Detailed information for compound 112472

Basic information

Technical information
  • TDR Targets ID: 112472
  • Name: 2-phenyl-1,3-thiazol-4-one
  • MW: 177.223 | Formula: C9H7NOS
  • H donors: 0 H acceptors: 1 LogP: 1.98 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CSC(=N1)c1ccccc1
  • InChi: 1S/C9H7NOS/c11-8-6-12-9(10-8)7-4-2-1-3-5-7/h1-5H,6H2
  • InChiKey: LFLIZASYILFMIO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-phenylthiazol-4-one
  • 2-phenyl-4-thiazolone
  • 2-phenyl-2-thiazolin-4-one
  • ZINC03844437

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0069 0.01
Schistosoma mansoni hypothetical protein 0.0051 0.0269 0.0257
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0233 0.1774 0.1876
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0313 0.0331
Schistosoma mansoni carbonic anhydrase 0.0027 0.0069 0.0056
Echinococcus multilocularis purine nucleoside phosphorylase 0.0028 0.0077 0.0111
Echinococcus multilocularis purine nucleoside phosphorylase 0.0028 0.0077 0.0111
Schistosoma mansoni hypothetical protein 0.011 0.0759 0.0747
Onchocerca volvulus Protein ultraspiracle homolog 0.0097 0.0648 0.3662
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.027 0.0272
Brugia malayi nuclear receptor NHR-67 0.0046 0.0225 0.0224
Trichomonas vaginalis set domain proteins, putative 0.023 0.1747 0.8652
Echinococcus granulosus dnaJ subfamily B 0.0803 0.6474 0.9922
Echinococcus multilocularis FTZ F1 alpha 0.0097 0.0648 0.094
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0157 0.0184
Loa Loa (eye worm) hypothetical protein 0.0046 0.0225 0.0238
Schistosoma mansoni cpg binding protein 0.0062 0.0356 0.0343
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0233 0.1774 0.1865
Trypanosoma brucei trypanothione reductase 0.0038 0.0165 0.0202
Schistosoma mansoni lamin 0.0028 0.0077 0.0064
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0157 0.0241
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0096 0.0139
Loa Loa (eye worm) DR-78 0.0046 0.0225 0.0238
Echinococcus multilocularis purine nucleoside phosphorylase 0.0028 0.0077 0.0111
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0558 0.4451 0.6821
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0157 0.0611
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0224 0.0237
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0105 0.0711 0.1199
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0069 0.0059
Onchocerca volvulus 0.0028 0.0077 0.0367
Schistosoma mansoni lamin 0.0028 0.0077 0.0064
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0051 0.027 0.0414
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0097 0.0648 0.0993
Loa Loa (eye worm) hypothetical protein 0.0126 0.0885 0.0936
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0014
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0013 0.0019
Mycobacterium ulcerans beta-lactamase 0.0105 0.0711 0.132
Brugia malayi nuclear receptor NHR-88 0.0097 0.0648 0.0672
Loa Loa (eye worm) hypothetical protein 0.011 0.0759 0.0803
Schistosoma mansoni ap endonuclease 0.0038 0.0157 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0237 0.0251
Trypanosoma brucei cytochrome P450, putative 0.0046 0.0224 0.0337
Toxoplasma gondii exonuclease III APE 0.0038 0.0157 0.0822
Trypanosoma brucei hypothetical protein, conserved 0.0105 0.0711 0.1449
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0105 0.0711 0.0698
Echinococcus multilocularis nAChR subunit 0.002 0.0013 0.0019
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0165 0.0174
Entamoeba histolytica rodhanase-like domain containing protein 0.0126 0.0885 0.6143
Echinococcus granulosus acetylcholinesterase 0.0065 0.0388 0.0595
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0135 0.0958 0.139
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0157 0.0184
Brugia malayi ecdysone receptor 0.0046 0.0225 0.0224
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0165 0.0167
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0046 0.0225 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0097 0.0648 0.0672
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0269 0.0285
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0388 0.305 0.3041
Schistosoma mansoni steroid hormone receptor ad4bp 0.0097 0.0648 0.0636
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0126 0.0885 0.1357
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0392 0.3081 0.4722
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.002 0.0013 0.002
Echinococcus multilocularis zinc finger protein 0.0028 0.0077 0.0111
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0269 0.0272
Echinococcus granulosus microtubule associated protein 2 0.0809 0.6525 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0014
Onchocerca volvulus 0.003 0.0096 0.0476
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.002 0.0013 0.0019
Brugia malayi intermediate filament protein 0.0028 0.0077 0.0067
Loa Loa (eye worm) hypothetical protein 0.0046 0.0225 0.0238
Echinococcus multilocularis thyroid hormone receptor alpha 0.0489 0.3882 0.5629
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.018 0.0783
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.1774 0.1763
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0097 0.0648 0.0672
Loa Loa (eye worm) hypothetical protein 0.0097 0.0648 0.0685
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0126 0.0885 0.419
Echinococcus granulosus tar DNA binding protein 0.0133 0.0949 0.1454
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0069 0.0059
Schistosoma mansoni cpg binding protein 0.0056 0.0313 0.03
Loa Loa (eye worm) hypothetical protein 0.0085 0.0545 0.0577
Schistosoma mansoni thyroid hormone receptor 0.0489 0.3882 0.3874
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0135 0.0958 0.1469
Echinococcus granulosus FTZ F1 alpha 0.0097 0.0648 0.0993
Schistosoma mansoni hypothetical protein 0.0392 0.3081 0.3072
Brugia malayi Rhodanese-like domain containing protein 0.0126 0.0885 0.0924
Echinococcus granulosus tumor protein p63 0.0396 0.3117 0.4777
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0097 0.0648 0.0672
Brugia malayi CXXC zinc finger family protein 0.0056 0.0313 0.0317
Brugia malayi hypothetical protein 0.0187 0.1393 0.1462
Echinococcus granulosus cpg binding protein 0.0062 0.0356 0.0546
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0046 0.0225 0.0212
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0046 0.0225 0.0212
Trichomonas vaginalis cdc25b, putative 0.0126 0.0885 0.419
Echinococcus granulosus Niemann Pick C1 protein 0.023 0.1743 0.267
Mycobacterium tuberculosis Conserved protein 0.0105 0.0711 0.1199
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0269 0.0413
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.0711 0.3284
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0105 0.0711 0.0739
Brugia malayi latrophilin 2 splice variant baaae 0.011 0.0759 0.0791
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.043 0.0624
Loa Loa (eye worm) hypothetical protein 0.0046 0.0225 0.0238
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.043 0.0809
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0073 0.0112
Echinococcus multilocularis beta LACTamase domain containing family member 0.0105 0.0711 0.103
Schistosoma mansoni coup transcription factor 0.0097 0.0648 0.0636
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0126 0.0885 0.419
Loa Loa (eye worm) hypothetical protein 0.0046 0.0225 0.0238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0097 0.0648 0.0685
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0231 0.0353
Schistosoma mansoni thyroid hormone receptor 0.0489 0.3882 0.3874
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.0033 0.0035
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.002 0.0013 0.002
Plasmodium vivax hypothetical protein, conserved 0.0105 0.0711 0.5888
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0118 0.082 0.0808
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0097 0.0648 0.0672
Echinococcus granulosus carboxylesterase 5A 0.0065 0.0388 0.0595
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0157 0.114 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0135 0.0958 0.1668
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0046 0.0225 0.0345
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0097 0.0648 0.0672
Schistosoma mansoni nuclear receptor nhr-48 0.0046 0.0225 0.0212
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.002 0.0013 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0711 0.1449
Schistosoma mansoni retinoic acid receptor RXR 0.0097 0.0648 0.0636
Echinococcus granulosus purine nucleoside phosphorylase 0.0028 0.0077 0.0117
Onchocerca volvulus 0.0126 0.0885 0.5031
Loa Loa (eye worm) uridine phosphorylase 0.0028 0.0077 0.0081
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0165 0.0202
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.002 0.0013 0.0019
Brugia malayi beta-lactamase 0.0105 0.0711 0.0739
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0558 0.4451 0.47
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0046 0.0225 0.1222
Plasmodium vivax glutathione reductase, putative 0.0038 0.0165 0.0664
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0225 0.0212
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0029 0.0031
Loa Loa (eye worm) hypothetical protein 0.0046 0.0225 0.0238
Loa Loa (eye worm) hypothetical protein 0.0051 0.027 0.0286
Echinococcus granulosus intermediate filament protein 0.0028 0.0077 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0097 0.0648 0.0672
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0014
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0558 0.4451 0.4444
Onchocerca volvulus 0.0126 0.0885 0.5031
Brugia malayi Bromodomain containing protein 0.0045 0.0216 0.0215
Mycobacterium ulcerans aldehyde dehydrogenase 0.0135 0.0958 0.1836
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0231 0.1294
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0157 0.0152
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.043 0.0659
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0157 0.0166
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.0711 0.3284
Trypanosoma cruzi cytochrome P450, putative 0.0046 0.0224 0.0337
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0096 0.0083
Brugia malayi uridine phosphorylase family protein 0.0028 0.0077 0.0067
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.0572 0.0937
Echinococcus granulosus sterol regulatory element binding protein 0.023 0.1743 0.267
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0097 0.0648 0.0672
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0231 0.0798
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0028 0.0077 0.0111
Mycobacterium tuberculosis Conserved protein 0.0105 0.0711 0.1199
Loa Loa (eye worm) hypothetical protein 0.0076 0.0472 0.0499
Loa Loa (eye worm) hypothetical protein 0.0046 0.0225 0.0238
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0118 0.082 0.0808
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0097 0.0648 0.094
Onchocerca volvulus Bile acid receptor homolog 0.0097 0.0648 0.3662
Echinococcus multilocularis acetylcholinesterase 0.0065 0.0388 0.0563
Mycobacterium tuberculosis Probable lipase LipE 0.0105 0.0711 0.1199
Onchocerca volvulus 0.0058 0.0326 0.1805
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0246 0.0377
Echinococcus granulosus geminin 0.0533 0.4246 0.6507
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0157 0.0228
Echinococcus granulosus ecdysone induced protein 78C 0.0097 0.0648 0.0993
Echinococcus multilocularis acetylcholinesterase 0.0065 0.0388 0.0563
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0388 0.305 0.3217
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0169 0.0245
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0073 0.0106
Brugia malayi Bromodomain containing protein 0.0087 0.0566 0.0586
Mycobacterium ulcerans aldehyde dehydrogenase 0.0135 0.0958 0.1836
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0157 0.0168
Schistosoma mansoni nuclear receptor 0.0046 0.0225 0.0212
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.0572 0.0937
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0014
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0069 0.01
Mycobacterium ulcerans short chain dehydrogenase 0.0561 0.4476 0.9159
Brugia malayi nuclear receptor NHR-88 0.0046 0.0225 0.0224
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0126 0.0885 0.1284
Trichomonas vaginalis conserved hypothetical protein 0.023 0.1743 0.863
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0097 0.0648 0.0993
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0027 0.0069 0.0059
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.027 0.0272
Brugia malayi Thioredoxin reductase 0.0038 0.0165 0.0161
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0097 0.0648 0.0993
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.043 0.0442
Echinococcus granulosus purine nucleoside phosphorylase 0.0028 0.0077 0.0117
Mycobacterium tuberculosis Conserved protein 0.0105 0.0711 0.1199
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0157 0.5
Brugia malayi beta-lactamase family protein 0.0105 0.0711 0.0739
Entamoeba histolytica rodhanase-like domain containing protein 0.0126 0.0885 0.6143
Loa Loa (eye worm) hypothetical protein 0.0046 0.0225 0.0238
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0097 0.0648 0.0672
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0225 0.0345
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0051 0.027 0.0286
Schistosoma mansoni methylthioadenosine phosphorylase 0.0028 0.0077 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0246 0.0233
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0065 0.0388 0.0375
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.1045 0.1602
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0013 0.0019
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0126 0.0885 0.419
Toxoplasma gondii thioredoxin reductase 0.0038 0.0165 0.0896
Schistosoma mansoni uridine phosphorylase 0.0028 0.0077 0.0064
Echinococcus multilocularis purine nucleoside phosphorylase 0.0028 0.0077 0.0111
Echinococcus multilocularis protein dispatched 1 0.023 0.1743 0.2527
Brugia malayi nuclear hormone receptor 0.0046 0.0225 0.0224
Brugia malayi nuclear hormone receptor family member nhr-6 0.0046 0.0225 0.0224
Loa Loa (eye worm) hypothetical protein 0.0097 0.0648 0.0685
Brugia malayi steroid hormone receptor 0.0097 0.0648 0.0672
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0262 0.2007 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0648 0.0685
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0262 0.2007 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.027 0.0286
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.1101 0.1596
Schistosoma mansoni transcription factor LCR-F1 0.0187 0.1393 0.1382
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0097 0.0648 0.0993
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0097 0.0648 0.094
Schistosoma mansoni hypothetical protein 0.0071 0.0431 0.0418
Onchocerca volvulus 0.0105 0.0711 0.4023
Brugia malayi nuclear hormone receptor family member odr-7 0.0046 0.0225 0.0224
Entamoeba histolytica rodhanase-like domain containing protein 0.0126 0.0885 0.6143
Echinococcus granulosus carbonic anhydrase II 0.0118 0.082 0.1256
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0118 0.082 0.0867
Loa Loa (eye worm) hypothetical protein 0.0065 0.0388 0.041
Treponema pallidum uridine phosphorylase (udp) 0.0157 0.114 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.002 0.0013 0.0014
Onchocerca volvulus 0.0056 0.0313 0.1728
Echinococcus multilocularis dnaJ subfamily B 0.0803 0.6474 0.9389
Echinococcus multilocularis lamin dm0 0.0028 0.0077 0.0111
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0431 0.0625
Schistosoma mansoni ap endonuclease 0.0038 0.0157 0.0144
Echinococcus multilocularis purine nucleoside phosphorylase 0.0028 0.0077 0.0111
Echinococcus multilocularis protein patched 0.023 0.1743 0.2527
Brugia malayi Nuclear hormone receptor-like 1 0.0097 0.0648 0.0672
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0126 0.0885 0.419
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0073
Loa Loa (eye worm) glutathione reductase 0.0038 0.0165 0.0174
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0096 0.0083
Schistosoma mansoni microtubule-associated protein tau 0.0809 0.6525 0.6521
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0013 0.002
Toxoplasma gondii ABC1 family protein 0.0105 0.0711 0.5991
Echinococcus multilocularis carbonic anhydrase II 0.0118 0.082 0.1188
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0262 0.2007 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0046 0.0225 0.1222
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.0653 0.109
Schistosoma mansoni bromodomain containing protein 0.0075 0.0463 0.045
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0081
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0233 0.1774 0.2718
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0051 0.027 0.0286
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0015 0.0002
Echinococcus granulosus jun protein 0.0087 0.0565 0.0866
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.0077
Echinococcus granulosus purine nucleoside phosphorylase 0.0028 0.0077 0.0117
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0097 0.0648 0.0636
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.002 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0073
Echinococcus multilocularis musashi 0.0028 0.0077 0.0111
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0097 0.0648 0.0636
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0014
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0118 0.082 0.0854
Echinococcus granulosus purine nucleoside phosphorylase 0.0028 0.0077 0.0117
Schistosoma mansoni uridine phosphorylase 0.0028 0.0077 0.0064
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.0653 0.109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.1774 0.1763
Schistosoma mansoni hypothetical protein 0.0051 0.0269 0.0257
Loa Loa (eye worm) hypothetical protein 0.0105 0.0711 0.0752
Echinococcus multilocularis geminin 0.0533 0.4246 0.6158
Brugia malayi tailless protein 0.0046 0.0225 0.0224
Brugia malayi hypothetical protein 0.0051 0.027 0.0272
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0028 0.0077 0.0081
Schistosoma mansoni aldehyde dehydrogenase 0.0135 0.0958 0.0947
Onchocerca volvulus 0.0105 0.0711 0.4023
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.002 0.0013 0.0019
Leishmania major hypothetical protein, conserved 0.0105 0.0711 0.1449
Echinococcus multilocularis tumor protein p63 0.0396 0.3117 0.452
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0014
Brugia malayi Cytochrome P450 family protein 0.0058 0.0324 0.033
Schistosoma mansoni nuclear hormone receptor 0.0097 0.0648 0.0636
Echinococcus granulosus beta LACTamase domain containing family member 0.0105 0.0711 0.1089
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.018 0.1033
Schistosoma mansoni methylthioadenosine phosphorylase 0.0028 0.0077 0.0064
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0097 0.0648 0.0636
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0014
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0118 0.082 0.0854
Brugia malayi hypothetical protein 0.0068 0.0411 0.0421
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0073
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0027 0.0069 0.0073
Echinococcus multilocularis tar DNA binding protein 0.0133 0.0949 0.1376
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0097 0.0648 0.0685
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.1774 0.1763
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0097 0.0648 0.0685
Loa Loa (eye worm) RNA binding protein 0.0133 0.0949 0.1004
Brugia malayi nuclear receptor RXR 0.0046 0.0225 0.0224
Schistosoma mansoni cpg binding protein 0.0062 0.0356 0.0343
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.043 0.0418
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.0572 0.7811
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0014
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.1101 0.1152
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0097 0.0648 0.0993
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0014
Trichomonas vaginalis cdc25c, putative 0.0126 0.0885 0.419
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0046 0.0225 0.0326
Trichomonas vaginalis cdc25b, putative 0.0126 0.0885 0.419
Brugia malayi hypothetical protein 0.0051 0.027 0.0272
Loa Loa (eye worm) hypothetical protein 0.0097 0.0648 0.0685
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0246 0.0357
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0431 0.0661
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0073 0.006
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.002 0.0013 0.0019
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.0653 0.9086
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0069 0.0059
Mycobacterium leprae Probable lipase LipE 0.0105 0.0711 1
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.018 0.0534
Echinococcus multilocularis ecdysone induced protein 78C 0.0097 0.0648 0.094
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.1914 0.2024
Brugia malayi RNA binding protein 0.0133 0.0949 0.0991
Schistosoma mansoni cellular tumor antigen P53 0.0058 0.0326 0.0313
Schistosoma mansoni hypothetical protein 0.0533 0.4246 0.4239
Mycobacterium tuberculosis Probable lipase LipD 0.0105 0.0711 0.1199
Schistosoma mansoni hypothetical protein 0.0022 0.0029 0.0016
Loa Loa (eye worm) hypothetical protein 0.0046 0.0225 0.0238
Toxoplasma gondii phosphorylase family protein 0.0028 0.0077 0.0071
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.1517 0.1605
Echinococcus granulosus uridine phosphorylase 1 0.0028 0.0077 0.0117
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0105 0.0711 0.0698
Echinococcus multilocularis cpg binding protein 0.0062 0.0356 0.0516
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0187 0.1393 0.2135
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0013 0.0019
Echinococcus granulosus purine nucleoside phosphorylase 0.0028 0.0077 0.0117
Trypanosoma brucei carbonic anhydrase-like protein 0.0118 0.082 0.1699
Loa Loa (eye worm) hypothetical protein 0.0105 0.0711 0.0752
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0013 0.002
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.0789 0.672
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0097 0.0648 0.0672
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0233 0.1774 0.2572
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0118 0.082 0.1699
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0013 0.0019
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0013 0.002
Brugia malayi nuclear hormone receptor 0.0097 0.0648 0.0672
Schistosoma mansoni hypothetical protein 0.0803 0.6474 0.647
Brugia malayi Cytochrome P450 family protein 0.0046 0.0224 0.0223
Mycobacterium tuberculosis Probable esterase LipL 0.0105 0.0711 0.1199
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0046 0.0225 0.0326
Plasmodium falciparum purine nucleoside phosphorylase 0.0157 0.114 1
Onchocerca volvulus 0.0097 0.0648 0.3662
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0225 0.0212
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0269 0.0391
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0157 0.0822
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.002 0.0013 0.002
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.002 0.0013 0.002
Brugia malayi Rhodanese-like domain containing protein 0.0126 0.0885 0.0924
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0185 0.0268
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.1101 0.1089
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0558 0.4451 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0097 0.0648 0.0672
Brugia malayi glutathione reductase 0.0038 0.0165 0.0161
Echinococcus granulosus acetylcholinesterase 0.0065 0.0388 0.0595
Schistosoma mansoni patched 1 0.023 0.1743 0.1732
Entamoeba histolytica hypothetical protein 0.0187 0.1393 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0246 0.0233
Echinococcus granulosus purine nucleoside phosphorylase 0.0028 0.0077 0.0117
Brugia malayi Calcitonin receptor-like protein seb-1 0.0162 0.1182 0.1238
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0118 0.082 0.1699
Onchocerca volvulus 0.0105 0.0711 0.4023
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0014
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0096 0.0249
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0097 0.0648 0.0636
Echinococcus granulosus nuclear receptor nhr 48 0.0046 0.0225 0.0345
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0157 0.114 0.5509
Brugia malayi bZIP transcription factor family protein 0.0087 0.0565 0.0585
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0157 0.0417
Brugia malayi conserved hypotetical protein 0.0046 0.0225 0.0224
Brugia malayi Nuclear hormone receptor E75 0.0046 0.0225 0.0224
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0097 0.0648 0.0993
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0014
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.043 0.2687
Toxoplasma gondii Purine nucleoside phosphorylase 0.0157 0.114 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.0653 0.109
Brugia malayi Steroid receptor seven-up type 2 0.0097 0.0648 0.0672
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0162 0.1182 0.1238
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0269 0.0272
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0262 0.2007 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.023 0.1743 0.1732
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0157 0.114 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0097 0.0648 0.0672
Trypanosoma cruzi cytochrome P450, putative 0.0046 0.0224 0.0337
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0097 0.0648 0.094
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0069 0.01
Schistosoma mansoni intermediate filament proteins 0.0028 0.0077 0.0064
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.002 0.0013 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0949 0.0937
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0013 0.002
Echinococcus multilocularis carboxylesterase 5A 0.0065 0.0388 0.0563
Schistosoma mansoni hypothetical protein 0.0051 0.0269 0.0257
Brugia malayi Carboxylesterase family protein 0.0065 0.0388 0.0397
Loa Loa (eye worm) hypothetical protein 0.0046 0.0225 0.0238
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0097 0.0648 0.3662
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0187 0.1393 0.202
Echinococcus multilocularis sterol regulatory element binding protein 0.023 0.1743 0.2527
Entamoeba histolytica hypothetical protein 0.0187 0.1393 1
Onchocerca volvulus 0.0126 0.0885 0.5031
Loa Loa (eye worm) hypothetical protein 0.0097 0.0648 0.0685
Echinococcus granulosus Nuclear hormone receptor HR96 0.0046 0.0225 0.0345
Echinococcus granulosus lamin 0.0028 0.0077 0.0117
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.002 0.0013 0.0014
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0157 0.114 0.8078
Loa Loa (eye worm) ACC-1 protein 0.002 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0046 0.0225 0.0238
Brugia malayi Carboxylesterase family protein 0.0065 0.0388 0.0397
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0157 0.0184
Loa Loa (eye worm) hypothetical protein 0.0105 0.0711 0.0752
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0854 0.6896 1
Plasmodium falciparum thioredoxin reductase 0.0038 0.0165 0.0896
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0157 0.0417
Mycobacterium ulcerans lipase LipD 0.0105 0.0711 0.132
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0046 0.0225 0.0326
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.0572 0.0937
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0105 0.0711 0.1199
Toxoplasma gondii phosphorylase family protein 0.0028 0.0077 0.0071
Mycobacterium ulcerans hypothetical protein 0.0105 0.0711 0.132
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0558 0.4451 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0233 0.1774 0.2572
Brugia malayi Pre-SET motif family protein 0.0202 0.1517 0.1593
Echinococcus multilocularis microtubule associated protein 2 0.0809 0.6525 0.9463
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.0711 0.3284
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0157 0.0184
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0558 0.4451 0.6455
Leishmania major carbonic anhydrase-like protein 0.0118 0.082 0.1699
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0157 0.0417
Mycobacterium ulcerans hydrolase/amidase 0.061 0.488 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0231 0.0798
Loa Loa (eye worm) hypothetical protein 0.0116 0.0804 0.0851
Schistosoma mansoni hypothetical protein 0.0187 0.1393 0.1382
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0013 0.0019
Brugia malayi Cytochrome P450 family protein 0.0046 0.0224 0.0223
Loa Loa (eye worm) hypothetical protein 0.0116 0.0804 0.0851
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.002 0.0013 0.002
Loa Loa (eye worm) acetyltransferase 0.0152 0.1101 0.1164
Brugia malayi Nuclear hormone receptor E75 0.0046 0.0225 0.0224
Loa Loa (eye worm) hypothetical protein 0.0097 0.0648 0.0685
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.002 0.0013 0.002
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0324 0.0343
Schistosoma mansoni memapsin-2 (A01 family) 0.0417 0.3288 0.3279
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0165 0.0252
Brugia malayi hypothetical protein 0.0046 0.0225 0.0224
Brugia malayi TAR-binding protein 0.0133 0.0949 0.0991
Mycobacterium ulcerans aldehyde dehydrogenase 0.0135 0.0958 0.1836
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0014
Echinococcus granulosus nAChR subunit 0.002 0.0013 0.002
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0087 0.0565 0.0866
Echinococcus multilocularis nuclear receptor nhr 48 0.0046 0.0225 0.0326
Loa Loa (eye worm) hypothetical protein 0.0065 0.0388 0.041
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0097 0.0648 0.0993
Echinococcus granulosus lamin dm0 0.0028 0.0077 0.0117
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0949 0.0937
Loa Loa (eye worm) hypothetical protein 0.1164 0.9455 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.0711 0.0752
Onchocerca volvulus 0.0068 0.0411 0.2294
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0097 0.0648 0.0636
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0069 0.0056
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.0572 0.0937
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.043 0.0455
Loa Loa (eye worm) hypothetical protein 0.0105 0.0711 0.0752
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.0572 0.0937
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0097 0.0648 0.094
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0126 0.0885 0.0873
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0077 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0949 0.0937
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0392 0.3081 0.4468
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0165 0.0239
Mycobacterium ulcerans esterase/lipase LipP 0.0105 0.0711 0.132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0097 0.0648 0.0685
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0097 0.0648 0.094
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0157 0.0588
Plasmodium falciparum glutathione reductase 0.0038 0.0165 0.0896
Onchocerca volvulus 0.0046 0.0225 0.1222
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0097 0.0648 0.0672
Schistosoma mansoni hypothetical protein 0.0533 0.4246 0.4239
Trichomonas vaginalis penicillin-binding protein, putative 0.0105 0.0711 0.3284
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.002 0.0013 0.0014
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0126 0.0885 0.419
Loa Loa (eye worm) hypothetical protein 0.0046 0.0225 0.0238
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0224 0.1693 0.1682
Loa Loa (eye worm) hypothetical protein 0.0051 0.027 0.0286
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0069 0.0056
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0135 0.0958 0.2016
Leishmania major cytochrome p450-like protein 0.0046 0.0224 0.0337
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0077 0.0067
Loa Loa (eye worm) CYP4Cod1 0.0046 0.0224 0.0237
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0224 0.0237
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0097 0.0648 0.0685
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.043 0.0809
Schistosoma mansoni hypothetical protein 0.0027 0.0069 0.0056
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0077 0.0117
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0046 0.0225 0.0238
Chlamydia trachomatis AMP nucleosidase 0.0028 0.0077 0.5
Brugia malayi MTAP 0.0028 0.0077 0.0067
Loa Loa (eye worm) hypothetical protein 0.0051 0.027 0.0286
Onchocerca volvulus 0.023 0.1747 1
Echinococcus multilocularis jun protein 0.0087 0.0565 0.0819
Echinococcus granulosus Nuclear hormone receptor HR96 0.0046 0.0225 0.0345
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0028 0.0077 0.0067
Loa Loa (eye worm) hypothetical protein 0.0558 0.4451 0.4708
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0133 0.0949 0.1004
Loa Loa (eye worm) beta-lactamase 0.0105 0.0711 0.0752
Brugia malayi hypothetical protein 0.1164 0.9455 1
Mycobacterium leprae conserved hypothetical protein 0.0105 0.0711 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0157 0.114 0.5509
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0157 0.0152
Echinococcus multilocularis lamin 0.0028 0.0077 0.0111
Loa Loa (eye worm) ACC-1 protein 0.002 0.0013 0.0014
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0046 0.0225 0.0326
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0185 0.0283
Echinococcus multilocularis GPCR, family 2 0.0051 0.0269 0.0391
Echinococcus multilocularis purine nucleoside phosphorylase 0.0028 0.0077 0.0111
Echinococcus granulosus thyroid hormone receptor alpha 0.0046 0.0225 0.0345
Brugia malayi hypothetical protein 0.0046 0.0225 0.0224
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0558 0.4451 1
Echinococcus granulosus GPCR family 2 0.0051 0.0269 0.0413
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0014
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0269 0.0391
Entamoeba histolytica hypothetical protein 0.0187 0.1393 1
Brugia malayi follicle stimulating hormone receptor 0.025 0.1914 0.2013
Echinococcus multilocularis Niemann Pick C1 protein 0.023 0.1743 0.2527
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0269 0.0413
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0027 0.0069 0.0059
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0013 0.002
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0949 0.0937
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0162 0.1182 0.125
Brugia malayi orphan nuclear receptor NR2E1 0.0046 0.0225 0.0224
Schistosoma mansoni RAR-like nuclear receptor 0.0097 0.0648 0.0636
Loa Loa (eye worm) hypothetical protein 0.0105 0.0711 0.0752
Loa Loa (eye worm) hypothetical protein 0.0027 0.0073 0.0077
Toxoplasma gondii aldehyde dehydrogenase 0.0135 0.0958 0.8305
Brugia malayi RNA recognition motif domain containing protein 0.0133 0.0949 0.0991
Loa Loa (eye worm) LGC-31 protein 0.002 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0097 0.0648 0.0685
Echinococcus granulosus carbonic anhydrase 0.0027 0.0069 0.0106
Brugia malayi beta-lactamase family protein 0.0105 0.0711 0.0739
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0013 0.0019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0233 0.1774 0.2718
Entamoeba histolytica hypothetical protein 0.0187 0.1393 1
Brugia malayi ecdysteroid receptor 0.0097 0.0648 0.0672
Schistosoma mansoni purine nucleoside phosphorylase 0.0028 0.0077 0.0064
Schistosoma mansoni zinc finger protein 0.0046 0.0225 0.0212
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0028 0.0077 0.0366
Loa Loa (eye worm) hypothetical protein 0.0126 0.0885 0.0936
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0046 0.0224 0.0307
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0668 0.5363 1
Echinococcus granulosus zinc finger protein 0.0028 0.0077 0.0118
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.023 0.1743 0.1843
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.027 0.0258
Echinococcus granulosus purine nucleoside phosphorylase 0.0028 0.0077 0.0117
Onchocerca volvulus 0.0046 0.0225 0.1222
Mycobacterium tuberculosis Probable reductase 0.0088 0.0572 0.0937
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0231 0.151
Trichomonas vaginalis penicillin-binding protein, putative 0.0105 0.0711 0.3284
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0097 0.0648 0.0672
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0014
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0231 0.151
Trichomonas vaginalis esterase, putative 0.0105 0.0711 0.3284
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0013 0.002
Onchocerca volvulus 0.0126 0.0885 0.5031
Loa Loa (eye worm) hypothetical protein 0.0046 0.0225 0.0238
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0711 0.1449
Echinococcus granulosus purine nucleoside phosphorylase 0.0028 0.0077 0.0117
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0558 0.4451 0.9107
Mycobacterium tuberculosis Probable oxidoreductase 0.0561 0.4476 0.8322
Loa Loa (eye worm) nuclear receptor NHR-67 0.0046 0.0225 0.0238
Loa Loa (eye worm) hypothetical protein 0.0052 0.0281 0.0297
Schistosoma mansoni aldehyde dehydrogenase 0.0135 0.0958 0.0947
Schistosoma mansoni nuclear receptor 0.0046 0.0225 0.0212
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0014
Brugia malayi PHD-finger family protein 0.0034 0.0124 0.0118
Loa Loa (eye worm) hypothetical protein 0.023 0.1743 0.1843
Loa Loa (eye worm) carbonic anhydrase 3 0.0118 0.082 0.0867
Loa Loa (eye worm) hypothetical protein 0.0097 0.0648 0.0685
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0014
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0388 0.305 0.4675
Echinococcus granulosus carbonic anhydrase 0.0027 0.0069 0.0106
Loa Loa (eye worm) nuclear hormone receptor 0.0046 0.0225 0.0238
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0558 0.4451 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0105 0.0711 0.0752
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0013 0.002
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.043 0.0809
Brugia malayi nuclear receptor RXR 0.0051 0.027 0.0272
Loa Loa (eye worm) hypothetical protein 0.0162 0.1182 0.125
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0225 0.0326
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.002 0.0013 0.0019
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0097 0.0648 0.094
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0097 0.0648 0.0685
Loa Loa (eye worm) carboxylesterase 0.0065 0.0388 0.041
Echinococcus multilocularis uridine phosphorylase 1 0.0028 0.0077 0.0111
Schistosoma mansoni purine nucleoside phosphorylase 0.0028 0.0077 0.0064
Schistosoma mansoni hypothetical protein 0.0051 0.0269 0.0257
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0097 0.0648 0.0636
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0097 0.0648 0.0672
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0077 0.0081
Schistosoma mansoni jun-related protein 0.0071 0.0431 0.0418
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0165 0.0664
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0014
Leishmania major trypanothione reductase 0.0038 0.0165 0.0202
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0388 0.305 0.3226
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0105 0.0711 0.132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0097 0.0648 0.0685
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0069 0.0056
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.043 0.0809
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0388 0.305 0.4424
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0051 0.027 0.0392
Loa Loa (eye worm) hypothetical protein 0.0051 0.0269 0.0285
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0157 0.0757
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0949 0.0937
Schistosoma mansoni methylthioadenosine phosphorylase 0.0028 0.0077 0.0064
Loa Loa (eye worm) hypothetical protein 0.0046 0.0225 0.0238
Loa Loa (eye worm) acetylcholinesterase 1 0.0065 0.0388 0.041
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0051 0.027 0.0258
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0169 0.0259
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0087 0.0565 0.0819
Onchocerca volvulus 0.0028 0.0077 0.0367
Echinococcus granulosus Protein patched homolog 1 0.023 0.1743 0.267
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0157 0.114 0.8078
Loa Loa (eye worm) hypothetical protein 0.0058 0.0326 0.0345
Brugia malayi Pre-SET motif family protein 0.003 0.0096 0.0087
Loa Loa (eye worm) hypothetical protein 0.0041 0.0186 0.0197
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.026
Loa Loa (eye worm) steroid hormone receptor 0.0097 0.0648 0.0685
Brugia malayi CHE-14 protein 0.023 0.1743 0.1832
Echinococcus granulosus methylthioadenosine phosphorylase 0.0028 0.0077 0.0117
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0105 0.0711 0.1199
Echinococcus granulosus carbonic anhydrase 0.0027 0.0069 0.0106
Schistosoma mansoni zinc finger protein 0.0028 0.0077 0.0064
Loa Loa (eye worm) TAR-binding protein 0.0133 0.0949 0.1004
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0843 0.0831
Mycobacterium tuberculosis Probable hydrolase 0.0105 0.0711 0.1199

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 26 % The compound was tested for the in vitro inhibition of 5-lipoxygenase (5-lo) from the 20000 g supernatant of RBI-1 cells measured at a concentration of 30 microM. ChEMBL. 2066989
Inhibition (binding) = 26 % The compound was tested for the in vitro inhibition of 5-lipoxygenase (5-lo) from the 20000 g supernatant of RBI-1 cells measured at a concentration of 30 microM. ChEMBL. 2066989

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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