Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.1425 | 0.2772 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1425 | 0.1425 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.5012 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.5012 | 0.5012 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.5012 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.5012 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.5012 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.5012 | 1 |
Echinococcus granulosus | lamin | 0.0028 | 0.1425 | 0.2772 |
Echinococcus multilocularis | musashi | 0.0028 | 0.1425 | 0.2772 |
Onchocerca volvulus | 0.0028 | 0.1425 | 0.5 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.1425 | 0.1425 |
Echinococcus multilocularis | lamin | 0.0028 | 0.1425 | 0.2772 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.1425 | 0.1425 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.5012 | 0.5012 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1376 | 0.1376 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.1425 | 0.1259 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.5012 | 0.4916 |
Brugia malayi | RNA binding protein | 0.0065 | 0.5012 | 0.4916 |
Onchocerca volvulus | 0.0028 | 0.1425 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.5012 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.1425 | 0.2772 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.5012 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.1425 | 0.1259 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.5012 | 0.5012 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.5012 | 0.4916 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.019 | 0.019 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0049 | 0.0049 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.1425 | 0.2772 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1312 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.