Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.3361 | 0.4076 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.9254 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0199 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.3361 | 0.4076 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0851 | 0.0914 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.3361 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0851 | 0.084 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.2838 | 0.3403 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.3361 | 0.4433 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.2686 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.3361 | 1 |
Brugia malayi | Inositol-1 | 0.0038 | 0.3361 | 0.3226 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.3361 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0199 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.3361 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.3361 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0199 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.3361 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0199 | 0.0215 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0518 | 0.0411 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.3186 | 0.4188 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.3186 | 0.4188 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.3361 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0034 | 0.2686 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.3361 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.5578 | 0.6028 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.5578 | 0.6028 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.5578 | 0.5489 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0061 | 0.7332 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0851 | 0.0914 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.4357 | 0.4709 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.7956 | 1 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0333 | 0.0188 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.5578 | 0.5489 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.3361 | 0.3632 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.1264 | 0.1086 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0518 | 0.0559 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.4024 | 0.4348 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0038 | 0.3361 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0061 | 0.7332 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.3599 | 0.3469 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0333 | 0.0188 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0199 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0333 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.2838 | 0.3067 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 0.3361 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.2838 | 0.2693 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.3611 | 0.3902 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.3361 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.3361 | 0.4433 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.