TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 280.22 | Formula: C14H8F4N2
H donors: 1 H acceptors: 1 LogP: 4.13 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)c1nc2c([nH]1)ccc(c2)C(F)(F)F
InChi: 1S/C14H8F4N2/c15-10-4-1-8(2-5-10)13-19-11-6-3-9(14(16,17)18)7-12(11)20-13/h1-7H,(H,19,20)
InChiKey: ZOLVXJWGJKILLK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.021	0.0168
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.021	0.0168
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0013	0.021	0.0168
Echinococcus granulosus	neuropeptide receptor	0.0013	0.021	0.0168
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0013	0.021	0.0168
Schistosoma mansoni	hypothetical protein	0.0039	0.0851	0.0812
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0013	0.021	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Echinococcus multilocularis	fmrfamide receptor	0.0013	0.021	0.0168
Echinococcus granulosus	neuropeptide FF receptor 2	0.0013	0.021	0.0168
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0024	0.0488	0.0569
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0013	0.021	0.0168
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.021	0.0168
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0013	0.021	0.0168
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.1395	0.1358
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0013	0.021	0.0168
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0599	0.1846
Loa Loa (eye worm)	importin-beta domain-containing protein	0.0006	0.0043	0.005
Schistosoma mansoni	neuropeptide receptor	0.0013	0.021	0.0168
Leishmania major	hypothetical protein, conserved	0.0036	0.0779	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0013	0.021	0.0168
Echinococcus granulosus	g-protein coupled receptor	0.0013	0.021	0.0168
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.021	0.0168
Brugia malayi	GnHR receptor homolog	0.0013	0.021	0.0648
Brugia malayi	neuropeptide F receptor	0.0013	0.021	0.0648
Brugia malayi	hypothetical protein	0.0013	0.021	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Schistosoma mansoni	tar DNA-binding protein	0.0135	0.3244	0.3215
Trichomonas vaginalis	helicase, putative	0.0006	0.005	0.0093
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0779	0.2401
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.021	0.0168
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0013	0.021	0.0168
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0013	0.021	0.0168
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0779	0.0739
Echinococcus granulosus	tm gpcr rhodopsin	0.0013	0.021	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0779	0.0907
Trichomonas vaginalis	ran, putative	0.0024	0.0488	0.6051
Echinococcus granulosus	g protein coupled receptor	0.0013	0.021	0.0168
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0013	0.021	0.0648
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0013	0.021	0.0168
Schistosoma mansoni	smad1 5 8 and	0.0008	0.009	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0779	0.0907
Echinococcus multilocularis	dro:myosuppressin receptor	0.0013	0.021	0.0168
Schistosoma mansoni	tar DNA-binding protein	0.0135	0.3244	0.3215
Schistosoma mansoni	tar DNA-binding protein	0.0135	0.3244	0.3215
Schistosoma mansoni	hypothetical protein	0.035	0.8583	0.8577
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0013	0.021	0.0168
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.021	0.0168
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0779	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0013	0.021	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0334	0.0389
Echinococcus granulosus	biogenic amine 5HT receptor	0.0013	0.021	0.0168
Schistosoma mansoni	Smad4	0.0008	0.009	0.0047
Schistosoma mansoni	neuropeptide F-like receptor	0.0013	0.021	0.0168
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0013	0.021	0.0168
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.021	0.0168
Trichomonas vaginalis	esterase, putative	0.0036	0.0779	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0013	0.021	0.0168
Echinococcus multilocularis	smad	0.0008	0.009	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Schistosoma mansoni	biogenic amine receptor	0.0013	0.021	0.0168
Entamoeba histolytica	Ran family GTPase	0.0024	0.0488	0.8795
Brugia malayi	larval opioid receptor	0.0013	0.021	0.0648
Echinococcus granulosus	tm gpcr rhodopsin	0.0013	0.021	0.0168
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0599	0.0698
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.021	0.0168
Toxoplasma gondii	ABC1 family protein	0.0036	0.0779	0.618
Brugia malayi	Melatonin receptor type 1A	0.0013	0.021	0.0648
Schistosoma mansoni	hypothetical protein	0.0013	0.021	0.0168
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0013	0.021	0.0168
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.005	0.0093
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0013	0.021	0.0168
Loa Loa (eye worm)	Smad1	0.0008	0.009	0.0105
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0334	0.0293
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.021	0.0168
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0779	0.0739
Schistosoma mansoni	hypothetical protein	0.0018	0.0334	0.0293
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.021	0.0168
Echinococcus granulosus	neuropeptides capa receptor	0.0013	0.021	0.0168
Schistosoma mansoni	biogenic amine receptor	0.0013	0.021	0.0168
Brugia malayi	beta-lactamase family protein	0.0036	0.0779	0.2401
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0334	0.0293
Brugia malayi	G protein-coupled receptor	0.0013	0.021	0.0648
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.021	0.0168
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.021	0.0168
Loa Loa (eye worm)	TYRA-2 protein	0.0013	0.021	0.0245
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0779	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0013	0.021	0.0168
Echinococcus granulosus	dro:myosuppressin receptor	0.0013	0.021	0.0168
Schistosoma mansoni	growth hormone secretagogue receptor	0.0013	0.021	0.0168
Onchocerca volvulus		0.0036	0.0779	1
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.009	0.0047
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0779	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.005	0.0093
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0013	0.021	0.0168
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0013	0.021	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Brugia malayi	Dopamine receptor	0.0013	0.021	0.0648
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0703	0.8973
Echinococcus granulosus	7tm_1 domain containing protein	0.0013	0.021	0.0168
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0013	0.021	0.0168
Brugia malayi	TAR-binding protein	0.0135	0.3244	1
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.009	0.0047
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0108	0.0126
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.005	0.0093
Brugia malayi	MH2 domain containing protein	0.0008	0.009	0.0277
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0549	0.688
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Brugia malayi	beta-lactamase family protein	0.0036	0.0779	0.2401
Schistosoma mansoni	hypothetical protein	0.0407	1	1
Brugia malayi	Dopamine receptor protein 2	0.0013	0.021	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Echinococcus granulosus	tar DNA binding protein	0.0135	0.3244	0.3215
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Brugia malayi	putative neuropeptide receptor NPR1	0.0013	0.021	0.0648
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0334	0.0293
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.284	0.3309
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0024	0.0488	0.6051
Loa Loa (eye worm)	kap beta 3 protein	0.0006	0.0043	0.005
Schistosoma mansoni	opsin-like receptor	0.0013	0.021	0.0168
Brugia malayi	AKH receptor	0.0013	0.021	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0779	0.0907
Echinococcus granulosus	somatostatin receptor	0.0013	0.021	0.0168
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0779	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0013	0.021	0.0168
Echinococcus granulosus	sex peptide receptor	0.0013	0.021	0.0168
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.005	0.0093
Brugia malayi	RNA, U transporter 1	0.0093	0.2205	0.6797
Schistosoma mansoni	smad1 5 8 and	0.0008	0.009	0.0047
Echinococcus granulosus	neuropeptides capa receptor	0.0013	0.021	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Brugia malayi	Dopamine receptor protein 1	0.0013	0.021	0.0648
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0013	0.021	0.0168
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.021	0.0168
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.005	0.0093
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0013	0.021	0.0168
Brugia malayi	hypothetical protein	0.0013	0.021	0.0648
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0013	0.021	0.0168
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.005	0.0093
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0013	0.021	0.0168
Echinococcus granulosus	biogenic amine 5HT receptor	0.0013	0.021	0.0168
Echinococcus granulosus	neuropeptide s receptor	0.0013	0.021	0.0168
Loa Loa (eye worm)	RNA binding protein	0.0135	0.3244	0.3779
Entamoeba histolytica	hypothetical protein	0.0027	0.0549	1
Echinococcus granulosus	neuropeptide Y receptor	0.0013	0.021	0.0168
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0013	0.021	0.0168
Echinococcus multilocularis	orexin receptor type 2	0.0013	0.021	0.0168
Brugia malayi	ORL1-like opioid receptor	0.0013	0.021	0.0648
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0013	0.021	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Brugia malayi	hypothetical protein	0.0013	0.021	0.0648
Brugia malayi	hypothetical protein	0.0013	0.021	0.0648
Schistosoma mansoni	amine GPCR	0.0013	0.021	0.0168
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.009	0.0047
Schistosoma mansoni	myosin xvIII	0.0013	0.021	0.0168
Echinococcus granulosus	importin subunit beta 1	0.0033	0.0703	0.0663
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0024	0.0488	0.5
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0108	0.0066
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0108	0.0066
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0779	0.5
Onchocerca volvulus		0.0036	0.0779	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0013	0.021	0.0168
Mycobacterium ulcerans	lipase LipD	0.0036	0.0779	0.5
Loa Loa (eye worm)	TAR-binding protein	0.0135	0.3244	0.3779
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.021	0.0168
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.005	0.0093
Brugia malayi	G protein-coupled receptor F59B2.13	0.0013	0.021	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Brugia malayi	hypothetical protein	0.0013	0.021	0.0648
Brugia malayi	Importin beta-1 subunit	0.0033	0.0703	0.2168
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0779	0.0907
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0013	0.021	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0779	0.0907
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.021	0.0168
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0024	0.0488	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0013	0.021	0.0168
Schistosoma mansoni	hypothetical protein	0.0018	0.0334	0.0293
Echinococcus granulosus	Smad4	0.0008	0.009	0.0047
Schistosoma mansoni	ran	0.0024	0.0488	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Brugia malayi	putative neuropeptide receptor	0.0013	0.021	0.0648
Schistosoma mansoni	histamine h1 receptor	0.0013	0.021	0.0168
Schistosoma mansoni	cpg binding protein	0.0029	0.0599	0.0558
Echinococcus granulosus	GPCR family 2	0.0018	0.0334	0.0293
Schistosoma mansoni	opsin-like receptor	0.0013	0.021	0.0168
Brugia malayi	hypothetical protein	0.0013	0.021	0.0648
Leishmania major	importin beta-1 subunit, putative	0.0027	0.0549	0.688
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0334	0.0293
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0024	0.0488	0.6051
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0013	0.021	0.0168
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0013	0.021	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.021	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Plasmodium vivax	importin-beta 2, putative	0.0033	0.0703	0.8973
Echinococcus multilocularis	g-protein coupled receptor	0.0013	0.021	0.0168
Echinococcus multilocularis	tar DNA binding protein	0.0135	0.3244	0.3215
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.1297	0.3998
Loa Loa (eye worm)	neuropeptide F receptor	0.0013	0.021	0.0245
Echinococcus multilocularis	neuropeptide receptor	0.0013	0.021	0.0168
Brugia malayi	MH2 domain containing protein	0.0119	0.284	0.8755
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.005	0.0093
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.021	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0703	0.0819
Echinococcus multilocularis	snurportin 1	0.035	0.8583	0.8577
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Echinococcus multilocularis	fmrfamide receptor	0.0013	0.021	0.0168
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0779	0.0907
Schistosoma mansoni	tar DNA-binding protein	0.0135	0.3244	0.3215
Echinococcus granulosus	neuropeptide Y receptor	0.0013	0.021	0.0168
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.005	0.0093
Echinococcus granulosus	allatostatin A receptor	0.0013	0.021	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Brugia malayi	hypothetical protein	0.0013	0.021	0.0648
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0013	0.021	0.0245
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.005	0.0093
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0013	0.021	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Schistosoma mansoni	smad	0.0008	0.009	0.0047
Echinococcus multilocularis	neuropeptides capa receptor	0.0013	0.021	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0779	0.0907
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0013	0.021	0.0168
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.035	0.8583	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.021	0.0168
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.005	0.0093
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0027	0.0549	0.2099
Schistosoma mansoni	importin beta-1	0.0033	0.0703	0.0663
Echinococcus granulosus	hypothetical protein	0.0013	0.021	0.0168
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0013	0.021	0.0168
Brugia malayi	sulfakinin receptor protein	0.0013	0.021	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0851	0.0992
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0779	0.5
Schistosoma mansoni	neuropeptide f receptor 76f	0.0013	0.021	0.0168
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0024	0.0488	0.1505
Echinococcus multilocularis	neuropeptide Y receptor	0.0013	0.021	0.0168
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.1297	0.3998
Brugia malayi	neuropeptide F receptor	0.0013	0.021	0.0648
Schistosoma mansoni	amine GPCR	0.0013	0.021	0.0168
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0334	0.0293
Echinococcus multilocularis	G protein coupled receptor 139	0.0013	0.021	0.0168
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0013	0.021	0.0648
Echinococcus multilocularis	g protein coupled receptor	0.0013	0.021	0.0168
Echinococcus multilocularis	cpg binding protein	0.003	0.0639	0.0599
Brugia malayi	beta-lactamase	0.0036	0.0779	0.2401
Brugia malayi	RE15519p	0.0013	0.021	0.0648
Plasmodium falciparum	importin beta, putative	0.0033	0.0703	1
Brugia malayi	hypothetical protein	0.0013	0.021	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0334	0.0389
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0013	0.021	0.0168
Onchocerca volvulus		0.0036	0.0779	1
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.009	0.0105
Brugia malayi	Serotonin receptor	0.0013	0.021	0.0648
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0703	0.8973
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0065	0.0022
Loa Loa (eye worm)	melatonin receptor type 1A	0.0013	0.021	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.009	0.0105
Schistosoma mansoni	hypothetical protein	0.0013	0.021	0.0168
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.1297	0.1511
Echinococcus multilocularis	serotonin receptor	0.0013	0.021	0.0168
Schistosoma mansoni	opsin-like receptor	0.0013	0.021	0.0168
Schistosoma mansoni	amine GPCR	0.0013	0.021	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Loa Loa (eye worm)	neuropeptide F receptor	0.0013	0.021	0.0245
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0779	1
Schistosoma mansoni	hypothetical protein	0.0018	0.0334	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Schistosoma mansoni	hypothetical protein	0.0013	0.021	0.0168
Brugia malayi	Serotonin receptor	0.0013	0.021	0.0648
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0013	0.021	0.0168
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0024	0.0488	0.0447
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.021	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Brugia malayi	hypothetical protein	0.0013	0.021	0.0648
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0135	0.3244	0.3779
Echinococcus granulosus	orexin receptor type 2	0.0013	0.021	0.0168
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0013	0.021	0.0168
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0013	0.021	0.0168
Schistosoma mansoni	hypothetical protein	0.0018	0.0334	0.0293
Echinococcus multilocularis	dnaJ subfamily B	0.0407	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0013	0.021	0.0168
Echinococcus granulosus	G protein coupled receptor 139	0.0013	0.021	0.0168
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.021	0.0168
Brugia malayi	kap beta 3 protein	0.0006	0.0043	0.0132
Brugia malayi	MH2 domain containing protein	0.0008	0.009	0.0277
Schistosoma mansoni	amine GPCR	0.0013	0.021	0.0168
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0065	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.005	0.0093
Brugia malayi	RNA binding protein	0.0135	0.3244	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.021	0.0168
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0024	0.0488	0.374
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0334	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0851	0.2624
Echinococcus granulosus	serotonin receptor	0.0013	0.021	0.0168
Brugia malayi	G-protein coupled receptor	0.0013	0.021	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0013	0.021	0.0168
Leishmania major	GTP-binding protein, putative	0.0024	0.0488	0.6051
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Schistosoma mansoni	tar DNA-binding protein	0.0135	0.3244	0.3215
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Brugia malayi	Smad1	0.0008	0.009	0.0277
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.009	0.0047
Schistosoma mansoni	neuropeptide receptor	0.0013	0.021	0.0168
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0013	0.021	0.0648
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.005	0.0093
Trichomonas vaginalis	importin beta-1, putative	0.0027	0.0549	0.688
Loa Loa (eye worm)	G-protein coupled receptor	0.0013	0.021	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0065	0.0022
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0229	0.5575	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.284	0.3309
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.009	0.0047
Schistosoma mansoni	neuropeptide F-like receptor	0.0013	0.021	0.0168
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0779	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0779	0.5
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0013	0.021	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Brugia malayi	hypothetical protein	0.0013	0.021	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.005	0.0093
Echinococcus multilocularis	neuropeptide Y receptor	0.0013	0.021	0.0168
Schistosoma mansoni	cpg binding protein	0.003	0.0639	0.0599
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0013	0.021	0.0168
Echinococcus granulosus	g protein coupled receptor	0.0013	0.021	0.0168
Echinococcus multilocularis	somatostatin receptor	0.0013	0.021	0.0168
Brugia malayi	RNA recognition motif domain containing protein	0.0135	0.3244	1
Echinococcus multilocularis	importin subunit beta 1	0.0033	0.0703	0.0663
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0065	0.0022
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0779	1
Echinococcus multilocularis	g protein coupled receptor	0.0013	0.021	0.0168
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0013	0.021	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0057	0.1297	0.1511
Brugia malayi	follicle stimulating hormone receptor	0.0013	0.021	0.0648
Echinococcus granulosus	g protein coupled receptor	0.0013	0.021	0.0168
Echinococcus multilocularis	serotonin receptor	0.0013	0.021	0.0168
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0779	0.5
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0334	0.1031
Schistosoma mansoni	biogenic amine receptor	0.0013	0.021	0.0168
Echinococcus granulosus	7TM GPCR rhodopsin	0.0013	0.021	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0779	0.0739
Echinococcus granulosus	fmrfamide receptor	0.0013	0.021	0.0168
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.005	0.0093
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0013	0.021	0.0648
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0779	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0013	0.021	0.0168
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0106	0.0326
Echinococcus granulosus	neuropeptide receptor	0.0013	0.021	0.0168
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.1234	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0065	0.0022
Echinococcus multilocularis	neuropeptide s receptor	0.0013	0.021	0.0168
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.021	0.0168
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0013	0.021	0.0168
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0024	0.0488	0.6744
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0779	0.0907
Brugia malayi	MH1 domain containing protein	0.0008	0.009	0.0277
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0779	1
Echinococcus granulosus	cpg binding protein	0.003	0.0639	0.0599
Schistosoma mansoni	neuropeptide receptor	0.0013	0.021	0.0168
Echinococcus granulosus	snurportin 1	0.035	0.8583	0.8577
Echinococcus multilocularis	g protein coupled receptor	0.0013	0.021	0.0168
Brugia malayi	G-protein coupled receptor	0.0013	0.021	0.0648
Onchocerca volvulus		0.0029	0.0599	0.6833
Schistosoma mansoni	smad1 5 8 and	0.0008	0.009	0.0047
Schistosoma mansoni	hypothetical protein	0.0013	0.021	0.0168
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.005	0.0093
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0549	0.688
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.021	0.0168
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.005	0.0093
Echinococcus multilocularis	neuropeptide receptor	0.0013	0.021	0.0168
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0779	0.5
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0779	0.0739
Schistosoma mansoni	neuropeptide receptor	0.0013	0.021	0.0168
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0013	0.021	0.0168
Brugia malayi	MH1 domain containing protein	0.0008	0.009	0.0277
Schistosoma mansoni	amine GPCR	0.0013	0.021	0.0168
Loa Loa (eye worm)	G-protein coupled receptor	0.0013	0.021	0.0245
Echinococcus multilocularis	sex peptide receptor	0.0013	0.021	0.0168
Schistosoma mansoni	ran	0.0024	0.0488	0.0447
Schistosoma mansoni	cpg binding protein	0.003	0.0639	0.0599
Echinococcus granulosus	neuropeptide receptor A26	0.0013	0.021	0.0168
Echinococcus granulosus	smad	0.0008	0.009	0.0047
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0013	0.021	0.0168
Toxoplasma gondii	HEAT repeat-containing protein	0.0033	0.0703	0.5545
Echinococcus multilocularis	allatostatin A receptor	0.0013	0.021	0.0168
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0779	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.021	0.0168
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0013	0.021	0.0245
Echinococcus multilocularis	Smad4	0.0008	0.009	0.0047
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0013	0.021	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0013	0.021	0.0245
Schistosoma mansoni	adenoreceptor	0.0013	0.021	0.0168

Activities

Activity type	Activity value	Assay description	Source	Reference
CC50 (ADMET)	= 22 uM	Cytotoxicity against human MT4 cells after 96 hrs by MTT assay	ChEMBL.	20359898

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1092979

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1122532