Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | NLI interacting factor-like phosphatase domain-containing protein | 0.0014 | 0.0039 | 0.0103 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.4501 | 0.4487 |
Brugia malayi | Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 | 0.0014 | 0.0039 | 0.0103 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0156 | 0.5059 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0119 | 0.3757 | 1 |
Echinococcus multilocularis | Small ubiquitin modifier 2 | 0.0033 | 0.0744 | 0.0748 |
Leishmania major | DNA polymerase eta, putative | 0.0069 | 0.2003 | 0.1983 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.1058 | 0.1036 |
Trypanosoma cruzi | DNA ligase I, putative | 0.0026 | 0.0482 | 0.0459 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0119 | 0.3757 | 0.3741 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0042 | 0.1058 | 0.2816 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0295 | 1 | 1 |
Echinococcus multilocularis | G protein coupled receptor kinase 1 | 0.0264 | 0.8878 | 0.8919 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0098 | 0.3032 | 0.3047 |
Echinococcus multilocularis | dna polymerase eta | 0.0098 | 0.3036 | 0.305 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0042 | 0.1058 | 0.1063 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0294 | 0.9953 | 1 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.0531 | 0.0508 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.014 | 0.4501 | 0.4487 |
Schistosoma mansoni | regulator of G protein signaling | 0.003 | 0.0635 | 0.0638 |
Schistosoma mansoni | axis inhibition protein axin | 0.003 | 0.0635 | 0.0638 |
Loa Loa (eye worm) | DNA ligase | 0.0026 | 0.0482 | 0.0485 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.0635 | 0.1691 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0031 | 0.0661 | 0.0664 |
Schistosoma mansoni | DNA polymerase eta | 0.0098 | 0.3036 | 0.305 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1068 | 0.1073 |
Trichomonas vaginalis | nuclear lim interactor-interacting factor, putative | 0.0014 | 0.0039 | 0.0103 |
Schistosoma mansoni | regulator of G protein signaling | 0.003 | 0.0635 | 0.0638 |
Plasmodium falciparum | DNA repair protein REV1, putative | 0.0013 | 0.0025 | 0.0332 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.1349 | 0.1327 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0042 | 0.1058 | 0.1063 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0098 | 0.3036 | 0.8081 |
Entamoeba histolytica | DNA ligase, putative | 0.0026 | 0.0482 | 0.1284 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0042 | 0.1058 | 0.2816 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0119 | 0.3757 | 0.3775 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.3036 | 0.305 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0027 | 0.0531 | 0.2652 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0013 | 0.0025 | 0.0124 |
Toxoplasma gondii | Dullard family phosphatase domain-containing protein | 0.0014 | 0.0039 | 0.0194 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0076 | 0.225 | 0.2261 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.0635 | 0.1691 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.1058 | 0.1036 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.1058 | 0.1036 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0261 | 0.1304 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0261 | 0.0695 |
Plasmodium vivax | DNA repair protein REV1, putative | 0.0013 | 0.0025 | 0.0332 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0032 | 0.0694 | 0.1237 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.003 | 0.0635 | 0.0638 |
Mycobacterium ulcerans | hypothetical protein | 0.0156 | 0.5059 | 1 |
Schistosoma mansoni | flap endonuclease-1 | 0.0025 | 0.0438 | 0.044 |
Brugia malayi | chromobox protein homolog 3 | 0.0043 | 0.1068 | 0.2842 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0042 | 0.1058 | 0.2816 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0119 | 0.3757 | 0.3741 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0635 | 0.0638 |
Leishmania major | small ubiquitin protein, putative | 0.0033 | 0.0744 | 0.0721 |
Trichomonas vaginalis | chromobox protein, putative | 0.0046 | 0.1182 | 0.3147 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0027 | 0.0531 | 0.49 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.1058 | 0.1036 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.003 | 0.0635 | 0.0638 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.003 | 0.0635 | 0.0638 |
Echinococcus granulosus | G protein coupled receptor kinase 1 | 0.0264 | 0.8878 | 0.8919 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0294 | 0.9953 | 1 |
Brugia malayi | DNA ligase | 0.0026 | 0.0482 | 0.1284 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0119 | 0.3757 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.0627 | 0.167 |
Plasmodium falciparum | small ubiquitin-related modifier | 0.0033 | 0.0744 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0119 | 0.3757 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0069 | 0.2003 | 0.1983 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.0593 | 0.057 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0032 | 0.0694 | 0.9319 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0261 | 0.0237 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0042 | 0.1058 | 0.1063 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.1058 | 0.1036 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.0635 | 0.1691 |
Plasmodium falciparum | flap endonuclease 1 | 0.0027 | 0.0531 | 0.7136 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0119 | 0.3757 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0119 | 0.3757 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0261 | 0.0237 |
Echinococcus multilocularis | DNA ligase 1 | 0.0026 | 0.0482 | 0.0485 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0043 | 0.1068 | 0.9031 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0033 | 0.0033 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.003 | 0.0635 | 0.1691 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.1068 | 0.2842 |
Echinococcus granulosus | dna polymerase eta | 0.0098 | 0.3036 | 0.305 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0261 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.1058 | 0.1036 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.1058 | 0.1036 |
Echinococcus granulosus | Carboxy terminal domain RNA polymerase II | 0.0014 | 0.0039 | 0.0039 |
Echinococcus multilocularis | chromobox protein 1 | 0.0076 | 0.225 | 0.2261 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.1058 | 0.1036 |
Giardia lamblia | Sentrin | 0.0033 | 0.0744 | 0.6963 |
Schistosoma mansoni | z-protein (S1r protein) | 0.003 | 0.0635 | 0.0638 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0098 | 0.3032 | 0.3047 |
Loa Loa (eye worm) | RGS-3 protein | 0.003 | 0.0635 | 0.0638 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0295 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0635 | 0.0638 |
Echinococcus multilocularis | regulator of G protein signaling | 0.003 | 0.0635 | 0.0638 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.003 | 0.0635 | 0.1691 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0032 | 0.0694 | 0.9319 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0119 | 0.3757 | 1 |
Trichomonas vaginalis | nuclear lim interactor-interacting factor, putative | 0.0014 | 0.0039 | 0.0103 |
Echinococcus granulosus | Small ubiquitin modifier 2 | 0.0033 | 0.0744 | 0.0748 |
Echinococcus multilocularis | expressed protein | 0.003 | 0.0635 | 0.0638 |
Loa Loa (eye worm) | SMO-1 protein | 0.0033 | 0.0744 | 0.0748 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0119 | 0.3757 | 0.3775 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0032 | 0.0694 | 0.1846 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0031 | 0.0661 | 0.176 |
Mycobacterium ulcerans | ATP-dependent DNA ligase | 0.0026 | 0.0482 | 0.0909 |
Plasmodium vivax | DNA ligase I, putative | 0.0026 | 0.0482 | 0.6482 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0032 | 0.0694 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.003 | 0.0635 | 0.0638 |
Trypanosoma brucei | unspecified product | 0.0042 | 0.1058 | 0.1036 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0032 | 0.0694 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0014 | 0.0039 | 0.0014 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0032 | 0.0694 | 0.1846 |
Toxoplasma gondii | DNA ligase 1, putative | 0.0026 | 0.0482 | 0.2409 |
Trypanosoma brucei | unspecified product | 0.0029 | 0.0593 | 0.057 |
Trypanosoma brucei | Mitochondrial import inner membrane translocase subunit TIM50 | 0.0014 | 0.0039 | 0.0014 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0098 | 0.3032 | 0.3047 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.1058 | 0.1036 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0032 | 0.0694 | 0.3464 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0013 | 0.0025 | 0.0124 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.003 | 0.0635 | 0.0638 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0119 | 0.3757 | 0.3775 |
Echinococcus multilocularis | 0.0014 | 0.0039 | 0.0039 | |
Schistosoma mansoni | regulator of G protein signaling | 0.003 | 0.0635 | 0.0638 |
Giardia lamblia | Nuclear LIM interactor-interacting factor 1 | 0.0014 | 0.0039 | 0.0136 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0098 | 0.3036 | 0.3019 |
Schistosoma mansoni | nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) | 0.0014 | 0.0039 | 0.0039 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.003 | 0.0635 | 0.0638 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0294 | 0.9953 | 1 |
Schistosoma mansoni | ubiquitin-like protein sumo/smt3-related | 0.0033 | 0.0744 | 0.0748 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0032 | 0.0694 | 0.9319 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.1058 | 0.1036 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0042 | 0.1058 | 0.2024 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0042 | 0.1058 | 0.1063 |
Plasmodium falciparum | NLI interacting factor-like phosphatase, putative | 0.0014 | 0.0039 | 0.0521 |
Trichomonas vaginalis | dullard protein, putative | 0.0014 | 0.0039 | 0.0103 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.1028 | 0.1005 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.1058 | 0.1036 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0119 | 0.3757 | 0.3775 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0261 | 0.0262 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.003 | 0.0635 | 0.0638 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0261 | 0.0262 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0119 | 0.3757 | 1 |
Trichomonas vaginalis | DNA ligase IV, putative | 0.0026 | 0.0482 | 0.1284 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0261 | 0.0262 |
Echinococcus multilocularis | dna polymerase kappa | 0.0042 | 0.1058 | 0.1063 |
Entamoeba histolytica | ubiquitin like protein | 0.0033 | 0.0744 | 0.1981 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.1058 | 0.1036 |
Schistosoma mansoni | DNA ligase I | 0.0026 | 0.0482 | 0.0485 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0032 | 0.0694 | 0.1846 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.0531 | 0.0508 |
Echinococcus granulosus | chromobox protein 1 | 0.0076 | 0.225 | 0.2261 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0119 | 0.3757 | 0.3775 |
Entamoeba histolytica | pyrophosphate-dependent phosphofructokinase | 0.0032 | 0.0694 | 0.1846 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0261 | 0.0695 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0098 | 0.3032 | 0.8071 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.0635 | 0.1691 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0261 | 0.2289 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0098 | 0.3036 | 0.3019 |
Echinococcus multilocularis | Carboxy terminal domain RNA polymerase II | 0.0014 | 0.0039 | 0.0039 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0119 | 0.3757 | 0.7405 |
Schistosoma mansoni | nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) | 0.0014 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0027 | 0.0531 | 0.0534 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0031 | 0.0661 | 0.0664 |
Echinococcus granulosus | dna polymerase kappa | 0.0042 | 0.1058 | 0.1063 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0032 | 0.0694 | 0.3464 |
Trypanosoma cruzi | small ubiquitin protein, putative | 0.0033 | 0.0744 | 0.0721 |
Leishmania major | DNA polymerase eta, putative | 0.0098 | 0.3036 | 0.3019 |
Echinococcus multilocularis | axis inhibition protein axin | 0.003 | 0.0635 | 0.0638 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.003 | 0.0635 | 0.0638 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0027 | 0.0531 | 0.7136 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0261 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0635 | 0.0638 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.1244 | 0.621 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0635 | 0.0638 |
Schistosoma mansoni | chromobox protein | 0.0076 | 0.225 | 0.2261 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0119 | 0.3757 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.1068 | 0.2842 |
Brugia malayi | phosphofructokinase | 0.0119 | 0.3757 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.0635 | 0.1691 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0032 | 0.0694 | 0.9319 |
Entamoeba histolytica | Flap nuclease, putative | 0.0027 | 0.0531 | 0.1414 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.003 | 0.0635 | 0.0638 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.003 | 0.0635 | 0.1691 |
Echinococcus granulosus | chromobox protein 1 | 0.0076 | 0.225 | 0.2261 |
Echinococcus granulosus | DNA ligase 1 | 0.0026 | 0.0482 | 0.0485 |
Schistosoma mansoni | regulator of G protein signaling | 0.003 | 0.0635 | 0.0638 |
Plasmodium falciparum | DNA ligase I | 0.0026 | 0.0482 | 0.6482 |
Trichomonas vaginalis | chromobox protein, putative | 0.0046 | 0.1182 | 0.3147 |
Echinococcus granulosus | CTD small phosphatase protein like | 0.0014 | 0.0039 | 0.0039 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0261 | 0.0262 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.003 | 0.0635 | 0.0638 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.1058 | 0.1036 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0744 | 0.1981 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0261 | 0.0695 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0261 | 0.0237 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0042 | 0.1028 | 0.1005 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.0531 | 0.0508 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0294 | 0.9953 | 1 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0294 | 0.9953 | 1 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.003 | 0.0635 | 0.0638 |
Brugia malayi | polk-prov protein | 0.0013 | 0.0025 | 0.0066 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.003 | 0.0635 | 0.0638 |
Echinococcus granulosus | expressed protein | 0.003 | 0.0635 | 0.0638 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.0635 | 0.1691 |
Schistosoma mansoni | regulator of G protein signaling | 0.003 | 0.0635 | 0.0638 |
Brugia malayi | PXA domain containing protein | 0.003 | 0.0635 | 0.1691 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0042 | 0.1058 | 0.2053 |
Trichomonas vaginalis | chromobox protein, putative | 0.0076 | 0.225 | 0.5989 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0032 | 0.0694 | 0.1846 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0261 | 0.351 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0032 | 0.0694 | 0.1846 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0261 | 0.351 |
Brugia malayi | 6-phosphofructokinase | 0.0119 | 0.3757 | 1 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.0635 | 0.1691 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0742 | 0.0745 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0261 | 0.0262 |
Onchocerca volvulus | 0.0033 | 0.0742 | 0.6276 | |
Schistosoma mansoni | DNA ligase I | 0.0026 | 0.0482 | 0.0485 |
Trypanosoma brucei | small ubiquitin-related modifier | 0.0033 | 0.0744 | 0.0721 |
Brugia malayi | 6-phosphofructokinase | 0.0119 | 0.3757 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0261 | 0.0237 |
Trichomonas vaginalis | dullard protein, putative | 0.0014 | 0.0039 | 0.0103 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.0593 | 0.057 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0098 | 0.3032 | 0.3047 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.1058 | 0.1036 |
Leishmania major | hypothetical protein, conserved | 0.0014 | 0.0039 | 0.0014 |
Echinococcus granulosus | axis inhibition protein axin | 0.003 | 0.0635 | 0.0638 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0261 | 0.0436 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.003 | 0.0635 | 0.1691 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0042 | 0.1028 | 0.1005 |
Brugia malayi | Heterochromatin protein 1 | 0.0076 | 0.225 | 0.5989 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.1058 | 0.1036 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0635 | 0.0638 |
Echinococcus granulosus | flap endonuclease 1 | 0.0027 | 0.0531 | 0.0534 |
Brugia malayi | Flap endonuclease-1 | 0.0027 | 0.0531 | 0.1414 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0032 | 0.0694 | 0.1846 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0119 | 0.3757 | 0.3741 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0027 | 0.0531 | 0.1414 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0261 | 0.0695 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0098 | 0.3032 | 0.3047 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.0627 | 0.167 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0119 | 0.3757 | 0.7414 |
Schistosoma mansoni | DNA polymerase IV / kappa | 0.0013 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0025 | 0.0025 |
Trichomonas vaginalis | 6-phosphofructokinase, putative | 0.0032 | 0.0694 | 0.1846 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.0593 | 0.057 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.1058 | 0.1036 |
Schistosoma mansoni | axis inhibition protein axin | 0.003 | 0.0635 | 0.0638 |
Loa Loa (eye worm) | phosphofructokinase | 0.0119 | 0.3757 | 0.3775 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0027 | 0.0531 | 0.0534 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0098 | 0.3032 | 0.3047 |
Schistosoma mansoni | chromobox protein | 0.0076 | 0.225 | 0.2261 |
Trichomonas vaginalis | chromobox protein, putative | 0.0076 | 0.225 | 0.5989 |
Plasmodium vivax | small ubiquitin-related modifier, putative | 0.0033 | 0.0744 | 1 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.003 | 0.0635 | 0.1691 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.1058 | 0.1036 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0042 | 0.1058 | 0.2816 |
Trypanosoma cruzi | small ubiquitin protein, putative | 0.0033 | 0.0744 | 0.0721 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.003 | 0.0635 | 0.0638 |
Trypanosoma cruzi | DNA ligase I, putative | 0.0026 | 0.0482 | 0.0459 |
Trichomonas vaginalis | nuclear lim interactor-interacting factor, putative | 0.0014 | 0.0039 | 0.0103 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.4501 | 0.4487 |
Brugia malayi | hypothetical protein | 0.003 | 0.0635 | 0.1691 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.003 | 0.0635 | 0.0638 |
Trichomonas vaginalis | nuclear lim interactor-interacting factor, putative | 0.0014 | 0.0039 | 0.0103 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0042 | 0.1058 | 0.2024 |
Leishmania major | DNA polymerase kappa, putative | 0.0042 | 0.1058 | 0.1036 |
Plasmodium vivax | NLI interacting factor-like phosphatase, putative | 0.0014 | 0.0039 | 0.0521 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0119 | 0.3757 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0098 | 0.3032 | 0.3047 |
Plasmodium vivax | NLI interacting factor-like phosphatase, putative | 0.0014 | 0.0039 | 0.0521 |
Giardia lamblia | DINP protein human, muc B family | 0.0042 | 0.1058 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0033 | 0.0033 |
Trypanosoma brucei | DNA ligase I, putative | 0.0026 | 0.0482 | 0.0459 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.003 | 0.0635 | 0.0638 |
Echinococcus multilocularis | axis inhibition protein axin | 0.003 | 0.0635 | 0.0638 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.0635 | 0.1691 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.003 | 0.0635 | 0.0638 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0635 | 0.0638 |
Trichomonas vaginalis | dullard protein, putative | 0.0014 | 0.0039 | 0.0103 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.003 | 0.0635 | 0.1691 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0042 | 0.1058 | 0.2053 |
Echinococcus granulosus | axis inhibition protein axin | 0.003 | 0.0635 | 0.0638 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0032 | 0.0694 | 0.3464 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.003 | 0.0635 | 0.0638 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.1028 | 0.1005 |
Trypanosoma brucei | unspecified product | 0.0029 | 0.0593 | 0.057 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0042 | 0.1058 | 0.1063 |
Giardia lamblia | DNA ligase | 0.0026 | 0.0482 | 0.4429 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0042 | 0.1058 | 0.1036 |
Brugia malayi | PXA domain containing protein | 0.003 | 0.0635 | 0.1691 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.0635 | 0.1691 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0069 | 0.2003 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0076 | 0.225 | 0.2261 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0032 | 0.0694 | 0.6473 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0119 | 0.3757 | 0.3775 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0098 | 0.3032 | 0.3047 |
Leishmania major | DNA ligase I, putative | 0.0026 | 0.0482 | 0.0459 |
Toxoplasma gondii | small ubiquitin family modifier, putative | 0.0033 | 0.0744 | 0.3717 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0295 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.0635 | 0.1691 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0046 | 0.1182 | 1 |
Brugia malayi | Ubiquitin-like protein SMT3 | 0.0033 | 0.0744 | 0.1981 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 51.4 % | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 assessed as inhibition of epimastigotes growth at 50 uM | ChEMBL. | 20116908 |
IC50 (functional) | = 35.6 uM | Antileishmanial activity against Leishmania (Viannia) braziliensis promastigotes | ChEMBL. | 20116908 |
IC50 (functional) | = 50 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 assessed as inhibition of epimastigotes growth | ChEMBL. | 20116908 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.