Detailed information for compound 1124498

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 355.79 | Formula: C20H15ClFNO2
  • H donors: 2 H acceptors: 2 LogP: 5.06 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C/C(=N/c1ccc(cc1)Cl)/c1ccc(c(c1)O)O
  • InChi: 1S/C20H15ClFNO2/c21-15-4-8-17(9-5-15)23-18(11-13-1-6-16(22)7-2-13)14-3-10-19(24)20(25)12-14/h1-10,12,24-25H,11H2/b23-18-
  • InChiKey: OUGMOCFSRDPMDX-NKFKGCMQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0234 0.2231 0.2231
Echinococcus granulosus cytochrome P450 2K1 0.0199 0.1811 0.247
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0221 0.2077 0.2077
Loa Loa (eye worm) cytochrome P450 family protein 0.0605 0.6733 0.6733
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.011 0.0727 0.1771
Giardia lamblia Kinase, CMGC CLK 0.0388 0.4105 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0058 0.0097 0.0097
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0127 0.0941 0.1283
Leishmania major protein kinase, putative 0.0388 0.4105 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0354 0.3691 0.8992
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0215 0.0523
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0234 0.2231 0.5296
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0058 0.0097 0.0236
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0178 0.1555 0.3638
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0068 0.0215 0.0523
Echinococcus multilocularis mitogen activated protein kinase 3 0.017 0.1458 0.1988
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0285 0.2847 0.7713
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0081 0.0375 0.0511
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.006 0.0121 0.0164
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0123 0.0888 0.0888
Trichomonas vaginalis PIKK family atypical protein kinase 0.0147 0.1178 0.2871
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0354 0.3691 0.8992
Echinococcus multilocularis 0.0199 0.1811 0.247
Entamoeba histolytica exodeoxyribonuclease III, putative 0.006 0.0121 0.0327
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0199 0.1811 0.4412
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0221 0.2077 0.506
Trichomonas vaginalis adenylate cyclase, putative 0.0068 0.0215 0.0523
Brugia malayi Cytochrome P450 family protein 0.0301 0.3053 0.3053
Mycobacterium ulcerans putative regulatory protein 0.0193 0.1733 0.55
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0081 0.0375 0.0912
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0215 0.0523
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0072 0.0269 0.0655
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0093 0.0525 0.1015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0375 0.0912
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0199 0.1811 0.5765
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.1031 0.2511
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0081 0.0375 0.0511
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0654 0.7331 1
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0388 0.4105 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.006 0.0121 0.0294
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0127 0.0941 0.2549
Leishmania major protein kinase, putative 0.0072 0.0269 0.043
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0199 0.1811 0.5765
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0072 0.0269 0.0655
Loa Loa (eye worm) cytochrome P450 family protein 0.0301 0.3053 0.3053
Mycobacterium leprae putative cytochrome p450 0.0199 0.1811 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.017 0.1458 0.3551
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0221 0.2077 0.2833
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0234 0.2231 0.3043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0375 0.0912
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0199 0.1811 0.5765
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.017 0.1458 0.3551
Trichomonas vaginalis guanylate cyclase, putative 0.0068 0.0215 0.0523
Loa Loa (eye worm) hypothetical protein 0.0068 0.0215 0.0215
Loa Loa (eye worm) phosphatidylinositol 3 0.0221 0.2077 0.2077
Brugia malayi Protein kinase domain containing protein 0.0388 0.4105 0.4105
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0199 0.1811 0.5765
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0234 0.2231 0.3043
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0234 0.2235 0.3049
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0072 0.0269 0.0655
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0899 0.2189
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0199 0.1811 1
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0121 0.0294
Trypanosoma cruzi cytochrome P450, putative 0.0301 0.3053 0.7437
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0068 0.0215 0.0523
Schistosoma mansoni lipoxygenase 0.0104 0.0655 0.0894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0899 0.2189
Schistosoma mansoni single-minded 0.026 0.2555 0.3485
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0199 0.1811 0.5765
Trichomonas vaginalis PIKK family atypical protein kinase 0.0178 0.1553 0.3783
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0068 0.0215 0.0523
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0234 0.2231 0.5434
Loa Loa (eye worm) hypothetical protein 0.0384 0.4051 0.4051
Schistosoma mansoni lipoxygenase 0.0176 0.1525 0.208
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0388 0.4105 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0058 0.0097 0.0236
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0234 0.2231 0.5324
Brugia malayi MAP kinase sur-1 0.017 0.1458 0.1458
Trypanosoma brucei protein kinase, putative 0.017 0.1458 0.3551
Brugia malayi Cytochrome P450 family protein 0.0605 0.6733 0.6733
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0058 0.0097 0.0132
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0199 0.1811 0.5765
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0234 0.2231 0.5434
Loa Loa (eye worm) hypothetical protein 0.012 0.0849 0.0849
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.1702 0.4147
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.017 0.1458 0.3551
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0058 0.0097 0.0236
Toxoplasma gondii cytochrome p450 superfamily protein 0.0199 0.1811 0.4412
Echinococcus granulosus dual specificity protein kinase clk2 0.0388 0.4105 0.5599
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0221 0.2077 0.5627
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0199 0.1811 0.5765
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0068 0.0215 0.0215
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0081 0.0375 0.0511
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0234 0.2231 0.5434
Echinococcus granulosus mitogen activated protein kinase 3 0.017 0.1458 0.1988
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0203 0.0494
Loa Loa (eye worm) hypothetical protein 0.0055 0.0055 0.0055
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0388 0.4105 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0167 0.1421 0.3461
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.006 0.0121 0.0121
Loa Loa (eye worm) cytochrome P450 0.0199 0.1811 0.1811
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0199 0.1811 0.5765
Loa Loa (eye worm) CYP4Cod1 0.0301 0.3053 0.3053
Schistosoma mansoni serine/threonine protein kinase 0.017 0.1458 0.1988
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0058 0.0097 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0178 0.1553 0.3783
Brugia malayi PAS domain containing protein 0.026 0.2555 0.2555
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0127 0.0941 0.2292
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0123 0.0888 0.2616
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0058 0.0097 0.0236
Schistosoma mansoni serine/threonine protein kinase 0.0388 0.4105 0.5599
Schistosoma mansoni caspase-7 (C14 family) 0.0065 0.0177 0.0241
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0199 0.1811 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0635 0.0635
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0199 0.1811 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0167 0.1421 0.3461
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.006 0.0121 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0165 0.1391 0.3769
Echinococcus multilocularis transfer RNA-Lys 0.0193 0.1733 0.2364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.2077 0.506
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.017 0.1458 0.3395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0899 0.2189
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0068 0.0215 0.0293
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0068 0.0215 0.0523
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0354 0.3691 0.8992
Toxoplasma gondii exonuclease III APE 0.006 0.0121 0.0294
Schistosoma mansoni aryl hydrocarbon receptor 0.026 0.2555 0.3485
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0199 0.1811 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0058 0.0097 0.0262
Schistosoma mansoni ap endonuclease 0.006 0.0121 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0896 0.2184
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0068 0.0215 0.0523
Loa Loa (eye worm) hypothetical protein 0.0874 1 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0199 0.1811 0.4412
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0123 0.0888 0.4538
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.006 0.0121 0.0294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0375 0.0912
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0058 0.0097 0.0262
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0123 0.0888 0.1973
Echinococcus granulosus mitogen activated protein kinase 0.017 0.1458 0.1988
Echinococcus multilocularis caspase 2 0.0065 0.0177 0.0241
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0354 0.3691 0.3691
Brugia malayi Cell death protein 3 precursor 0.0065 0.0177 0.0177
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0234 0.2235 0.2235
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0199 0.1811 0.5765
Trichomonas vaginalis PIKK family atypical protein kinase 0.0178 0.1553 0.3783
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0234 0.2235 0.3049
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0121 0.0059
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0199 0.1811 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0899 0.2189
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0199 0.1811 0.4277
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0388 0.4105 1
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.03 0.3033 0.3033
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0123 0.0888 0.1211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0375 0.0912
Loa Loa (eye worm) phosphatidylinositol 3 0.0104 0.0653 0.0653
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.006 0.0121 0.0059
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0121 0.0294
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0081 0.0375 0.0912
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0058 0.0097 0.0236
Echinococcus multilocularis aryl hydrocarbon receptor 0.0068 0.0215 0.0293
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0234 0.2231 0.5434
Brugia malayi Cytochrome P450 family protein 0.0301 0.3053 0.3053
Echinococcus multilocularis 0.0384 0.4051 0.5525
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0221 0.2077 0.494
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0234 0.2231 0.3043
Echinococcus multilocularis ubiquitin specific protease 41 0.0234 0.2231 0.3043
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0068 0.0215 0.0523
Echinococcus granulosus ubiquitin specific protease 41 0.0234 0.2231 0.3043
Trichomonas vaginalis guanylate cyclase, putative 0.0068 0.0215 0.0523
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.017 0.1458 0.3395
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0234 0.2231 0.3043
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0388 0.4105 1
Trichomonas vaginalis CMGC family protein kinase 0.017 0.1458 0.3551
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0199 0.1811 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0081 0.0375 0.0912
Leishmania major phosphatidylinositol 3-kinase, putative 0.0081 0.0375 0.0693
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0388 0.4105 0.4105
Loa Loa (eye worm) cytochrome P450 family protein 0.0301 0.3053 0.3053
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0354 0.3691 0.8992
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0199 0.1811 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0178 0.1553 0.3595
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0199 0.1811 1
Trichomonas vaginalis conserved hypothetical protein 0.0234 0.2231 0.5434
Echinococcus multilocularis dual specificity protein kinase clk2 0.0388 0.4105 0.5599
Leishmania major cytochrome p450-like protein 0.0199 0.1811 0.4277
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0178 0.1555 0.3788
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0375 0.0912
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0199 0.1811 0.5765
Giardia lamblia Kinase, CMGC MAPK 0.017 0.1458 0.3356
Brugia malayi Cytochrome P450 family protein 0.0199 0.1811 0.1811
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0234 0.2231 0.5434
Schistosoma mansoni serine/threonine protein kinase 0.0388 0.4105 0.5599
Schistosoma mansoni cytochrome P450 0.0199 0.1811 0.247
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0221 0.2077 0.494
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0127 0.0941 0.0941
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0127 0.0941 0.2292
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.017 0.1458 0.3551
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0098 0.0579 0.1412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0178 0.1553 0.3783
Trypanosoma cruzi cytochrome P450, putative 0.0301 0.3053 0.7437
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0199 0.1811 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0058 0.0097 0.0236
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0199 0.1811 0.5765
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0199 0.1811 0.5765
Giardia lamblia GTOR 0.0221 0.2077 0.491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0896 0.2184
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0127 0.0941 0.2292
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0068 0.0215 0.0293
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0081 0.0375 0.0693
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0081 0.0375 0.0912
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0068 0.0215 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0167 0.1421 0.3461
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0199 0.1811 1
Echinococcus granulosus caspase 2 0.0065 0.0177 0.0241
Entamoeba histolytica hypothetical protein 0.0285 0.2847 0.7713
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0058 0.0097 0.0236
Plasmodium vivax serine/threonine kinase-1, putative 0.0388 0.4105 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0199 0.1811 1
Schistosoma mansoni hypothetical protein 0.0199 0.1811 0.247
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.033 0.3403 0.9221
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0221 0.2077 0.506
Trypanosoma brucei cytochrome P450, putative 0.0301 0.3053 0.7437
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0199 0.1811 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0058 0.0097 0.0132
Toxoplasma gondii target of rapamycin (TOR), putative 0.0167 0.1421 0.3461
Echinococcus granulosus aryl hydrocarbon receptor 0.0068 0.0215 0.0293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0178 0.1553 0.3783
Loa Loa (eye worm) hypothetical protein 0.0234 0.2231 0.2231
Leishmania major cytochrome p450-like protein 0.0301 0.3053 0.7375
Echinococcus multilocularis Zinc finger, PHD finger 0.0058 0.0097 0.0132
Mycobacterium leprae Conserved hypothetical protein 0.0199 0.1811 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.006 0.0121 0.0294
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0234 0.2231 0.3043
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0199 0.1811 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0354 0.3691 0.8992
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0503 0.5499 0.5499
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0199 0.1811 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.017 0.1458 0.1458
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0177
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0199 0.1811 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0121 0.0059
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0354 0.3691 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.017 0.1458 0.3551
Echinococcus multilocularis mitogen activated protein kinase 0.017 0.1458 0.1988
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0123 0.0888 0.2616
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0199 0.1811 0.5765
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0654 0.7331 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0234 0.2231 0.6043
Brugia malayi bHLH-PAS transcription factor 0.0193 0.1733 0.1733
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0221 0.2077 0.506
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0896 0.2184
Brugia malayi cytochrome P450 0.0199 0.1811 0.1811
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.1031 0.2511
Trichomonas vaginalis PIKK family atypical protein kinase 0.0136 0.1046 0.2548
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0199 0.1811 0.4412
Onchocerca volvulus 0.0068 0.0215 0.0244
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0388 0.4105 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0176 0.1525 0.208
Brugia malayi hypoxia-induced factor 1 0.0806 0.9178 0.9178
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0221 0.2077 0.506
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0199 0.1811 0.5765
Trichomonas vaginalis CMGC family protein kinase 0.0388 0.4105 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0167 0.1421 0.3461
Plasmodium falciparum protein serine/threonine kinase-1 0.0388 0.4105 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0136 0.1046 0.2548
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0127 0.0941 0.2549
Trichomonas vaginalis PIKK family atypical protein kinase 0.0167 0.1421 0.3461
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0199 0.1811 0.5765
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0199 0.1811 0.5765
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0055 0.0055 0.0135
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0247 0.2397 0.5839
Schistosoma mansoni ap endonuclease 0.006 0.0121 0.0164
Loa Loa (eye worm) hypothetical protein 0.0234 0.2235 0.2235
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0199 0.1811 0.4412
Loa Loa (eye worm) phosphatidylinositol 3 0.0584 0.6487 0.6487
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0388 0.4105 1
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0055 0.0135
Leishmania major protein kinase, putative 0.0072 0.0269 0.043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.2077 0.506
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0221 0.2077 0.2833
Trichomonas vaginalis PIKK family atypical protein kinase 0.0167 0.1421 0.3461
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0199 0.1811 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0806 0.9178 0.9178
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0199 0.1811 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0176 0.1525 0.208
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0221 0.2077 0.5627
Trichomonas vaginalis PIKK family atypical protein kinase 0.0167 0.1421 0.3461
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0215 0.0523
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0375 0.0375
Echinococcus granulosus hypothetical protein 0.0384 0.4051 0.5525
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0199 0.1811 0.5765
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0221 0.2077 0.2833
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0104 0.0653 0.1591
Brugia malayi exodeoxyribonuclease III family protein 0.006 0.0121 0.0121
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0199 0.1811 0.5765
Trichomonas vaginalis CMGC family protein kinase 0.017 0.1458 0.3551
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0072 0.0269 0.0655
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0301 0.3053 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0068 0.0215 0.0295
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0058 0.0097 0.0132
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0123 0.0888 0.1211
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0058 0.0097 0.0097
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0123 0.0888 0.1211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.2077 0.506
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.006 0.0121 0.0164
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0199 0.1811 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0178 0.1555 0.3788
Trichomonas vaginalis PIKK family atypical protein kinase 0.0152 0.1234 0.3005
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0654 0.7331 1
Trichomonas vaginalis CMGC family protein kinase 0.017 0.1458 0.3551
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.017 0.1458 0.3551
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0234 0.2231 0.3043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0136 0.1046 0.2548
Leishmania major protein kinase, putative 0.0388 0.4105 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0058 0.0097 0.0132
Brugia malayi follicle stimulating hormone receptor 0.0503 0.5499 0.5499
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0375 0.0375
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0127 0.0941 0.2292
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0127 0.0941 0.2292
Trichomonas vaginalis CMGC family protein kinase 0.017 0.1458 0.3551
Leishmania major cytochrome p450-like protein 0.0199 0.1811 0.4277
Echinococcus granulosus single minded 2 0.0193 0.1733 0.2364
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0199 0.1811 0.5765
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0199 0.1811 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0199 0.1811 0.5765
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0058 0.0097 0.0236
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0111 0.0738 0.0738
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0247 0.2397 0.5839
Onchocerca volvulus 0.0193 0.1733 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0068 0.0215 0.0523
Treponema pallidum exodeoxyribonuclease (exoA) 0.006 0.0121 0.5
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0199 0.1811 1

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 6.25 ug ml-1 Antibacterial activity against Escherichia coli ATCC 35218 ChEMBL. 20153183
MIC (functional) > 50 ug ml-1 Antifungal activity against Candida albicans ATCC 10231 ChEMBL. 20153183

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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