Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0057 | 0.4516 | 0.3771 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0061 | 0.4999 | 0.432 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0104 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0104 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0104 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.1196 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0104 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.1196 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0104 | 1 | 1 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0061 | 0.4999 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0104 | 1 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0061 | 0.4999 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0104 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0104 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0029 | 0.1196 | 0.1196 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0104 | 1 | 0.5 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0061 | 0.4999 | 0.4999 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0104 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0104 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0104 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0104 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0104 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0104 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0104 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0104 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0104 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.1196 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0061 | 0.4999 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0104 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.