Detailed information for compound 112384

Basic information

Technical information
  • TDR Targets ID: 112384
  • Name: 4-(hexadecanoylamino)-5-hydroxynaphthalene-2, 7-disulfonic acid
  • MW: 557.72 | Formula: C26H39NO8S2
  • H donors: 4 H acceptors: 8 LogP: 7.37 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCCCCCCCCCC(=O)Nc1cc(cc2c1c(O)cc(c2)S(=O)(=O)O)S(=O)(=O)O
  • InChi: 1S/C26H39NO8S2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-25(29)27-23-18-21(36(30,31)32)16-20-17-22(37(33,34)35)19-24(28)26(20)23/h16-19,28H,2-15H2,1H3,(H,27,29)(H,30,31,32)(H,33,34,35)
  • InChiKey: MBSMDBVNMCKYRD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(hexadecanoylamino)-5-hydroxy-naphthalene-2,7-disulfonic acid
  • 4-hydroxy-5-(1-oxohexadecylamino)naphthalene-2,7-disulfonic acid
  • 4-hydroxy-5-palmitamido-naphthalene-2,7-disulfonic acid
  • 130798-62-8
  • 130798-63-9 (SODIUM SALT)
  • 2,7-Naphthalenedisulfonic acid, 4-hydroxy-5-[(1-oxohexadecyl)amino]-
  • 4-(Palmitoylamino)-5-hydroxy-2,7-naphthalenedisulfonic acid
  • AIDS-002506
  • AIDS002506
  • N-[(3,6-Disulfo-8-hydroxy)naphth-1-yl]hexadecanamide
  • PalNHNaph
  • 2,7-Naphthalenedisulfonic acid, 4-hydroxy-5-((1-oxohexadecyl)amino)-
  • N-((3,6-Disulfo-8-hydroxy)naphth-1-yl)hexadecanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Smad4 0.0016 0.0016 0.0016
Entamoeba histolytica hypothetical protein 0.002 0.0046 0.0337
Brugia malayi Cell death protein 3 precursor 0.0084 0.0572 0.0572
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0039 0.0039
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0479 0.8835
Schistosoma mansoni regulator of G protein signaling 0.002 0.0046 0.0046
Toxoplasma gondii aldehyde dehydrogenase 0.0038 0.0191 0.2718
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0046
Mycobacterium tuberculosis Conserved protein 0.0038 0.0193 0.0744
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.0694 0.1225
Brugia malayi Bromodomain containing protein 0.0035 0.0167 0.0167
Giardia lamblia PHD finger protein 15 0.003 0.0132 0.1439
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0039 0.0206 0.0354
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0239 0.0401
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0221 0.0309
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0239 0.0401
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0089 0.0611 0.0611
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0601 0.4836 0.8622
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0098 0.1222
Trichomonas vaginalis inositol monophosphatase, putative 0.0023 0.0069 0.0114
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0039 0.0039
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0033 0.0152 0.0152
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0536 0.5
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0239 0.3432
Brugia malayi PXA domain containing protein 0.002 0.0046 0.0046
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0601 0.4836 0.8622
Echinococcus granulosus expressed protein 0.0026 0.0097 0.0097
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0107 0.0764 0.0764
Onchocerca volvulus 0.004 0.0214 0.0298
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.0694 0.1225
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0019 0.0036 0.0036
Brugia malayi beta-lactamase 0.0038 0.0193 0.0193
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.021 0.021
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0039 0.0039
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0019 0.0036 0.0036
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0444 0.0444
Mycobacterium ulcerans aldehyde dehydrogenase 0.0038 0.0191 0.0343
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.0214 0.0214
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0089 0.0611 0.0611
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0074
Onchocerca volvulus 0.0038 0.0193 0.0261
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0193 0.0323
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0027 0.0042
Loa Loa (eye worm) hypothetical protein 0.0308 0.2418 0.2418
Mycobacterium tuberculosis Conserved hypothetical protein 0.0073 0.0479 0.1897
Schistosoma mansoni inositol monophosphatase 0.0023 0.0069 0.0069
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0046 0.0046
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.002 0.0049 0.0167
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0039 0.0039
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0534 0.0534
Schistosoma mansoni hypothetical protein 0.0041 0.022 0.022
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0037 0.006
Schistosoma mansoni hypothetical protein 0.0041 0.022 0.022
Schistosoma mansoni gynecophoral canal protein 0.0073 0.0479 0.0479
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0091 0.0633 0.0633
Brugia malayi chromobox protein homolog 3 0.0038 0.0197 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0479 0.0809
Mycobacterium tuberculosis Cadmium inducible protein CadI 0.0073 0.0479 0.1897
Brugia malayi 4-hydroxyphenylpyruvate dioxygenase family protein 0.0494 0.3957 0.3957
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0052 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.0099 0.07 0.07
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0031 0.0133 0.0133
Plasmodium falciparum histone acetyltransferase GCN5 0.0024 0.008 0.1368
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.0694 0.0694
Echinococcus multilocularis neuropeptide receptor A26 0.0454 0.3621 0.3621
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.0694 0.1117
Echinococcus multilocularis geminin 0.0421 0.3349 0.3349
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.008 0.054 0.0951
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0107 0.0764 0.0764
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.1051 0.1051
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0055 0.0335 0.0335
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.031 0.031
Mycobacterium ulcerans hypothetical protein 0.0073 0.0479 0.0987
Loa Loa (eye worm) hypothetical protein 0.004 0.021 0.021
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0046 0.0046
Plasmodium falciparum ataxin-2 like protein, putative 0.0042 0.0228 0.4164
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0239 0.0401
Schistosoma mansoni regulator of G protein signaling 0.002 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0089 0.0611 0.0611
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0284 0.2226 0.3961
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0694 0.1174
Schistosoma mansoni hypothetical protein 0.0089 0.0611 0.0611
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0008 0.0008
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0091 0.0633 0.1116
Schistosoma mansoni hypothetical protein 0.0089 0.0611 0.0611
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0132 0.1842
Echinococcus multilocularis chromobox protein 1 0.0068 0.0444 0.0444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.044 0.0743
Trypanosoma cruzi metacaspase 5, putative 0.0043 0.0239 0.0412
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0017 0.0023 0.0023
Trypanosoma brucei polo-like protein kinase 0.0099 0.0694 0.1225
Brugia malayi Intermediate filament tail domain containing protein 0.0083 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0039
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0085 0.0578 0.1017
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0046 0.0046
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0039 0.0039
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0228 0.0392
Loa Loa (eye worm) hypothetical protein 0.0083 0.0563 0.0563
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0015 0.0001 0.0001
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0046 0.0046
Trypanosoma brucei metacaspase MCA2 0.0043 0.0239 0.0412
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0089 0.0611 0.0611
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0132 0.0132
Toxoplasma gondii hypothetical protein 0.0027 0.0106 0.1465
Loa Loa (eye worm) glutaminase 0.0562 0.4513 0.4513
Brugia malayi Probable ClpP-like protease 0.0079 0.0536 0.0536
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0644 0.0644
Loa Loa (eye worm) RGS-3 protein 0.002 0.0046 0.0046
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0039 0.0039
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0016 0.0016
Brugia malayi SET domain containing protein 0.0015 0.0006 0.0006
Schistosoma mansoni caspase-7 (C14 family) 0.0115 0.0827 0.0827
Onchocerca volvulus 0.0104 0.0736 0.1189
Schistosoma mansoni chromobox protein 0.0068 0.0444 0.0444
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0039 0.0039
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0212 0.0212
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0028 0.0115 0.1593
Mycobacterium tuberculosis Conserved protein 0.0073 0.0479 0.1897
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0228 0.0383
Trypanosoma cruzi metacaspase, putative 0.0043 0.0239 0.0412
Brugia malayi Inositol-1 0.0023 0.0069 0.0069
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0091 0.0633 0.9007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0039 0.0206 0.0354
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0023 0.0069 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0039
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0536 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0091 0.0633 0.1116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0039 0.0206 0.0354
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.004 0.0214 0.0214
Schistosoma mansoni transcription factor LCR-F1 0.0089 0.0613 0.0613
Toxoplasma gondii hypothetical protein 0.0097 0.068 1
Echinococcus multilocularis ferritin 0.0026 0.0098 0.0098
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0074
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0038 0.0193 0.0331
Trypanosoma brucei PAB1-binding protein , putative 0.0042 0.0228 0.0392
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0114 0.0823 0.0823
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0023 0.0069 0.0109
Loa Loa (eye worm) hypothetical protein 0.0038 0.0193 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0385 0.065
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0037 0.0037
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.0536 0.0536
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0037 0.006
Plasmodium falciparum ataxin-2 like protein, putative 0.0042 0.0228 0.4164
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0038 0.0191 0.0191
Echinococcus multilocularis dnaJ subfamily B 0.041 0.3264 0.3264
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.0536 0.0536
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.0694 0.0694
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0239 0.3628
Echinococcus granulosus neuropeptide receptor A26 0.0454 0.3621 0.3621
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0046 0.0046
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0106 0.1549
Schistosoma mansoni hypothetical protein 0.1227 1 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0232
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0193 0.0744
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0193 0.0323
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0132 0.0132
Loa Loa (eye worm) inositol-1 0.0023 0.0069 0.0069
Toxoplasma gondii peptidylprolyl isomerase 0.0026 0.0092 0.1248
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0193 0.0323
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0016 0.0016
Onchocerca volvulus Putative protein 0.0494 0.3957 0.6686
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0232 0.0391
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0046 0.0046
Brugia malayi hypothetical protein 0.002 0.0046 0.0046
Leishmania major glyoxalase I,trypanothione-dependent glyoxalase I 0.0073 0.0479 0.0841
Schistosoma mansoni tar DNA-binding protein 0.0325 0.2559 0.2559
Schistosoma mansoni hypothetical protein 0.004 0.0214 0.0214
Schistosoma mansoni regulator of G protein signaling 0.002 0.0046 0.0046
Brugia malayi RNA binding protein 0.0325 0.2559 0.2559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0287 0.0483
Onchocerca volvulus Alhambra homolog 0.003 0.0132 0.0158
Schistosoma mansoni axis inhibition protein axin 0.002 0.0046 0.0046
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0017 0.0023 0.0027
Schistosoma mansoni smad1 5 8 and 0.0016 0.0016 0.0016
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.031 0.1217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0133 0.0222
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0046 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.0633 0.107
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0193 0.0347
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0193 0.2943
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0286 0.0482
Toxoplasma gondii glyoxalase I, putative 0.0073 0.0479 0.701
Schistosoma mansoni inositol monophosphatase 0.0023 0.0069 0.0069
Brugia malayi Muscleblind-like protein 0.0308 0.2418 0.2418
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0228 0.0228
Brugia malayi MH2 domain containing protein 0.0016 0.0016 0.0016
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0046 0.0046
Echinococcus multilocularis tumor protein p63 0.0704 0.5681 0.5681
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0046 0.0046
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.008 0.054 0.0951
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0239 0.0401
Loa Loa (eye worm) beta-lactamase 0.0038 0.0193 0.0193
Schistosoma mansoni bromodomain containing protein 0.0058 0.0361 0.0361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0039 0.0206 0.0354
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0193 0.0193
Echinococcus multilocularis peregrin 0.0035 0.0167 0.0167
Mycobacterium ulcerans aldehyde dehydrogenase 0.0038 0.0191 0.0343
Schistosoma mansoni tar DNA-binding protein 0.0325 0.2559 0.2559
Trypanosoma cruzi cruzipain precursor, putative 0.0039 0.0206 0.0354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0023 0.0036
Leishmania major mitochondrial DNA polymerase beta 0.0601 0.4836 0.8622
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0193 0.0744
Schistosoma mansoni patched 1 0.0043 0.0232 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0133 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.0633 0.107
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0008 0.0008
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0043 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0038 0.0198 0.0198
Mycobacterium tuberculosis Conserved protein 0.0038 0.0193 0.0744
Echinococcus granulosus expressed conserved protein 0.0093 0.065 0.065
Echinococcus multilocularis Smad4 0.0016 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0023 0.0036
Trypanosoma cruzi metacaspase, putative 0.0043 0.0239 0.0412
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.008 0.054 0.1124
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0037 0.046
Onchocerca volvulus 0.0029 0.0118 0.0135
Entamoeba histolytica hypothetical protein 0.002 0.0046 0.0337
Schistosoma mansoni hypothetical protein 0.0089 0.0611 0.0611
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0106 0.1866
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0098 0.0363
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0023 0.0069 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0039 0.0039
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0039 0.0039
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0193 0.0744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0479 0.0809
Echinococcus granulosus chromobox protein 1 0.0068 0.0444 0.0444
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0046 0.0046
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0048 0.0048
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0118 0.0118
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0091 0.0633 0.1116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0133 0.0222
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0046 0.0074
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0133 0.0133
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.0694 0.9914
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0039 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0039 0.0039
Echinococcus granulosus lamin 0.0083 0.0563 0.0563
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0037 0.0037
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0039 0.0039
Echinococcus granulosus intermediate filament protein 0.0083 0.0563 0.0563
Schistosoma mansoni tar DNA-binding protein 0.0325 0.2559 0.2559
Schistosoma mansoni cpg binding protein 0.0029 0.0118 0.0118
Leishmania major hypothetical protein, conserved 0.0042 0.0228 0.0392
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0008 0.0008
Onchocerca volvulus 0.0103 0.073 0.1178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0326 0.0549
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0023 0.0036
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0027 0.0042
Schistosoma mansoni chromobox protein 0.0068 0.0444 0.0444
Loa Loa (eye worm) hypothetical protein 0.0081 0.0551 0.0551
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0027 0.0042
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0114 0.0823 0.3282
Schistosoma mansoni apoferritin-2 0.0026 0.0098 0.0098
Mycobacterium ulcerans hypothetical protein 0.0073 0.0479 0.0987
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0074
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0228 0.0228
Giardia lamblia Kinase, PLK 0.0099 0.0694 1
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0694 0.1174
Brugia malayi hypothetical protein 0.0027 0.0105 0.0105
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0031 0.0135 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.044 0.0743
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0039 0.0039
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0039 0.0039
Plasmodium falciparum metacaspase 1 0.0043 0.0239 0.437
Echinococcus granulosus lamin dm0 0.0083 0.0563 0.0563
Echinococcus multilocularis protein dispatched 1 0.0049 0.0282 0.0282
Echinococcus granulosus serine protein kinase ATM 0.0017 0.0023 0.0023
Echinococcus granulosus expressed protein 0.0026 0.0098 0.0098
Mycobacterium tuberculosis Conserved hypothetical protein 0.0317 0.2491 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0536 0.7853
Brugia malayi Smad1 0.0016 0.0016 0.0016
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0048 0.0048
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0132 0.0132
Brugia malayi beta-lactamase family protein 0.0038 0.0193 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0039 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0694 0.1174
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0016 0.0016
Giardia lamblia GTOR 0.0091 0.0633 0.9066
Echinococcus granulosus dnaJ subfamily B 0.041 0.3264 0.3264
Echinococcus granulosus histone acetyltransferase KAT2B 0.0087 0.06 0.06
Echinococcus multilocularis expressed protein 0.0026 0.0097 0.0097
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.1227 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0037 0.0187 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0479 0.0809
Echinococcus multilocularis caspase 2 0.0084 0.0572 0.0572
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0039 0.0039
Echinococcus multilocularis caspase 8 0.0043 0.0239 0.0239
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0046 0.0046
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0046 0.0046
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0246 0.0246
Brugia malayi TAR-binding protein 0.0325 0.2559 0.2559
Plasmodium vivax glyoxalase I, putative 0.0073 0.0479 0.7411
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0046 0.0046
Schistosoma mansoni rotamase 0.0026 0.0097 0.0097
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0133 0.0223
Echinococcus granulosus zinc finger protein 0.0021 0.0051 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0479 0.0809
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0193 0.0744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0133 0.0222
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0028 0.0115 0.1685
Trypanosoma cruzi target of rapamycin kinase 3 0.0073 0.0479 0.0842
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0038 0.0191 0.0326
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0093 0.0644 0.0644
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0098 0.0363
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0283 0.0477
Loa Loa (eye worm) TAR-binding protein 0.0325 0.2559 0.2559
Schistosoma mansoni zinc finger protein 0.0021 0.0051 0.0051
Onchocerca volvulus Cell death protein 3 homolog 0.0084 0.0572 0.0909
Echinococcus granulosus peregrin 0.0035 0.0167 0.0167
Schistosoma mansoni methyl-cpg binding protein mbd 0.0015 0.0001 0.0001
Onchocerca volvulus 0.0038 0.0193 0.0261
Toxoplasma gondii FATC domain-containing protein 0.0017 0.0023 0.0223
Plasmodium vivax ataxin-2 like protein, putative 0.0042 0.0228 0.3457
Schistosoma mansoni glutaminase 0.0562 0.4513 0.4513
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0089 0.0611 0.0611
Echinococcus granulosus histone lysine methyltransferase setb 0.0107 0.0764 0.0764
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0193 0.0744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0287 0.0483
Schistosoma mansoni ferritin 0.0026 0.0098 0.0098
Echinococcus granulosus GPCR family 2 0.0089 0.0611 0.0611
Brugia malayi Latrophilin receptor protein 2 0.0089 0.0611 0.0611
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0039
Brugia malayi CXXC zinc finger family protein 0.0029 0.0118 0.0118
Echinococcus multilocularis neuropeptide s receptor 0.0454 0.3621 0.3621
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0039 0.0039
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.031 0.031
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0212 0.0212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0091 0.0633 0.0633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0479 0.0809
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0228 0.0383
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.0536 1
Echinococcus granulosus smad 0.0016 0.0016 0.0016
Schistosoma mansoni fkbp-rapamycin associated protein 0.0017 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.003 0.0128 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0286 0.0482
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0232 0.0232
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0037 0.0554
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0133 0.0222
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0039
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0026 0.0092 0.015
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0694 0.1174
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0114 0.0823 0.1756
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0444 0.075
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0193 0.0744
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0039 0.0206 0.0354
Loa Loa (eye worm) hypothetical protein 0.0038 0.0193 0.0193
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0039 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0228 0.0383
Loa Loa (eye worm) RNA binding protein 0.0325 0.2559 0.2559
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0228 0.0392
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0008 0.0008
Echinococcus granulosus fetal alzheimer antigen falz 0.0021 0.0054 0.0054
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0017 0.0023 0.0023
Mycobacterium tuberculosis Conserved protein TB27.3 0.0073 0.0479 0.1897
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0479 0.0809
Loa Loa (eye worm) PHD-finger family protein 0.0018 0.0027 0.0027
Schistosoma mansoni tar DNA-binding protein 0.0325 0.2559 0.2559
Brugia malayi PHD-finger family protein 0.0025 0.0089 0.0089
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0039 0.0039
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.1872 0.1872
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0114 0.0823 0.0823
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0232 0.0232
Onchocerca volvulus 0.0083 0.0563 0.0894
Echinococcus granulosus expressed protein 0.039 0.3094 0.3094
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0039
Brugia malayi MH1 domain containing protein 0.0016 0.0016 0.0016
Echinococcus granulosus citrate lyase subunit beta protein 0.008 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Echinococcus multilocularis musashi 0.0083 0.0563 0.0563
Trypanosoma cruzi PAB1-binding protein , putative 0.0042 0.0228 0.0392
Entamoeba histolytica hypothetical protein 0.0089 0.0613 0.8725
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.044 0.0743
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0037 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0039 0.0039
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.0694 0.1225
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0038 0.0191 0.0191
Echinococcus granulosus tumor protein p63 0.0704 0.5681 0.5681
Loa Loa (eye worm) hypothetical protein 0.0052 0.0311 0.0311
Schistosoma mansoni ferritin 0.0026 0.0098 0.0098
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0115 0.0827 0.0827
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0393 0.5737
Brugia malayi acetyltransferase, GNAT family protein 0.0092 0.0637 0.0637
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0092 0.0637 0.0637
Loa Loa (eye worm) hypothetical protein 0.0038 0.0193 0.0193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0039 0.0206 0.0354
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0039 0.0039
Echinococcus granulosus chromobox protein 1 0.0068 0.0444 0.0444
Loa Loa (eye worm) hypothetical protein 0.0061 0.0382 0.0382
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.0536 1
Mycobacterium ulcerans hypothetical protein 0.0073 0.0479 0.0987
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0092 0.0637 0.0637
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0039 0.0039
Schistosoma mansoni caspase-7 (C14 family) 0.0084 0.0572 0.0572
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0039 0.0039
Brugia malayi CHE-14 protein 0.0043 0.0232 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.033 0.0557
Brugia malayi intermediate filament protein 0.0083 0.0563 0.0563
Schistosoma mansoni aldehyde dehydrogenase 0.0038 0.0191 0.0191
Trichomonas vaginalis glutaminase, putative 0.0562 0.4513 0.7651
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0023 0.0069 0.0912
Schistosoma mansoni hypothetical protein 0.0421 0.3349 0.3349
Brugia malayi hypothetical protein 0.004 0.0214 0.0214
Toxoplasma gondii target of rapamycin (TOR), putative 0.0068 0.044 0.6428
Echinococcus granulosus inositol monophosphatase 1 0.0023 0.0069 0.0069
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0017 0.0023 0.0027
Onchocerca volvulus Lactoylglutathione lyase homolog 0.0073 0.0479 0.075
Echinococcus granulosus axis inhibition protein axin 0.002 0.0046 0.0046
Plasmodium vivax hypothetical protein, conserved 0.003 0.0132 0.1948
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0133 0.0223
Loa Loa (eye worm) hypothetical protein 0.0073 0.0479 0.0479
Trichomonas vaginalis bromodomain-containing protein, putative 0.0028 0.0115 0.0192
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0221 0.0371
Leishmania major cathepsin L-like protease 0.0039 0.0206 0.0354
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0107 0.076 0.076
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0228 0.0228
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0694 0.0694
Trypanosoma brucei hypothetical protein, conserved 0.0695 0.5608 1
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0077 0.0077
Mycobacterium ulcerans hypothetical protein 0.0317 0.2491 0.5482
Schistosoma mansoni lamin 0.0083 0.0563 0.0563
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0039 0.0039
Schistosoma mansoni smad 0.0016 0.0016 0.0016
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0031 0.0133 0.0223
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0039 0.0206 0.0354
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0239 0.3432
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.008 0.054 0.1124
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0037 0.0118
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0046
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0027 0.0042
Mycobacterium ulcerans biphenyl-2,3-diol 1,2-dioxygenase 0.0073 0.0479 0.0987
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0239 0.0401
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.07 0.07
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0085 0.0578 0.1017
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0197 0.033
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0021 0.0054 0.0054
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0185 0.0185
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0089 0.0611 0.0611
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0037 0.0037
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0017 0.0023 0.0023
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0026 0.0092 0.1017
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0039 0.0039
Schistosoma mansoni smad1 5 8 and 0.0016 0.0016 0.0016
Mycobacterium ulcerans hypothetical protein 0.008 0.054 0.1124
Brugia malayi nuclear hormone receptor 0.0019 0.0039 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.033 0.0557
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0039 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0097 0.0161
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0107 0.0764 0.0764
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.0703 0.0703
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0228 0.0228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0039 0.0206 0.0354
Brugia malayi steroid hormone receptor 0.0019 0.0039 0.0039
Loa Loa (eye worm) 4-hydroxyphenylpyruvate dioxygenase 0.0494 0.3957 0.3957
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0073 0.0479 0.0842
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0026 0.0092 0.015
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0712 0.0712
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.1227 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0085 0.0584 0.0584
Trichomonas vaginalis Citrate lyase beta chain, putative 0.008 0.054 0.0913
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0197 0.033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0412 0.0412
Echinococcus multilocularis protein patched 0.0043 0.0232 0.0232
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0031 0.0133 0.0223
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0039 0.0039
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.008 0.054 0.0951
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.044 0.0743
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0089 0.0611 0.0611
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0444 0.075
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0074
Plasmodium falciparum glyoxalase I 0.0073 0.0479 0.8927
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.0694 0.0694
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.008 0.054 0.2144
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0046 0.0046
Plasmodium falciparum glyoxalase I 0.0073 0.0479 0.8927
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0082 0.0137
Loa Loa (eye worm) hypothetical protein 0.0103 0.073 0.073
Mycobacterium tuberculosis Conserved protein 0.0038 0.0193 0.0744
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0048 0.0048
Entamoeba histolytica hypothetical protein 0.0089 0.0613 0.8725
Echinococcus granulosus neuropeptide s receptor 0.0454 0.3621 0.3621
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0039 0.0206 0.0354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.0523 0.0883
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0008 0.0008
Loa Loa (eye worm) intermediate filament protein 0.0083 0.0563 0.0563
Loa Loa (eye worm) latrophilin receptor protein 2 0.0089 0.0611 0.0611
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0043 0.0236 0.0408
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0536 0.5
Brugia malayi glutaminase DH11.1 0.0562 0.4513 0.4513
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0039 0.0206 0.0354
Trypanosoma cruzi cysteine peptidase, putative 0.0039 0.0206 0.0354
Echinococcus granulosus ferritin 0.0026 0.0098 0.0098
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0694 0.1174
Plasmodium vivax metacaspase 1, putative 0.0043 0.0239 0.3628
Brugia malayi Calcitonin receptor-like protein seb-1 0.028 0.219 0.219
Trypanosoma cruzi metacaspase, putative 0.0043 0.0239 0.0412
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0104 0.0736 0.0736
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0132 0.1842
Brugia malayi hypothetical protein 0.0042 0.0228 0.0228
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0048 0.0048
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0694 0.1174
Schistosoma mansoni hypothetical protein 0.0018 0.0027 0.0027
Onchocerca volvulus Huntingtin homolog 0.0134 0.0983 0.1611
Echinococcus multilocularis muscleblind protein 0.0308 0.2418 0.2418
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.1051 0.1051
Trypanosoma cruzi lactoylglutathione lyase-like protein, putative 0.0073 0.0479 0.0841
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0027 0.0042
Loa Loa (eye worm) hypothetical protein 0.0038 0.0198 0.0198
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0228 0.0392
Schistosoma mansoni lamin 0.0083 0.0563 0.0563
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.003 0.0132 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0239 0.0401
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0028 0.0115 0.0192
Echinococcus multilocularis caspase 0.0115 0.0827 0.0827
Mycobacterium ulcerans beta-lactamase 0.0038 0.0193 0.0347
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0091 0.0633 0.9007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0039 0.0039
Trypanosoma cruzi cysteine peptidase, putative 0.0039 0.0206 0.0354
Schistosoma mansoni hypothetical protein 0.1227 1 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0091 0.0633 0.1116
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0193 0.0347
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0399 0.0399
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0193 0.0193
Mycobacterium ulcerans hypothetical protein 0.0073 0.0479 0.0987
Entamoeba histolytica hypothetical protein 0.0089 0.0613 0.8725
Trypanosoma brucei metacaspase MCA3 0.0043 0.0239 0.0412
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0048 0.0048
Echinococcus granulosus microtubule associated protein 2 0.0682 0.5506 0.5506
Brugia malayi hypothetical protein 0.0089 0.0613 0.0613
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0089 0.0611 0.0611
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0037 0.0211
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0039
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.1872 0.1872
Onchocerca volvulus 0.073 0.5898 1
Echinococcus granulosus tar DNA binding protein 0.0325 0.2559 0.2559
Toxoplasma gondii ABC1 family protein 0.0038 0.0193 0.2748
Loa Loa (eye worm) glutaminase 2 0.0562 0.4513 0.4513
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0091 0.0633 0.1116
Leishmania major cathepsin L-like protease 0.0039 0.0206 0.0354
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0242 0.1873 0.7512
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0048 0.0048
Loa Loa (eye worm) phosphatidylinositol 3 0.0091 0.0633 0.0633
Trypanosoma cruzi hypothetical protein, conserved 0.0695 0.5608 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0041 0.022 0.022
Echinococcus multilocularis zinc finger protein 0.0021 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0019 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0041 0.022 0.022
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0091 0.0633 0.0633
Echinococcus multilocularis expressed protein 0.0026 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0046
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0039 0.0039
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0114 0.0823 0.1756
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0098 0.0136
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0042 0.0228 0.0228
Schistosoma mansoni regulator of G protein signaling 0.002 0.0046 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0479 0.0809
Echinococcus multilocularis muscleblind protein 1 0.0308 0.2418 0.2418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.044 0.0743
Mycobacterium ulcerans aldehyde dehydrogenase 0.0038 0.0191 0.0343
Echinococcus granulosus Smad4 0.0016 0.0016 0.0016
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0023 0.0069 0.0109
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0043 0.0239 0.0239
Onchocerca volvulus 0.0038 0.0193 0.0261
Brugia malayi MH1 domain containing protein 0.0016 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0191 0.1459 0.1459
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0093 0.0644 0.9459
Loa Loa (eye worm) hypothetical protein 0.0134 0.0983 0.0983
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0085 0.0584 0.0584
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0104 0.0174
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0016 0.0016
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0193 0.2905
Schistosoma mansoni caspase-3 (C14 family) 0.0115 0.0827 0.0827
Mycobacterium ulcerans glyoxalase GloA 0.0073 0.0479 0.0987
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0083 0.0563 0.0563
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0239 0.0401
Echinococcus granulosus axis inhibition protein axin 0.002 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0038 0.0193 0.0193
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0228 0.0228
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.023 0.023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0037 0.0052
Echinococcus granulosus caspase 2 0.0084 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0131 0.0961 0.0961
Brugia malayi Heterochromatin protein 1 0.0068 0.0444 0.0444
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0104 0.0174
Mycobacterium tuberculosis Conserved protein 0.008 0.054 0.2144
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0134 0.0983 0.0983
Brugia malayi nuclear receptor NHR-88 0.0019 0.0039 0.0039
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.0536 0.8303
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0008 0.0008
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0021 0.0054 0.0054
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0536 0.1114
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0114 0.0823 0.0823
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0017 0.0023 0.0027
Loa Loa (eye worm) hypothetical protein 0.0308 0.2418 0.2418
Echinococcus multilocularis expressed protein 0.039 0.3094 0.3094
Trypanosoma brucei metacaspase 0.0043 0.0239 0.0412
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0039 0.0039
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0193 0.0323
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0031 0.0133 0.0223
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0536 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0228 0.0228
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0039 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.044 0.0743
Trypanosoma cruzi metacaspase, putative 0.0043 0.0239 0.0412
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.07 0.07
Echinococcus granulosus histone acetyltransferase KAT2B 0.0028 0.0115 0.0115
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0098 0.1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0239 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.044 0.0743
Trypanosoma cruzi major cysteine proteinase, putative 0.0031 0.0137 0.023
Schistosoma mansoni intermediate filament proteins 0.0083 0.0563 0.0563
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.0703 0.0703
Echinococcus multilocularis tar DNA binding protein 0.0325 0.2559 0.2559
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0079 0.0536 0.0536
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0212 0.0212
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0085 0.0584 0.0584
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0326 0.0549
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0048 0.0048
Mycobacterium ulcerans glutaminase 0.0562 0.4513 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0024 0.008 0.0845
Brugia malayi isocitrate dehydrogenase 0.0015 0.0008 0.0008
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0046 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0039 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.003 0.0132 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0239 0.0401
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0085 0.0584 0.0584
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0038 0.0191 0.0736
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0089 0.0613 0.0613
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0193 0.033
Brugia malayi MH2 domain containing protein 0.0242 0.1872 0.1872
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0026 0.0092 0.015
Brugia malayi hypothetical protein 0.0134 0.0983 0.0983
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0027 0.0042
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0055 0.0335 0.0335
Loa Loa (eye worm) acetyltransferase 0.0092 0.0637 0.0637
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0016 0.0016
Echinococcus multilocularis cpg binding protein 0.0032 0.0145 0.0145
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0026 0.0097 0.0097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0085 0.0584 0.0584
Echinococcus multilocularis expressed conserved protein 0.0093 0.065 0.065
Schistosoma mansoni tar DNA-binding protein 0.0325 0.2559 0.2559
Schistosoma mansoni 4-hydroxyphenylpyruvate dioxygenase 0.0073 0.0479 0.0479
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0091 0.0633 0.0633
Mycobacterium tuberculosis Conserved protein 0.0073 0.0479 0.1897
Schistosoma mansoni ferritin light chain 0.0026 0.0098 0.0098
Trichomonas vaginalis rotamase, putative 0.0026 0.0092 0.0153
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0039 0.0039
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0228 0.0228
Trichomonas vaginalis set domain proteins, putative 0.073 0.5898 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0039 0.0039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0085 0.0584 0.0584
Brugia malayi lactoylglutathione lyase 0.0073 0.0479 0.0479
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0228 0.0228
Leishmania major metacaspase, putative 0.0043 0.0239 0.0412
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0115 0.0827 0.0827
Leishmania major cathepsin L-like protease 0.0039 0.0206 0.0354
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0239 0.3432
Schistosoma mansoni microtubule-associated protein tau 0.0682 0.5506 0.5506
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0114 0.0823 0.0823
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0212 0.0212
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.07 0.07
Trichomonas vaginalis rotamase, putative 0.0026 0.0097 0.0161
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0026 0.0092 0.015
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0039 0.0039
Echinococcus multilocularis chromobox protein 1 0.0068 0.0444 0.0444
Schistosoma mansoni coup transcription factor 0.0019 0.0039 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0039 0.0206 0.0354
Schistosoma mansoni aldehyde dehydrogenase 0.0038 0.0191 0.0191
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0028 0.0115 0.1593
Plasmodium falciparum phd finger protein, putative 0.003 0.0132 0.2346
Loa Loa (eye worm) Smad1 0.0016 0.0016 0.0016
Echinococcus multilocularis lamin dm0 0.0083 0.0563 0.0563
Echinococcus granulosus geminin 0.0421 0.3349 0.3349
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0089 0.0613 0.0613
Echinococcus multilocularis smad 0.0016 0.0016 0.0016
Echinococcus granulosus caspase 3 0.0071 0.0469 0.0469
Trichomonas vaginalis esterase, putative 0.0038 0.0193 0.0323
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0246 0.0246
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.031 0.1217
Schistosoma mansoni hypothetical protein 0.0421 0.3349 0.3349
Brugia malayi Bromodomain containing protein 0.0035 0.017 0.017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.005 0.005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0023 0.0023
Brugia malayi jmjC domain containing protein 0.01 0.0703 0.0703
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0369 0.0622
Loa Loa (eye worm) hypothetical protein 0.0043 0.0239 0.0239
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0039 0.0039
Plasmodium vivax glyoxalase I, putative 0.0073 0.0479 0.7411
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0046 0.0046
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0283 0.0477
Brugia malayi jmjC domain containing protein 0.004 0.0212 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.033 0.0557
Onchocerca volvulus 0.0131 0.0961 0.1573
Mycobacterium leprae Probable lipase LipE 0.0038 0.0193 0.2943
Loa Loa (eye worm) pigment dispersing factor receptor c 0.028 0.219 0.219
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0193 0.0193
Mycobacterium ulcerans hypothetical protein 0.008 0.054 0.1124
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0232 0.0232
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0037 0.0052
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.021 0.021
Brugia malayi ecdysteroid receptor 0.0019 0.0039 0.0039
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0023 0.0069 0.0684
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0085 0.0584 0.0584
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0008 0.0008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0133 0.0133
Echinococcus granulosus muscleblind protein 0.0308 0.2418 0.2418
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0193 0.0744
Loa Loa (eye worm) hypothetical protein 0.0038 0.0193 0.0193
Entamoeba histolytica hypothetical protein 0.0089 0.0613 0.8725
Brugia malayi Pre-SET motif family protein 0.0093 0.0644 0.0644
Schistosoma mansoni axis inhibition protein axin 0.002 0.0046 0.0046
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0103 0.073 0.1289
Entamoeba histolytica hypothetical protein 0.002 0.0046 0.0337
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0221 0.0371
Plasmodium vivax SET domain protein, putative 0.0093 0.0644 1
Schistosoma mansoni ferritin light chain 0.0026 0.0098 0.0098
Leishmania major hypothetical protein, conserved 0.0695 0.5608 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0197 0.0268
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0641 0.5169 0.5169
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0085 0.0584 0.0584
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.031 0.5359
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0027 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0228 0.0228
Giardia lamblia Histone acetyltransferase GCN5 0.0024 0.008 0.0654
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0039 0.0039
Mycobacterium ulcerans hypothetical protein 0.0038 0.0193 0.0347
Onchocerca volvulus 0.003 0.0128 0.0152
Trypanosoma cruzi PAB1-binding protein , putative 0.0042 0.0228 0.0392
Loa Loa (eye worm) hypothetical protein 0.0107 0.0764 0.0764
Schistosoma mansoni smad1 5 8 and 0.0016 0.0016 0.0016
Echinococcus multilocularis citrate lyase subunit beta protein 0.008 0.054 0.054
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0008 0.0008
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0106 0.1388
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0091 0.0633 0.1116
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.028 0.219 0.219
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0239 0.0401
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0031 0.0135 0.0135
Echinococcus granulosus methyl CpG binding domain protein 2 0.0015 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.041 0.3264 0.3264
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0026 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.0633 0.107
Echinococcus multilocularis microtubule associated protein 2 0.0682 0.5506 0.5506
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0046
Schistosoma mansoni kinase 0.005 0.0294 0.0294
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0048 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0074
Toxoplasma gondii glyoxalase family protein 0.0073 0.0479 0.701
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0098 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0039 0.0039
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0536 0.1114
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0239 0.0401
Onchocerca volvulus Huntingtin homolog 0.0134 0.0983 0.1611
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0098 0.1222
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0024 0.0024
Brugia malayi Bromodomain containing protein 0.0068 0.0444 0.0444
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.008 0.054 0.1124
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0023 0.0069 0.0114
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0039 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0286 0.0482
Schistosoma mansoni cpg binding protein 0.0032 0.0145 0.0145
Brugia malayi beta-lactamase family protein 0.0038 0.0193 0.0193
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.0536 0.0536
Brugia malayi PXA domain containing protein 0.002 0.0046 0.0046
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0036 0.0178 0.0304
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0536 0.7853
Schistosoma mansoni cellular tumor antigen P53 0.0103 0.073 0.073
Brugia malayi MH2 domain containing protein 0.0016 0.0016 0.0016
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0046 0.0046
Trypanosoma cruzi lactoylglutathione lyase-like protein, putative 0.0073 0.0479 0.0841
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0023 0.0069 0.0109
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0228 0.2899
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0046 0.0046
Brugia malayi hypothetical protein 0.0131 0.0961 0.0961
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0106 0.1171
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.0694 0.0694
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0114 0.0823 0.1456
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0031 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0084 0.0572 0.0572
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0031 0.0133 0.0133
Onchocerca volvulus 0.0083 0.0563 0.0894
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0016 0.0016
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0325 0.2559 0.2559
Schistosoma mansoni ferritin 0.0026 0.0098 0.0098
Schistosoma mansoni hypothetical protein 0.0089 0.0613 0.0613
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0694 0.1174
Loa Loa (eye worm) hypothetical protein 0.0038 0.0193 0.0193
Echinococcus granulosus jumonji domain containing protein 0.0042 0.023 0.023
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0193 0.0323
Brugia malayi latrophilin 2 splice variant baaae 0.0191 0.1459 0.1459
Mycobacterium ulcerans hypothetical protein 0.0073 0.0479 0.0987
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0039 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0239 0.0401
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0037 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0695 0.5608 1
Leishmania major hypothetical protein, conserved 0.0038 0.0193 0.033
Echinococcus granulosus cpg binding protein 0.0032 0.0145 0.0145
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0039 0.0039
Trypanosoma brucei metacaspase 5, putative 0.0043 0.0239 0.0412
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0284 0.2226 0.3961
Echinococcus granulosus caspase 8 0.0043 0.0239 0.0239
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0039 0.0039
Schistosoma mansoni ap endonuclease 0.0019 0.0037 0.0037
Schistosoma mansoni methyl-cpg binding protein mbd 0.0015 0.0001 0.0001
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0228 0.0228
Schistosoma mansoni regulator of G protein signaling 0.002 0.0046 0.0046
Echinococcus multilocularis inositol monophosphatase 1 0.0023 0.0069 0.0069
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0008 0.0008
Mycobacterium ulcerans glyoxalase GloA 0.0073 0.0479 0.0987
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0027 0.0042
Echinococcus multilocularis GPCR, family 2 0.0089 0.0611 0.0611
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0073 0.0479 0.0842
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0046 0.0046
Schistosoma mansoni ferritin 0.0026 0.0098 0.0098
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0085 0.0578 0.1017
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.0214 0.0214
Schistosoma mansoni ap endonuclease 0.0019 0.0037 0.0037
Echinococcus multilocularis lamin 0.0083 0.0563 0.0563
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0039 0.0039
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0239 0.0401
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0023 0.0069 0.0642
Trypanosoma brucei Metacaspase-4 0.0043 0.0239 0.0412
Brugia malayi hypothetical protein 0.002 0.0046 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0193 0.033
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0039
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0019 0.0039 0.0465
Echinococcus multilocularis caspase 3 0.0071 0.0469 0.0469
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0039 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0193 0.033
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0039 0.0039
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0046 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0287 0.0483
Mycobacterium ulcerans lipase LipD 0.0038 0.0193 0.0347
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0232 0.0232
Schistosoma mansoni cpg binding protein 0.0032 0.0145 0.0145
Echinococcus multilocularis serine protein kinase ATM 0.0017 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.028 0.219 0.219
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0228 0.0392
Mycobacterium ulcerans hypothetical protein 0.0073 0.0479 0.0987
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0046 0.0046
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.07 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0601 0.4836 0.8622
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0023 0.0069 0.0109
Loa Loa (eye worm) hypothetical protein 0.0038 0.0197 0.0197
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0039 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0085 0.0584 0.0584
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0039 0.0039
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.1227 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0039 0.0206 0.0354
Echinococcus granulosus caspase 0.0115 0.0827 0.0827
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0085 0.0578 0.1017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0193 0.0193
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0239 0.0401
Loa Loa (eye worm) hypothetical protein 0.004 0.0214 0.0214
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0193 0.0193
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0239 0.0401
Brugia malayi PHD-finger family protein 0.003 0.0132 0.0132
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0046 0.0046
Toxoplasma gondii LsmAD domain-containing protein 0.0042 0.0228 0.327
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0228 0.3024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0039 0.0039
Brugia malayi Pre-SET motif family protein 0.0641 0.5169 0.5169
Trypanosoma cruzi metacaspase 5, putative 0.0043 0.0239 0.0412
Schistosoma mansoni hypothetical protein 0.0191 0.1459 0.1459
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0287 0.0483
Trichomonas vaginalis ferritin, putative 0.0026 0.0098 0.0163
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0284 0.2226 0.3961
Plasmodium falciparum metacaspase-like protein 0.0043 0.0239 0.437
Brugia malayi RNA recognition motif domain containing protein 0.0325 0.2559 0.2559
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0039 0.0039
Toxoplasma gondii exonuclease III APE 0.0019 0.0037 0.0435
Schistosoma mansoni apoferritin-2 0.0026 0.0098 0.0098
Leishmania major phosphatidylinositol 3-kinase, putative 0.0031 0.0133 0.0223

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 250 uM Evaluated for 50% cytotoxic concentration based on reduction of viability of mock-infected cells ChEMBL. 1282569
CD50 (functional) > 100 ug ml-1 Compound tested for its ability to reduce viability of mock-infected MT-4 cells. ChEMBL. 1704064
CD50 (functional) > 100 ug ml-1 Compound tested for its ability to reduce viability of mock-infected MT-4 cells. ChEMBL. 1704064
Cell viability (functional) = 0 Cell viability of the compound was determined at a concentration of 100(167) microg/mL (microM). ChEMBL. 1704064
Cell viability (functional) = 0 Cell viability of the compound was determined at a concentration of 4(6.7) microg/mL (microM). ChEMBL. 1704064
Cell viability (functional) = 0 Cell viability of the compound was determined at a concentration of 0.8(1.3) microg/mL (microM). ChEMBL. 1704064
Cell viability (functional) = 1 Cell viability of the compound was determined at a concentration of 20(33.4) microg/mL (microM). ChEMBL. 1704064
EC50 (functional) = 37 uM Evaluated for 50% antiviral effective concentration based on inhibition of HIV-1(HTLV-IIIB) induced cytopathogenicity in MT-4 cells ChEMBL. 1282569
ED50 (functional) = 40 ug ml-1 Compound tested for its inhibition of HIV-2 induced cytopathogenicity in MT-4 cells. ChEMBL. 1704064
ED50 (functional) = 40 ug ml-1 Compound tested for its inhibition of HIV-2 induced cytopathogenicity in MT-4 cells. ChEMBL. 1704064
ED50 (functional) = 42 ug ml-1 Compound tested for its inhibition of HIV-1 induced cytopathogenicity in MT-4 cells. ChEMBL. 1704064
ED50 (functional) = 42 ug ml-1 Compound tested for its inhibition of HIV-1 induced cytopathogenicity in MT-4 cells. ChEMBL. 1704064
IC50 (binding) = 3.7 uM Inhibition of purified HIV-2 reverse transcriptase ChEMBL. 1282569
IC50 (binding) = 4.8 uM Inhibition of purified HIV-1 reverse transcriptase ChEMBL. 1282569
ID50 (functional) = 46 ug ml-1 Inhibitory dose at a concentration 835 microM against gaint cell formation. ChEMBL. 1704064
ID50 (functional) = 46 ug ml-1 Inhibitory dose at a concentration 835 microM against gaint cell formation. ChEMBL. 1704064
ID50 (binding) = 50 ug ml-1 Inhibitory dose at a concentration 835 microM cell-free HIV-1 Reverse Transcriptase ChEMBL. 1704064
ID50 (binding) = 50 ug ml-1 Inhibitory dose at a concentration 835 microM cell-free HIV-1 Reverse Transcriptase ChEMBL. 1704064
Inhibition (functional) = 0 % Compound was evaluated for inhibitory effect against MT-4 cells of HIV-1 at a concentration of 4(6.7) microg/mL (microM). ChEMBL. 1704064
Inhibition (functional) = 0 % Compound tested for % inhibition of giant cell formation at a concentration of 835 microM. ChEMBL. 1704064
Inhibition (functional) = 0 % Compound tested for % inhibition of giant cell formation at a concentration of 1.3 microM. ChEMBL. 1704064
Inhibition (binding) = 0 % Compound tested for % inhibition of cell-free HIV-1 Reverse Transcriptase at a concentration of 835 microM; Toxic ChEMBL. 1704064
Inhibition (functional) = 0 % Compound was evaluated for inhibitory effect against MT-4 cells of HIV-1 at a concentration of 4(6.7) microg/mL (microM). ChEMBL. 1704064
Inhibition (functional) = 0 % Compound tested for % inhibition of giant cell formation at a concentration of 1.3 microM. ChEMBL. 1704064
Inhibition (functional) = 3 % Compound was evaluated for inhibitory effect against MT-4 cells of HIV-2 at a concentration of 4(6.7) microg/mL (microM). ChEMBL. 1704064
Inhibition (functional) = 3 % Compound was evaluated for inhibitory effect against MT-4 cells of HIV-2 at a concentration of 4(6.7) microg/mL (microM). ChEMBL. 1704064
Inhibition (functional) = 4 % Compound tested for % inhibition of giant cell formation at a concentration of 33.4 uM. ChEMBL. 1704064
Inhibition (binding) = 4 % Compound tested for % inhibition of cell-free HIV-1 Reverse Transcriptase at a concentration of 33.4 microM. ChEMBL. 1704064
Inhibition (binding) = 4 % Compound tested for % inhibition of cell-free HIV-1 Reverse Transcriptase at a concentration of 33.4 microM. ChEMBL. 1704064
Inhibition (functional) = 4 % Compound tested for % inhibition of giant cell formation at a concentration of 33.4 uM. ChEMBL. 1704064
Inhibition (functional) = 5 % Compound was evaluated for inhibitory effect against MT-4 cells of HIV-1 at a concentration of 0.8(1.3) microg/mL (microM). ChEMBL. 1704064
Inhibition (functional) = 5 % Compound was evaluated for inhibitory effect against MT-4 cells of HIV-1 at a concentration of 0.8(1.3) microg/mL (microM). ChEMBL. 1704064
Inhibition (functional) = 6 % Compound was evaluated for inhibitory effect against MT-4 cells of HIV-2 at a concentration of 0.8(1.3) microg/mL (microM). ChEMBL. 1704064
Inhibition (functional) = 6 % Compound was evaluated for inhibitory effect against MT-4 cells of HIV-2 at a concentration of 0.8(1.3) microg/mL (microM). ChEMBL. 1704064
Inhibition (functional) = 7 % Compound was evaluated for inhibitory effect against MT-4 cells of HIV-1 at a concentration of 20(33.4) microg/mL (microM). ChEMBL. 1704064
Inhibition (functional) = 7 % Compound was evaluated for inhibitory effect against MT-4 cells of HIV-1 at a concentration of 20(33.4) microg/mL (microM). ChEMBL. 1704064
Inhibition (functional) = 9 % Compound tested for % inhibition of giant cell formation at a concentration of 6.7 microM. ChEMBL. 1704064
Inhibition (binding) = 9 % Compound tested for % inhibition of cell-free HIV-1 Reverse Transcriptase at a concentration of 6.7 microM. ChEMBL. 1704064
Inhibition (binding) = 9 % Compound tested for % inhibition of cell-free HIV-1 Reverse Transcriptase at a concentration of 6.7 microM. ChEMBL. 1704064
Inhibition (functional) = 9 % Compound tested for % inhibition of giant cell formation at a concentration of 6.7 microM. ChEMBL. 1704064
Inhibition (functional) = 12 % Compound was evaluated for inhibitory effect against MT-4 cells of HIV-2 at a concentration of 20(33.4) microg/mL (microM). ChEMBL. 1704064
Inhibition (functional) = 12 % Compound was evaluated for inhibitory effect against MT-4 cells of HIV-2 at a concentration of 20(33.4) microg/mL (microM). ChEMBL. 1704064
Inhibition (functional) = 95 % Compound tested for % inhibition of giant cell formation at a concentration of 167 microM. ChEMBL. 1704064
Inhibition (binding) = 95 % Compound tested for % inhibition of giant cell formation at a concentration of 167 microM. ChEMBL. 1704064
Inhibition (binding) = 95 % Compound tested for % inhibition of giant cell formation at a concentration of 167 microM. ChEMBL. 1704064
Inhibition (functional) = 95 % Compound tested for % inhibition of giant cell formation at a concentration of 167 microM. ChEMBL. 1704064
Inhibition (functional) = 100 % Compound was evaluated for inhibitory effect against MT-4 cells of HIV-1 at a concentration of 100(167) microg/mL (microM). ChEMBL. 1704064
Inhibition (functional) = 100 % Compound was evaluated for inhibitory effect against MT-4 cells of HIV-2 at a concentration of 100(167) microg/mL (microM). ChEMBL. 1704064
Inhibition (functional) = 100 % Compound was evaluated for inhibitory effect against MT-4 cells of HIV-1 at a concentration of 100(167) microg/mL (microM). ChEMBL. 1704064
Inhibition (functional) = 100 % Compound was evaluated for inhibitory effect against MT-4 cells of HIV-2 at a concentration of 100(167) microg/mL (microM). ChEMBL. 1704064

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.