TDR Targets

Basic information

Technical information

TDR Targets ID: 112496
Name: 2-[4-[(2-oxocyclopentyl)methyl]phenyl]acetic acid
MW: 232.275 | Formula: C14H16O3
H donors: 1 H acceptors: 3 LogP: 1.85 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)Cc1ccc(cc1)CC1CCCC1=O
InChi: 1S/C14H16O3/c15-13-3-1-2-12(13)8-10-4-6-11(7-5-10)9-14(16)17/h4-7,12H,1-3,8-9H2,(H,16,17)
InChiKey: ZTILNNBAMDTFFE-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-[4-[(2-oxocyclopentyl)methyl]phenyl]ethanoic acid
2-[4-[(2-ketocyclopentyl)methyl]phenyl]acetic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	RNA binding protein	0.0126	0.1184	0.1349
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.0064	0.0352	0.0401
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	0.0415	0.502	0.5719
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0346	0.0395
Echinococcus granulosus	frizzled	0.0202	0.2194	0.2503
Echinococcus multilocularis	secreted frizzled protein	0.0202	0.2194	0.2503
Toxoplasma gondii	endonuclease IV APN	0.0093	0.0733	0.2055
Brugia malayi	6-phosphofructokinase	0.0131	0.1248	0.1421
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0089	0.0679	0.1848
Loa Loa (eye worm)	animal heme peroxidase	0.0063	0.0346	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0279	0.3209	0.3655
Brugia malayi	6-phosphofructokinase	0.0131	0.1248	0.1421
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0217	0.2389	1
Loa Loa (eye worm)	phosphofructokinase	0.0131	0.1248	0.1421
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.0415	0.502	0.5727
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0103	0.0875	0.1744
Echinococcus multilocularis	frizzled	0.0202	0.2194	0.2503
Echinococcus granulosus	poly adp ribose polymerase 2	0.0089	0.0687	0.0784
Brugia malayi	wnt family protein	0.0279	0.3209	0.3655
Loa Loa (eye worm)	hypothetical protein	0.0698	0.8779	1
Brugia malayi	hypothetical protein	0.0063	0.0346	0.0395
Mycobacterium tuberculosis	Probable reductase	0.013	0.1234	0.4302
Schistosoma mansoni	wnt related	0.0279	0.3209	0.366
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0687	0.0783
Loa Loa (eye worm)	frizzled/Smoothened family membrane region containing protein	0.0202	0.2194	0.25
Mycobacterium ulcerans	6-phosphofructokinase	0.0131	0.1248	0.2485
Echinococcus multilocularis	WNT	0.0279	0.3209	0.366
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0415	0.502	1
Echinococcus granulosus	netrin 1	0.0587	0.7308	0.8336
Schistosoma mansoni	frizzled	0.0202	0.2194	0.2503
Schistosoma mansoni	peroxidasin	0.0063	0.0346	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0279	0.3209	0.3655
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0227	0.2523	1
Echinococcus multilocularis	frizzled 10	0.0202	0.2194	0.2503
Loa Loa (eye worm)	hypothetical protein	0.0587	0.7308	0.8324
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0733	0.0835
Echinococcus granulosus	Protein patched homolog 1	0.0171	0.1774	0.2023
Brugia malayi	glutathione reductase	0.0057	0.0261	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0383	0.4597	0.5237
Schistosoma mansoni	wnt inhibitor frzb2	0.0202	0.2194	0.2503
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.0162	0.1659	1
Entamoeba histolytica	phosphofructokinase, putative	0.0131	0.1248	0.7519
Echinococcus multilocularis	dihydrofolate reductase	0.0089	0.0679	0.0775
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.0415	0.502	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.1248	0.5967
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0131	0.1248	0.5
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0346	0.0395
Echinococcus multilocularis	WNT	0.0279	0.3209	0.366
Brugia malayi	Animal haem peroxidase family protein	0.0063	0.0346	0.0395
Echinococcus granulosus	dihydrofolate reductase	0.0089	0.0679	0.0775
Brugia malayi	Animal haem peroxidase family protein	0.0063	0.0346	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0279	0.3209	0.3655
Brugia malayi	CHE-14 protein	0.0171	0.1774	0.2021
Echinococcus multilocularis	tar DNA binding protein	0.0126	0.1184	0.1351
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0306	0.3566	1
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0306	0.3566	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0346	0.0395
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.0875	0.4187
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.1248	0.5967
Brugia malayi	DNA-(Apurinic or apyrimidinic site) lyase	0.0093	0.0733	0.0835
Echinococcus granulosus	6 phosphofructokinase	0.0131	0.1248	0.1423
Onchocerca volvulus	Huntingtin homolog	0.0148	0.147	0.1164
Entamoeba histolytica	phosphofructokinase, putative	0.0131	0.1248	0.7519
Brugia malayi	wnt family protein	0.0279	0.3209	0.3655
Loa Loa (eye worm)	sfrp2	0.0202	0.2194	0.25
Schistosoma mansoni	netrin	0.0587	0.7308	0.8336
Schistosoma mansoni	wnt-5	0.0279	0.3209	0.366
Brugia malayi	Dihydrofolate reductase	0.0089	0.0679	0.0774
Echinococcus granulosus	peroxidasin	0.0063	0.0346	0.0395
Echinococcus multilocularis	frizzled	0.0202	0.2194	0.2503
Brugia malayi	Unc-6 protein precursor	0.0587	0.7308	0.8324
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0346	0.0395
Loa Loa (eye worm)	Wnt2 protein	0.0279	0.3209	0.3655
Echinococcus granulosus	microtubule associated protein 2	0.0697	0.8767	1
Schistosoma mansoni	wnt related	0.0279	0.3209	0.366
Onchocerca volvulus		0.0217	0.2389	0.2116
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0346	0.0395
Echinococcus granulosus	smoothened	0.0202	0.2194	0.2503
Loa Loa (eye worm)	hypothetical protein	0.0202	0.2194	0.25
Echinococcus granulosus	frizzled 5	0.0202	0.2194	0.2503
Echinococcus granulosus	Protein Wnt-11b	0.0279	0.3209	0.366
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0346	0.0395
Mycobacterium ulcerans	thymidylate synthase	0.0217	0.2389	0.4759
Echinococcus granulosus	secreted frizzled protein 5	0.0202	0.2194	0.2503
Echinococcus granulosus	thioredoxin glutathione reductase	0.0057	0.0261	0.0298
Echinococcus granulosus	frizzled 4	0.0202	0.2194	0.2503
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0195	0.2091	1
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0131	0.1248	0.2485
Brugia malayi	wnt family protein	0.0279	0.3209	0.3655
Brugia malayi	RNA recognition motif domain containing protein	0.0126	0.1184	0.1349
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0089	0.0687	0.1369
Echinococcus multilocularis	protein Wnt 1	0.0279	0.3209	0.366
Echinococcus granulosus	poly (ADP ribose) polymerase	0.005	0.0172	0.0196
Loa Loa (eye worm)	frizzled/Smoothened family membrane region containing protein	0.0202	0.2194	0.25
Loa Loa (eye worm)	hypothetical protein	0.0148	0.147	0.1674
Loa Loa (eye worm)	hypothetical protein	0.0279	0.3209	0.3655
Brugia malayi	Thioredoxin reductase	0.0057	0.0261	0.0298
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0131	0.1248	0.4362
Brugia malayi	Wnt-4 protein precursor	0.0279	0.3209	0.3655
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0346	0.0395
Echinococcus multilocularis	smoothened	0.0202	0.2194	0.2503
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0057	0.0261	0.0298
Echinococcus multilocularis	Niemann Pick C1 protein	0.0171	0.1774	0.2023
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.013	0.1234	0.4302
Echinococcus granulosus	frizzled	0.0202	0.2194	0.2503
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.1184	0.1351
Echinococcus granulosus	thymidylate synthase	0.0217	0.2389	0.2725
Brugia malayi	Animal haem peroxidase family protein	0.0063	0.0346	0.0395
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0195	0.2091	1
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.1184	0.1351
Brugia malayi	WGR domain containing protein	0.0162	0.1659	0.189
Brugia malayi	Frizzled/Smoothened family membrane region containing protein	0.0202	0.2194	0.25
Brugia malayi	Blistered cuticle protein 3	0.0063	0.0346	0.0395
Giardia lamblia	3-hydroxy-3-methylglutaryl-coenzyme A reductase	0.0195	0.2091	0.5
Loa Loa (eye worm)	6-phosphofructokinase	0.0131	0.1248	0.1421
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.1248	0.5967
Mycobacterium tuberculosis	Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase)	0.0093	0.0733	0.2085
Leishmania major	ATP-dependent phosphofructokinase	0.0131	0.1248	0.2485
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.013	0.1234	0.3246
Mycobacterium ulcerans	endonuclease IV	0.0093	0.0733	0.146
Echinococcus granulosus	protein Wnt 1	0.0279	0.3209	0.366
Echinococcus granulosus	frizzled	0.0202	0.2194	0.2503
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0037	0	0.5
Brugia malayi	Fz domain containing protein	0.0202	0.2194	0.25
Echinococcus multilocularis	protein dispatched 1	0.0171	0.1774	0.2023
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0126	0.1184	0.1349
Mycobacterium leprae	PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE)	0.0093	0.0733	0.0314
Echinococcus multilocularis	6 phosphofructokinase	0.0131	0.1248	0.1423
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.0415	0.502	0.5727
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0346	0.0395
Schistosoma mansoni	wnt related	0.0279	0.3209	0.366
Brugia malayi	dihydrofolate reductase family protein	0.0089	0.0679	0.0774
Brugia malayi	Wnt-2 protein precursor	0.0279	0.3209	0.3655
Loa Loa (eye worm)	glutathione reductase	0.0057	0.0261	0.0298
Brugia malayi	Animal haem peroxidase family protein	0.0063	0.0346	0.0395
Echinococcus multilocularis	frizzled 4	0.0202	0.2194	0.2503
Schistosoma mansoni	netrin	0.0587	0.7308	0.8336
Echinococcus multilocularis	frizzled 5	0.0202	0.2194	0.2503
Loa Loa (eye worm)	6-phosphofructokinase	0.0131	0.1248	0.1421
Schistosoma mansoni	dihydrofolate reductase	0.0089	0.0679	0.0775
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0306	0.3566	1
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0089	0.0687	0.1369
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0306	0.3566	0.7104
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.013	0.1234	0.4302
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0346	0.0395
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0306	0.3566	0.7104
Echinococcus multilocularis	netrin 1	0.0587	0.7308	0.8336
Loa Loa (eye worm)	blistered cuticle protein 3	0.0063	0.0346	0.0395
Mycobacterium tuberculosis	Probable dehydrogenase	0.013	0.1234	0.4302
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.1774	0.8484
Loa Loa (eye worm)	hypothetical protein	0.0202	0.2194	0.25
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0089	0.0687	0.0784
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0195	0.2091	1
Brugia malayi	Frizzled/Smoothened family membrane region containing protein	0.0202	0.2194	0.25
Echinococcus multilocularis	wnt family member wnt11 2	0.0279	0.3209	0.366
Loa Loa (eye worm)	thymidylate synthase	0.0217	0.2389	0.2721
Echinococcus granulosus	tar DNA binding protein	0.0126	0.1184	0.1351
Schistosoma mansoni	microtubule-associated protein tau	0.0697	0.8767	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0145	0.1428	0.5157
Brugia malayi	thymidylate synthase	0.0217	0.2389	0.2721
Entamoeba histolytica	phosphofructokinase, putative	0.0131	0.1248	0.7519
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.1184	0.1351
Leishmania major	trypanothione reductase	0.0057	0.0261	0.0521
Loa Loa (eye worm)	TAR-binding protein	0.0126	0.1184	0.1349
Echinococcus granulosus	Protein Wnt-111	0.0279	0.3209	0.366
Chlamydia trachomatis	endonuclease IV	0.0093	0.0733	1
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.0415	0.502	1
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.1184	0.1351
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.1184	0.1351
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1144	0.1303
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.013	0.1234	0.4302
Echinococcus multilocularis	thymidylate synthase	0.0217	0.2389	0.2725
Schistosoma mansoni	frizzled-like receptor	0.0202	0.2194	0.2503
Schistosoma mansoni	frizzled-like receptor	0.0202	0.2194	0.2503
Brugia malayi	wnt family protein	0.0279	0.3209	0.3655
Onchocerca volvulus	Huntingtin homolog	0.0148	0.147	0.1164
Brugia malayi	hypothetical protein	0.0147	0.1457	0.166
Loa Loa (eye worm)	hypothetical protein	0.0148	0.147	0.1674
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0162	0.1659	0.1893
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0131	0.1248	0.2485
Echinococcus granulosus	Protein Wnt-04	0.0279	0.3209	0.366
Echinococcus granulosus	sterol regulatory element binding protein	0.0171	0.1774	0.2023
Brugia malayi	Animal haem peroxidase family protein	0.0063	0.0346	0.0395
Loa Loa (eye worm)	dihydrofolate reductase	0.0089	0.0679	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0346	0.0395
Echinococcus granulosus	protein Wnt 2	0.0279	0.3209	0.366
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0415	0.502	1
Echinococcus multilocularis	microtubule associated protein 2	0.0697	0.8767	1
Echinococcus granulosus	Protein Wnt-5	0.0279	0.3209	0.366
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.013	0.1234	0.4302
Echinococcus multilocularis	protein Wnt 2	0.0279	0.3209	0.366
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.0415	0.502	1
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.0089	0.0687	0.0784
Brugia malayi	hypothetical protein	0.0148	0.147	0.1674
Loa Loa (eye worm)	animal heme peroxidase	0.0063	0.0346	0.0395
Echinococcus granulosus	secreted frizzled protein	0.0202	0.2194	0.2503
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.1248	0.5967
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0131	0.1248	0.3325
Trypanosoma brucei	trypanothione reductase	0.0057	0.0261	0.0521
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0145	0.1428	0.4377
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0217	0.2389	0.9409
Brugia malayi	Fz domain containing protein	0.0202	0.2194	0.25
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0077	0.0527	0.0601
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0217	0.2389	0.2725
Echinococcus granulosus	WGR domain containing protein	0.005	0.0172	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0346	0.0395
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0171	0.1774	0.2023
Brugia malayi	RNA binding protein	0.0126	0.1184	0.1349
Schistosoma mansoni	patched 1	0.0171	0.1774	0.2023
Schistosoma mansoni	6-phosphofructokinase	0.0131	0.1248	0.1423
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0089	0.0679	0.1353
Echinococcus multilocularis	protein patched	0.0171	0.1774	0.2023
Loa Loa (eye worm)	CWN-2 protein	0.0279	0.3209	0.3655
Brugia malayi	TAR-binding protein	0.0126	0.1184	0.1349
Schistosoma mansoni	secreted frizzled-related protein	0.0202	0.2194	0.2503
Echinococcus multilocularis	peroxidasin	0.0063	0.0346	0.0395
Echinococcus multilocularis	secreted frizzled protein	0.0202	0.2194	0.2503
Plasmodium falciparum	apurinic/apyrimidinic endonuclease Apn1, putative	0.0093	0.0733	0.1427
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0306	0.3566	0.7104
Echinococcus multilocularis	secreted frizzled protein 5	0.0202	0.2194	0.2503
Brugia malayi	hypothetical protein	0.0103	0.0875	0.0997
Loa Loa (eye worm)	animal heme peroxidase	0.0063	0.0346	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0346	0.0395
Brugia malayi	small heat shock protein	0.0698	0.8779	1
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0162	0.1659	0.1893
Toxoplasma gondii	thioredoxin reductase	0.0057	0.0261	0.0733
Brugia malayi	WGR domain containing protein	0.0089	0.0687	0.0783
Echinococcus multilocularis	sterol regulatory element binding protein	0.0171	0.1774	0.2023
Echinococcus multilocularis	wingless type MMTV integration site family	0.0279	0.3209	0.366
Trypanosoma cruzi	trypanothione reductase, putative	0.0057	0.0261	0.0521
Schistosoma mansoni	peroxidasin	0.0063	0.0346	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0415	0.502	0.5719
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0169	0.1744	0.489
Mycobacterium tuberculosis	Probable oxidoreductase	0.0145	0.1428	0.5157
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0171	0.1774	0.2021
Loa Loa (eye worm)	wnt-4 protein	0.0279	0.3209	0.3655
Plasmodium vivax	apurinic/apyrimidinic endonuclease Apn1, putative	0.0093	0.0733	0.1427
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0346	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1774	0.2021
Loa Loa (eye worm)	thioredoxin reductase	0.0057	0.0261	0.0298
Schistosoma mansoni	6-phosphofructokinase	0.0131	0.1248	0.1423
Loa Loa (eye worm)	animal heme peroxidase	0.0063	0.0346	0.0395
Brugia malayi	Peroxidasin	0.0063	0.0346	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0279	0.3209	0.3655
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0145	0.1428	0.5157
Brugia malayi	phosphofructokinase	0.0131	0.1248	0.1421
Mycobacterium tuberculosis	Hypothetical protein	0.0103	0.0875	0.2716
Schistosoma mansoni	wnt related	0.0279	0.3209	0.366
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0346	0.0395
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0162	0.1659	0.1893
Echinococcus granulosus	Niemann Pick C1 protein	0.0171	0.1774	0.2023
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.0415	0.502	0.5727
Trypanosoma brucei	poly(adp-ribose) polymerase	0.0089	0.0687	0.1369

Activities

Activity type	Activity value	Assay description	Source	Reference
ID50 (functional)	= 9.1 mg kg-1	Antiinflammatory activity on peroral administration against carrageenan paw edema	ChEMBL.	6607354
ID50 (functional)	= 23 mg kg-1	Analgesic activity on peroral administration against Scald induced pain in rat paw	ChEMBL.	6607354

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL68758
PubChem: 19922618

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 112496