Detailed information for compound 112322

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 264.727 | Formula: C14H15ClNO2-
  • H donors: 1 H acceptors: 1 LogP: 2.41 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C(=COC21CCNCC2)c1ccccc1.[Cl-]
  • InChi: 1S/C14H15NO2.ClH/c16-13-12(11-4-2-1-3-5-11)10-17-14(13)6-8-15-9-7-14;/h1-5,10,15H,6-9H2;1H/p-1
  • InChiKey: FMHSCAAVUDTCCE-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi glutathione reductase 0.0055 0.0127 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0502 0.1818 0.2816
Loa Loa (eye worm) hypothetical protein 0.0101 0.0302 0.0474
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0228 0.0783 0.1306
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0502 0.1818 0.2816
Brugia malayi CXXC zinc finger family protein 0.0068 0.0177 0.0231
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0045 0.0075
Schistosoma mansoni hypothetical protein 0.04 0.1432 0.239
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0111 0.1122
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0049 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0085 0.1376
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0291 0.0291
Brugia malayi tailless protein 0.0228 0.0783 0.1185
Schistosoma mansoni hypothetical protein 0.0033 0.0045 0.0075
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0228 0.0783 0.1306
Echinococcus granulosus expressed conserved protein 0.0095 0.0279 0.0466
Loa Loa (eye worm) hypothetical protein 0.0228 0.0783 0.1227
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0054 0.0185
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0127 0.043
Leishmania major hypothetical protein, conserved 0.0035 0.0054 0.0185
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0063 0.0046
Echinococcus multilocularis nuclear receptor nhr 48 0.0228 0.0783 0.0783
Onchocerca volvulus 0.0055 0.0129 0.0128
Brugia malayi steroid hormone receptor 0.0502 0.1818 0.2816
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0061 0.0061
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0502 0.1818 0.3034
Onchocerca volvulus 0.0075 0.0204 0.023
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0034 0.0057
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0037 0.0057
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.0053
Loa Loa (eye worm) glutathione reductase 0.0055 0.0127 0.0199
Schistosoma mansoni microtubule-associated protein tau 0.1608 0.5991 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.0302 1
Schistosoma mansoni importin beta-1 0.0034 0.0049 0.0082
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0111 0.0333
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0111 0.0545
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0502 0.1818 0.3034
Brugia malayi ecdysteroid receptor 0.0859 0.3164 0.4938
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0034 0.0053
Giardia lamblia PHD finger protein 15 0.003 0.0034 0.2603
Brugia malayi ecdysone receptor 0.0228 0.0783 0.1185
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.009 0.0262 0.3406
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0131 0.0675
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0131 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0502 0.1818 0.3034
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0131 0.0675
Loa Loa (eye worm) hypothetical protein 0.0055 0.0129 0.0201
Schistosoma mansoni cellular tumor antigen P53 0.0105 0.0317 0.0529
Loa Loa (eye worm) DR-78 0.0228 0.0783 0.1227
Mycobacterium ulcerans aldehyde dehydrogenase 0.0206 0.0698 1
Schistosoma mansoni intermediate filament proteins 0.0055 0.0129 0.0215
Brugia malayi conserved hypotetical protein 0.0228 0.0783 0.1185
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0031 0.1186
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0037 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0502 0.1818 0.2851
Echinococcus granulosus importin subunit beta 1 0.0034 0.0049 0.0082
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0001 0.0001
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0054 0.0185
Loa Loa (eye worm) hypothetical protein 0.0033 0.0045 0.007
Brugia malayi PHD-finger family protein 0.003 0.0034 0.0005
Echinococcus granulosus lamin dm0 0.0055 0.0129 0.0215
Echinococcus granulosus neuropeptide receptor A26 0.0537 0.1948 0.3252
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0054 0.0185
Loa Loa (eye worm) CXXC zinc finger family protein 0.0068 0.0177 0.0277
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.0098
Loa Loa (eye worm) hypothetical protein 0.0228 0.0783 0.1227
Onchocerca volvulus 0.0359 0.1275 0.1682
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.0098
Plasmodium vivax importin-beta 2, putative 0.0034 0.0049 0.188
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0127 0.0649
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0291 0.0486
Echinococcus granulosus tumor protein p63 0.0716 0.2622 0.4377
Onchocerca volvulus 0.0228 0.0783 0.1015
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0032 0.0002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0045 0.007
Brugia malayi Muscleblind-like protein 0.016 0.0524 0.0777
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.063 0.23 0.3839
Onchocerca volvulus 0.005 0.0111 0.0104
Plasmodium falciparum thioredoxin reductase 0.0055 0.0127 0.4858
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0073 0.0121
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0035 0.0054 0.0054
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0409 0.0682
Mycobacterium ulcerans beta-lactamase 0.0075 0.0204 0.2534
Brugia malayi jmjC domain containing protein 0.0098 0.0291 0.041
Schistosoma mansoni hypothetical protein 0.0042 0.0079 0.0132
Loa Loa (eye worm) hypothetical protein 0.0228 0.0783 0.1227
Loa Loa (eye worm) CYP4Cod1 0.0031 0.0037 0.0057
Loa Loa (eye worm) hypothetical protein 0.0075 0.0204 0.0319
Brugia malayi jmjC domain containing protein 0.004 0.0073 0.0065
Echinococcus granulosus GPCR family 2 0.0033 0.0045 0.0075
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0034 0.049
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0204 0.089
Brugia malayi Steroid receptor seven-up type 2 0.0502 0.1818 0.2816
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0204 0.0341
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0045 0.0045
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0206 0.0698 0.0698
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.0098
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0206 0.0698 0.4272
Loa Loa (eye worm) hypothetical protein 0.0227 0.0779 0.1221
Loa Loa (eye worm) hypothetical protein 0.0228 0.0783 0.1227
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0078 0.0131
Plasmodium vivax acyl-CoA synthetase, putative 0.0038 0.0063 0.2403
Echinococcus granulosus Nuclear hormone receptor HR96 0.0228 0.0783 0.1306
Loa Loa (eye worm) hypothetical protein 0.0228 0.0783 0.1227
Schistosoma mansoni steroid hormone receptor ad4bp 0.0502 0.1818 0.3034
Echinococcus multilocularis musashi 0.0055 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0359 0.1275 0.1999
Mycobacterium tuberculosis Probable reductase 0.0124 0.0391 0.2007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0502 0.1818 0.2816
Loa Loa (eye worm) hypothetical protein 0.0502 0.1818 0.2851
Brugia malayi hypothetical protein 0.0243 0.0837 0.127
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0204 0.1104
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0131 0.0639
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0502 0.1818 0.2816
Loa Loa (eye worm) cytochrome P450 family protein 0.0065 0.0165 0.0258
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0204 0.2534
Schistosoma mansoni nuclear receptor 0.0228 0.0783 0.1306
Loa Loa (eye worm) hypothetical protein 0.0274 0.0956 0.1499
Trypanosoma brucei protein kinase, putative 0.0056 0.0131 0.0639
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0204 0.0204
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0502 0.1818 0.2816
Loa Loa (eye worm) beta-lactamase 0.0075 0.0204 0.0319
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0479 0.1728 1
Brugia malayi nuclear receptor RXR 0.0274 0.0956 0.1458
Loa Loa (eye worm) hypothetical protein 0.0075 0.0204 0.0319
Brugia malayi CHE-14 protein 0.0043 0.0085 0.0085
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0063 0.2403
Loa Loa (eye worm) hypothetical protein 0.0228 0.0783 0.1227
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.009 0.0262 0.5514
Loa Loa (eye worm) hypothetical protein 0.0053 0.0122 0.019
Brugia malayi RNA binding protein 0.0129 0.0409 0.0595
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0111 0.3663
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0502 0.1818 0.2851
Echinococcus granulosus muscleblind protein 0.016 0.0524 0.0874
Plasmodium vivax glutathione reductase, putative 0.0055 0.0127 0.4858
Mycobacterium leprae Probable lipase LipE 0.0075 0.0204 0.409
Brugia malayi beta-lactamase family protein 0.0075 0.0204 0.0273
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0152 0.0495 0.0826
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0409 0.0682
Echinococcus granulosus nuclear receptor nhr 48 0.0228 0.0783 0.1306
Brugia malayi AMP-binding enzyme family protein 0.005 0.0111 0.0126
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0054 0.0776
Brugia malayi Cytochrome P450 family protein 0.0031 0.0037 0.0009
Brugia malayi Bromodomain containing protein 0.003 0.0034 0.0005
Schistosoma mansoni RAR-like nuclear receptor 0.0502 0.1818 0.3034
Onchocerca volvulus 0.0049 0.0108 0.01
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0129 0.0154
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0204 0.089
Echinococcus multilocularis geminin 0.04 0.1432 0.1432
Schistosoma mansoni nuclear receptor 0.0228 0.0783 0.1306
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.0302 0.0505
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0108 0.0121
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0131 0.2128
Loa Loa (eye worm) hypothetical protein 0.0228 0.0783 0.1227
Brugia malayi Nuclear hormone receptor E75 0.0228 0.0783 0.1185
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0189 0.0249
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0458 0.1648 0.1648
Brugia malayi Nuclear hormone receptor-like 1 0.1057 0.3911 0.6116
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0131 0.0675
Plasmodium falciparum phd finger protein, putative 0.003 0.0034 0.1306
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0204 0.409
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0058 0.0058
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0037 0.0057
Loa Loa (eye worm) hypothetical protein 0.0075 0.0204 0.0319
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0206 0.0698 0.1165
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0111 0.1122
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0228 0.0783 0.1015
Loa Loa (eye worm) hypothetical protein 0.0502 0.1818 0.2851
Brugia malayi TAR-binding protein 0.0129 0.0409 0.0595
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0131 0.1882
Loa Loa (eye worm) hypothetical protein 0.0445 0.1599 0.2508
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0502 0.1818 0.1818
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.0403 0.0631
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.0308 0.0515
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0215 0.0359
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.009 0.0262 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0502 0.1818 0.2816
Schistosoma mansoni hypothetical protein 0.0362 0.1287 0.2148
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0038 0.0063 0.0398
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0035 0.0054 0.009
Mycobacterium tuberculosis Conserved protein 0.0075 0.0204 0.089
Brugia malayi Nuclear hormone receptor-like 1 0.0829 0.3049 0.4758
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0228 0.0783 0.1306
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0111 0.3663
Echinococcus granulosus cpg binding protein 0.0072 0.0192 0.032
Entamoeba histolytica hypothetical protein 0.0037 0.0061 0.2003
Brugia malayi nuclear hormone receptor 0.0502 0.1818 0.2816
Brugia malayi beta-lactamase family protein 0.0075 0.0204 0.0273
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0059 0.0144 0.0534
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0127 0.0212
Echinococcus multilocularis neuropeptide receptor A26 0.0537 0.1948 0.1948
Schistosoma mansoni hypothetical protein 0.0033 0.0045 0.0075
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0124 0.0391 0.8705
Echinococcus multilocularis expressed conserved protein 0.0095 0.0279 0.0279
Schistosoma mansoni peptidase Clp (S14 family) 0.009 0.0262 0.0437
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0228 0.0783 0.1185
Onchocerca volvulus 0.0068 0.0177 0.0194
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0138 0.0443 0.232
Mycobacterium ulcerans aldehyde dehydrogenase 0.0206 0.0698 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0022 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.0495 0.0826
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0049 0.0049
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0228 0.0783 0.0783
Loa Loa (eye worm) hypothetical protein 0.005 0.0111 0.0173
Loa Loa (eye worm) hypothetical protein 0.0105 0.0317 0.0496
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0204 0.1138
Echinococcus multilocularis lamin 0.0055 0.0129 0.0129
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0061 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0409 0.0682
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0502 0.1818 0.3034
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0502 0.1818 0.3034
Brugia malayi MH2 domain containing protein 0.0128 0.0403 0.0586
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0274 0.0956 0.0956
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0111 0.1122
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.0837 0.0837
Mycobacterium tuberculosis Probable dehydrogenase 0.0124 0.0391 0.2007
Brugia malayi nuclear receptor RXR 0.0228 0.0783 0.1185
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0204 0.089
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0031 0.0038
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.009 0.0262 0.0437
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0131 0.0219
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0124 0.0391 0.2007
Toxoplasma gondii thioredoxin reductase 0.0055 0.0127 0.1823
Mycobacterium tuberculosis Conserved protein 0.0075 0.0204 0.089
Echinococcus granulosus thyroid hormone receptor alpha 0.0228 0.0783 0.1306
Schistosoma mansoni zinc finger protein 0.0228 0.0783 0.1306
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0085 0.0142
Toxoplasma gondii ABC1 family protein 0.0075 0.0204 0.2926
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0204 0.3309
Echinococcus granulosus geminin 0.04 0.1432 0.239
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0124 0.0391 0.2007
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0154 0.0241
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0025 0.0406
Brugia malayi beta-lactamase 0.0075 0.0204 0.0273
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0031 0.1186
Mycobacterium ulcerans lipase LipD 0.0075 0.0204 0.2534
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0131 0.2128
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0502 0.1818 0.3034
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0204 0.1138
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0039 0.1475
Echinococcus multilocularis microtubule associated protein 2 0.1608 0.5991 0.5991
Onchocerca volvulus 0.0228 0.0783 0.1015
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0152 0.0495 0.0776
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0502 0.1818 0.2851
Plasmodium falciparum glutathione reductase 0.0055 0.0127 0.4858
Echinococcus multilocularis tar DNA binding protein 0.0129 0.0409 0.0409
Onchocerca volvulus 0.0075 0.0204 0.023
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0025 0.0406
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.009 0.0262 1
Schistosoma mansoni nuclear hormone receptor 0.0502 0.1818 0.3034
Schistosoma mansoni nuclear hormone receptor 0.0228 0.0783 0.1306
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0049 0.0705
Echinococcus multilocularis peptidase Clp (S14 family) 0.0059 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.009 0.0262 0.041
Brugia malayi hypothetical protein 0.0037 0.0061 0.0047
Brugia malayi hypothetical protein 0.0228 0.0783 0.1185
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.0617 1
Echinococcus multilocularis muscleblind protein 1 0.016 0.0524 0.0524
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0502 0.1818 0.2816
Loa Loa (eye worm) hypothetical protein 0.016 0.0524 0.0821
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0502 0.1818 0.2816
Schistosoma mansoni patched 1 0.0043 0.0085 0.0142
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0131 0.2128
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0033
Echinococcus granulosus snurportin 1 0.0362 0.1287 0.2148
Loa Loa (eye worm) nuclear hormone receptor 0.0228 0.0783 0.1227
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0048
Echinococcus granulosus tar DNA binding protein 0.0129 0.0409 0.0682
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0502 0.1818 0.3034
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0131 0.0219
Schistosoma mansoni hypothetical protein 0.0033 0.0045 0.0075
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.0409 0.0595
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0111 0.1784
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0045 0.0022
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.1599 1
Trichomonas vaginalis esterase, putative 0.0075 0.0204 0.3309
Echinococcus multilocularis ecdysone induced protein 78C 0.0502 0.1818 0.1818
Loa Loa (eye worm) hypothetical protein 0.0228 0.0783 0.1227
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0152 0.0495 0.0826
Echinococcus multilocularis thyroid hormone receptor alpha 0.0502 0.1818 0.1818
Echinococcus granulosus intermediate filament protein 0.0055 0.0129 0.0215
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0031 0.0445
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0204 0.089
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0045 0.0045
Schistosoma mansoni cpg binding protein 0.0072 0.0192 0.032
Loa Loa (eye worm) hypothetical protein 0.0502 0.1818 0.2851
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.0837 0.1397
Echinococcus multilocularis cpg binding protein 0.0072 0.0192 0.0192
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0131 0.2128
Loa Loa (eye worm) hypothetical protein 0.0075 0.0204 0.0319
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0111 0.1122
Schistosoma mansoni hypothetical protein 0.0042 0.0079 0.0132
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.009 0.0262 0.0262
Trypanosoma brucei cytochrome P450, putative 0.0031 0.0037 0.0036
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.009 0.0262 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0502 0.1818 0.1818
Echinococcus multilocularis lamin dm0 0.0055 0.0129 0.0129
Brugia malayi photoreceptor-specific nuclear receptor 0.0502 0.1818 0.2816
Loa Loa (eye worm) hypothetical protein 0.0502 0.1818 0.2851
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.1599 1
Brugia malayi Probable ClpP-like protease 0.009 0.0262 0.0364
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0111 0.3663
Brugia malayi AMP-binding enzyme family protein 0.005 0.0111 0.0126
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0124 0.0391 0.2007
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0204 0.7798
Echinococcus granulosus dnaJ subfamily B 0.0485 0.1753 0.2926
Loa Loa (eye worm) TAR-binding protein 0.0129 0.0409 0.064
Brugia malayi Cytochrome P450 family protein 0.0065 0.0165 0.0211
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0502 0.1818 0.1818
Brugia malayi orphan nuclear receptor NR2E1 0.0228 0.0783 0.1185
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0138 0.0443 1
Onchocerca volvulus 0.0055 0.0129 0.0128
Schistosoma mansoni hypothetical protein 0.003 0.0034 0.0057
Onchocerca volvulus 0.0502 0.1818 0.2418
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0031 0.1186
Mycobacterium ulcerans aldehyde dehydrogenase 0.0206 0.0698 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0059 0.0144 0.2616
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0502 0.1818 0.2851
Loa Loa (eye worm) RNA binding protein 0.0129 0.0409 0.064
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0144 0.0464 0.0775
Schistosoma mansoni hypothetical protein 0.0037 0.0061 0.0101
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.009 0.0262 0.3752
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0502 0.1818 0.2816
Loa Loa (eye worm) hypothetical protein 0.0274 0.0956 0.1499
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0129 0.0201
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0049 0.0116
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0228 0.0783 0.1015
Schistosoma mansoni hypothetical protein 0.04 0.1432 0.239
Entamoeba histolytica hypothetical protein 0.0037 0.0061 0.2003
Loa Loa (eye worm) hypothetical protein 0.0783 0.2876 0.4511
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0138 0.0443 0.232
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0111 0.0545
Echinococcus multilocularis dnaJ subfamily B 0.0485 0.1753 0.1753
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0204 0.089
Schistosoma mansoni hypothetical protein 0.0042 0.0079 0.0132
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.009 0.0262 1
Echinococcus multilocularis protein patched 0.0043 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.1482 0.5513 0.8649
Echinococcus granulosus Niemann Pick C1 protein 0.0144 0.0466 0.0778
Brugia malayi Nuclear hormone receptor E75 0.0228 0.0783 0.1185
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0204 0.3309
Schistosoma mansoni coup transcription factor 0.0502 0.1818 0.3034
Loa Loa (eye worm) hypothetical protein 0.0228 0.0783 0.1227
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0204 0.3309
Onchocerca volvulus 0.0075 0.0204 0.023
Schistosoma mansoni aldehyde dehydrogenase 0.0206 0.0698 0.1165
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0204 0.3309
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.0302 0.0428
Schistosoma mansoni nuclear hormone receptor 0.0228 0.0783 0.1306
Mycobacterium ulcerans hypothetical protein 0.005 0.0111 0.1122
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0313 0.0444
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0071 0.0189 0.0316
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.1984 0.741 1
Brugia malayi hypothetical protein 0.0274 0.0956 0.1458
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.0495 0.0826
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0204 0.0273
Loa Loa (eye worm) hypothetical protein 0.0104 0.0313 0.049
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0502 0.1818 0.2816
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0085 0.0142
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0054 0.2067
Brugia malayi hypothetical protein 0.0274 0.0956 0.1458
Brugia malayi hypothetical protein 0.0359 0.1275 0.196
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0204 0.089
Onchocerca volvulus 0.0105 0.0317 0.0383
Echinococcus granulosus peptidase Clp S14 family 0.0059 0.0144 0.0241
Loa Loa (eye worm) hypothetical protein 0.0274 0.0956 0.1499
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0078 0.0078
Brugia malayi nuclear receptor NHR-67 0.0228 0.0783 0.1185
Brugia malayi Thioredoxin reductase 0.0055 0.0127 0.0152
Echinococcus granulosus FTZ F1 alpha 0.0502 0.1818 0.3034
Trypanosoma brucei trypanothione reductase 0.0055 0.0127 0.0613
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0409 0.0682
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.009 0.0262 1
Brugia malayi Augmenter of liver regeneration 0.0035 0.0054 0.0036
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0054 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0502 0.1818 0.2851
Schistosoma mansoni lamin 0.0055 0.0129 0.0215
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.009 0.0262 0.3406
Schistosoma mansoni aldehyde dehydrogenase 0.0206 0.0698 0.1165
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0274 0.0956 0.1596
Leishmania major hypothetical protein, conserved 0.0029 0.0031 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0502 0.1818 0.2816
Entamoeba histolytica hypothetical protein 0.0037 0.0061 0.2003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0228 0.0783 0.0783
Loa Loa (eye worm) hypothetical protein 0.0054 0.0125 0.0195
Toxoplasma gondii aldehyde dehydrogenase 0.0206 0.0698 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0204 0.0341
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0036 0.0008
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.1599 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0111 0.1784
Loa Loa (eye worm) hypothetical protein 0.0071 0.0189 0.0296
Plasmodium falciparum importin beta, putative 0.0034 0.0049 0.188
Loa Loa (eye worm) hypothetical protein 0.0228 0.0783 0.1227
Brugia malayi nuclear hormone receptor 0.171 0.6375 1
Brugia malayi Importin beta-1 subunit 0.0034 0.0049 0.0029
Brugia malayi hypothetical protein 0.0228 0.0783 0.1185
Loa Loa (eye worm) hypothetical protein 0.0034 0.0049 0.0076
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0409 0.0682
Loa Loa (eye worm) hypothetical protein 0.005 0.0111 0.0173
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0021 0.0036
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0502 0.1818 0.1818
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0502 0.1818 0.2816
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.009 0.0262 0.3752
Loa Loa (eye worm) hypothetical protein 0.0502 0.1818 0.2851
Echinococcus granulosus Nuclear hormone receptor HR96 0.0228 0.0783 0.1306
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.1599 0.2472
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0085 0.0085
Brugia malayi nuclear receptor NHR-88 0.0228 0.0783 0.1185
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0073 0.0113
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0054 0.0776
Brugia malayi nuclear hormone receptor family member odr-7 0.0228 0.0783 0.1185
Echinococcus granulosus neuropeptide s receptor 0.0537 0.1948 0.3252
Echinococcus multilocularis GPCR, family 2 0.0033 0.0045 0.0045
Onchocerca volvulus Bile acid receptor homolog 0.0859 0.3164 0.4243
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0073 0.0121
Loa Loa (eye worm) hypothetical protein 0.0228 0.0783 0.1227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0502 0.1818 0.2851
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.019 0.0637 0.0955
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0829 0.3049 0.4783
Schistosoma mansoni thyroid hormone receptor 0.0502 0.1818 0.3034
Schistosoma mansoni thyroid hormone receptor 0.0502 0.1818 0.3034
Echinococcus granulosus microtubule associated protein 2 0.1608 0.5991 1
Loa Loa (eye worm) hypothetical protein 0.016 0.0524 0.0821
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0039 0.1475
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0502 0.1818 0.1818
Mycobacterium ulcerans hypothetical protein 0.0075 0.0204 0.2534
Schistosoma mansoni hypothetical protein 0.0042 0.0079 0.0132
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0037 0.0074
Schistosoma mansoni nuclear receptor nhr-48 0.0228 0.0783 0.1306
Loa Loa (eye worm) nuclear receptor NHR-67 0.0228 0.0783 0.1227
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0502 0.1818 0.3034
Mycobacterium tuberculosis Probable oxidoreductase 0.0138 0.0443 0.232
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0362 0.1287 0.2018
Loa Loa (eye worm) hypothetical protein 0.0243 0.0837 0.1312
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.0409 0.064
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0274 0.0956 0.1596
Onchocerca volvulus Protein ultraspiracle homolog 0.0502 0.1818 0.2418
Schistosoma mansoni survival motor neuron protein 0.0049 0.0108 0.018
Loa Loa (eye worm) hypothetical protein 0.0075 0.0204 0.0319
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.0098
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0152 0.0495 0.0731
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0204 0.3309
Loa Loa (eye worm) hypothetical protein 0.0043 0.0085 0.0132
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0204 0.2534
Loa Loa (eye worm) hypothetical protein 0.019 0.0637 0.0998
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0502 0.1818 0.3034
Leishmania major trypanothione reductase 0.0055 0.0127 0.0649
Schistosoma mansoni lamin 0.0055 0.0129 0.0215
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0111 0.1122
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0025 0.0406
Loa Loa (eye worm) hypothetical protein 0.0859 0.3164 0.4963
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0034 0.049
Echinococcus multilocularis neuropeptide s receptor 0.0537 0.1948 0.1948
Loa Loa (eye worm) hypothetical protein 0.0274 0.0956 0.1499
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0152 0.0495 0.0495
Echinococcus granulosus ecdysone induced protein 78C 0.0502 0.1818 0.3034
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0111 0.1122
Leishmania major hypothetical protein, conserved 0.0075 0.0204 0.1138
Entamoeba histolytica hypothetical protein 0.0027 0.0025 0.0827
Echinococcus granulosus lamin 0.0055 0.0129 0.0215
Echinococcus granulosus peregrin 0.003 0.0034 0.0057
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0131 0.0675
Plasmodium vivax hypothetical protein, conserved 0.003 0.0034 0.1306
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0111 0.0333
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0111 0.1122
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.0403 0.0631
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0204 0.0319
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0502 0.1818 0.3034
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0502 0.1818 0.2851
Brugia malayi intermediate filament protein 0.0055 0.0129 0.0154
Schistosoma mansoni retinoic acid receptor RXR 0.0732 0.2683 0.4479
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0127 0.0127
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0131 0.0205
Loa Loa (eye worm) hypothetical protein 0.0502 0.1818 0.2851
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0034 0.0057
Loa Loa (eye worm) hypothetical protein 0.0051 0.0115 0.0179
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.0098
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0127 0.0199
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0034 0.0034
Echinococcus multilocularis protein dispatched 1 0.0049 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.0049 0.0108 0.018
Loa Loa (eye worm) nuclear receptor nhr-7B 0.171 0.6375 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0152 0.0495 0.0495
Schistosoma mansoni hypothetical protein 0.0485 0.1753 0.2926
Loa Loa (eye worm) hepatopoietin HPO2 0.0035 0.0054 0.0084
Loa Loa (eye worm) hypothetical protein 0.0274 0.0956 0.1499
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0027
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0127 0.4858
Schistosoma mansoni cpg binding protein 0.0068 0.0177 0.0296
Mycobacterium tuberculosis Conserved protein 0.0075 0.0204 0.089
Brugia malayi nuclear receptor NHR-88 0.0502 0.1818 0.2816
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0131 0.0219
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0131 0.0131
Schistosoma mansoni hypothetical protein 0.0033 0.0045 0.0075
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0502 0.1818 0.2816
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0206 0.0698 0.384
Toxoplasma gondii histone lysine methyltransferase SET1 0.0129 0.0406 0.5824
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0204 0.089
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0045 0.0075
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0054 0.2067
Leishmania major cytochrome p450-like protein 0.0031 0.0037 0.0074
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0274 0.0956 0.1596
Loa Loa (eye worm) hypothetical protein 0.0228 0.0783 0.1227
Echinococcus multilocularis muscleblind protein 0.016 0.0524 0.0524
Entamoeba histolytica hypothetical protein 0.0037 0.0061 0.2003
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0129 0.0201
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0313 0.0444
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0031 0.0038
Loa Loa (eye worm) steroid hormone receptor 0.0502 0.1818 0.2851
Echinococcus multilocularis Niemann Pick C1 protein 0.0144 0.0466 0.0466
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0502 0.1818 0.3034
Toxoplasma gondii hypothetical protein 0.0031 0.0039 0.0553
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0502 0.1818 0.1818
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0059 0.0144 0.0534
Brugia malayi Cytochrome P450 family protein 0.0031 0.0037 0.0009
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0131 0.0131
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0061 0.0101
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0204 0.0341
Loa Loa (eye worm) hypothetical protein 0.0502 0.1818 0.2851
Brugia malayi AMP-binding enzyme family protein 0.005 0.0111 0.0126
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0732 0.2683 0.4479
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0228 0.0783 0.0783
Echinococcus multilocularis snurportin 1 0.0362 0.1287 0.1287
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0111 0.0545
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0045 0.0022
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0502 0.1818 0.3034
Brugia malayi nuclear hormone receptor family member nhr-6 0.0228 0.0783 0.1185
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0313 0.049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.0495 0.0826
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0032 0.005
Echinococcus multilocularis tumor protein p63 0.0716 0.2622 0.2622
Brugia malayi Nuclear hormone receptor-like 1 0.0829 0.3049 0.4758
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0085 0.0132
Brugia malayi MAP kinase sur-1 0.0056 0.0131 0.0158
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0228 0.0783 0.0783
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0073 0.0121
Brugia malayi RNA, U transporter 1 0.0096 0.0285 0.04
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.009 0.0262 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0027
Echinococcus multilocularis peregrin 0.003 0.0034 0.0034
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0131 0.0675
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0124 0.0391 0.2007
Schistosoma mansoni cpg binding protein 0.0072 0.0192 0.032
Loa Loa (eye worm) hypothetical protein 0.0075 0.0204 0.0319
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0131 0.0675
Echinococcus multilocularis FTZ F1 alpha 0.0502 0.1818 0.1818
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.005 0.0111 0.0173

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 6220 nM Binding affinity for sigma receptor in guinea pig brain membrane using radiolabeled ligand [3H]-(+)-SKF- 10,047 was determined ChEMBL. No reference
Ki (binding) = 10000 nM Binding affinity for dopamine receptor D2 in guinea pig striatal membrane using radiolabeled ligand [3H]-spiperone ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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