Detailed information for compound 1125648

Basic information

Technical information
  • TDR Targets ID: 1125648
  • Name: N'-(1-phenylpyrazolo[4,5-e]pyrimidin-4-yl)ben zohydrazide
  • MW: 330.343 | Formula: C18H14N6O
  • H donors: 2 H acceptors: 4 LogP: 3.33 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)NNc1ncnc2c1cnn2c1ccccc1
  • InChi: 1S/C18H14N6O/c25-18(13-7-3-1-4-8-13)23-22-16-15-11-21-24(17(15)20-12-19-16)14-9-5-2-6-10-14/h1-12H,(H,23,25)(H,19,20,22)
  • InChiKey: QIFDHXXKXVYIIH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-(1-phenyl-4-pyrazolo[4,5-e]pyrimidinyl)benzohydrazide
  • ZINC00549237
  • K405-3808
  • NCGC00141860-01
  • STOCK3S-11648

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0066 0.2502 0.225
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.2502 1
Entamoeba histolytica hypothetical protein 0.0073 0.3059 0.5
Schistosoma mansoni tar DNA-binding protein 0.0066 0.2502 0.225
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.3059 0.2825
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.1499 0.599
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.1499 0.49
Echinococcus multilocularis geminin 0.017 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.2502 0.818
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.3059 0.2213
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.3059 0.2213
Entamoeba histolytica hypothetical protein 0.0073 0.3059 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1087 0.3553
Entamoeba histolytica hypothetical protein 0.0073 0.3059 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1087 0.4344
Echinococcus granulosus tar DNA binding protein 0.0066 0.2502 0.1588
Schistosoma mansoni tar DNA-binding protein 0.0066 0.2502 0.225
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1087 0.0787
Brugia malayi hypothetical protein 0.0073 0.3059 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1087 0.0787
Schistosoma mansoni hypothetical protein 0.0073 0.3059 0.2825
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0326 0.1065
Loa Loa (eye worm) RNA binding protein 0.0066 0.2502 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1087 0.0787
Loa Loa (eye worm) hypothetical protein 0.0052 0.1499 0.599
Brugia malayi TAR-binding protein 0.0066 0.2502 0.818
Schistosoma mansoni tar DNA-binding protein 0.0066 0.2502 0.225
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.1499 0.49
Schistosoma mansoni tar DNA-binding protein 0.0066 0.2502 0.225
Brugia malayi RNA binding protein 0.0066 0.2502 0.818
Loa Loa (eye worm) TAR-binding protein 0.0066 0.2502 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0326 0.1302
Schistosoma mansoni hypothetical protein 0.017 1 1
Echinococcus multilocularis tar DNA binding protein 0.0066 0.2502 0.1588
Entamoeba histolytica hypothetical protein 0.0073 0.3059 0.5
Schistosoma mansoni hypothetical protein 0.017 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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