Detailed information for compound 112234

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 207.226 | Formula: C11H13NO3
  • H donors: 3 H acceptors: 3 LogP: 1.28 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNC(=O)/C=C/c1ccc(c(c1)O)O
  • InChi: 1S/C11H13NO3/c1-2-12-11(15)6-4-8-3-5-9(13)10(14)7-8/h3-7,13-14H,2H2,1H3,(H,12,15)/b6-4+
  • InChiKey: RJWIODMCPUQQLM-GQCTYLIASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0562 0.0735 1
Trichomonas vaginalis conserved hypothetical protein 0.1453 0.1956 0.3209
Toxoplasma gondii subtilisin SUB6 0.0321 0.0405 0.5512
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0092 0.0092 0.0092
Onchocerca volvulus 0.007 0.0062 0.0841
Brugia malayi hypothetical protein 0.0194 0.0231 0.0231
Chlamydia trachomatis protoporphyrinogen oxidase 0.0103 0.0106 1
Toxoplasma gondii subtilisin SUB12 0.0321 0.0405 0.5512
Brugia malayi transcriptional regulator, Sir2 family protein 0.0092 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0562 0.0735 0.0735
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0321 0.0405 1
Trichomonas vaginalis conserved hypothetical protein 0.0321 0.0405 0.0665
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0037 0.0037
Leishmania major UDP-galactopyranose mutase 0.0103 0.0106 0.1223
Loa Loa (eye worm) fatty acid synthase 0.0079 0.0073 0.0073
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4473 0.6095 0.6095
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0077 0.0071 0.1229
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0606 0.0795 0.0795
Echinococcus granulosus chromatin regulatory protein sir2 0.0624 0.0821 0.0821
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0092 0.0092 0.0092
Echinococcus granulosus sodium:glucose cotransporter 2 0.2201 0.2981 0.2981
Onchocerca volvulus 0.0562 0.0735 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0023
Toxoplasma gondii subtilisin SUB11 0.0321 0.0405 0.5512
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0092 0.0092 0.015
Onchocerca volvulus 0.0025 0 0.0005
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0092 0.0092 0.015
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Echinococcus multilocularis high affinity choline transporter 1 0.0562 0.0735 0.0918
Mycobacterium leprae Possible secreted protease 0.0321 0.0405 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0006 0.0006
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0103 0.0106 0.1885
Plasmodium vivax plasmepsin V, putative 0.0415 0.0535 1
Loa Loa (eye worm) aspartyl protease 6 0.0037 0.0016 0.0016
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0321 0.0405 1
Plasmodium falciparum plasmepsin VII 0.0037 0.0016 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0321 0.0405 0.0665
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Schistosoma mansoni chromatin regulatory protein sir2 0.0092 0.0092 0.0092
Mycobacterium ulcerans polyketide synthase Pks13 0.0116 0.0125 0.2447
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0116 0.0125 0.2909
Toxoplasma gondii PA14 domain-containing protein 0.0043 0.0024 0.0319
Plasmodium falciparum plasmepsin IV 0.0037 0.0016 0.0178
Brugia malayi Protein kinase domain containing protein 0.0043 0.0024 0.0024
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4473 0.6095 1
Mycobacterium leprae Polyketide synthase Pks13 0.0116 0.0125 0.2644
Schistosoma mansoni hypothetical protein 0.007 0.0062 0.0062
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0016 0.0016
Trypanosoma cruzi arginine N-methyltransferase, type III 0.007 0.0061 0.0668
Loa Loa (eye worm) hypothetical protein 0.0052 0.0037 0.0037
Echinococcus multilocularis 0.587 0.8009 1
Schistosoma mansoni high-affinity choline transporter 0.0562 0.0735 0.0735
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0037 0.0037
Schistosoma mansoni amine oxidase 0.0103 0.0106 0.0106
Schistosoma mansoni discoidin domain receptor 0.0043 0.0024 0.0024
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0046 0.0029 0.0029
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0321 0.0405 1
Trypanosoma brucei SIR2-like protein 4, putative 0.0092 0.0092 0.0403
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0024 0.0039
Onchocerca volvulus 0.007 0.0062 0.0841
Mycobacterium tuberculosis Probable thioesterase TesA 0.0066 0.0056 0.1182
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0043 0.0024 0.0039
Onchocerca volvulus 0.0321 0.0405 0.5514
Trypanosoma cruzi arginine N-methyltransferase, type I 0.007 0.0061 0.0668
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.0024 0.0319
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.0024 0.0319
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Onchocerca volvulus Chorion peroxidase homolog 0.0052 0.0037 0.0498
Plasmodium vivax aspartyl protease, putative 0.0037 0.0016 0.0178
Schistosoma mansoni chromatin regulatory protein sir2 0.0624 0.0821 0.0821
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0321 0.0405 0.0405
Loa Loa (eye worm) integrin beta-2 0.0654 0.0862 0.0862
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0061 0.0049 0.067
Loa Loa (eye worm) hypothetical protein 0.0052 0.0037 0.0037
Echinococcus granulosus Furin 1 0.1774 0.2396 0.2396
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0043 0.0024 0.003
Echinococcus granulosus glutamate receptor subunit protein glur 0.0031 0.0007 0.0007
Onchocerca volvulus Peroxidasin homolog 0.0052 0.0037 0.0498
Onchocerca volvulus 0.0025 0 0.0005
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0624 0.0821 0.1346
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0074 0.0067 0.0067
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Mycobacterium leprae Probable polyketide synthase Pks1 0.0082 0.0077 0.1407
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0321 0.0405 0.0405
Schistosoma mansoni peroxidasin 0.0052 0.0037 0.0037
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0124 0.0135 0.1834
Loa Loa (eye worm) hypothetical protein 0.7323 1 1
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0043 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0016
Brugia malayi celfurPC protein 0.587 0.8009 0.8009
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0077 0.0071 0.1545
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0031 0.0007 0.0009
Mycobacterium ulcerans Type I modular polyketide synthase 0.0077 0.0071 0.0995
Plasmodium vivax aspartyl proteinase, putative 0.0037 0.0016 0.0178
Brugia malayi Blistered cuticle protein 3 0.0052 0.0037 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0024 0.0039
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0092 0.0092 0.015
Brugia malayi Furin-like cysteine rich region family protein 0.047 0.0609 0.0609
Entamoeba histolytica hypothetical protein, conserved 0.0092 0.0092 0.0848
Brugia malayi Will die slowly protein 0.007 0.0062 0.0062
Echinococcus granulosus serine:threonine protein kinase N2 0.0076 0.007 0.007
Brugia malayi transcriptional regulator, Sir2 family protein 0.0624 0.0821 0.0821
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0043 0.0024 0.003
Brugia malayi hypothetical protein 0.0037 0.0016 0.0016
Schistosoma mansoni inositol transporter 0.2201 0.2981 0.2981
Toxoplasma gondii subtilisin SUB5 0.0321 0.0405 0.5512
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0624 0.0821 0.1024
Onchocerca volvulus Dual oxidase homolog 0.0052 0.0037 0.0498
Brugia malayi transcriptional regulator, Sir2 family protein 0.0092 0.0092 0.0092
Echinococcus multilocularis sodium:glucose cotransporter 2 0.2201 0.2981 0.3722
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0346 0.044 0.5322
Loa Loa (eye worm) transcriptional regulator 0.0092 0.0092 0.0092
Onchocerca volvulus 0.0025 0 0.0005
Mycobacterium ulcerans NAD-dependent deacetylase 0.0092 0.0092 0.1557
Giardia lamblia Hypothetical protein 0.0624 0.0821 0.2238
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1774 0.2396 0.3931
Onchocerca volvulus 0.0043 0.0024 0.0324
Echinococcus multilocularis tissue type plasminogen activator 0.003 0.0007 0.0008
Onchocerca volvulus Slit protein homolog 0.0025 0 0.0005
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0321 0.0405 1
Schistosoma mansoni btb and poz domain-containing protein 0.0043 0.0024 0.0024
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.007 0.0061 0.0464
Loa Loa (eye worm) hypothetical protein 0.285 0.387 0.387
Schistosoma mansoni protein kinase 0.0126 0.0138 0.0138
Schistosoma mansoni SWI/SNF complex-related 0.0043 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0024 0.0039
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.004 0.0021 0.0275
Brugia malayi Sex muscle abnormal protein 5 0.0123 0.0134 0.0134
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0321 0.0405 0.4898
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0031 0.0007 0.0009
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0082 0.0077 0.1717
Loa Loa (eye worm) hypothetical protein 0.0145 0.0165 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0024 0.0039
Loa Loa (eye worm) TK/ALK protein kinase 0.007 0.0062 0.0062
Leishmania major subtilisin-like serine peptidase 0.0321 0.0405 0.4898
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0126 0.0139 0.0139
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0061 0.0049 0.0421
Onchocerca volvulus Putative cubilin 0.0051 0.0035 0.0475
Echinococcus granulosus high affinity choline transporter 1 0.0562 0.0735 0.0735
Trichomonas vaginalis conserved hypothetical protein 0.1453 0.1956 0.3209
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.007 0.0061 0.0826
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0103 0.0106 0.216
Brugia malayi aspartic protease BmAsp-2, identical 0.0037 0.0016 0.0016
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1774 0.2396 0.3931
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0046 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0052 0.0037 0.0037
Brugia malayi Eukaryotic aspartyl protease family protein 0.0037 0.0016 0.0016
Onchocerca volvulus 0.0025 0 0.0005
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0061 0.0049 0.0421
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0057 0.0044 0.0866
Brugia malayi NAD-dependent deacetylase SIRT1 0.0092 0.0092 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0024 0.0039
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Leishmania major arginine N-methyltransferase-like protein 0.0124 0.0135 0.1578
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0077 0.0071 0.1545
Echinococcus granulosus growth factor receptor bound protein 2 0.0123 0.0134 0.0134
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4473 0.6095 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0103 0.0106 0.195
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0094 0.0094
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0624 0.0821 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0052 0.0037 0.0037
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0024 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.1453 0.1956 0.3209
Echinococcus multilocularis MAM 0.007 0.0062 0.0077
Loa Loa (eye worm) endoprotease bli-4 0.7323 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Plasmodium falciparum plasmepsin IX 0.0037 0.0016 0.0178
Loa Loa (eye worm) TK/EGFR protein kinase 0.047 0.0609 0.0609
Brugia malayi Probable ATP-dependent helicase DHX35 0.0031 0.0009 0.0009
Giardia lamblia Sirtuin type 2 0.0092 0.0092 0.0249
Leishmania major sir2-family protein-like protein 0.0092 0.0092 0.1044
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0079 0.0073 0.1605
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.007 0.0061 0.0076
Echinococcus granulosus solute carrier family 5 0.2201 0.2981 0.2981
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0346 0.044 0.4988
Brugia malayi hypothetical protein 0.0103 0.0106 0.0106
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0024 0.0325
Schistosoma mansoni furin-1 (S08 family) 0.3171 0.431 0.431
Schistosoma mansoni peroxidasin 0.0052 0.0037 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0024 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.1453 0.1956 0.3209
Schistosoma mansoni amine oxidase 0.0103 0.0106 0.0106
Brugia malayi Protein arginine N-methyltransferase 0.007 0.0061 0.0061
Brugia malayi Pepsin A precursor 0.0037 0.0016 0.0016
Echinococcus multilocularis protein will die slowly 0.007 0.0062 0.0077
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0077 0.0071 0.1557
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0079 0.0073 0.5
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0094 0.0094 0.0094
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0092 0.0092 0.1044
Loa Loa (eye worm) hypothetical protein 0.007 0.0062 0.0062
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0043 0.0024 0.0039
Onchocerca volvulus 0.0037 0.0016 0.0218
Giardia lamblia hypothetical protein 0.0043 0.0024 0.0065
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0037 0.0016 0.0214
Plasmodium falciparum plasmepsin X 0.0037 0.0016 0.0178
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0131 0.0145 0.0145
Onchocerca volvulus 0.0043 0.0024 0.0324
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0124 0.0135 0.2432
Brugia malayi SWIRM domain containing protein 0.0043 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0092 0.0092 0.0092
Brugia malayi hypothetical protein 0.007 0.0062 0.0062
Onchocerca volvulus Neurogenic locus notch homolog 0.0025 0 0.0005
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.007 0.0061 0.0826
Schistosoma mansoni glutamate receptor AMPA 0.0031 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0024 0.0039
Schistosoma mansoni glutamate receptor AMPA 0.0031 0.0007 0.0007
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0624 0.0821 0.1346
Schistosoma mansoni hypothetical protein 0.007 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0548 0.0717 0.0717
Onchocerca volvulus 0.0548 0.0717 0.9751
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0043 0.0024 0.0024
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0006 0.0006
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0124 0.0135 0.0222
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.0024 0.003
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0037 0.0037
Loa Loa (eye worm) proprotein convertase 2 0.1774 0.2396 0.2396
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1453 0.1956 0.3209
Plasmodium vivax aspartyl proteinase, putative 0.0037 0.0016 0.0178
Echinococcus multilocularis serine:threonine protein kinase N2 0.0086 0.0083 0.0103
Brugia malayi aspartic protease BmAsp-1, identical 0.0037 0.0016 0.0016
Echinococcus granulosus sodium:glucose cotransporter 0.2201 0.2981 0.2981
Plasmodium vivax LCCL domain-containing protein 0.0043 0.0024 0.0325
Echinococcus multilocularis protoporphyrinogen oxidase 0.0103 0.0106 0.0133
Toxoplasma gondii subtilisin SUB2 0.0321 0.0405 0.5512
Plasmodium vivax NAD-dependent deacetylase, putative 0.0092 0.0092 0.1608
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0092 0.0092 0.1608
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0321 0.0405 1
Loa Loa (eye worm) Carm1-pending protein 0.007 0.0061 0.0061
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0123 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.007 0.0062 0.0062
Brugia malayi Angiotensin-converting enzyme family protein 0.0606 0.0795 0.0795
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.0024 0.003
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0066 0.0056 0.0853
Echinococcus granulosus glutamate NMDA receptor subunit 0.0258 0.032 0.032
Toxoplasma gondii bicoid-interacting protein BIN3 0.007 0.0061 0.0826
Echinococcus granulosus furin 0.7323 1 1
Plasmodium vivax plasmepsin IV, putative 0.0037 0.0016 0.0178
Plasmodium falciparum plasmepsin I 0.0037 0.0016 0.0178
Brugia malayi Protein kinase domain containing protein 0.003 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.1453 0.1956 0.3209
Onchocerca volvulus 0.0074 0.0067 0.0916
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0103 0.0106 0.1441
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0037 0.0016 0.0016
Brugia malayi neuroendocrine convertase 1 precursor 0.4623 0.6301 0.6301
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0124 0.0135 0.0135
Toxoplasma gondii SWIRM domain-containing protein 0.0043 0.0024 0.0322
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1774 0.2396 0.2396
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0092 0.0092 0.2073
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0124 0.0135 0.0135
Schistosoma mansoni memapsin-2 (A01 family) 0.0037 0.0016 0.0016
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0037 0.0037
Schistosoma mansoni site-1 peptidase (S08 family) 0.0321 0.0405 0.0405
Schistosoma mansoni hypothetical protein 0.0043 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0194 0.0231 0.0231
Echinococcus multilocularis protein kinase c epsilon type 0.0094 0.0094 0.0117
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0109 0.0115 0.0144
Loa Loa (eye worm) transcriptional regulator 0.0624 0.0821 0.0821
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1453 0.1956 0.3209
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0624 0.0821 0.0821
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0124 0.0135 0.2432
Mycobacterium tuberculosis Conserved hypothetical protein 0.0103 0.0106 0.2442
Plasmodium falciparum subtilisin-like protease 1 0.0321 0.0405 0.7548
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0092 0.0092 0.015
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0074 0.0067 0.1461
Loa Loa (eye worm) hypothetical protein 0.0051 0.0035 0.0035
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0103 0.0106 0.195
Toxoplasma gondii subtilisin SUB10 0.0321 0.0405 0.5512
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0024 0.0039
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0321 0.0405 1
Echinococcus granulosus protein arginine N methyltransferase 8 0.0124 0.0135 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.1453 0.1956 0.3209
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.011 0.0117 0.0117
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0092 0.0092 0.0848
Loa Loa (eye worm) transcriptional regulator 0.0092 0.0092 0.0092
Plasmodium falciparum subtilisin-like protease 3 0.0321 0.0405 0.7548
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0043 0.0024 0.0039
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0016
Mycobacterium ulcerans polyketide synthase 0.0082 0.0077 0.1177
Trichomonas vaginalis conserved hypothetical protein 0.1453 0.1956 0.3209
Toxoplasma gondii aspartyl protease ASP5 0.0379 0.0484 0.6586
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.007 0.0061 0.0668
Plasmodium vivax subtilisin-like protease 2, putative 0.0321 0.0405 0.7548
Echinococcus granulosus lysine specific histone demethylase 1A 0.0506 0.0658 0.0658
Brugia malayi Sodium:solute symporter family protein 0.0562 0.0735 0.0735
Echinococcus granulosus neuroendocrine convertase 2 0.4623 0.6301 0.6301
Giardia lamblia High cysteine membrane protein Group 2 0.27 0.3665 1
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0052 0.0036 0.0488
Toxoplasma gondii subtilisin SUB9 0.0321 0.0405 0.5512
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0562 0.0735 0.0918
Loa Loa (eye worm) acyl carrier protein 0.0037 0.0016 0.0016
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0092 0.0092 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0024 0.0039
Brugia malayi GH02984p 0.0562 0.0735 0.0735
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.011 0.0117 0.0117
Schistosoma mansoni chromatin regulatory protein sir2 0.0092 0.0092 0.0092
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0092 0.0092 0.0848
Echinococcus granulosus protein arginine N methyltransferase 7 0.007 0.0061 0.0061
Brugia malayi Protein kinase domain containing protein 0.007 0.0062 0.0062
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0092 0.0092 0.0114
Brugia malayi Calcium binding EGF domain containing protein 0.0051 0.0035 0.0035
Giardia lamblia Furin precursor putative serine protease 0.1453 0.1956 0.5337
Loa Loa (eye worm) hypothetical protein 0.0103 0.0106 0.0106
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0037 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0101 0.0104 0.0104
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0046 0.0029 0.0036
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.007 0.0061 0.01
Toxoplasma gondii subtilisin SUB7 0.0321 0.0405 0.5512
Schistosoma mansoni hypothetical protein 0.1453 0.1956 0.1956
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1774 0.2396 0.3931
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0562 0.0735 0.0735
Echinococcus granulosus epidermal growth factor receptor 0.047 0.0609 0.0609
Trichomonas vaginalis conserved hypothetical protein 0.1453 0.1956 0.3209
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0016
Echinococcus multilocularis growth factor receptor bound protein 2 0.0123 0.0134 0.0167
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Trypanosoma cruzi UDP-galactopyranose mutase 0.0103 0.0106 0.1223
Toxoplasma gondii type I fatty acid synthase, putative 0.0057 0.0043 0.0582
Onchocerca volvulus Peroxidase homolog 0.0052 0.0037 0.0498
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0031 0.0007 0.0009
Mycobacterium ulcerans polyketide synthase 0.0077 0.0071 0.0995
Brugia malayi hypothetical protein 0.0052 0.0037 0.0037
Echinococcus granulosus lysine specific histone demethylase 1A 0.0103 0.0106 0.0106
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0046 0.0029 0.0036
Echinococcus granulosus histone arginine methyltransferase CARMER 0.007 0.0061 0.0061
Mycobacterium ulcerans dehydrogenase 0.0103 0.0106 0.195
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0321 0.0405 0.0405
Brugia malayi amine oxidase, flavin-containing family protein 0.0145 0.0165 0.0165
Echinococcus granulosus peroxidasin 0.0052 0.0037 0.0037
Toxoplasma gondii histone deacetylase SIR2 0.0092 0.0092 0.1242
Loa Loa (eye worm) hypothetical protein 0.0052 0.0037 0.0037
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0234 0.0286 0.0286
Schistosoma mansoni dock 0.0043 0.0024 0.0024
Loa Loa (eye worm) sirtuin 4 0.0092 0.0092 0.0092
Brugia malayi Carm1-pending protein 0.007 0.0061 0.0061
Brugia malayi hypothetical protein 0.0037 0.0016 0.0016
Plasmodium vivax hypothetical protein, conserved 0.0103 0.0106 0.1885
Toxoplasma gondii type I fatty acid synthase, putative 0.0082 0.0077 0.105
Loa Loa (eye worm) hypothetical protein 0.0052 0.0037 0.0037
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0126 0.0138 0.0172
Schistosoma mansoni chromatin regulatory protein sir2 0.0092 0.0092 0.0092
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0016 0.0016
Echinococcus granulosus glutamate receptor 2 0.0046 0.0029 0.0029
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0321 0.0405 0.0506
Trypanosoma brucei subtilisin peptidase 0.0321 0.0405 0.4533
Loa Loa (eye worm) hypothetical protein 0.0052 0.0037 0.0037
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1774 0.2396 0.3931
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0037 0.0016 0.0026
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0082 0.0077 0.1177
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0016 0.0016
Toxoplasma gondii subtilisin SUB1 0.0321 0.0405 0.5512
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0079 0.0073 0.1058
Plasmodium vivax aspartyl protease, putative 0.0037 0.0016 0.0178
Mycobacterium tuberculosis Possible oxidoreductase 0.0103 0.0106 0.2442
Schistosoma mansoni hypothetical protein 0.007 0.0061 0.0061
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Entamoeba histolytica hypothetical protein 0.0194 0.0231 0.2594
Mycobacterium ulcerans thioesterase TesA 0.0066 0.0056 0.0608
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Loa Loa (eye worm) hypothetical protein 0.0052 0.0037 0.0037
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0082 0.0077 0.1407
Echinococcus granulosus integrin beta 2 0.0481 0.0625 0.0625
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0148 0.0168 0.0168
Echinococcus multilocularis Furin 1 0.1774 0.2396 0.2991
Toxoplasma gondii kringle domain-containing protein 0.003 0.0007 0.0086
Plasmodium falciparum subtilisin-like protease 2 0.0321 0.0405 0.7548
Brugia malayi Glutamate receptor 1 precursor 0.0031 0.0007 0.0007
Onchocerca volvulus 0.0037 0.0016 0.0218
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0037 0.0037
Giardia lamblia Transcriptional regulator, Sir2 family 0.0092 0.0092 0.0249
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0092 0.0092 0.0114
Echinococcus multilocularis protein arginine N methyltransferase 7 0.007 0.0061 0.0076
Loa Loa (eye worm) WD40 repeat protein 0.007 0.0062 0.0062
Entamoeba histolytica PH domain containing protein kinase, putative 0.0076 0.007 0.0579
Trichomonas vaginalis WD repeat domain, putative 0.007 0.0062 0.0101
Echinococcus multilocularis epidermal growth factor receptor 0.047 0.0609 0.0761
Onchocerca volvulus 0.0025 0 0.0005
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0037 0.0037
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0016 0.0016
Echinococcus granulosus protein kinase c epsilon type 0.0094 0.0094 0.0094
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Loa Loa (eye worm) hypothetical protein 0.0052 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0052 0.0037 0.0037
Plasmodium vivax subtilisin-like serine protease, putative 0.0321 0.0405 0.7548
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0082 0.0077 0.1407
Mycobacterium ulcerans Type I modular polyketide synthase 0.0077 0.0071 0.0995
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0031 0.0007 0.0007
Echinococcus multilocularis neuroendocrine convertase 2 0.4623 0.6301 0.7867
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.007 0.0062 0.0062
Loa Loa (eye worm) blistered cuticle protein 3 0.0052 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0043 0.0024 0.0024
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0037 0.0016 0.0016
Loa Loa (eye worm) protein arginine N-methyltransferase 0.007 0.0061 0.0061
Mycobacterium ulcerans Sir2-like regulatory protein 0.0092 0.0092 0.1557
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0124 0.0135 0.0135
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0077 0.0071 0.0071
Leishmania major arginine N-methyltransferase, type I 0.007 0.0061 0.0668
Schistosoma mansoni chromatin regulatory protein sir2 0.0092 0.0092 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0321 0.0405 0.0665
Loa Loa (eye worm) subtilase 0.0321 0.0405 0.0405
Mycobacterium ulcerans Type I modular polyketide synthase 0.0077 0.0071 0.0995
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0103 0.0106 0.1885
Plasmodium falciparum plasmepsin VI 0.0037 0.0016 0.0178
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0092 0.0092 0.015
Schistosoma mansoni glutamate receptor kainate 0.0031 0.0007 0.0007
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1453 0.1956 0.3209
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0077 0.0071 0.1229
Echinococcus granulosus sodium:myo inositol cotransporter 0.2201 0.2981 0.2981
Loa Loa (eye worm) DEAH box polypeptide 35 0.0031 0.0009 0.0009
Mycobacterium ulcerans monoamine oxidase 0.0103 0.0106 0.195
Brugia malayi Kelch motif family protein 0.0126 0.0139 0.0139
Onchocerca volvulus 0.0052 0.0037 0.0498
Brugia malayi Glutamate receptor 2 precursor 0.0031 0.0007 0.0007
Plasmodium vivax subtilisin-like protease 1 0.0321 0.0405 0.7548
Schistosoma mansoni cathepsin D (A01 family) 0.0037 0.0016 0.0016
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.0024 0.0319
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0031 0.0007 0.0007
Schistosoma mansoni protein kinase 0.0126 0.0138 0.0138
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0346 0.044 0.5322
Echinococcus multilocularis sodium:myo inositol cotransporter 0.2201 0.2981 0.3722
Brugia malayi hypothetical protein 0.0101 0.0104 0.0104
Toxoplasma gondii histone lysine-specific demethylase 0.0103 0.0106 0.1441
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Plasmodium vivax aspartyl protease, putative 0.0037 0.0016 0.0178
Loa Loa (eye worm) hypothetical protein 0.0052 0.0037 0.0037
Schistosoma mansoni chromatin regulatory protein sir2 0.0624 0.0821 0.0821
Onchocerca volvulus Peroxidase homolog 0.0052 0.0037 0.0498
Schistosoma mansoni sodium/solute symporter 0.0562 0.0735 0.0735
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.0024 0.0024
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0321 0.0405 1
Echinococcus multilocularis 0.0103 0.0106 0.0133
Plasmodium vivax hypothetical protein, conserved 0.0103 0.0106 0.1885
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0624 0.0821 1
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0067 0.0067
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0124 0.0135 0.0222
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0103 0.0106 0.0106
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0037 0.0037
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0321 0.0405 1
Schistosoma mansoni glutamate receptor kainate 0.0031 0.0007 0.0007
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0103 0.0106 0.1885
Echinococcus multilocularis membrane bound transcription factor site 1 0.0321 0.0405 0.0506
Brugia malayi Integrin beta pat-3 precursor 0.0654 0.0862 0.0862
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0092 0.0092 0.015
Trichomonas vaginalis conserved hypothetical protein 0.1453 0.1956 0.3209
Onchocerca volvulus Peroxidasin homolog 0.0052 0.0037 0.0498
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0052 0.0037 0.0037
Echinococcus granulosus protein will die slowly 0.007 0.0062 0.0062
Brugia malayi proprotein convertase 2 0.4623 0.6301 0.6301
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0077 0.0071 0.1545
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0037 0.0016 0.0214
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0092 0.0092 0.015
Loa Loa (eye worm) hypothetical protein 0.0506 0.0658 0.0658
Plasmodium falciparum plasmepsin II 0.0037 0.0016 0.0178
Schistosoma mansoni growth factor receptor-bound protein 0.0123 0.0134 0.0134
Plasmodium falciparum plasmepsin III 0.0037 0.0016 0.0178
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0062 0.0051 0.1043
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0024 0.0039
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0092 0.0092 0.015
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0321 0.0405 1
Schistosoma mansoni hypothetical protein 0.003 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0031 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0024 0.0039
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0092 0.0092 0.0249
Schistosoma mansoni chromatin regulatory protein sir2 0.0624 0.0821 0.0821
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0194 0.0231 0.2752
Onchocerca volvulus 0.0139 0.0155 0.2113
Loa Loa (eye worm) TK/ROR protein kinase 0.003 0.0007 0.0007
Echinococcus granulosus membrane bound transcription factor site 1 0.0321 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0052 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0043 0.0024 0.0024
Brugia malayi Subtilase family protein 0.0321 0.0405 0.0405
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0624 0.0821 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0024 0.0039
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Echinococcus granulosus tissue type plasminogen activator 0.003 0.0007 0.0007
Onchocerca volvulus 0.007 0.0062 0.0841
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1287 0.173 0.173
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0624 0.0821 1
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0194 0.0231 0.2594
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0092 0.0092 0.1608
Plasmodium vivax LCCL domain-containing protein 0.0043 0.0024 0.0325
Brugia malayi Kringle domain containing protein 0.003 0.0007 0.0007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Schistosoma mansoni tyrosine kinase 0.047 0.0609 0.0609
Trypanosoma cruzi UDP-galactopyranose mutase 0.0103 0.0106 0.1223
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0092 0.0092 0.1044
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1774 0.2396 0.3931
Trichomonas vaginalis conserved hypothetical protein 0.1453 0.1956 0.3209
Schistosoma mansoni growth factor receptor-bound protein 0.0123 0.0134 0.0134
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0092 0.0092 0.0114
Onchocerca volvulus 0.003 0.0007 0.0091
Brugia malayi protein kinase C II. 0.0094 0.0094 0.0094
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0126 0.0138 0.0138
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.7323 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1774 0.2396 0.3931
Echinococcus multilocularis chromatin regulatory protein sir2 0.0624 0.0821 0.1024
Brugia malayi Peroxidasin 0.0052 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0506 0.0658 0.0658
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0024 0.0039
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0045 0.0027 0.0452
Echinococcus granulosus discoidin domain receptor 0.0043 0.0024 0.0024
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0046 0.0029 0.0036
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0016 0.0016
Schistosoma mansoni cathepsin D (A01 family) 0.0037 0.0016 0.0016
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0124 0.0135 0.0169
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0077 0.0071 0.1557
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0092 0.0092 0.1044
Loa Loa (eye worm) glutamate receptor 1 0.0031 0.0007 0.0007
Schistosoma mansoni protein arginine n-methyltransferase 0.007 0.0061 0.0061
Brugia malayi SWIRM domain containing protein 0.0548 0.0717 0.0717
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0046 0.0029 0.0036
Loa Loa (eye worm) hypothetical protein 0.007 0.0062 0.0062
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0506 0.0658 0.0822
Schistosoma mansoni protein kinase 0.0126 0.0138 0.0138
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0046 0.0029 0.0029
Schistosoma mansoni septate junction protein 0.0068 0.0059 0.0059
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0037 0.0037
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.005 0.0034 0.026
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0082 0.0077 0.1717
Loa Loa (eye worm) hypothetical protein 0.0321 0.0405 0.0405
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.0024 0.0024
Schistosoma mansoni discoidin domain receptor 0.0043 0.0024 0.0024
Echinococcus multilocularis glutamate receptor 2 0.0031 0.0007 0.0009
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0624 0.0821 1
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4473 0.6095 0.761
Loa Loa (eye worm) hypothetical protein 0.0052 0.0037 0.0037
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0082 0.0077 0.1177
Plasmodium falciparum plasmepsin V 0.0415 0.0535 1
Schistosoma mansoni site-1 peptidase (S08 family) 0.0321 0.0405 0.0405
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0103 0.0106 0.1885
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0024 0.0039
Schistosoma mansoni glutamate receptor kainate 0.0031 0.0007 0.0007
Onchocerca volvulus 0.0137 0.0153 0.2079
Echinococcus multilocularis nmda type glutamate receptor 0.0109 0.0115 0.0144
Loa Loa (eye worm) hypothetical protein 0.0103 0.0106 0.0106
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Loa Loa (eye worm) hypothetical protein 0.0043 0.0024 0.0024
Toxoplasma gondii aspartyl protease ASP1 0.0037 0.0016 0.0214
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0321 0.0405 0.0405
Toxoplasma gondii subtilisin SUB4 0.0321 0.0405 0.5512
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0194 0.0231 0.2752
Echinococcus granulosus methyltransferase protein 5 0.007 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.1453 0.1956 0.3209
Toxoplasma gondii aspartyl protease 0.0037 0.0016 0.0214
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0124 0.0135 0.0222
Trypanosoma cruzi subtilisin peptidase 0.0321 0.0405 0.4898
Echinococcus granulosus protein arginine methyltransferase 0.0124 0.0135 0.0135
Plasmodium falciparum plasmepsin VIII, putative 0.0037 0.0016 0.0178
Schistosoma mansoni ATP-binding cassette transporter 0.0031 0.0007 0.0007
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0025 0 0.0005
Echinococcus granulosus MAM 0.007 0.0062 0.0062
Echinococcus multilocularis peroxidasin 0.0052 0.0037 0.0046
Plasmodium falciparum protoporphyrinogen oxidase 0.0103 0.0106 0.1885
Trichomonas vaginalis hypothetical protein 0.1453 0.1956 0.3209
Loa Loa (eye worm) hypothetical protein 0.0562 0.0735 0.0735
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0016 0.0016
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0079 0.0073 0.5
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.0024 0.003
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0092 0.0092 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0321 0.0405 0.0665
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0077 0.0071 0.0995
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.0024 0.0024
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0031 0.0007 0.0007
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0043 0.0024 0.0361
Schistosoma mansoni integrin beta subunit 0.038 0.0487 0.0487
Plasmodium vivax hypothetical protein, conserved 0.0092 0.0092 0.1608
Toxoplasma gondii histone deacetylase SIR2-like 0.0092 0.0092 0.1242
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0194 0.0231 0.2234
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0103 0.0106 0.195
Schistosoma mansoni glutamate receptor NMDA 0.0046 0.0029 0.0029
Leishmania major silent information regulator 2, putative 0.0624 0.0821 1
Trichomonas vaginalis conserved hypothetical protein 0.0321 0.0405 0.0665
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0071 0.0062 0.0062
Echinococcus multilocularis glutamate receptor 2 0.0046 0.0029 0.0036
Schistosoma mansoni inositol transporter 0.2201 0.2981 0.2981
Toxoplasma gondii subtilisin SUB8 0.0321 0.0405 0.5512
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0258 0.032 0.0399
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0037 0.0037
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0082 0.0077 0.1717
Mycobacterium ulcerans oxidoreductase 0.0103 0.0106 0.195
Echinococcus multilocularis NMDA receptor 0.0031 0.0007 0.0009
Echinococcus granulosus nmda type glutamate receptor 0.0109 0.0115 0.0115
Echinococcus multilocularis protein arginine methyltransferase 0.0124 0.0135 0.0169
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0506 0.0658 0.0658
Toxoplasma gondii aspartyl protease ASP3 0.0037 0.0016 0.0214
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Trichomonas vaginalis hypothetical protein 0.0043 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0031 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0068 0.0058 0.0058
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0046 0.0029 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0024 0.0039
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0116 0.0125 0.2909
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0043 0.0024 0.003
Loa Loa (eye worm) glutamate receptor 2 0.0031 0.0007 0.0007
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0092 0.0092 0.0403
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0321 0.0405 0.0665
Schistosoma mansoni glutamate receptor NMDA 0.0258 0.032 0.032
Mycobacterium ulcerans thioesterase 0.0066 0.0056 0.0608
Onchocerca volvulus 0.0052 0.0037 0.0498
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0024 0.0039
Echinococcus multilocularis solute carrier family 5 0.2201 0.2981 0.3722
Trypanosoma cruzi arginine N-methyltransferase, type I 0.007 0.0061 0.0668
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.007 0.0061 0.01
Echinococcus multilocularis integrin beta 2 0.0481 0.0625 0.0781
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0321 0.0405 0.0405
Onchocerca volvulus 0.0052 0.0037 0.0498
Onchocerca volvulus Fatty acid synthase homolog 0.0144 0.0162 0.2205
Echinococcus multilocularis discoidin domain receptor 0.0043 0.0024 0.003
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0037 0.0016 0.002
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.007 0.0061 0.01
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.007 0.0061 0.0668

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 2.7 uM Evaluated for the antioxidant property by measuring the inhibition of microsomal lipid peroxidation ChEMBL. 11206462
MIC (functional) > 50 ug ml-1 Antifungal activity against Candida albicans ATCC 10231 after 48 hrs by MTT assay ChEMBL. 20181415

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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