Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.5667 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0038 | 0.1877 | 0.1877 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5667 | 0.9081 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1877 | 0.3008 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.5667 | 0.5667 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.5667 | 0.5667 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0082 | 0.624 | 0.624 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.624 | 0.624 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5667 | 0.9081 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.1877 | 0.3312 |
Echinococcus granulosus | GPCR family 2 | 0.0038 | 0.1877 | 0.3312 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5667 | 0.9081 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.1877 | 0.3312 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5667 | 0.9081 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.1877 | 0.3312 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1877 | 0.3008 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 1 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.5667 | 0.5667 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.5667 | 0.5667 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.1877 | 0.3312 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.5667 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.5667 | 0.5667 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1877 | 0.3008 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5667 | 0.9081 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0038 | 0.1877 | 0.1877 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.624 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.5667 | 0.5667 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1877 | 0.3008 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0038 | 0.1877 | 0.1877 |
Echinococcus multilocularis | GPCR, family 2 | 0.0038 | 0.1877 | 0.3312 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1877 | 0.1877 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.