocerca volvulus 0.0061 0.0452 0.1697
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0061 0.0452 0.0546
Onchocerca volvulus 0.0129 0.1213 0.4724
Brugia malayi hypothetical protein 0.0129 0.1213 0.1466
Loa Loa (eye worm) hypothetical protein 0.0129 0.1213 0.1466
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0061 0.0452 0.0478
Echinococcus multilocularis survival motor neuron protein 1 0.0744 0.8053 0.8399
Schistosoma mansoni hypothetical protein 0.0041 0.0235 0.0255
Mycobacterium ulcerans hypothetical protein 0.0072 0.0577 0.121
Loa Loa (eye worm) hypothetical protein 0.0072 0.0577 0.0698
Echinococcus multilocularis GPCR, family 2 0.0032 0.0132 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0061 0.0452 0.0546
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0884 0.1069
Mycobacterium tuberculosis Conserved protein 0.0072 0.0577 0.1135
Loa Loa (eye worm) hypothetical protein 0.0029 0.0096 0.0116
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0129 0.1213 0.1035
Loa Loa (eye worm) hypothetical protein 0.0032 0.0134 0.0162
Brugia malayi nuclear hormone receptor 0.0029 0.0096 0.0116
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0588 0.0589
Giardia lamblia Fructose-bisphosphate aldolase 0.0919 1 0.5
Onchocerca volvulus 0.0129 0.1213 0.4724
Mycobacterium ulcerans dehydrogenase 0.0022 0.0025 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0276 0.0304
Echinococcus multilocularis musashi 0.0028 0.0092 0.007
Loa Loa (eye worm) hypothetical protein 0.0083 0.0697 0.0842
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0162 0.0166
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0577 0.0618
Echinococcus granulosus lamin dm0 0.0028 0.0092 0.0075
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.1677 0.2027
Brugia malayi ecdysteroid receptor 0.0061 0.0452 0.0546
Loa Loa (eye worm) hypothetical protein 0.0069 0.0544 0.0657
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.0031
Schistosoma mansoni nuclear hormone receptor 0.0061 0.0452 0.0517
Loa Loa (eye worm) carboxylesterase 0.0764 0.8275 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0061 0.0452 0.0546
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0134 0.0162
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0577 0.0386
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0092 0.0111
Loa Loa (eye worm) hypothetical protein 0.0028 0.0092 0.0111
Loa Loa (eye worm) hypothetical protein 0.0072 0.0577 0.0698
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.0096 0.0116
Echinococcus multilocularis BC026374 protein (S09 family) 0.0129 0.1213 0.1243
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0577 0.0386
Schistosoma mansoni hypothetical protein 0.0525 0.5621 0.6783
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0096 0.0074
Schistosoma mansoni nuclear receptor 0.0029 0.0096 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0061 0.0452 0.0546
Mycobacterium ulcerans carboxylesterase, LipT 0.0129 0.1213 0.2543
Schistosoma mansoni RAR-like nuclear receptor 0.0061 0.0452 0.0517
Brugia malayi Bromodomain containing protein 0.0078 0.0642 0.0775
Loa Loa (eye worm) DR-78 0.0029 0.0096 0.0116
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.0096 0.0079
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0121 0.1125 0.1231
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.0031
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.1677 0.1728
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0132 0.016
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0162 0.0166
Trichomonas vaginalis set domain proteins, putative 0.0248 0.254 0.2388
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0061 0.0452 0.0517
Schistosoma mansoni lamin 0.0028 0.0092 0.0081
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0096 0.0079
Loa Loa (eye worm) hypothetical protein 0.0744 0.8053 0.9732
Onchocerca volvulus 0.0129 0.1213 0.4724
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0022 0.0025 0.5
Loa Loa (eye worm) hypothetical protein 0.0129 0.1213 0.1466
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0129 0.1213 0.1243
Brugia malayi Carboxylesterase family protein 0.0764 0.8275 1
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0577 0.1135
Schistosoma mansoni thyroid hormone receptor 0.0061 0.0452 0.0517
Loa Loa (eye worm) hypothetical protein 0.0032 0.0134 0.0162
Loa Loa (eye worm) hypothetical protein 0.0029 0.0096 0.0116
Brugia malayi nuclear receptor RXR 0.0029 0.0096 0.0116
Trypanosoma cruzi ISWI complex protein 0.0031 0.0123 0.2126
Brugia malayi beta-lactamase 0.0072 0.0577 0.0698
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0486 0.0558
Schistosoma mansoni patched 1 0.0043 0.0253 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0061 0.0452 0.0546
Onchocerca volvulus Bile acid receptor homolog 0.0061 0.0452 0.1697
Schistosoma mansoni bromodomain containing protein 0.0128 0.1205 0.143
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.0096 0.0116
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0577 0.121
Schistosoma mansoni neuroligin 3 (S09 family) 0.0129 0.1213 0.144
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0061 0.0452 0.0517
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0061 0.0452 0.0546
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0096 0.0116
Echinococcus granulosus ecdysone induced protein 78C 0.0061 0.0452 0.0478
Echinococcus multilocularis serotonin transporter 0.0109 0.0996 0.1015
Loa Loa (eye worm) hypothetical protein 0.0028 0.0086 0.0104
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0032 0.0134 0.0162
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0126 0.0105
Echinococcus multilocularis para nitrobenzyl esterase 0.0129 0.1213 0.1243
Treponema pallidum fructose-bisphosphate aldolase 0.0919 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0577 0.0386
Loa Loa (eye worm) steroid hormone receptor 0.0061 0.0452 0.0546
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0061 0.0452 0.0546
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0276 0.0304
Echinococcus granulosus fetal alzheimer antigen falz 0.0046 0.0286 0.0292
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0061 0.0452 0.0546
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0764 0.8275 1
Brugia malayi hypothetical protein 0.0022 0.0025 0.0031
Echinococcus granulosus intermediate filament protein 0.0028 0.0092 0.0075
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0257 0.264 0.2928
Echinococcus multilocularis lamin dm0 0.0028 0.0092 0.007
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0061 0.0452 0.0446
Brugia malayi hypothetical protein 0.0032 0.0134 0.0162
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0096 0.028
Onchocerca volvulus 0.0028 0.0092 0.0265
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0919 1 1
Echinococcus granulosus carboxylesterase 5A 0.0764 0.8275 0.9238
Brugia malayi beta-lactamase family protein 0.0072 0.0577 0.0698
Brugia malayi CHE-14 protein 0.0043 0.0253 0.0305
Brugia malayi photoreceptor-specific nuclear receptor 0.0061 0.0452 0.0546
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0884 0.0962
Schistosoma mansoni sodium/chloride dependent transporter 0.0109 0.0996 0.1176
Brugia malayi Zinc finger, C2H2 type family protein 0.0324 0.3384 0.4089
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0132 0.0112
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0486 0.0481
Loa Loa (eye worm) hypothetical protein 0.0032 0.0134 0.0162
Loa Loa (eye worm) hypothetical protein 0.0109 0.0996 0.1203
Echinococcus multilocularis lamin 0.0028 0.0092 0.007
Brugia malayi MH2 domain containing protein 0.0121 0.112 0.1353
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.0096 0.0074
Echinococcus granulosus acetylcholinesterase 0.0764 0.8275 0.9238
Onchocerca volvulus 0.0072 0.0577 0.2194
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0129 0.1213 0.144
Mycobacterium leprae Probable lipase LipE 0.0072 0.0577 0.1163
Echinococcus multilocularis expressed conserved protein 0.0093 0.0817 0.0828
Schistosoma mansoni hypothetical protein 0.0032 0.0132 0.0129
Schistosoma mansoni nuclear receptor 0.0029 0.0096 0.0085
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0061 0.0452 0.0546
Loa Loa (eye worm) hypothetical protein 0.0133 0.1259 0.1522
Plasmodium vivax SET domain protein, putative 0.0031 0.0126 0.1816
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0884 0.0699
Schistosoma mansoni hypothetical protein 0.0042 0.0243 0.0264
Onchocerca volvulus 0.0038 0.0201 0.0697
Echinococcus multilocularis acetylcholinesterase 0.0764 0.8275 0.8631
Onchocerca volvulus Protein ultraspiracle homolog 0.0061 0.0452 0.1697
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0199 0.3148
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0577 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0316 0.3298 0.6912
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.0096 0.0079
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0577 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0449 0.4771 0.9763
Brugia malayi Carboxylesterase family protein 0.0129 0.1213 0.1466
Schistosoma mansoni hypothetical protein 0.0041 0.0235 0.0255
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.0452 0.0446
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0061 0.0452 0.0546
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0253 0.0305
Schistosoma mansoni alpha-glucosidase 0.0147 0.1413 0.1682
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0902 0.1062
Chlamydia trachomatis protoporphyrinogen oxidase 0.0022 0.0025 0.5
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0126 0.1816
Toxoplasma gondii ABC1 family protein 0.0072 0.0577 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0096 0.0074
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0134 0.0131
Schistosoma mansoni transcription factor LCR-F1 0.0257 0.264 0.317
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0919 1 1
Loa Loa (eye worm) hypothetical protein 0.017 0.1669 0.2018
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0577 0.0698
Loa Loa (eye worm) hypothetical protein 0.0143 0.1373 0.166
Brugia malayi steroid hormone receptor 0.0061 0.0452 0.0546
Onchocerca volvulus 0.0248 0.254 1
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0132 0.016
Brugia malayi Muscleblind-like protein 0.047 0.5005 0.6049
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0061 0.0452 0.0546
Trichomonas vaginalis spcc417.12 protein, putative 0.0129 0.1213 0.1035
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.0096 0.0116
Loa Loa (eye worm) hypothetical protein 0.0029 0.0096 0.0116
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0061 0.0452 0.0478
Brugia malayi hypothetical protein 0.0133 0.1259 0.1522
Echinococcus granulosus GPCR family 2 0.0032 0.0132 0.012
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0486 0.834
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0919 1 1
Leishmania major hypothetical protein, conserved 0.0072 0.0577 1
Echinococcus granulosus survival motor neuron protein 1 0.0744 0.8053 0.8989
Schistosoma mansoni hypothetical protein 0.0032 0.0132 0.0129
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0129 0.1213 0.2444
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0199 0.0194
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0276 0.0281
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0046 0.0286 0.0316
Echinococcus multilocularis zinc finger transcription factor gli2 0.0324 0.3384 0.3514
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.0096 0.0074
Brugia malayi Pre-SET motif family protein 0.0031 0.0126 0.0152
Brugia malayi nuclear receptor NHR-88 0.0061 0.0452 0.0546
Loa Loa (eye worm) hypothetical protein 0.0061 0.0452 0.0546
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0096 0.0079
Loa Loa (eye worm) hypothetical protein 0.0072 0.0577 0.0698
Trypanosoma cruzi UDP-galactopyranose mutase 0.0022 0.0025 0.0442
Schistosoma mansoni hypothetical protein 0.0152 0.1465 0.1746
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0132 0.012
Loa Loa (eye worm) norepinephrine transporter 0.0109 0.0996 0.1203
Loa Loa (eye worm) hypothetical protein 0.0061 0.0452 0.0546
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0032 0.0134 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0061 0.0452 0.0546
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0884 0.0899
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0092 0.0111
Loa Loa (eye worm) hypothetical protein 0.0078 0.0643 0.0777
Mycobacterium ulcerans oxidoreductase 0.0022 0.0025 0.0053
Loa Loa (eye worm) hypothetical protein 0.0029 0.0096 0.0116
Loa Loa (eye worm) hypothetical protein 0.0029 0.0096 0.0116
Entamoeba histolytica hypothetical protein 0.0257 0.264 0.2491
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0276 0.0262
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0132 0.016
Echinococcus multilocularis muscleblind protein 0.047 0.5005 0.521
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0109 0.0996 0.1176
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0061 0.0452 0.0546
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0126 0.0121
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0577 0.1135
Schistosoma mansoni hypothetical protein 0.0525 0.5621 0.6783
Mycobacterium ulcerans monoamine oxidase 0.0022 0.0025 0.0053
Loa Loa (eye worm) hypothetical protein 0.0129 0.1213 0.1466
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0022 0.0025 0.0053
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0061 0.0452 0.0517
Loa Loa (eye worm) hypothetical protein 0.0129 0.1213 0.1466
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.1359 0.1396
Trypanosoma cruzi UDP-galactopyranose mutase 0.0022 0.0025 0.0442
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0276 0.0262
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.0096 0.0085
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0109 0.0996 0.1203
Schistosoma mansoni lamin 0.0028 0.0092 0.0081
Loa Loa (eye worm) hypothetical protein 0.0061 0.0452 0.0546
Loa Loa (eye worm) hypothetical protein 0.0072 0.0577 0.0698
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.0096 0.0074

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 601 nM Inhibition of [3H]-WIN- 35248 binding to the dopamine transporter in rat striatal membranes. ChEMBL. 1588560

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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