Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Huntingtin homolog | 0.0134 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0509 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0509 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3878 | 0.472 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2382 | 0.1964 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2382 | 0.1964 |
Schistosoma mansoni | transient receptor potential channel | 0.0064 | 0.3951 | 0.4854 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.4591 | 0.4591 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0064 | 0.3951 | 0.4854 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.1316 | 0.085 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.4591 | 0.6034 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1287 | 0.1287 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0509 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0509 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0509 | 0.5 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0064 | 0.3951 | 0.4854 |
Brugia malayi | RNA binding protein | 0.0063 | 0.3878 | 0.355 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0096 | 0.6744 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.7413 | 0.7413 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0104 | 0.7413 | 0.7274 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0104 | 0.7413 | 0.7413 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1873 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0509 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0064 | 0.3951 | 0.4854 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.3878 | 0.472 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0509 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0509 | 0.0509 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.1873 | 0.1026 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.1316 | 0.085 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.6744 | 0.6744 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2382 | 0.1964 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.3878 | 0.355 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0509 | 1 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0093 | 0.6469 | 0.9493 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.1316 | 0.1316 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0036 | 0.1563 | 0.0454 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3878 | 0.472 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.2382 | 0.1973 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.1873 | 0.1026 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.3878 | 0.3878 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0509 | 0.0509 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0036 | 0.1563 | 0.0454 |
Schistosoma mansoni | transient receptor potential channel | 0.0064 | 0.3951 | 0.4854 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.3878 | 0.472 |
Brugia malayi | Transient-receptor-potential like protein | 0.0036 | 0.1563 | 0.111 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0509 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3878 | 0.472 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1873 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0509 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.1873 | 0.1026 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0064 | 0.3951 | 0.4854 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.1873 | 0.1026 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2382 | 0.1964 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0509 | 0.5 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0096 | 0.6744 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.3878 | 0.3878 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.3878 | 0.355 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1873 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3676 | 0.3676 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1873 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1316 | 0.1316 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2382 | 0.1964 |
Onchocerca volvulus | Huntingtin homolog | 0.0134 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0509 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0104 | 0.7413 | 0.7274 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0509 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2382 | 0.1964 |
Brugia malayi | hypothetical protein | 0.0039 | 0.1873 | 0.1437 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3878 | 0.472 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 1 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0096 | 0.6744 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1563 | 0.1563 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2382 | 0.1964 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.3878 | 0.3878 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.2382 | 0.2382 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.4591 | 0.4301 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0509 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0509 | 0.0509 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0509 | 0.5 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0093 | 0.6469 | 0.9493 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3878 | 0.472 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0096 | 0.6744 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.