Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0035 | 0.2763 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.3258 | 0.4427 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.3431 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.3431 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0618 | 0.0667 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.3431 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0435 | 0.0592 |
Brugia malayi | Inositol-1 | 0.004 | 0.3431 | 0.2401 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4417 | 0.4769 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0947 | 0.1287 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 0.3431 | 0.5 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.004 | 0.3431 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0064 | 0.736 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0435 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.9262 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.0106 | 0.0114 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.004 | 0.3431 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0435 | 0.0592 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.3431 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.3431 | 0.4301 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0064 | 0.736 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.004 | 0.3431 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4087 | 0.4413 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0618 | 0.0774 |
Schistosoma mansoni | bromodomain containing protein | 0.0068 | 0.7978 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.004 | 0.3431 | 0.4662 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3679 | 0.3972 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.3431 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.3258 | 0.4427 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.3431 | 0.5 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0035 | 0.2763 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.3431 | 0.4301 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.004 | 0.3431 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0947 | 0.1287 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.004 | 0.3431 | 0.4662 |
Loa Loa (eye worm) | inositol-1 | 0.004 | 0.3431 | 0.3705 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.3667 | 0.2673 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0947 | 0.1188 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.9 uM | Cytotoxicity against human HL60 cells after 2 days by automatic ELISA reader system | ChEMBL. | 20392646 |
IC50 (functional) | = 2.5 uM | Cytotoxicity against human HCT15 cells after 2 days by automatic ELISA reader system | ChEMBL. | 20392646 |
IC50 (functional) | = 4.6 uM | Cytotoxicity against human MDA-MB-231 cells after 2 days by automatic ELISA reader system | ChEMBL. | 20392646 |
IC50 (functional) | = 4.9 uM | Cytotoxicity against human DU145 cells after 2 days by automatic ELISA reader system | ChEMBL. | 20392646 |
IC50 (functional) | = 9.7 uM | Cytotoxicity against human HeLa cells after 2 days by automatic ELISA reader system | ChEMBL. | 20392646 |
Inhibition (binding) | = 1.5 % | Inhibition of human recombinant TOP1-mediated relaxation of supercoiled Escherichia coli pBR322 DNA at 100 uM after 30 mins by transillumination | ChEMBL. | 20392646 |
Inhibition (binding) | = 3.1 % | Inhibition of human recombinant TOP2A-mediated relaxation of supercoiled Escherichia coli pBR322 DNA at 20 uM after 30 mins by transillumination | ChEMBL. | 20392646 |
Inhibition (binding) | = 31.2 % | Inhibition of human recombinant TOP2A-mediated relaxation of supercoiled Escherichia coli pBR322 DNA at 100 uM after 30 mins by transillumination | ChEMBL. | 20392646 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 20392646 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.