Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.0019 | 0.0791 | 1 | |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0019 | 0.0791 | 0.0791 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0118 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0791 | 0.0791 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0019 | 0.0791 | 0.0791 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0118 | 1 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0118 | 1 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0019 | 0.0791 | 0.0791 |
Onchocerca volvulus | 0.0019 | 0.0791 | 1 | |
Loa Loa (eye worm) | ACC-1 protein | 0.0019 | 0.0791 | 0.0791 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0019 | 0.0791 | 0.0791 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0118 | 1 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0019 | 0.0791 | 0.0791 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0019 | 0.0791 | 0.0791 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0019 | 0.0791 | 0.0791 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0019 | 0.0791 | 0.0791 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0118 | 1 | 1 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0082 | 0.6671 | 0.6671 |
Schistosoma mansoni | nAChR subunit | 0.0019 | 0.0791 | 0.0791 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0019 | 0.0791 | 0.0791 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0019 | 0.0791 | 0.0791 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0019 | 0.0791 | 0.0791 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0118 | 1 | 0.5 |
Onchocerca volvulus | 0.0019 | 0.0791 | 1 | |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0019 | 0.0791 | 0.0791 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0082 | 0.6671 | 0.6671 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0019 | 0.0791 | 0.0791 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0118 | 1 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0019 | 0.0791 | 0.0791 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.6671 | 0.6671 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.6671 | 0.6671 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0019 | 0.0791 | 0.0791 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0118 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0118 | 1 | 0.5 |
Onchocerca volvulus | 0.0019 | 0.0791 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0791 | 0.0791 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0791 | 0.0791 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0791 | 0.0791 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0019 | 0.0791 | 0.0791 |
Onchocerca volvulus | 0.0019 | 0.0791 | 1 | |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0019 | 0.0791 | 0.0791 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0019 | 0.0791 | 0.0791 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0118 | 1 | 0.5 |
Onchocerca volvulus | Putative nachr subunit | 0.0019 | 0.0791 | 1 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0019 | 0.0791 | 0.0791 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.6671 | 0.6671 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0019 | 0.0791 | 0.0791 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0019 | 0.0791 | 0.0791 |
Onchocerca volvulus | 0.0019 | 0.0791 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0791 | 0.0791 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0019 | 0.0791 | 0.0791 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0019 | 0.0791 | 0.0791 |
Trypanosoma brucei | protein kinase, putative | 0.0118 | 1 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0019 | 0.0791 | 0.0791 |
Schistosoma mansoni | nAChR subunit | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0791 | 0.0791 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0118 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0791 | 0.0791 |
Schistosoma mansoni | nAChR subunit | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0791 | 0.0791 |
Brugia malayi | Cation transporter family protein | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0019 | 0.0791 | 0.0791 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0019 | 0.0791 | 0.0791 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0019 | 0.0791 | 0.0791 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0019 | 0.0791 | 0.0791 |
Schistosoma mansoni | nAChR subunit | 0.0019 | 0.0791 | 0.0791 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0118 | 1 | 0.5 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0082 | 0.6671 | 0.6671 |
Echinococcus granulosus | nAChR subunit | 0.0019 | 0.0791 | 0.0791 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0082 | 0.6671 | 0.6671 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0791 | 0.0791 |
Schistosoma mansoni | apoptosis regulator bax | 0.0082 | 0.6671 | 0.6671 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0019 | 0.0791 | 0.0791 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0118 | 1 | 1 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0019 | 0.0791 | 0.0791 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0118 | 1 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0019 | 0.0791 | 0.0791 |
Schistosoma mansoni | nAChR subunit | 0.0019 | 0.0791 | 0.0791 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0118 | 1 | 0.5 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0019 | 0.0791 | 0.0791 |
Echinococcus multilocularis | nAChR subunit | 0.0019 | 0.0791 | 0.0791 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | ACC-1 protein | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0118 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0791 | 0.0791 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0019 | 0.0791 | 0.0791 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0019 | 0.0791 | 0.0791 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0791 | 0.0791 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0019 | 0.0791 | 0.0791 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0019 | 0.0791 | 0.0791 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.6671 | 0.6671 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0082 | 0.6671 | 0.6671 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0019 | 0.0791 | 0.0791 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0019 | 0.0791 | 0.0791 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0019 | 0.0791 | 0.0791 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0118 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0118 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0118 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | LGC-31 protein | 0.0019 | 0.0791 | 0.0791 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0082 | 0.6671 | 0.6671 |
Brugia malayi | Cation transporter family protein | 0.0019 | 0.0791 | 0.0791 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0019 | 0.0791 | 0.0791 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0019 | 0.0791 | 0.0791 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0019 | 0.0791 | 0.0791 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0019 | 0.0791 | 0.0791 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0019 | 0.0791 | 0.0791 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0019 | 0.0791 | 0.0791 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0019 | 0.0791 | 0.0791 |
Schistosoma mansoni | nAChR subunit | 0.0019 | 0.0791 | 0.0791 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0082 | 0.6671 | 0.6671 |
Brugia malayi | Cation transporter family protein | 0.0019 | 0.0791 | 0.0791 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.