Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.2036 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.2036 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.2036 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.2036 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2036 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.2036 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2036 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2036 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2036 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.2036 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.2036 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2036 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.2036 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2036 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.2036 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.2036 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2036 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2036 | 0.5 | 0.5 |
Onchocerca volvulus | 0.2036 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.2036 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.2036 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.2036 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.2036 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2036 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.2036 | 0.5 | 0.5 |
Onchocerca volvulus | 0.2036 | 0.5 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.2036 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.2036 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.2036 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.2036 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2036 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.2036 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.2036 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2036 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.2036 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2036 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2036 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.2036 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.2036 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Dose (functional) | = 50 mg kg-1 | Antitumor activity against B16 melanoma cells in mice. Activity is expressed as optimal effective dose. | ChEMBL. | 3669023 |
Dose (functional) | = 50 mg kg-1 | Antitumor activity against L1210 leukemia cells in mice, activity is expressed as optimal effective dose. | ChEMBL. | 3669023 |
Dose (functional) | = 50 mg kg-1 | Antitumor activity against B16 melanoma cells in mice. Activity is expressed as optimal effective dose. | ChEMBL. | 3669023 |
Dose (functional) | = 50 mg kg-1 | Antitumor activity against L1210 leukemia cells in mice, activity is expressed as optimal effective dose. | ChEMBL. | 3669023 |
T/C (functional) | = 185 % | Antitumor activity against L1210 leukemia cells in mice (activity expressed as average survival time of treated/control animals x 100) | ChEMBL. | 3669023 |
T/C (functional) | = 185 % | Antitumor activity against L1210 leukemia cells in mice (activity expressed as average survival time of treated/control animals x 100) | ChEMBL. | 3669023 |
T/C (functional) | = 208 % | Antitumor activity against B16 melanoma cells in mice, activity is expressed as average survival time of treated/control animals x 100. | ChEMBL. | 3669023 |
Weight change (functional) | = -3.1 % | Antitumor activity against L1210 leukemia cells in mice calculated as average change in body weight from onset to termination of therapy | ChEMBL. | 3669023 |
Weight change (functional) | = -3.1 % | Antitumor activity against L1210 leukemia cells in mice calculated as average change in body weight from onset to termination of therapy | ChEMBL. | 3669023 |
Weight change (functional) | = -1.5 % | Antitumor activity against mouse B16 melanoma cells, calculated as average change in body weight from onset to termination of therapy | ChEMBL. | 3669023 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.