TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 460.594 | Formula: C25H28N6OS
H donors: 3 H acceptors: 3 LogP: 4.31 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CN(CCNc1nc(NCc2ccc(cc2)NC(=O)C)c2c(n1)cc(s2)c1ccccc1)C
InChi: 1S/C25H28N6OS/c1-17(32)28-20-11-9-18(10-12-20)16-27-24-23-21(29-25(30-24)26-13-14-31(2)3)15-22(33-23)19-7-5-4-6-8-19/h4-12,15H,13-14,16H2,1-3H3,(H,28,32)(H2,26,27,29,30)
InChiKey: ZNXQPFHEJYULNF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	RAD52 homolog (S. cerevisiae)	Starlite/ChEMBL	No references
Homo sapiens	isocitrate dehydrogenase 1 (NADP+), soluble	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	C terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Trypanosoma brucei	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania donovani	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	Isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	similar to S. cerevisiae RAD52 (YML032C) dsDNA break repair annealing factor	Get druggable targets OG5_130806	All targets in OG5_130806
Candida albicans	cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Echinococcus multilocularis	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	hypothetical protein	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	similar to S. cerevisiae RAD52 (YML032C) dsDNA break repair annealing factor	Get druggable targets OG5_130806	All targets in OG5_130806
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania braziliensis	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania mexicana	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Theileria parva	isocitrate dehydrogenase (NADP+), putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium berghei	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium knowlesi	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	N terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Entamoeba histolytica	DNA repair and recombination protein RAD52, putative	Get druggable targets OG5_130806	All targets in OG5_130806
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	Isocitrate dehydrogenase-like protein, related	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania infantum	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative	Get druggable targets OG5_127057	All targets in OG5_127057
Giardia lamblia	DNA repair protein RAD52	Get druggable targets OG5_130806	All targets in OG5_130806
Babesia bovis	isocitrate dehydrogenase, NADP-dependent family protein	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	glucosidase, putative	0.0035	0.0298	0.2436
Schistosoma mansoni	nuclear receptor	0.0013	0.0052	0.0056
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0262	0.2857	0.5354
Schistosoma mansoni	thyroid hormone receptor	0.0028	0.022	0.027
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0015	0.007	0.007
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0103	0.1067	0.8435
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1539	0.2884
Loa Loa (eye worm)	DR-78	0.0013	0.0052	0.0098
Trichomonas vaginalis	alpha-glucosidase, putative	0.0013	0.005	0.0392
Entamoeba histolytica	Rad52/22 family double-strand break repair protein, putative	0.0119	0.1248	0.2615
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0345	0.0647
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.004	0.0356	0.301
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0345	1
Echinococcus multilocularis	geminin	0.0706	0.785	0.785
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0035	0.0298	0.2732
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0141	0.1496	0.1897
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0103	0.1067	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.0345	0.1238
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0013	0.0052	0.0052
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0013	0.0052	0.0052
Echinococcus granulosus	nuclear receptor nhr 48	0.0013	0.0052	0.0067
Loa Loa (eye worm)	MH1 domain-containing protein	0.001	0.0013	0.0025
Echinococcus granulosus	smad	0.001	0.0013	0.0017
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0158	0.1682	0.1682
Toxoplasma gondii	aldehyde dehydrogenase	0.0119	0.1244	1
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0019	0.0117	0.0666
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0028	0.022	0.0281
Schistosoma mansoni	nuclear receptor nhr-48	0.0013	0.0052	0.0056
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0028	0.022	0.027
Echinococcus multilocularis	tar DNA binding protein	0.0262	0.2857	0.2857
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0028	0.022	0.022
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0071	0.0699	0.0891
Brugia malayi	Protein kinase domain containing protein	0.0088	0.0891	0.1649
Brugia malayi	beta-lactamase	0.0039	0.0345	0.0624
Echinococcus granulosus	dnaJ subfamily B	0.0398	0.4383	0.5583
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0052	0.0098
Brugia malayi	Latrophilin receptor protein 2	0.0065	0.0631	0.1161
Schistosoma mansoni	ap endonuclease	0.004	0.0356	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0052	0.0098
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0028	0.022	0.0389
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0028	0.022	0.022
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0035	0.0298	0.0541
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0117	0.0117
Trichomonas vaginalis	alpha-glucosidase, putative	0.0013	0.005	0.0392
Schistosoma mansoni	hypothetical protein	0.0038	0.0328	0.0408
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0028	0.022	0.027
Brugia malayi	Nuclear hormone receptor-like 1	0.0015	0.007	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0052	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0015	0.007	0.0132
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0035	0.0298	0.2732
Echinococcus granulosus	tar DNA binding protein	0.0262	0.2857	0.3639
Trichomonas vaginalis	alpha-glucosidase, putative	0.0013	0.005	0.0392
Schistosoma mansoni	thyroid hormone receptor	0.0028	0.022	0.027
Mycobacterium ulcerans	lipase LipD	0.0039	0.0345	0.2727
Brugia malayi	ecdysone receptor	0.0013	0.0052	0.0074
Echinococcus granulosus	expressed protein	0.0009	0.0008	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0028	0.022	0.0413
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.004	0.0356	0.0669
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.0345	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0028	0.022	0.0413
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0103	0.1067	0.8524
Echinococcus multilocularis	neuropeptide receptor A26	0.0452	0.4991	0.4991
Loa Loa (eye worm)	hypothetical protein	0.0015	0.007	0.0132
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.004	0.0356	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.004	0.0356	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0019	0.0117	0.015
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.0345	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0028	0.022	0.0413
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0013	0.0052	0.0098
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0028	0.022	0.0389
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0028	0.022	0.0389
Echinococcus granulosus	neuropeptide s receptor	0.0452	0.4991	0.6358
Echinococcus granulosus	muscleblind protein	0.0145	0.1539	0.196
Onchocerca volvulus		0.0091	0.0932	0.5732
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0119	0.1244	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0119	0.1244	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0035	0.0298	0.0558
Echinococcus multilocularis	muscleblind protein	0.0145	0.1539	0.1539
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0013	0.0052	0.0067
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0013	0.0052	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0028	0.022	0.0413
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0298	0.2732
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0013	0.0052	0.0074
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0141	0.1496	0.2804
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0141	0.1496	0.1897
Schistosoma mansoni	smad	0.001	0.0013	0.0006
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0345	0.3181
Schistosoma mansoni	hypothetical protein	0.0065	0.0631	0.0795
Schistosoma mansoni	smad1 5 8 and	0.001	0.0013	0.0006
Trichomonas vaginalis	CMGC family protein kinase	0.0103	0.1067	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.022	0.0413
Echinococcus granulosus	ferritin	0.0009	0.0008	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0875	0.164
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0028	0.022	0.0413
Schistosoma mansoni	smad1 5 8 and	0.001	0.0013	0.0006
Schistosoma mansoni	Smad4	0.001	0.0013	0.0006
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0028	0.022	0.0389
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0103	0.1067	1
Schistosoma mansoni	zinc finger protein	0.0013	0.0052	0.0056
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0071	0.0699	0.0881
Entamoeba histolytica	hypothetical protein	0.0038	0.0328	0.0608
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0013	0.0052	0.0074
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0088	0.0891	0.8264
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.057	0.0716
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0019	0.0117	0.0117
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0328	0.0408
Echinococcus granulosus	dual specificity	0.0088	0.0891	0.1135
Onchocerca volvulus		0.0013	0.0052	0.0018
Brugia malayi	beta-lactamase family protein	0.0039	0.0345	0.0624
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0345	0.2903
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0205	0.2206	0.4119
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0015	0.007	0.0079
Loa Loa (eye worm)	steroid hormone receptor	0.0028	0.022	0.0413
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.0345	0.1238
Onchocerca volvulus	Bile acid receptor homolog	0.0028	0.022	0.1107
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0028	0.022	0.022
Loa Loa (eye worm)	hypothetical protein	0.0015	0.007	0.0132
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.004	0.0356	0.301
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0028	0.022	0.027
Echinococcus granulosus	mitogen activated protein kinase	0.0103	0.1067	0.136
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0052	0.0098
Echinococcus multilocularis	FTZ F1 alpha	0.0028	0.022	0.022
Schistosoma mansoni	nuclear hormone receptor	0.0013	0.0052	0.0056
Brugia malayi	hypothetical protein	0.0038	0.0328	0.0592
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0141	0.1496	0.1496
Brugia malayi	RNA binding protein	0.0262	0.2857	0.5343
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0345	0.043
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.001	0.0013	0.0013
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0088	0.0891	0.8264
Echinococcus granulosus	neutral alpha glucosidase AB	0.0035	0.0298	0.0379
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0117	0.0666
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0013	0.0052	0.0056
Entamoeba histolytica	protein kinase, putative	0.0088	0.0891	0.1836
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0141	0.1496	0.1897
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0013	0.0052	0.0018
Echinococcus multilocularis	Smad4	0.001	0.0013	0.0013
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.004	0.0356	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0028	0.022	0.027
Echinococcus multilocularis	cpg binding protein	0.003	0.0235	0.0235
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0119	0.1244	0.1244
Schistosoma mansoni	nuclear hormone receptor	0.0013	0.0052	0.0056
Brugia malayi	hypothetical protein	0.015	0.1589	0.2961
Brugia malayi	ecdysteroid receptor	0.0028	0.022	0.0389
Schistosoma mansoni	tar DNA-binding protein	0.0262	0.2857	0.3633
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.0345	0.1238
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0217	0.0383
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0141	0.1496	0.1496
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0028	0.022	0.1107
Echinococcus granulosus	GPCR family 2	0.0065	0.0631	0.0804
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.004	0.0356	0.0356
Brugia malayi	follicle stimulating hormone receptor	0.0483	0.5335	1
Schistosoma mansoni	tar DNA-binding protein	0.0262	0.2857	0.3633
Giardia lamblia	DNA repair protein RAD52	0.042	0.463	1
Brugia malayi	Muscleblind-like protein	0.0145	0.1539	0.2866
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0345	0.0647
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.004	0.0356	0.2566
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0345	0.0624
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0028	0.022	0.027
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0015	0.007	0.0079
Brugia malayi	nuclear receptor RXR	0.0013	0.0052	0.0074
Loa Loa (eye worm)	Smad1	0.001	0.0013	0.0025
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0328	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0631	0.1183
Schistosoma mansoni	cpg binding protein	0.003	0.0235	0.0289
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0065	0.0631	0.1161
Echinococcus granulosus	mothers against decapentaplegic 5	0.001	0.0013	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0052	0.0098
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0345	0.1238
Brugia malayi	latrophilin 2 splice variant baaae	0.014	0.1477	0.275
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0028	0.022	0.0281
Echinococcus multilocularis	nuclear receptor nhr 48	0.0013	0.0052	0.0052
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0035	0.0298	0.1599
Brugia malayi	Nuclear hormone receptor E75	0.0013	0.0052	0.0074
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0345	0.9541
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0071	0.0699	0.1311
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.004	0.0356	0.301
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0028	0.022	0.0281
Brugia malayi	isocitrate dehydrogenase	0.0019	0.0117	0.0196
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0013	0.0052	0.0067
Brugia malayi	Nuclear hormone receptor-like 1	0.0015	0.007	0.0107
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0119	0.1244	0.4539
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0028	0.022	0.0413
Echinococcus multilocularis	mitogen activated protein kinase	0.0103	0.1067	0.1067
Echinococcus multilocularis	dual specificity	0.0088	0.0891	0.0891
Leishmania major	alpha glucosidase II subunit, putative	0.0035	0.0298	0.2076
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0217	0.0407
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0071	0.0699	0.5442
Schistosoma mansoni	cpg binding protein	0.0028	0.0217	0.0267
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0298	0.2732
Loa Loa (eye worm)	hypothetical protein	0.0015	0.007	0.0132
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0013	0.0052	0.0052
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0158	0.1682	0.1682
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.1526	0.286
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0035	0.0298	0.2732
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0071	0.0699	0.1419
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0019	0.0117	0.0401
Brugia malayi	conserved hypotetical protein	0.0013	0.0052	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0875	0.164
Loa Loa (eye worm)	hypothetical protein	0.0013	0.005	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0028	0.022	0.0413
Brugia malayi	nuclear receptor NHR-88	0.0028	0.022	0.0389
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0298	0.2732
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0028	0.022	0.027
Toxoplasma gondii	exonuclease III APE	0.004	0.0356	0.2119
Onchocerca volvulus		0.015	0.1589	1
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0345	0.0647
Brugia malayi	tailless protein	0.0013	0.0052	0.0074
Onchocerca volvulus		0.0039	0.0345	0.1919
Brugia malayi	beta-lactamase family protein	0.0039	0.0345	0.0624
Trypanosoma brucei	protein kinase, putative	0.0103	0.1067	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0013	0.005	0.0392
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0028	0.022	0.0389
Echinococcus multilocularis	expressed protein	0.0009	0.0008	0.0008
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0013	0.0052	0.0052
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.004	0.0356	0.1278
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0013	0.0052	0.0067
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0035	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0345	0.0647
Entamoeba histolytica	hypothetical protein	0.0088	0.0891	0.1836
Schistosoma mansoni	hypothetical protein	0.0398	0.4383	0.5578
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0065	0.0631	0.0631
Echinococcus multilocularis	isocitrate dehydrogenase	0.0019	0.0117	0.0117
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0345	1
Brugia malayi	MH2 domain containing protein	0.0144	0.1526	0.2842
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.004	0.0356	0.0454
Onchocerca volvulus		0.0039	0.0345	0.1919
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0028	0.022	0.0389
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0028	0.022	0.022
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0141	0.1496	0.1906
Loa Loa (eye worm)	TAR-binding protein	0.0262	0.2857	0.5354
Echinococcus multilocularis	neuropeptide s receptor	0.0452	0.4991	0.4991
Echinococcus granulosus	TGF beta signal transducer SmadC	0.001	0.0013	0.0017
Brugia malayi	orphan nuclear receptor NR2E1	0.0013	0.0052	0.0074
Schistosoma mansoni	hypothetical protein	0.014	0.1477	0.1873
Trichomonas vaginalis	alpha-glucosidase, putative	0.0013	0.005	0.0392
Brugia malayi	nuclear hormone receptor	0.0013	0.0052	0.0074
Entamoeba histolytica	hypothetical protein	0.0038	0.0328	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0345	0.0647
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0119	0.1244	1
Echinococcus granulosus	neuropeptide receptor A26	0.0452	0.4991	0.6358
Trichomonas vaginalis	CMGC family protein kinase	0.0103	0.1067	1
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0117	0.0666
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0028	0.022	0.0389
Loa Loa (eye worm)	nuclear hormone receptor	0.0013	0.0052	0.0098
Schistosoma mansoni	ap endonuclease	0.004	0.0356	0.0444
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0141	0.1496	0.1906
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0328	0.0328
Brugia malayi	nuclear hormone receptor family member odr-7	0.0013	0.0052	0.0074
Brugia malayi	nuclear receptor RXR	0.0015	0.007	0.0107
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0028	0.022	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1539	0.2884
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.0699	0.6385
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.0345	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0015	0.007	0.0132
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0345	0.044
Brugia malayi	photoreceptor-specific nuclear receptor	0.0028	0.022	0.0389
Brugia malayi	TAR-binding protein	0.0262	0.2857	0.5343
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0015	0.007	0.0132
Echinococcus multilocularis	ferritin	0.0009	0.0008	0.0008
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0028	0.022	0.0389
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0019	0.0117	0.0666
Onchocerca volvulus		0.0013	0.0052	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0052	0.0098
Schistosoma mansoni	hypothetical protein	0.0065	0.0631	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0205	0.2206	0.4134
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0052	0.0098
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0028	0.022	0.0413
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.1526	0.286
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0028	0.022	0.0281
Schistosoma mansoni	smad1 5 8 and	0.001	0.0013	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0052	0.0098
Entamoeba histolytica	hypothetical protein	0.0038	0.0328	0.0608
Schistosoma mansoni	hypothetical protein	0.0706	0.785	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0298	0.2436
Brugia malayi	Steroid receptor seven-up type 2	0.0028	0.022	0.0389
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0013	0.005	0.0392
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0103	0.1067	0.1067
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0028	0.022	0.0413
Schistosoma mansoni	serine/threonine protein kinase	0.0103	0.1067	0.1351
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0103	0.1067	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0028	0.022	0.1107
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0013	0.0052	0.0098
Echinococcus multilocularis	muscleblind protein 1	0.0145	0.1539	0.1539
Entamoeba histolytica	hypothetical protein	0.0119	0.1248	0.2615
Trichomonas vaginalis	ap endonuclease, putative	0.004	0.0356	0.3284
Brugia malayi	nuclear receptor NHR-88	0.0013	0.0052	0.0074
Brugia malayi	Isocitrate dehydrogenase	0.0019	0.0117	0.0196
Trichomonas vaginalis	CMGC family protein kinase	0.0103	0.1067	1
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0088	0.0891	0.7044
Echinococcus granulosus	Smad4	0.001	0.0013	0.0017
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0345	0.043
Brugia malayi	Nuclear hormone receptor-like 1	0.0028	0.022	0.0389
Loa Loa (eye worm)	hypothetical protein	0.015	0.1589	0.2978
Echinococcus multilocularis	transcription factor Dp 1	0.0041	0.0364	0.0364
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0028	0.022	0.022
Echinococcus granulosus	thyroid hormone receptor alpha	0.0013	0.0052	0.0067
Echinococcus granulosus	ecdysone induced protein 78C	0.0028	0.022	0.0281
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0103	0.1067	1
Echinococcus granulosus	lysosomal alpha glucosidase	0.0158	0.1682	0.2143
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0035	0.0298	0.2732
Brugia malayi	nuclear receptor NHR-67	0.0013	0.0052	0.0074
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0345	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0052	0.0098
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0028	0.022	0.0389
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0028	0.022	0.0413
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0117	0.0117
Schistosoma mansoni	alpha-glucosidase	0.0136	0.1435	0.1819
Onchocerca volvulus		0.0039	0.0345	0.1919
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0345	0.3181
Treponema pallidum	exodeoxyribonuclease (exoA)	0.004	0.0356	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0013	0.005	0.0069
Echinococcus granulosus	mitogen activated protein kinase 3	0.0103	0.1067	0.136
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.004	0.0356	0.0667
Trichomonas vaginalis	ap endonuclease, putative	0.004	0.0356	0.3284
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0028	0.022	0.0413
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0103	0.1067	1
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0088	0.0891	0.8264
Brugia malayi	MAP kinase sur-1	0.0103	0.1067	0.1981
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0019	0.0117	0.022
Echinococcus multilocularis	mothers against decapentaplegic 5	0.001	0.0013	0.0013
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0028	0.022	0.027
Echinococcus multilocularis	smad	0.001	0.0013	0.0013
Echinococcus multilocularis	dnaJ subfamily B	0.0398	0.4383	0.4383
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0028	0.022	0.0281
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0345	0.3181
Brugia malayi	hypothetical protein	0.0013	0.0052	0.0074
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0028	0.022	0.0281
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0298	0.2732
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0483	0.5335	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0119	0.1244	1
Leishmania major	hypothetical protein, conserved	0.0039	0.0345	0.2474
Echinococcus granulosus	transcription factor Dp 1	0.0041	0.0364	0.0464
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0141	0.1496	0.2786
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0345	0.1238
Brugia malayi	RNA recognition motif domain containing protein	0.0262	0.2857	0.5343
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.004	0.0356	0.2816
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0035	0.0298	0.0541
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.001	0.0013	0.0006
Brugia malayi	hypothetical protein	0.0013	0.0052	0.0074
Brugia malayi	exodeoxyribonuclease III family protein	0.004	0.0356	0.0644
Toxoplasma gondii	ABC1 family protein	0.0039	0.0345	0.2022
Schistosoma mansoni	aldehyde dehydrogenase	0.0119	0.1244	0.1575
Loa Loa (eye worm)	RNA binding protein	0.0262	0.2857	0.5354
Entamoeba histolytica	DNA repair and recombination protein RAD52, putative	0.042	0.463	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0013	0.005	0.0392
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0103	0.1067	0.8524
Trichomonas vaginalis	esterase, putative	0.0039	0.0345	0.3181
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0119	0.1244	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0345	0.0647
Brugia malayi	Nuclear hormone receptor E75	0.0013	0.0052	0.0074
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0117	0.0567
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.0345	0.1238
Echinococcus granulosus	geminin	0.0706	0.785	1
Schistosoma mansoni	hypothetical protein	0.0065	0.0631	0.0795
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0345	0.0345
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0345	0.2727
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0345	0.3181
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0028	0.022	0.022
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0345	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0052	0.0098
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0065	0.0631	0.0804
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0028	0.022	0.0389
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0103	0.1067	0.2001
Loa Loa (eye worm)	hypothetical protein	0.014	0.1477	0.2768
Brugia malayi	nuclear hormone receptor	0.0028	0.022	0.0389
Trichomonas vaginalis	CMGC family protein kinase	0.0103	0.1067	1
Brugia malayi	hypothetical protein	0.0015	0.007	0.0107
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0251	0.273	1
Schistosoma mansoni	nuclear hormone receptor	0.0028	0.022	0.027
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0065	0.0631	0.0804
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.0699	0.6385
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0158	0.1682	0.3136
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0205	0.2206	0.4119
Schistosoma mansoni	hypothetical protein	0.0065	0.0631	0.0795
Schistosoma mansoni	serine/threonine protein kinase	0.0088	0.0891	0.1125
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0298	0.2732
Schistosoma mansoni	nuclear receptor	0.0013	0.0052	0.0056
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0298	0.2436
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0117	0.0117
Giardia lamblia	Kinase, CMGC MAPK	0.0103	0.1067	0.1664
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0028	0.022	0.0389
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0015	0.007	0.009
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0065	0.0631	0.1183
Schistosoma mansoni	RAR-like nuclear receptor	0.0028	0.022	0.027
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0013	0.0052	0.0052
Schistosoma mansoni	alpha-glucosidase	0.0136	0.1435	0.1819
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0052	0.0098
Schistosoma mansoni	aldehyde dehydrogenase	0.0119	0.1244	0.1575
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0088	0.0891	0.1669
Echinococcus multilocularis	ecdysone induced protein 78C	0.0028	0.022	0.022
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0345	0.1238
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0028	0.022	0.0281
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.0699	0.6385
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0158	0.1682	0.3153
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0345	0.3181
Echinococcus granulosus	FTZ F1 alpha	0.0028	0.022	0.0281
Schistosoma mansoni	alpha glucosidase	0.0035	0.0298	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0028	0.022	0.0413
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0345	0.2727
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0052	0.0098
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0345	0.2727
Onchocerca volvulus		0.0028	0.0217	0.1088
Schistosoma mansoni	tar DNA-binding protein	0.0262	0.2857	0.3633
Echinococcus granulosus	cpg binding protein	0.003	0.0235	0.03
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0019	0.0117	0.0139
Schistosoma mansoni	hypothetical protein	0.0706	0.785	1
Onchocerca volvulus		0.0028	0.022	0.1107
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0071	0.0699	0.0699
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0345	0.2903
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0013	0.0052	0.0067
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0013	0.0052	0.0018
Schistosoma mansoni	tar DNA-binding protein	0.0262	0.2857	0.3633
Schistosoma mansoni	cpg binding protein	0.003	0.0235	0.0289
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0028	0.022	0.0413
Entamoeba histolytica	protein kinase domain containing protein	0.0088	0.0891	0.1836
Schistosoma mansoni	coup transcription factor	0.0028	0.022	0.027
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0345	0.2727
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0028	0.022	0.022
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0065	0.0631	0.0631
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.0499	0.3385
Loa Loa (eye worm)	hypothetical protein	0.0028	0.022	0.0413
Brugia malayi	steroid hormone receptor	0.0028	0.022	0.0389
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0035	0.0298	0.0534
Entamoeba histolytica	hypothetical protein	0.0038	0.0328	0.0608
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0028	0.022	0.0389
Brugia malayi	hypothetical protein	0.0015	0.007	0.0107
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0071	0.0699	0.1289
Entamoeba histolytica	protein kinase, putative	0.0088	0.0891	0.1836
Echinococcus multilocularis	GPCR, family 2	0.0065	0.0631	0.0631
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0205	0.2206	0.4134
Loa Loa (eye worm)	MH2 domain-containing protein	0.001	0.0013	0.0025
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0013	0.005	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0052	0.0098
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0028	0.022	0.027
Schistosoma mansoni	tar DNA-binding protein	0.0262	0.2857	0.3633
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0345	0.2903

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)	= 1.37 uM	PubChem BioAssay. FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.5821 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1869892

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1125491