Detailed information for compound 1125387

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 344.41 | Formula: C12H16N4O4S2
  • H donors: 3 H acceptors: 6 LogP: 0.13 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1nc(SC)c2c(n1)n(cn2)C1O[C@@H]([C@H]([C@H]1O)O)CO
  • InChi: 1S/C12H16N4O4S2/c1-21-10-6-9(14-12(15-10)22-2)16(4-13-6)11-8(19)7(18)5(3-17)20-11/h4-5,7-8,11,17-19H,3H2,1-2H3/t5-,7-,8-,11?/m1/s1
  • InChiKey: FTGZLZPNEHEUMH-YNJARDAQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0235 0.0375
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0828 0.0824
Brugia malayi Bromodomain containing protein 0.0026 0.014 0.0224
Schistosoma mansoni hypothetical protein 0.0041 0.0356 0.0837
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0068 0.0746 0.119
Trichomonas vaginalis CAMK family protein kinase 0.0085 0.099 0.2806
Leishmania major DNA polymerase eta, putative 0.0022 0.0073 0.074
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0073 0.0014
Echinococcus granulosus expressed conserved protein 0.0094 0.1113 0.2643
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.003 0.0191 0.0422
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0235 0.0507
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0235 0.2773
Loa Loa (eye worm) hypothetical protein 0.0026 0.014 0.0224
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0073 0.074
Loa Loa (eye worm) TAR-binding protein 0.019 0.2513 0.4008
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0261 0.0663
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0241 0.2438
Onchocerca volvulus 0.0035 0.0261 0.0585
Entamoeba histolytica hypothetical protein 0.0074 0.0828 0.671
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0261 0.0663
Brugia malayi TAR-binding protein 0.019 0.2513 0.4008
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0746 0.7528
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0212 0.2493
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0261 0.0573
Loa Loa (eye worm) hypothetical protein 0.0074 0.0837 0.1335
Toxoplasma gondii PHD-finger domain-containing protein 0.0026 0.014 0.1633
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0033 0.0241 0.3559
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0195 0.0455
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0678 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0069 0.0699
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0073 0.0165
Loa Loa (eye worm) hypothetical protein 0.045 0.6269 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0235 0.0575
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0261 0.0611
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0068 0.0746 0.598
Loa Loa (eye worm) hypothetical protein 0.0025 0.0127 0.0203
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0241 0.2438
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0025 0.0127 0.0178
Leishmania major pyruvate kinase 0.0033 0.0235 0.2375
Trichomonas vaginalis set domain proteins, putative 0.0248 0.3341 1
Loa Loa (eye worm) RNA binding protein 0.019 0.2513 0.4008
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0068 0.0746 0.8902
Brugia malayi hypothetical protein 0.0074 0.0837 0.1335
Schistosoma mansoni jumonji domain containing protein 0.0068 0.0748 0.1769
Loa Loa (eye worm) hypothetical protein 0.0247 0.3335 0.532
Loa Loa (eye worm) hypothetical protein 0.0035 0.0261 0.0416
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.003 0.0191 0.6368
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0069 0.1021
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0073 0.0069
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0261 0.061
Echinococcus multilocularis pyruvate kinase 0.0033 0.0235 0.0231
Schistosoma mansoni smad1 5 8 and 0.0024 0.0109 0.0248
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0212 0.0208
Trichomonas vaginalis alpha-glucosidase, putative 0.0025 0.0127 0.0166
Entamoeba histolytica hypothetical protein 0.0074 0.0828 0.671
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0081 0.0934 0.2215
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0837 0.8452
Loa Loa (eye worm) hypothetical protein 0.0031 0.0212 0.0338
Trichomonas vaginalis inositol monophosphatase, putative 0.0033 0.0241 0.0515
Schistosoma mansoni survival motor neuron protein 0.005 0.049 0.1154
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0378 0.0892
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0073 0.074
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.3335 0.3332
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0378 0.0604
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0033 0.0241 0.0515
Echinococcus granulosus lysosomal alpha glucosidase 0.0307 0.42 1
Schistosoma mansoni tar DNA-binding protein 0.019 0.2513 0.5965
Trichomonas vaginalis CAMK family protein kinase 0.0085 0.099 0.2806
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0261 0.0416
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0378 0.0892
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0073 0.074
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0026 0.014 0.0323
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0261 0.3841
Echinococcus multilocularis lysosomal alpha glucosidase 0.0307 0.42 0.4198
Trypanosoma brucei glycosyl hydrolase-like protein 0.0025 0.0127 0.1287
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0261 0.0663
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0142 0.182 0.4327
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0678 0.0675
Loa Loa (eye worm) hypothetical protein 0.0035 0.0261 0.0416
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0235 0.0507
Trichomonas vaginalis CAMK family protein kinase 0.0085 0.099 0.2806
Brugia malayi MH2 domain containing protein 0.0353 0.4869 0.7767
Mycobacterium ulcerans lipase LipD 0.0035 0.0261 0.3841
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0073 0.074
Loa Loa (eye worm) hypothetical protein 0.0035 0.0261 0.0416
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0261 0.0573
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0212 0.0495
Brugia malayi CHE-14 protein 0.0043 0.0378 0.0604
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0081 0.0934 0.2215
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0073 0.074
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0746 0.7528
Echinococcus multilocularis jumonji domain containing protein 0.0037 0.0289 0.0285
Loa Loa (eye worm) pigment dispersing factor receptor c 0.045 0.6269 1
Leishmania major glycosyl hydrolase-like protein 0.0025 0.0127 0.1287
Schistosoma mansoni hypothetical protein 0.0041 0.0356 0.0837
Trypanosoma brucei unspecified product 0.0022 0.0073 0.074
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0085 0.099 0.2351
Onchocerca volvulus 0.0035 0.0261 0.0585
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0235 0.0375
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0069 0.1021
Toxoplasma gondii ABC1 family protein 0.0035 0.0261 0.3078
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0828 0.1964
Echinococcus multilocularis tar DNA binding protein 0.019 0.2513 0.251
Echinococcus granulosus neutral alpha glucosidase AB 0.0068 0.0746 0.1767
Schistosoma mansoni tar DNA-binding protein 0.019 0.2513 0.5965
Brugia malayi MH2 domain containing protein 0.0024 0.0109 0.0173
Brugia malayi jmjC domain containing protein 0.0032 0.022 0.0351
Trypanosoma brucei polo-like protein kinase 0.0085 0.099 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0109 0.0104
Onchocerca volvulus Serine\/threonine kinase homolog 0.0085 0.099 0.2815
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0033 0.0243 0.057
Loa Loa (eye worm) hypothetical protein 0.01 0.12 0.1915
Trypanosoma cruzi polo-like protein kinase, putative 0.0085 0.099 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0032 0.022 0.0513
Echinococcus multilocularis neutral alpha glucosidase AB 0.0068 0.0746 0.0742
Trichomonas vaginalis alpha-glucosidase, putative 0.0068 0.0746 0.2057
Trichomonas vaginalis maltase-glucoamylase, putative 0.0068 0.0746 0.2057
Plasmodium falciparum phd finger protein, putative 0.0026 0.014 0.1633
Brugia malayi RNA recognition motif domain containing protein 0.019 0.2513 0.4008
Brugia malayi MH1 domain containing protein 0.0024 0.0109 0.0173
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.019 0.2513 0.4008
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0073 0.1081
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0068 0.0746 0.2057
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0025 0.0127 0.0166
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0073 0.0117
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0142 0.182 0.1816
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0025 0.0127 0.1287
Loa Loa (eye worm) hypothetical protein 0.0021 0.0069 0.011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0212 0.0494
Schistosoma mansoni pyruvate kinase 0.0033 0.0235 0.0549
Brugia malayi serine/threonine-protein kinase plk-2 0.0085 0.099 0.158
Giardia lamblia Pyruvate kinase 0.0033 0.0235 0.2342
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0086 0.1004 0.2382
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0073 0.0014
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0142 0.182 0.2903
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0033 0.0241 0.0515
Schistosoma mansoni hypothetical protein 0.0074 0.0828 0.196
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0069 0.1021
Giardia lamblia PHD finger protein 15 0.0026 0.014 0.1379
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0081 0.0934 0.149
Schistosoma mansoni DNA polymerase eta 0.0022 0.0073 0.0164
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0235 0.0375
Brugia malayi Calcitonin receptor-like protein seb-1 0.045 0.6269 1
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0261 1
Echinococcus granulosus dna polymerase eta 0.0022 0.0073 0.0165
Onchocerca volvulus 0.0178 0.2328 0.6904
Loa Loa (eye worm) hypothetical protein 0.0033 0.0235 0.0375
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0678 1
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0069 0.011
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0261 0.2631
Brugia malayi RNA binding protein 0.019 0.2513 0.4008
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0156 0.0249
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0081 0.0934 0.093
Trypanosoma cruzi polo-like protein kinase, putative 0.0085 0.099 1
Leishmania major hypothetical protein, conserved 0.0074 0.0837 0.8452
Trichomonas vaginalis maltase-glucoamylase, putative 0.0025 0.0127 0.0166
Schistosoma mansoni hypothetical protein 0.005 0.049 0.1154
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0069 0.011
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0235 0.8674
Loa Loa (eye worm) hypothetical protein 0.0035 0.0261 0.0416
Mycobacterium tuberculosis Conserved protein 0.0035 0.0261 0.0663
Giardia lamblia Kinase, PLK 0.0085 0.099 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0678 0.1603
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0073 0.074
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0033 0.0241 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0378 0.0934
Brugia malayi Pre-SET motif family protein 0.0031 0.0212 0.0338
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0073 0.074
Schistosoma mansoni hypothetical protein 0.0041 0.0356 0.0837
Echinococcus multilocularis expressed conserved protein 0.0094 0.1113 0.1109
Trichomonas vaginalis alpha-glucosidase, putative 0.0025 0.0127 0.0166
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0073 0.0036
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0033 0.0243 0.0239
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0678 0.1607
Echinococcus granulosus dna polymerase kappa 0.0022 0.0073 0.0165
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0678 0.8095
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0307 0.42 0.67
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0828 0.196
Loa Loa (eye worm) hypothetical protein 0.0035 0.0261 0.0416
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0369 0.0906
Brugia malayi beta-lactamase family protein 0.0035 0.0261 0.0416
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0073 0.1081
Echinococcus granulosus lysine specific demethylase 5A 0.0032 0.022 0.0514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0081 0.0934 0.093
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0069 0.0699
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.1818 0.4323
Schistosoma mansoni hypothetical protein 0.0033 0.0243 0.0569
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0073 0.074
Loa Loa (eye worm) MH2 domain-containing protein 0.0353 0.4869 0.7767
Brugia malayi hypothetical protein 0.0247 0.3335 0.532
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0261 0.2631
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0109 0.0249
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0212 0.0494
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0378 0.0374
Loa Loa (eye worm) hypothetical protein 0.0052 0.0517 0.0825
Schistosoma mansoni hypothetical protein 0.0142 0.182 0.4317
Echinococcus multilocularis pyruvate kinase 0.0033 0.0235 0.0231
Echinococcus granulosus Smad4 0.0024 0.0109 0.0249
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0085 0.099 0.0987
Loa Loa (eye worm) hypothetical protein 0.0045 0.0411 0.0656
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0069 0.1021
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0261 0.0663
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0073 0.074
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.12 1
Brugia malayi latrophilin 2 splice variant baaae 0.0308 0.4209 0.6715
Trichomonas vaginalis CAMK family protein kinase 0.0085 0.099 0.2806
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0261 0.0573
Schistosoma mansoni patched 1 0.0043 0.0378 0.089
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0109 0.0173
Echinococcus granulosus smad 0.0024 0.0109 0.0249
Echinococcus granulosus inositol monophosphatase 1 0.0033 0.0241 0.0566
Brugia malayi Pre-SET motif family protein 0.0218 0.2907 0.4637
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0073 0.074
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0261 0.3078
Schistosoma mansoni hypothetical protein 0.0142 0.182 0.4317
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0261 0.0416
Echinococcus multilocularis GPCR, family 2 0.0142 0.182 0.1816
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0068 0.0746 0.598
Plasmodium falciparum pyruvate kinase 0.0033 0.0235 0.2773
Loa Loa (eye worm) Smad1 0.0024 0.0109 0.0173
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0033 0.0241 0.2849
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0073 0.074
Echinococcus multilocularis dna polymerase eta 0.0022 0.0073 0.0069
Trichomonas vaginalis alpha-glucosidase, putative 0.0025 0.0127 0.0166
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.0544 0.0868
Schistosoma mansoni alpha glucosidase 0.0068 0.0746 0.1763
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0261 0.3841
Trichomonas vaginalis alpha-glucosidase, putative 0.0068 0.0746 0.2057
Schistosoma mansoni pyruvate kinase 0.0033 0.0235 0.0549
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0073 0.0164
Brugia malayi Glycosyl hydrolases family 31 protein 0.0068 0.0746 0.119
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.12 0.2851
Mycobacterium tuberculosis Conserved protein 0.0035 0.0261 0.0663
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0081 0.0934 0.221
Onchocerca volvulus Alhambra homolog 0.0026 0.014 0.0217
Trichomonas vaginalis CAMK family protein kinase 0.0085 0.099 0.2806
Echinococcus multilocularis smad 0.0024 0.0109 0.0104
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0212 0.0494
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0235 0.0375
Toxoplasma gondii LsmAD domain-containing protein 0.0074 0.0837 1
Schistosoma mansoni Smad4 0.0024 0.0109 0.0248
Echinococcus multilocularis Smad4 0.0024 0.0109 0.0104
Echinococcus multilocularis PHD finger protein rhinoceros 0.0026 0.014 0.0136
Leishmania major alpha glucosidase II subunit, putative 0.0068 0.0746 0.7528
Chlamydia trachomatis pyruvate kinase 0.0033 0.0235 0.5
Schistosoma mansoni hypothetical protein 0.0142 0.182 0.4317
Trypanosoma brucei PAB1-binding protein , putative 0.0074 0.0837 0.8452
Leishmania major DNA polymerase kappa, putative 0.0022 0.0073 0.074
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0021 0.0069 0.1021
Brugia malayi MH1 domain containing protein 0.0024 0.0109 0.0173
Toxoplasma gondii PHD-finger domain-containing protein 0.0026 0.014 0.1633
Trypanosoma brucei glucosidase, putative 0.0068 0.0746 0.7528
Schistosoma mansoni tar DNA-binding protein 0.019 0.2513 0.5965
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0109 0.0248
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0073 0.074
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0235 0.2773
Echinococcus granulosus tar DNA binding protein 0.019 0.2513 0.5979
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0261 0.0573
Loa Loa (eye worm) hypothetical protein 0.0043 0.0378 0.0604
Trichomonas vaginalis alpha-glucosidase, putative 0.0025 0.0127 0.0166
Brugia malayi Inositol-1 0.0033 0.0241 0.0385
Echinococcus granulosus pyruvate kinase 0.0033 0.0235 0.0551
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0025 0.0127 0.0166
Brugia malayi MH2 domain containing protein 0.0024 0.0109 0.0173
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0241 0.2438
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0033 0.0241 0.1523
Echinococcus granulosus pyruvate kinase 0.0033 0.0235 0.0551
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0369 0.0906
Trichomonas vaginalis esterase, putative 0.0035 0.0261 0.0573
Loa Loa (eye worm) hypothetical protein 0.0035 0.0261 0.0416
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0092 0.0197
Schistosoma mansoni tar DNA-binding protein 0.019 0.2513 0.5965
Mycobacterium ulcerans beta-lactamase 0.0035 0.0261 0.3841
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.2907 0.4637
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0146
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0025 0.0127 0.1287
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0241 0.2438
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0837 1
Schistosoma mansoni hypothetical protein 0.0026 0.014 0.0323
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0109 0.0104
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.049 0.0781
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0142 0.182 0.1816
Mycobacterium leprae Probable lipase LipE 0.0035 0.0261 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0092 0.0146
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0021 0.0069 0.1021
Loa Loa (eye worm) inositol-1 0.0033 0.0241 0.0385
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0085 0.099 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0142 0.182 0.2903
Loa Loa (eye worm) hypothetical protein 0.0021 0.0069 0.011
Echinococcus multilocularis lysine specific demethylase 5A 0.0032 0.022 0.0216
Schistosoma mansoni hypothetical protein 0.0041 0.0356 0.0837
Schistosoma mansoni alpha-glucosidase 0.0264 0.3582 0.8507
Schistosoma mansoni jumonji/arid domain-containing protein 0.0032 0.022 0.0513
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0073 0.074
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0142 0.182 0.4327
Entamoeba histolytica hypothetical protein 0.0074 0.0828 0.671
Entamoeba histolytica serine/threonine protein kinase, putative 0.0085 0.099 0.8145
Echinococcus multilocularis inositol monophosphatase 1 0.0033 0.0241 0.0237
Brugia malayi Cytochrome P450 family protein 0.0027 0.0156 0.0249
Echinococcus multilocularis protein patched 0.0043 0.0378 0.0374
Brugia malayi beta-lactamase 0.0035 0.0261 0.0416
Brugia malayi Latrophilin receptor protein 2 0.0142 0.182 0.2903
Brugia malayi Glycosyl hydrolases family 31 protein 0.0307 0.42 0.67
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0261 0.0256
Schistosoma mansoni kinase 0.0043 0.0386 0.0907
Loa Loa (eye worm) transcription factor SMAD2 0.0353 0.4869 0.7767
Onchocerca volvulus 0.0248 0.3341 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0261 0.0663
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0073 0.074
Schistosoma mansoni smad 0.0024 0.0109 0.0248
Echinococcus granulosus peregrin 0.0026 0.014 0.0324
Schistosoma mansoni inositol monophosphatase 0.0033 0.0241 0.0564
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.12 0.1197
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0068 0.0746 0.2057
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0678 0.2111
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0025 0.0127 0.0515
Onchocerca volvulus 0.005 0.049 0.1285
Brugia malayi hypothetical protein 0.0048 0.0456 0.0727
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0109 0.0173
Schistosoma mansoni hypothetical protein 0.0308 0.4209 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0081 0.0934 0.221
Echinococcus multilocularis peregrin 0.0026 0.014 0.0136
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0261 0.0663
Onchocerca volvulus 0.0031 0.0212 0.0436
Plasmodium vivax hypothetical protein, conserved 0.0026 0.014 0.1633
Onchocerca volvulus 0.0035 0.0261 0.0585
Loa Loa (eye worm) beta-lactamase 0.0035 0.0261 0.0416
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0212 0.0208
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0678 0.1603
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0073 0.074
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0073 0.0069
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0235 0.0495
Brugia malayi jmjC domain containing protein 0.0086 0.1004 0.1601
Loa Loa (eye worm) hypothetical protein 0.0142 0.182 0.2903
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.099 0.2345
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0837 1
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0073 0.074
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0235 0.0495
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0235 0.2375
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0235 0.2375
Schistosoma mansoni inositol monophosphatase 0.0033 0.0241 0.0564
Loa Loa (eye worm) hypothetical protein 0.0021 0.0069 0.011
Echinococcus granulosus GPCR family 2 0.0142 0.182 0.4327
Loa Loa (eye worm) hypothetical protein 0.0308 0.4209 0.6715
Trichomonas vaginalis CAMK family protein kinase 0.0085 0.099 0.2806
Plasmodium vivax SET domain protein, putative 0.0031 0.0212 0.2493
Trichomonas vaginalis sucrase-isomaltase, putative 0.0068 0.0746 0.2057
Echinococcus granulosus jumonji domain containing protein 0.0037 0.0289 0.0678
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.1223 0.2897
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.1818 0.1815
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0073 0.0164
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0837 0.8452
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0261 0.2631
Trichomonas vaginalis alpha-glucosidase, putative 0.0068 0.0746 0.2057
Leishmania major hypothetical protein, conserved 0.0035 0.0261 0.2631
Plasmodium vivax ataxin-2 like protein, putative 0.0074 0.0837 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0025 0.0127 0.0166
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0678 0.685
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0235 0.0375
Entamoeba histolytica hypothetical protein 0.0074 0.0828 0.671
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0073 0.0117
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0081 0.0934 0.149
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.022 0.0351
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0678 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0261 0.061
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0261 0.0573
Giardia lamblia DINP protein human, muc B family 0.0022 0.0073 0.0701
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0086 0.1004 0.1
Schistosoma mansoni hypothetical protein 0.0142 0.182 0.4317
Mycobacterium ulcerans hypothetical protein 0.0021 0.0069 0.1021
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0073 0.074
Schistosoma mansoni alpha-glucosidase 0.0264 0.3582 0.8507
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0235 0.3467
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0085 0.099 0.158
Schistosoma mansoni smad1 5 8 and 0.0024 0.0109 0.0248
Brugia malayi PHD-finger family protein 0.0026 0.014 0.0224
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0073 0.0117
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0117
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0073 0.074
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.12 0.1915
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.045 0.6269 1
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0261 0.0663
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0081 0.0934 0.221
Brugia malayi beta-lactamase family protein 0.0035 0.0261 0.0416
Brugia malayi hypothetical protein 0.0074 0.0828 0.1321
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0212 0.0494
Trichomonas vaginalis alpha-glucosidase, putative 0.0068 0.0746 0.2057
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.3335 0.7939
Trichomonas vaginalis alpha-glucosidase, putative 0.0068 0.0746 0.2057
Echinococcus multilocularis lysosomal alpha glucosidase 0.0307 0.42 0.4198
Mycobacterium ulcerans hypothetical protein 0.0035 0.0261 0.3841
Brugia malayi Glycosyl hydrolases family 31 protein 0.0025 0.0127 0.0203
Trichomonas vaginalis CAMK family protein kinase 0.0085 0.099 0.2806
Schistosoma mansoni tar DNA-binding protein 0.019 0.2513 0.5965
Echinococcus granulosus PHD finger protein rhinoceros 0.0026 0.014 0.0324
Echinococcus multilocularis pyruvate kinase 0.0026 0.0135 0.0131
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0069 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0073 0.074
Schistosoma mansoni smad1 5 8 and 0.0024 0.0109 0.0248
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0073 0.074
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0221 0.2955 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0235 0.2375
Brugia malayi Smad1 0.0024 0.0109 0.0173
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0069 0.0699
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0235 0.0507
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0109 0.0249
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0235 0.2375
Leishmania major pyruvate kinase 0.0033 0.0235 0.2375
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0069 0.1021
Echinococcus multilocularis protein dispatched 1 0.0049 0.0466 0.0462
Loa Loa (eye worm) PHD-finger family protein 0.0026 0.014 0.0224
Mycobacterium tuberculosis Conserved protein 0.0035 0.0261 0.0663

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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