Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1479 | 0.5379 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0023 | 0.0413 | 0.1501 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0035 | 0.0856 | 0.3112 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0023 | 0.0413 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0413 | 0.0473 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0023 | 0.0413 | 0.1501 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0023 | 0.0413 | 0.0473 |
Brugia malayi | steroid hormone receptor | 0.0023 | 0.0413 | 0.0473 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1479 | 0.5379 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0023 | 0.0413 | 0.0473 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0023 | 0.0413 | 0.0473 |
Brugia malayi | Pre-SET motif family protein | 0.0242 | 0.873 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1479 | 0.5379 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0023 | 0.0413 | 0.1501 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0023 | 0.0413 | 0.0473 |
Schistosoma mansoni | hypothetical protein | 0.0085 | 0.275 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0023 | 0.0413 | 0.0473 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0023 | 0.0413 | 0.1501 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0023 | 0.0413 | 0.0473 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0023 | 0.0413 | 0.1501 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0035 | 0.0856 | 0.3112 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0023 | 0.0413 | 0.1501 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0035 | 0.0856 | 0.3112 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0085 | 0.275 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0856 | 0.3112 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0023 | 0.0413 | 0.0473 |
Entamoeba histolytica | hypothetical protein | 0.0085 | 0.275 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1479 | 0.5379 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0023 | 0.0413 | 0.1501 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0023 | 0.0413 | 0.0473 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0023 | 0.0413 | 0.1501 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0023 | 0.0413 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0413 | 0.0473 |
Entamoeba histolytica | hypothetical protein | 0.0085 | 0.275 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0242 | 0.873 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0023 | 0.0413 | 0.1501 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0023 | 0.0413 | 0.1501 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0023 | 0.0413 | 0.0473 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0023 | 0.0413 | 0.0473 |
Schistosoma mansoni | nuclear hormone receptor | 0.0023 | 0.0413 | 0.1501 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0856 | 0.3112 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.1479 | 0.1695 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1479 | 0.5379 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0023 | 0.0413 | 0.1501 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0023 | 0.0413 | 0.1501 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0023 | 0.0413 | 0.0473 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0023 | 0.0413 | 0.1501 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0023 | 0.0413 | 0.1501 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0035 | 0.0856 | 0.3112 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0413 | 0.0473 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0023 | 0.0413 | 0.0473 |
Brugia malayi | Pre-SET motif family protein | 0.0035 | 0.0856 | 0.0981 |
Brugia malayi | hypothetical protein | 0.0085 | 0.275 | 0.315 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1479 | 0.5379 |
Entamoeba histolytica | hypothetical protein | 0.0085 | 0.275 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0413 | 0.0473 |
Onchocerca volvulus | 0.0035 | 0.0856 | 0.0462 | |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0023 | 0.0413 | 0.1501 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0856 | 0.3112 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0023 | 0.0413 | 0.1501 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0023 | 0.0413 | 0.1501 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0023 | 0.0413 | 0.0473 |
Plasmodium vivax | SET domain protein, putative | 0.0035 | 0.0856 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0085 | 0.275 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0023 | 0.0413 | 0.0473 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0023 | 0.0413 | 0.0473 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0023 | 0.0413 | 0.1501 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0033 | 0.0808 | 0.2936 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0085 | 0.275 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0413 | 0.0473 |
Entamoeba histolytica | hypothetical protein | 0.0085 | 0.275 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0023 | 0.0413 | 0.0473 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0023 | 0.0413 | 0.0473 |
Schistosoma mansoni | thyroid hormone receptor | 0.0023 | 0.0413 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0413 | 0.0473 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0023 | 0.0413 | 0.0473 |
Schistosoma mansoni | coup transcription factor | 0.0023 | 0.0413 | 0.1501 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0023 | 0.0413 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0856 | 0.0981 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0413 | 0.0473 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0023 | 0.0413 | 0.0473 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0023 | 0.0413 | 0.1501 |
Echinococcus granulosus | FTZ F1 alpha | 0.0023 | 0.0413 | 0.1501 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0023 | 0.0413 | 0.0473 |
Trichomonas vaginalis | set domain proteins, putative | 0.0276 | 1 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0023 | 0.0413 | 0.1501 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0023 | 0.0413 | 0.0473 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.1479 | 0.1695 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0023 | 0.0413 | 0.0473 |
Schistosoma mansoni | thyroid hormone receptor | 0.0023 | 0.0413 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0413 | 0.0473 |
Brugia malayi | nuclear receptor NHR-88 | 0.0023 | 0.0413 | 0.0473 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0023 | 0.0413 | 0.0473 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0023 | 0.0413 | 0.1501 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0023 | 0.0413 | 0.0473 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0023 | 0.0413 | 0.1501 |
Brugia malayi | nuclear hormone receptor | 0.0023 | 0.0413 | 0.0473 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0035 | 0.0856 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1479 | 0.5379 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0023 | 0.0413 | 0.1501 |
Brugia malayi | ecdysteroid receptor | 0.0023 | 0.0413 | 0.0473 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CD50 (functional) | > 200 ug ml-1 | Dose required to inhibit Murine leukemia (L1210) cell proliferation by 50% | ChEMBL. | 2540332 |
CD50 (functional) | > 200 ug ml-1 | Dose required to inhibit Human B-Lymphoblast(Raji) cell proliferation by 50% | ChEMBL. | 2540332 |
MCC (functional) | > 200 ug ml-1 | Minimum cytotoxic concentration required to cause a microscopically detectable alteration of normal cell morphology and show antiviral activity in HeLa cells | ChEMBL. | 2540332 |
MIC (functional) | > 200 ug ml-1 | Minimum inhibitory concentration required to reduce vesicular stomatitis virus induced cytopathogenicity by 50% in HeLa cells | ChEMBL. | 2540332 |
MIC (functional) | > 200 ug ml-1 | Minimum inhibitory concentration required to reduce polio virus -1 induced cytopathogenicity by 50% in HeLa cells | ChEMBL. | 2540332 |
MIC (functional) | > 200 ug ml-1 | Minimum inhibitory concentration required to reduce Coxsackie virus B4 induced cytopathogenicity by 50% in HeLa cells | ChEMBL. | 2540332 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.