Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.011 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.003 | 0.2583 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.003 | 0.2583 | 0.2501 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.011 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.2583 | 0.9367 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.011 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.011 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.011 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.011 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0031 | 0.2758 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.003 | 0.2583 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.2583 | 0.9367 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0031 | 0.2758 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.011 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.011 | 0.0399 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.011 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.2583 | 0.934 |
Loa Loa (eye worm) | CYP4Cod1 | 0.003 | 0.2583 | 0.9367 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.2583 | 0.934 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.003 | 0.2583 | 1 |
Leishmania major | cytochrome p450-like protein | 0.003 | 0.2583 | 0.2501 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Antiinflammatory activity against mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 48 hrs by Griess reaction relative to control | ChEMBL. | 19691309 |
Inhibition (functional) | = 80.8 % | Antiinflammatory activity against mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production at 1 uM after 48 hrs by Griess reaction relative to control | ChEMBL. | 19691309 |
Inhibition (functional) | = 101.5 % | Antiinflammatory activity against mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production at 30 uM after 48 hrs by Griess reaction relative to control | ChEMBL. | 19691309 |
Inhibition (functional) | = 108.4 % | Antiinflammatory activity against mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production at 10 uM after 48 hrs by Griess reaction relative to control | ChEMBL. | 19691309 |
Inhibition (functional) | = 113.4 % | Antiinflammatory activity against mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production at 3 uM after 48 hrs by Griess reaction relative to control | ChEMBL. | 19691309 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.