Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0317632 | 1 | 1 |
Brugia malayi | Kringle domain containing protein | 0.015706 | 0.249761 | 0.249761 |
Echinococcus granulosus | thymidylate synthase | 0.0217781 | 0.533463 | 0.378149 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0317632 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0317632 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0317632 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0317632 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0317632 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0317632 | 1 | 0.5 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0317632 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0217781 | 0.533463 | 0.533463 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0306584 | 0.948379 | 0.948379 |
Loa Loa (eye worm) | thymidylate synthase | 0.0217781 | 0.533463 | 0.378149 |
Onchocerca volvulus | 0.0217781 | 0.533463 | 1 | |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0317632 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0306584 | 0.948379 | 0.931194 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0317632 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0317632 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0317632 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0317632 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0306584 | 0.948379 | 0.931194 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0306584 | 0.948379 | 0.931194 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0317632 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0317632 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0217781 | 0.533463 | 0.533463 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.015706 | 0.249761 | 0.249761 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0317632 | 1 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0317632 | 1 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0317632 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.015706 | 0.249761 | 0.249761 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0217781 | 0.533463 | 0.378149 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0306584 | 0.948379 | 0.931194 |
Echinococcus multilocularis | thymidylate synthase | 0.0217781 | 0.533463 | 0.378149 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 9622557 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.