Detailed information for compound 1122830

Basic information

Technical information
  • TDR Targets ID: 1122830
  • Name: N-cyclohexyl-N'-(2,4,6-trimethylphenyl)pyrrol idine-1,2-dicarboxamide
  • MW: 357.49 | Formula: C21H31N3O2
  • H donors: 2 H acceptors: 2 LogP: 3.88 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCCN1C(=O)NC1CCCCC1)Nc1c(C)cc(cc1C)C
  • InChi: 1S/C21H31N3O2/c1-14-12-15(2)19(16(3)13-14)23-20(25)18-10-7-11-24(18)21(26)22-17-8-5-4-6-9-17/h12-13,17-18H,4-11H2,1-3H3,(H,22,26)(H,23,25)
  • InChiKey: XULSGESQHBAQDL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • MLS000121999
  • Pyrrolidine-1,2-dicarboxylic acid 2-cyclohexylamide 1-[(2,4,6-trimethyl-phenyl)-amide]
  • SMR000119403
  • ASN 06482112

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0192 0.0149
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.1229 0.119
Brugia malayi jmjC domain containing protein 0.0016 0.0192 0.0165
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.1729 0.1693
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0023 0.04 0.1679
Brugia malayi Muscleblind-like protein 0.032 0.9032 1
Echinococcus granulosus bloom syndrome protein 0.0025 0.0478 0.0436
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0944 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0308 0.0265
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0028 0.0542 0.05
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.5259 0.6392
Loa Loa (eye worm) hypothetical protein 0.0044 0.1018 0.0978
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0023 0.04 0.0357
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0192 0.0149
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0028 0.0542 0.5042
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0044 0.00000000082975
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0023 0.04 0.3283
Loa Loa (eye worm) hypothetical protein 0.0016 0.0192 0.0149
Loa Loa (eye worm) hypothetical protein 0.0042 0.0944 0.0904
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0944 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0519 0.048
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0067 0.1689 0.686
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0028 0.0542 0.2579
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0192 0.0149
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.8152 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0256 0.0213
Leishmania major cytochrome P450 reductase, putative 0.002 0.0325 0.1205
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0192 0.072
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0308 0.0265
Brugia malayi RNA binding protein 0.0064 0.1594 0.1724
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0023 0.04 0.4085
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.8152 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0944 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0519 0.475
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0023 0.04 0.3283
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0792 0.0752
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0388 0.5241
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.029 0.8152 0.8144
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.5259 0.6392
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0028 0.0542 0.5042
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0308 0.0265
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0308 0.0265
Loa Loa (eye worm) hypothetical protein 0.002 0.0308 0.0265
Giardia lamblia Hypothetical protein 0.002 0.0325 0.3118
Schistosoma mansoni zinc finger protein 0.0018 0.0249 0.0206
Treponema pallidum hypothetical protein 0.0032 0.0678 1
Echinococcus multilocularis importin subunit beta 1 0.0033 0.07 0.0659
Plasmodium vivax flavodoxin domain containing protein 0.002 0.0325 0.2607
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0944 0.0904
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.1229 0.1319
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0944 0.101
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0354 1 1
Schistosoma mansoni hypothetical protein 0.0024 0.0427 0.0385
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0199 0.5515 0.6711
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0792 0.0752
Brugia malayi FAD binding domain containing protein 0.0023 0.04 0.0396
Loa Loa (eye worm) hypothetical protein 0.0047 0.1097 0.1058
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0038 0.0842 0.3419
Echinococcus multilocularis snurportin 1 0.0354 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0944 0.101
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0427 0.0385
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0067 0.1689 0.4738
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0944 0.0904
Loa Loa (eye worm) FAD binding domain-containing protein 0.0014 0.0147 0.0103
Echinococcus granulosus muscleblind protein 0.032 0.9032 0.9027
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.029 0.8152 0.9021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1229 0.119
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1594 0.1556
Brugia malayi hypothetical protein 0.0036 0.0792 0.0833
Trichomonas vaginalis aldehyde oxidase, putative 0.0199 0.5515 0.6711
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1717 0.4817
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.1717 0.1681
Entamoeba histolytica hypothetical protein 0.0036 0.0792 0.813
Brugia malayi jmjC domain containing protein 0.0059 0.1437 0.155
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0094 0.2462 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0944 0.0904
Entamoeba histolytica hypothetical protein 0.0036 0.0792 0.813
Echinococcus multilocularis methionine synthase reductase 0.0014 0.0147 0.0103
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0192 0.072
Treponema pallidum quinoline 2-oxidoreductase 0.0032 0.0656 0.8682
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0023 0.04 0.0357
Loa Loa (eye worm) hypothetical protein 0.0122 0.3277 0.3247
Entamoeba histolytica hypothetical protein 0.0036 0.0792 0.813
Echinococcus multilocularis muscleblind protein 0.032 0.9032 0.9027
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0519 0.048
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.1501 0.1463
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0023 0.04 0.1121
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0023 0.04 0.3283
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0542 0.0509
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0192 0.0149
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1717 0.4817
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0519 0.048
Loa Loa (eye worm) TAR-binding protein 0.0064 0.1594 0.1556
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0023 0.04 0.3283
Echinococcus granulosus importin subunit beta 1 0.0033 0.07 0.0659
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.8152 1
Giardia lamblia Rrm3p helicase 0.0028 0.0542 0.5536
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0023 0.04 0.3283
Brugia malayi hypothetical protein 0.0122 0.3277 0.3597
Schistosoma mansoni hypothetical protein 0.0028 0.0542 0.05
Echinococcus granulosus tar DNA binding protein 0.0064 0.1594 0.1556
Schistosoma mansoni cytochrome P450 reductase 0.0023 0.04 0.0357
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0937 0.0897
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0028 0.0542 0.5042
Brugia malayi jmjC domain containing protein 0.0016 0.0192 0.0165
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0491 0.0449
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0944 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.6427 0.6411
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.07 0.6994
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0059 0.1451 0.4071
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.5259 0.6392
Echinococcus granulosus phd:f box containing protein 0.0016 0.0192 0.0149
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0192 0.0149
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.5259 0.6392
Loa Loa (eye worm) RNA binding protein 0.0064 0.1594 0.1556
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0478 0.0429
Entamoeba histolytica hypothetical protein 0.0036 0.0792 0.813
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0094 0.2462 0.6907
Brugia malayi Importin beta-1 subunit 0.0033 0.07 0.073
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.1717 0.1681
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1229 0.119
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0256 0.0213
Trypanosoma brucei ISWI complex protein 0.0018 0.0249 0.1425
Echinococcus multilocularis zinc finger protein 0.0023 0.0392 0.0349
Schistosoma mansoni bromodomain containing protein 0.0073 0.1849 0.1813
Loa Loa (eye worm) hypothetical protein 0.0016 0.0192 0.0149
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0491 0.0449
Loa Loa (eye worm) hypothetical protein 0.0049 0.1161 0.1122
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0308 0.0265
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0308 0.0265
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0944 1
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.07 0.3923
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0944 0.0904
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.1717 0.6974
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.8152 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0937 0.0897
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0038 0.0842 0.2362
Leishmania major hypothetical protein, conserved 0.0018 0.0249 0.0729
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0192 0.0149
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0192 0.2255
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0192 0.0149
Loa Loa (eye worm) FAD binding domain-containing protein 0.0023 0.04 0.0357
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0192 0.0885
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1594 0.1556
Loa Loa (eye worm) hypothetical protein 0.0122 0.3277 0.3247
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0478 0.0482
Schistosoma mansoni jumonji domain containing protein 0.0059 0.1437 0.1399
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.07 0.6994
Brugia malayi jmjC domain containing protein 0.0061 0.1501 0.1621
Toxoplasma gondii flavodoxin domain-containing protein 0.0011 0.0067 0.0137
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.1437 0.1399
Echinococcus granulosus zinc finger protein 0.0023 0.0392 0.0349
Brugia malayi follicle stimulating hormone receptor 0.0231 0.6427 0.7102
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.1501 0.1463
Plasmodium falciparum importin beta, putative 0.0033 0.07 1
Trichomonas vaginalis sulfite reductase, putative 0.0023 0.04 0.0332
Toxoplasma gondii flavodoxin domain-containing protein 0.0011 0.0067 0.0137
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0192 0.0149
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0132 0.3565 1
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.1594 0.1724
Brugia malayi Bromodomain containing protein 0.0044 0.1016 0.1081
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.1717 0.1681
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1594 0.1556
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0944 0.0904
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0308 0.0265
Plasmodium falciparum nitric oxide synthase, putative 0.0023 0.04 0.5419
Brugia malayi Bromodomain containing protein 0.0086 0.2239 0.2442
Entamoeba histolytica DNA repair and recombination protein, putative 0.0028 0.0542 0.5042
Onchocerca volvulus Glucosylceramidase homolog 0.019 0.5259 1
Loa Loa (eye worm) RecQ helicase 0.0025 0.0478 0.0436
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.1717 1
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0328 0.0285
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0192 0.0149
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0944 0.1001
Trichomonas vaginalis glucosylceramidase, putative 0.0201 0.5556 0.6763
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0192 0.0149
Entamoeba histolytica hypothetical protein 0.0027 0.0519 0.475
Leishmania major p450 reductase, putative 0.0023 0.04 0.1679
Brugia malayi jmjC domain containing protein 0.0016 0.0192 0.0165
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0023 0.04 0.3283
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1594 0.1556
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0028 0.0542 0.05
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1229 0.119
Plasmodium vivax importin-beta 2, putative 0.0033 0.07 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0239 0.0914
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.1717 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0192 0.0885
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0038 0.0842 0.2362
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0192 0.0149
Schistosoma mansoni hypothetical protein 0.0354 1 1
Brugia malayi PHD-finger family protein 0.0029 0.057 0.0585
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0192 0.072
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0308 0.0265
Schistosoma mansoni hypothetical protein 0.0036 0.0792 0.0752
Trypanosoma cruzi p450 reductase, putative 0.0023 0.04 0.3283
Trichomonas vaginalis glucosylceramidase, putative 0.0201 0.5556 0.6763
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0094 0.2462 0.6907
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1229 0.119
Leishmania major importin beta-1 subunit, putative 0.0027 0.0519 0.243
Schistosoma mansoni zinc finger protein 0.0023 0.0392 0.0349
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0233 0.1127
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0944 0.5116
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0014 0.0147 0.0103
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0023 0.04 0.0357
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0944 0.0904
Loa Loa (eye worm) hypothetical protein 0.0023 0.04 0.0357
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1594 0.1556
Trypanosoma cruzi ISWI complex protein 0.0018 0.0249 0.1425
Schistosoma mansoni importin beta-1 0.0033 0.07 0.0659
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1229 0.119
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.1437 0.1399
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0028 0.0542 0.5042
Brugia malayi TAR-binding protein 0.0064 0.1594 0.1724
Chlamydia trachomatis sulfite reductase 0.0014 0.0147 1
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.5259 0.6392
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.8152 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.1717 0.1681
Echinococcus granulosus methionine synthase reductase 0.0014 0.0147 0.0103
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0944 0.101
Entamoeba histolytica hypothetical protein, conserved 0.0028 0.0542 0.5042
Trypanosoma cruzi ISWI complex protein 0.0018 0.0249 0.1425
Schistosoma mansoni NADPH flavin oxidoreductase 0.0011 0.0072 0.0028
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0023 0.04 0.0357
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.1594 0.1556
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.5259 0.6392
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0478 0.0436
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.1501 0.1463
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0199 0.5515 0.6711
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.1501 0.1463
Echinococcus multilocularis muscleblind protein 1 0.032 0.9032 0.9027
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0023 0.04 0.3283
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0028 0.0542 0.5042
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0192 0.0149
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.1729 0.1693
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0491 0.0449
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0944 0.0904
Schistosoma mansoni hypothetical protein 0.0018 0.0249 0.0206
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0067 0.1689 0.4738
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.8152 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.3456 0.3427
Loa Loa (eye worm) hypothetical protein 0.0016 0.0192 0.0149
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0478 0.0429
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.1437 0.1399
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0192 0.0149
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1717 0.4817
Brugia malayi flavodoxin family protein 0.0023 0.04 0.0396
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0944 0.0904
Echinococcus multilocularis tar DNA binding protein 0.0064 0.1594 0.1556
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.5259 0.6392
Giardia lamblia Nitric oxide synthase, inducible 0.002 0.0325 0.3118
Loa Loa (eye worm) hypothetical protein 0.032 0.9032 0.9027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1229 0.119
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0192 0.0149
Schistosoma mansoni diflavin oxidoreductase 0.0011 0.0067 0.0023
Leishmania major hypothetical protein, conserved 0.0016 0.0192 0.0368
Brugia malayi jmjC domain containing protein 0.0016 0.0192 0.0165
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0028 0.0542 0.2579
Loa Loa (eye worm) hypothetical protein 0.032 0.9032 0.9027
Brugia malayi FAD binding domain containing protein 0.0014 0.0147 0.0115
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0192 0.0149
Mycobacterium ulcerans hypothetical protein 0.0032 0.0678 0.1902
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0322 0.0279
Brugia malayi RNA, U transporter 1 0.0094 0.2472 0.2702
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0792 0.0752
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.002 0.0325 0.0238
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1229 0.119
Loa Loa (eye worm) hypothetical protein 0.0033 0.07 0.0659
Loa Loa (eye worm) hypothetical protein 0.0081 0.2097 0.2062

Activities

Activity type Activity value Assay description Source Reference
AbsAC40 (functional) = 10.39 uM PubChem BioAssay. HTS for the detection of C. neoformans cell lysis via adenylate kinase (AK) release Measured in Microorganism System Using Plate Reader - 2162-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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