Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0038 | 0.1367 | 0.1367 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.004 | 0.152 | 0.152 |
Trypanosoma brucei | trypanothione reductase | 0.0049 | 0.2064 | 0.6226 |
Trichomonas vaginalis | ap endonuclease, putative | 0.004 | 0.1479 | 0.9733 |
Brugia malayi | glutathione reductase | 0.0049 | 0.2064 | 0.2064 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1226 | 0.1226 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1226 | 0.1366 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0111 | 0.6111 | 0.8837 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.004 | 0.152 | 0.4584 |
Leishmania major | trypanothione reductase | 0.0049 | 0.2064 | 0.6226 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.004 | 0.152 | 0.1692 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0068 | 0.3315 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0038 | 0.1367 | 0.4125 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0039 | 0.1458 | 0.1458 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.1367 | 0.4125 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0038 | 0.1367 | 0.8998 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.3219 | 0.2272 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.004 | 0.152 | 0.0782 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.3315 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0123 | 0.688 | 0.688 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0038 | 0.1367 | 0.1367 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0171 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.1367 | 0.8998 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0123 | 0.6915 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0068 | 0.3315 | 0.3315 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0038 | 0.1367 | 0.1367 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.3315 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.1367 | 0.8998 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.004 | 0.1479 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.004 | 0.1479 | 0.7166 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.004 | 0.152 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.004 | 0.1479 | 0.7166 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0068 | 0.3315 | 0.3692 |
Mycobacterium tuberculosis | Probable reductase | 0.0111 | 0.6111 | 0.8837 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0141 | 0.8072 | 0.8072 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.004 | 0.152 | 0.152 |
Trichomonas vaginalis | ap endonuclease, putative | 0.004 | 0.1479 | 0.9733 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0111 | 0.6111 | 0.8837 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0111 | 0.6111 | 0.8837 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3219 | 0.3585 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.23 | 0.1224 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.004 | 0.1479 | 0.2139 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.004 | 0.152 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0147 | 0.8455 | 0.9417 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0141 | 0.8072 | 0.899 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 0.688 | 0.6444 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3219 | 0.3585 |
Toxoplasma gondii | thioredoxin reductase | 0.0049 | 0.2064 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0171 | 1 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0038 | 0.1367 | 0.1523 |
Plasmodium vivax | glutathione reductase, putative | 0.0049 | 0.2064 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.004 | 0.1479 | 0.1479 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.004 | 0.152 | 0.152 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.23 | 0.23 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.004 | 0.152 | 0.4584 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.004 | 0.1479 | 0.0573 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0123 | 0.6915 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0147 | 0.8455 | 0.9417 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0068 | 0.3315 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.3315 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.3219 | 0.3219 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.1367 | 0.8998 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0141 | 0.8072 | 0.8072 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.1367 | 0.8998 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.1367 | 0.4125 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0038 | 0.1367 | 0.6624 |
Onchocerca volvulus | 0.0099 | 0.5322 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.152 | 0.0335 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0049 | 0.2064 | 0.2064 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.004 | 0.1479 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0049 | 0.2064 | 0.0955 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.1367 | 0.8998 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.3219 | 0.3219 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0038 | 0.1367 | 0.0161 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0068 | 0.3315 | 0.2381 |
Toxoplasma gondii | exonuclease III APE | 0.004 | 0.1479 | 0.7166 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0141 | 0.8072 | 0.8072 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3219 | 0.3585 |
Brugia malayi | Thioredoxin reductase | 0.0049 | 0.2064 | 0.2064 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.004 | 0.1479 | 0.4462 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.3219 | 0.2272 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0049 | 0.2064 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.004 | 0.1479 | 0.4462 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.004 | 0.152 | 0.152 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.004 | 0.152 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.004 | 0.152 | 0.1692 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0141 | 0.8072 | 0.8072 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0171 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.3219 | 0.3219 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 0.3315 | 0.3315 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.004 | 0.1479 | 1 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.004 | 0.152 | 0.152 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.1367 | 0.8998 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3219 | 0.3585 |
Plasmodium falciparum | glutathione reductase | 0.0049 | 0.2064 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.23 | 0.1224 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.004 | 0.1479 | 0.9733 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.004 | 0.152 | 0.4584 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.004 | 0.1479 | 0.1479 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.004 | 0.1479 | 0.4462 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.004 | 0.1479 | 0.1479 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0038 | 0.1367 | 0.8998 |
Schistosoma mansoni | ap endonuclease | 0.004 | 0.1479 | 0.1647 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0049 | 0.2064 | 0.2985 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0039 | 0.1458 | 0.1458 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0141 | 0.8072 | 0.899 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.004 | 0.152 | 0.4584 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3219 | 0.3585 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0049 | 0.2064 | 0.0955 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.004 | 0.152 | 0.152 |
Schistosoma mansoni | ap endonuclease | 0.004 | 0.1479 | 0.1647 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 0.688 | 0.6444 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0123 | 0.6915 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0141 | 0.8072 | 0.8072 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.23 | 0.23 |
Brugia malayi | RNA binding protein | 0.0066 | 0.3219 | 0.3219 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.004 | 0.152 | 0.152 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0171 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0049 | 0.2064 | 0.2064 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0141 | 0.8072 | 0.899 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0017 | 0 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.004 | 0.1479 | 0.4462 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0123 | 0.6915 | 1 |
Trypanosoma brucei | glucosidase, putative | 0.0038 | 0.1367 | 0.4125 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.004 | 0.1479 | 0.0288 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.152 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0141 | 0.8072 | 0.7803 |
Plasmodium falciparum | thioredoxin reductase | 0.0049 | 0.2064 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 0.3315 | 0.3315 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0049 | 0.2064 | 0.6226 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0111 | 0.6111 | 0.8837 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0111 | 0.6111 | 0.8837 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.1367 | 0.8998 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.3219 | 0.3219 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.3219 | 0.2272 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.