Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor alpha 1A | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 1D | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 1B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Alpha-1D adrenergic receptor, putative | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Schistosoma mansoni | amine GPCR | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | trypanothione reductase | 0.0829 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0829 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0829 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0287 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0829 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0829 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0287 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0718 | 0.795 | 0.795 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0287 | 0 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0829 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0829 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0829 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0829 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0829 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0829 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0491 | 0.3757 | 0.3757 |
Loa Loa (eye worm) | glutathione reductase | 0.0829 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0287 | 0 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0287 | 0 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0287 | 0 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0287 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0829 | 1 | 1 |
Schistosoma mansoni | amine GPCR | 0.0409 | 0.2237 | 0.2237 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0287 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0718 | 0.795 | 0.6716 |
Plasmodium falciparum | glutathione reductase | 0.0829 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0718 | 0.795 | 0.795 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0287 | 0 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0287 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0718 | 0.795 | 0.6716 |
Schistosoma mansoni | hypothetical protein | 0.0491 | 0.3757 | 0.3757 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0287 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.23 nM | Binding affinity towards cloned human alpha-1A adrenergic receptor was determined using [125]-HEAT as radioligand | ChEMBL. | 10841797 |
Ki (binding) | = 0.23 nM | Binding affinity towards cloned human alpha-1A adrenergic receptor was determined using [125]-HEAT as radioligand | ChEMBL. | 10841797 |
Ki (binding) | = 124 nM | Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand | ChEMBL. | 10841797 |
Ki (binding) | = 124 nM | Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand | ChEMBL. | 10841797 |
Ki (binding) | > 1750 nM | Binding affinity towards cloned human alpha-1B adrenergic receptor was determined using [125]-HEAT as radioligand | ChEMBL. | 10841797 |
Ki (binding) | > 1750 nM | Binding affinity towards cloned human alpha-1B adrenergic receptor was determined using [125]-HEAT as radioligand | ChEMBL. | 10841797 |
Ratio (binding) | = 539 | Ratio of binding affinity towards Alpha1d to alpha1a | ChEMBL. | 10841797 |
Ratio (binding) | > 7610 | Ratio of binding affinity towards Alpha1b to alpha1a | ChEMBL. | 10841797 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.