Detailed information for compound 1122790

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 342.301 | Formula: C14H18N2O8
  • H donors: 4 H acceptors: 6 LogP: -1.65 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)/C=C/c1cc(=O)[nH]c(=O)n1C1O[C@@H]([C@H]([C@H]1O)O)CO
  • InChi: 1S/C14H18N2O8/c1-2-23-10(19)4-3-7-5-9(18)15-14(22)16(7)13-12(21)11(20)8(6-17)24-13/h3-5,8,11-13,17,20-21H,2,6H2,1H3,(H,15,18,22)/b4-3+/t8-,11-,12-,13?/m1/s1
  • InChiKey: SYDODRXPXZCBJN-HCEFWUBBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0135 0.0153 0.0153
Onchocerca volvulus 0.0037 0.0028 0.0084
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0029 0.0003
Echinococcus granulosus lysine specific demethylase 5A 0.0181 0.0212 0.0211
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0021 0.002
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0047 0.0208
Schistosoma mansoni hypothetical protein 0.0346 0.0426 0.0425
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0047 0.0948
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.017 0.0199 0.0199
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0028 0.0123
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0049 0.0043 0.0042
Trypanosoma cruzi polo-like protein kinase, putative 0.0187 0.0221 0.0395
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0028 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0028 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0047 0.0046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0021 0.002
Brugia malayi beta-lactamase 0.0037 0.0028 0.0028
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0028 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0021 0.0021
Echinococcus granulosus muscleblind protein 0.0154 0.0178 0.0177
Schistosoma mansoni alpha-glucosidase 0.0146 0.0168 0.0167
Trypanosoma brucei protein kinase, putative 0.0052 0.0047 0.004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0021 0.002
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0029 0.0028
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0002 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0061 0.006
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0135 0.0153 0.0152
Loa Loa (eye worm) hypothetical protein 0.0456 0.0567 0.0567
Brugia malayi Dihydrofolate reductase 0.7775 1 1
Echinococcus multilocularis muscleblind protein 1 0.0154 0.0178 0.0177
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.001 0.0008
Echinococcus granulosus JmjC domain containing protein 4 0.0048 0.0041 0.004
Trichomonas vaginalis glutaminase, putative 0.0275 0.0334 0.1511
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0029 0.0029
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0028 0.0028
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0028 0.0027
Loa Loa (eye worm) glutaminase 2 0.0275 0.0334 0.0334
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0028 0.0122
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0028 0.0053
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0221 0.0998
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0021 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0061 0.006
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0663 0.0835 0.0833
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0316 0.0386 0.0732
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0047 0.004
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0028 0.0122
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.016 0.0158
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0048 0.0041 0.0028
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0135 0.0134
Echinococcus multilocularis cpg binding protein 0.003 0.0019 0.0018
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0028 0.0027
Onchocerca volvulus 0.0663 0.0835 0.376
Echinococcus multilocularis transcription factor Dp 1 0.0078 0.008 0.0079
Loa Loa (eye worm) hypothetical protein 0.0069 0.0069 0.0069
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0221 0.0998
Onchocerca volvulus 0.0037 0.0028 0.0084
Schistosoma mansoni hypothetical protein 0.0144 0.0165 0.0164
Brugia malayi ecdysteroid receptor 0.0032 0.0021 0.0021
Schistosoma mansoni inositol monophosphatase 0.0037 0.0027 0.0026
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0021 0.0021
Brugia malayi jmjC domain containing protein 0.0048 0.0041 0.0041
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0021 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0021 0.002
Brugia malayi glutaminase DH11.1 0.0275 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Echinococcus granulosus intermediate filament protein 0.0029 0.0018 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0047 0.0208
Echinococcus multilocularis jumonji domain containing 1A 0.0048 0.0041 0.004
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0028 0.0122
Schistosoma mansoni hypothetical protein 0.0409 0.0507 0.0505
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0047 0.0208
Schistosoma mansoni peptidase Clp (S14 family) 0.0234 0.0282 0.028
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0187 0.0221 0.022
Echinococcus granulosus dnaJ subfamily B 0.0409 0.0507 0.0505
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0028 0.0002
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0028 0.0123
Schistosoma mansoni intermediate filament proteins 0.0029 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0037 0.0028 0.0028
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0001 0.0001
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0027 0.0026
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0135 0.0153 0.6801
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0135 0.0153 0.0153
Echinococcus multilocularis dihydrofolate reductase 0.7775 1 1
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0028 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0221 0.0998
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.016 0.0158
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0021 0.002
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0099 0.0446
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0028 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0023 0.001 0.001
Echinococcus multilocularis survival motor neuron protein 1 0.0705 0.0889 0.0888
Brugia malayi MAP kinase sur-1 0.0052 0.0047 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0021 0.0021
Mycobacterium ulcerans beta-lactamase 0.0037 0.0028 0.0027
Loa Loa (eye worm) runx1 0.0057 0.0053 0.0053
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0028 0.0027
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0135 0.0153 0.0152
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0029 0.0982
Schistosoma mansoni phosphatidylserine receptor 0.0048 0.0041 0.004
Echinococcus granulosus peptidase Clp S14 family 0.0154 0.0178 0.0176
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0021 0.002
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.3844 0.4934 1
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.0221 0.022
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0028 0.0002
Onchocerca volvulus 0.0029 0.0017 0.0032
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0021
Schistosoma mansoni ap endonuclease 0.0038 0.0029 0.0028
Loa Loa (eye worm) inositol-1 0.0037 0.0027 0.0027
Echinococcus granulosus lamin 0.0029 0.0018 0.0016
Brugia malayi follicle stimulating hormone receptor 0.0459 0.0571 0.0571
Loa Loa (eye worm) hypothetical protein 0.0037 0.0028 0.0028
Brugia malayi CXXC zinc finger family protein 0.0029 0.0017 0.0017
Mycobacterium ulcerans glutaminase 0.0275 0.0334 0.0333
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0047 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.016 0.0158
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.001 0.0009
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0061 0.0061
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0081 0.0084 0.0082
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0021 0.0051
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0028 0.088
Echinococcus granulosus jumonji domain containing 1A 0.0048 0.0041 0.004
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0834 0.1055 0.1054
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0068 0.0067
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0018 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0021 0.0021
Schistosoma mansoni coup transcription factor 0.0032 0.0021 0.002
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0154 0.0178 0.0178
Brugia malayi AMP-binding enzyme family protein 0.0023 0.001 0.001
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0029 0.0029
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0047 0.004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0021
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0154 0.0178 0.0178
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0021 0.0021
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0221 0.0998
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1516 0.1933 0.1933
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0022 0.0021
Brugia malayi jmjC domain containing protein 0.0048 0.0041 0.0041
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0084 0.0165
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0021 0.0021
Brugia malayi AMP-binding enzyme family protein 0.0023 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0028 0.0028
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0028 0.088
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.0135 0.0134
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0021
Plasmodium vivax JmjC domain containing protein 0.0048 0.0041 0.0079
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0021
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0234 0.0282 0.028
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0029 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0028 0.0002
Trypanosoma brucei glucosidase, putative 0.0038 0.0028 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0218 0.0261 0.0259
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0027 0.0036
Loa Loa (eye worm) hypothetical protein 0.0048 0.0041 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0221 0.0998
Echinococcus multilocularis peptidase Clp (S14 family) 0.0154 0.0178 0.0176
Echinococcus granulosus thymidylate synthase 0.0663 0.0835 0.0833
Echinococcus multilocularis neuropeptide s receptor 0.0471 0.0587 0.0586
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.0199 0.0197
Brugia malayi Muscleblind-like protein 0.0154 0.0178 0.0178
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0029 0.0901
Brugia malayi thymidylate synthase 0.0663 0.0835 0.0835
Mycobacterium tuberculosis Conserved protein 0.0037 0.0028 0.0027
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0028 0.0027
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.011 0.011
Onchocerca volvulus Huntingtin homolog 0.0128 0.0144 0.0613
Toxoplasma gondii hypothetical protein 0.0081 0.0084 0.0115
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0154 0.0178 0.0177
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0028 0.0122
Loa Loa (eye worm) hypothetical protein 0.0101 0.011 0.011
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0234 0.0282 0.0567
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0032 0.0021 0.002
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0663 0.0835 0.0834
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0069 0.0069
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0021 0.002
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0021 0.002
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0047 0.004
Brugia malayi TAR-binding protein 0.0063 0.0061 0.0061
Schistosoma mansoni survival motor neuron protein 0.0144 0.0165 0.0164
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0047 0.004
Mycobacterium tuberculosis Conserved protein 0.0037 0.0028 0.0027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0021 0.0021
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0028 0.0027
Schistosoma mansoni alpha glucosidase 0.0038 0.0028 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0021
Mycobacterium leprae Probable lipase LipE 0.0037 0.0028 0.0027
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0187 0.0221 0.0429
Brugia malayi jmjC domain containing protein 0.0181 0.0212 0.0212
Schistosoma mansoni phd/f-box containing protein 0.0048 0.0041 0.004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.016 0.0158
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.016 0.0158
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0135 0.0134
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.0135 0.0134
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0021 0.0021
Leishmania major hypothetical protein, conserved 0.0048 0.0041 0.0064
Echinococcus multilocularis lamin 0.0029 0.0018 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0021 0.0021
Brugia malayi hypothetical protein 0.0128 0.0144 0.0144
Echinococcus granulosus neuropeptide receptor A26 0.0471 0.0587 0.0586
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0028 0.0027
Brugia malayi jmjC domain containing protein 0.0048 0.0041 0.0041
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0144 0.0165 0.0165
Brugia malayi hypothetical protein 0.0456 0.0567 0.0567
Onchocerca volvulus 0.0029 0.0018 0.0036
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0048 0.0041 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0021 0.0021
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.001 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0221 0.0998
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0027 0.0026
Onchocerca volvulus 0.0032 0.0021 0.0051
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0021 0.0021
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.7775 1 1
Echinococcus multilocularis geminin 0.0346 0.0426 0.0425
Schistosoma mansoni cpg binding protein 0.003 0.0019 0.0018
Schistosoma mansoni ap endonuclease 0.0038 0.0029 0.0028
Loa Loa (eye worm) thymidylate synthase 0.0663 0.0835 0.0835
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0021 0.002
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0001 0.0001
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0027 0.0118
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0028 0.0123
Onchocerca volvulus Huntingtin homolog 0.0128 0.0144 0.0613
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0001 0.0001
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0028 0.0027
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0027 0.0832
Trichomonas vaginalis conserved hypothetical protein 0.0316 0.0386 0.1749
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.001 0.0008
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0021 0.002
Echinococcus multilocularis lysine specific demethylase 6a 0.0048 0.0041 0.004
Echinococcus granulosus dihydrofolate reductase 0.7775 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0021 0.002
Schistosoma mansoni glutaminase 0.0275 0.0334 0.0333
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0021 0.002
Onchocerca volvulus 0.0029 0.0018 0.0036
Loa Loa (eye worm) hypothetical protein 0.0705 0.0889 0.0889
Echinococcus granulosus lamin dm0 0.0029 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Loa Loa (eye worm) glutaminase 0.0275 0.0334 0.0334
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.001 0.0008
Leishmania major hypothetical protein, conserved 0.0037 0.0028 0.0037
Schistosoma mansoni kinase 0.0095 0.0103 0.0101
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0021 0.002
Echinococcus multilocularis phd:f box containing protein 0.0048 0.0041 0.004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.016 0.0158
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0001 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0135 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0021 0.0021
Onchocerca volvulus 0.0098 0.0106 0.0441
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0459 0.0571 0.0571
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0047 0.0208
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.001 0.0008
Brugia malayi intermediate filament protein 0.0029 0.0018 0.0018
Onchocerca volvulus 0.0037 0.0028 0.0084
Brugia malayi nuclear receptor NHR-88 0.0032 0.0021 0.0021
Brugia malayi beta-lactamase family protein 0.0037 0.0028 0.0028
Schistosoma mansoni jumonji domain containing protein 0.0179 0.021 0.0209
Echinococcus granulosus neuropeptide s receptor 0.0471 0.0587 0.0586
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0028 0.0122
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0028 0.0027
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.001 0.0008
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0028 0.0123
Brugia malayi hypothetical protein 0.0017 0.0001 0.0001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0218 0.0261 0.0259
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0234 0.0282 0.0518
Mycobacterium ulcerans hypothetical protein 0.0037 0.0028 0.0027
Toxoplasma gondii ABC1 family protein 0.0037 0.0028 0.0002
Echinococcus multilocularis musashi 0.0029 0.0018 0.0016
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0029 0.0982
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.016 0.0158
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0179 0.021 0.0209
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0061 0.0061
Brugia malayi hypothetical protein 0.0017 0.0001 0.0001
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.0288 0.0288
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.006 0.0067
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0021 0.002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0021 0.0021
Loa Loa (eye worm) jmjC domain-containing protein 0.0048 0.0041 0.0041
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0021 0.002
Brugia malayi Inositol-1 0.0037 0.0027 0.0027
Echinococcus granulosus tar DNA binding protein 0.0063 0.0061 0.006
Leishmania major dihydrofolate reductase-thymidylate synthase 0.3844 0.4934 1
Brugia malayi Pre-SET motif family protein 0.1516 0.1933 0.1933
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.016 0.016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0021 0.0021
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0135 0.0134
Trichomonas vaginalis set domain proteins, putative 0.1725 0.2203 1
Loa Loa (eye worm) hypothetical protein 0.0456 0.0567 0.0567
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0021 0.002
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0234 0.0282 0.028
Loa Loa (eye worm) jmjC domain-containing protein 0.0048 0.0041 0.0041
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0153 0.0257
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0021 0.002
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0187 0.0221 0.022
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.001
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0028 0.0027
Loa Loa (eye worm) hypothetical protein 0.0048 0.0041 0.0041
Onchocerca volvulus 0.0218 0.0261 0.1144
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0021 0.002
Echinococcus granulosus lysine specific demethylase 6a 0.0048 0.0041 0.004
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0029 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0028 0.0002
Plasmodium falciparum JmjC domain-containing protein, putative 0.0048 0.0041 0.0079
Schistosoma mansoni protein phosphatase 2C 0.0048 0.0041 0.004
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0027 0.0118
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0047 0.0046
Giardia lamblia Kinase, PLK 0.0187 0.0221 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0047 0.0046
Echinococcus granulosus lysosomal alpha glucosidase 0.017 0.0199 0.0197
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0218 0.0261 0.0259
Toxoplasma gondii exonuclease III APE 0.0038 0.0029 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0021 0.0021
Schistosoma mansoni jumonji/arid domain-containing protein 0.0181 0.0212 0.0211
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0218 0.0261 0.0261
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0028 0.0123
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0154 0.0178 0.0176
Brugia malayi nuclear receptor RXR 0.0017 0.0001 0.0001
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.0135 0.0219
Brugia malayi hypothetical protein 0.0316 0.0386 0.0386
Schistosoma mansoni hypothetical protein 0.0032 0.0021 0.002
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0027 0.0026
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0234 0.0282 0.028
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.3844 0.4934 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0021 0.002
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0021 0.0021
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0061 0.006
Echinococcus granulosus transcription factor Dp 1 0.0078 0.008 0.0079
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0028 0.0028
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0028 0.0123
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0021 0.0021
Trichomonas vaginalis esterase, putative 0.0037 0.0028 0.0122
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0029 0.0028
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0021 0.002
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0047 0.0047
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0021 0.002
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0061 0.0061
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0002 0.0001
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.0199 0.0197
Echinococcus granulosus survival motor neuron protein 1 0.0705 0.0889 0.0888
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0028 0.0038
Echinococcus granulosus GPCR family 2 0.0032 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0234 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0021
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0021 0.002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0021 0.002
Schistosoma mansoni inositol monophosphatase 0.0037 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0021
Schistosoma mansoni lamin 0.0029 0.0018 0.0016
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0209 0.025 0.0248
Loa Loa (eye worm) RNA binding protein 0.0063 0.0061 0.0061
Loa Loa (eye worm) dihydrofolate reductase 0.7775 1 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0234 0.0282 0.028
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0346 0.0426 0.0425
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0218 0.0261 0.0259
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0027 0.0118
Loa Loa (eye worm) beta-lactamase 0.0037 0.0028 0.0028
Onchocerca volvulus 0.1725 0.2203 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0029 0.0054
Schistosoma mansoni lamin 0.0029 0.0018 0.0016
Brugia malayi steroid hormone receptor 0.0032 0.0021 0.0021
Echinococcus multilocularis thymidylate synthase 0.0663 0.0835 0.0833
Entamoeba histolytica serine/threonine protein kinase, putative 0.0187 0.0221 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0179 0.021 0.0209
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0028 0.0027
Echinococcus granulosus phd:f box containing protein 0.0048 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.0048 0.0041 0.0041
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0028 0.0123
Onchocerca volvulus 0.0144 0.0165 0.0709
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0029 0.0125
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0084 0.2942
Mycobacterium tuberculosis Conserved protein 0.0037 0.0028 0.0027
Loa Loa (eye worm) hypothetical protein 0.0037 0.0028 0.0028
Echinococcus multilocularis JmjC domain containing protein 4 0.0048 0.0041 0.004
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0021 0.0051
Brugia malayi RNA binding protein 0.0063 0.0061 0.0061
Chlamydia trachomatis dihydrofolate reductase 0.7775 1 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0179 0.021 0.0209
Mycobacterium ulcerans lipase LipD 0.0037 0.0028 0.0027
Loa Loa (eye worm) jmjC domain-containing protein 0.0048 0.0041 0.0041
Brugia malayi nuclear hormone receptor 0.0032 0.0021 0.0021
Mycobacterium ulcerans thymidylate synthase 0.0663 0.0835 0.0833
Brugia malayi jmjC domain containing protein 0.0048 0.0041 0.0041
Echinococcus multilocularis lamin dm0 0.0029 0.0018 0.0016
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0017 0.0017
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.011 0.011
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0048 0.0041 0.0028
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0047 0.0046
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.0135 0.0254
Echinococcus multilocularis neuropeptide receptor A26 0.0471 0.0587 0.0586
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0017
Schistosoma mansoni jumonji/arid domain-containing protein 0.0181 0.0212 0.0211
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0021
Loa Loa (eye worm) jmjC domain-containing protein 0.0181 0.0212 0.0212
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0234 0.0282 0.028
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0021 0.0021
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0028 0.0027
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0154 0.0178 0.0177
Schistosoma mansoni hypothetical protein 0.0032 0.0021 0.002
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0047 0.0076
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0218 0.0261 0.0476
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0234 0.0282 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0218 0.0261 0.0259
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0029 0.0003
Echinococcus multilocularis muscleblind protein 0.0154 0.0178 0.0177
Echinococcus multilocularis GPCR, family 2 0.0032 0.0021 0.002
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0028 0.0123
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.011 0.011
Schistosoma mansoni dihydrofolate reductase 0.7775 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0135 0.0134
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0028 0.0027
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.001 0.0008
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.0135 0.0134
Mycobacterium ulcerans hypothetical protein 0.0023 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0018
Trypanosoma cruzi polo-like protein kinase, putative 0.0187 0.0221 0.0395
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0021 0.002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0021 0.0021
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.3844 0.4934 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0234 0.0282 0.0567
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0153 0.0257
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0018 0.0018
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0135 0.0153 0.0152
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.001 0.0008
Brugia malayi hypothetical protein 0.0705 0.0889 0.0889
Mycobacterium tuberculosis Hypothetical protein 0.0316 0.0386 0.0385
Schistosoma mansoni hypothetical protein 0.0069 0.0069 0.0068
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0234 0.0282 1
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.7775 1 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0084 0.0165
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.3844 0.4934 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0021 0.0021
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0221 0.0998
Loa Loa (eye worm) hypothetical protein 0.0128 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0021
Brugia malayi Probable ClpP-like protease 0.0234 0.0282 0.0282
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.001
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0234 0.0282 0.028
Brugia malayi beta-lactamase family protein 0.0037 0.0028 0.0028
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0029 0.0054
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0021 0.002
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0047 0.004
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0001 0.0001
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0029 0.0028
Onchocerca volvulus Serine\/threonine kinase homolog 0.0187 0.0221 0.0963
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.001 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0061 0.006
Brugia malayi Pre-SET motif family protein 0.0218 0.0261 0.0261
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0153 0.0257
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0234 0.0282 0.028
Onchocerca volvulus 0.0456 0.0567 0.2541
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0021 0.002
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0048 0.0041 0.0028
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0187 0.0221 0.0221
Plasmodium vivax SET domain protein, putative 0.0218 0.0261 0.0524
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0048 0.0041 0.0028
Echinococcus granulosus histone lysine methyltransferase setb 0.0218 0.0261 0.0259
Loa Loa (eye worm) hypothetical protein 0.0037 0.0028 0.0028
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0049 0.0043 0.0042
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0047 0.004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0021 0.002
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0028 0.0028
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0021 0.0051
Brugia malayi Glycosyl hydrolases family 31 protein 0.017 0.0199 0.0199
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0028 0.0027
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0028 0.0027
Schistosoma mansoni jumonji domain containing protein 0.0048 0.0041 0.004
Schistosoma mansoni hypothetical protein 0.0032 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0663 0.0835 0.0833
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0028 0.0028
Schistosoma mansoni cpg binding protein 0.003 0.0019 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0061 0.006
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.0507 0.0505
Brugia malayi jmjC domain containing protein 0.0179 0.021 0.021
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0048 0.0041 0.004
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0047 0.0046
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0135 0.0153 0.0292
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0027 0.093
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0218 0.0261 0.0259
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0234 0.0282 0.0518
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0099 0.0446
Echinococcus multilocularis Protein lozenge 0.0057 0.0053 0.0052
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0021 0.002
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0021 0.0021
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.7775 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0028 0.0123
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0128 0.0144 0.0144
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.016 0.016
Echinococcus granulosus geminin 0.0346 0.0426 0.0425
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0061 0.006
Schistosoma mansoni alpha-glucosidase 0.0146 0.0168 0.0167
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.3844 0.4934 1
Echinococcus granulosus cpg binding protein 0.003 0.0019 0.0018
Trypanosoma brucei polo-like protein kinase 0.0187 0.0221 0.0395
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0022 0.0021
Schistosoma mansoni cpg binding protein 0.0029 0.0017 0.0015
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0029 0.0125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0021 0.0021
Brugia malayi serine/threonine-protein kinase plk-2 0.0187 0.0221 0.0221
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0021 0.002
Schistosoma mansoni lozenge 0.0057 0.0053 0.0052

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 35 uM In vitro growth inhibitory activity against mouse L1210 leukemia cells ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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