TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 340.133 | Formula: C11H10BrN5O3
H donors: 3 H acceptors: 5 LogP: -0.65 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: BrC#C[C@H]1OC([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N
InChi: 1S/C11H10BrN5O3/c12-2-1-5-7(18)8(19)11(20-5)17-4-16-6-9(13)14-3-15-10(6)17/h3-5,7-8,11,18-19H,(H2,13,14,15)/t5-,7-,8-,11?/m1/s1
InChiKey: VVLGLSZQEHAISI-YNJARDAQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	adenosylhomocysteinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Babesia bovis	adenosylhomocysteinase (S-adenosyl-L-homocysteinehydrolase)	Get druggable targets OG5_127233	All targets in OG5_127233
Trypanosoma cruzi	S-adenosylhomocysteine hydrolase, putative	Get druggable targets OG5_127233	All targets in OG5_127233
Candida albicans	Putative S-adenosyl-L-homocysteine hydrolase	Get druggable targets OG5_127233	All targets in OG5_127233
Entamoeba histolytica	adenosylhomocysteinase, putative	Get druggable targets OG5_127233	All targets in OG5_127233
Trypanosoma cruzi	S-adenosylhomocysteine hydrolase, putative	Get druggable targets OG5_127233	All targets in OG5_127233
Mycobacterium ulcerans	S-adenosyl-L-homocysteine hydrolase	Get druggable targets OG5_127233	All targets in OG5_127233
Plasmodium falciparum	adenosylhomocysteinase	Get druggable targets OG5_127233	All targets in OG5_127233
Loa Loa (eye worm)	adenosylhomocysteinase	Get druggable targets OG5_127233	All targets in OG5_127233
Trypanosoma congolense	S-adenosylhomocysteine hydrolase, putative	Get druggable targets OG5_127233	All targets in OG5_127233
Leishmania infantum	S-adenosylhomocysteine hydrolase	Get druggable targets OG5_127233	All targets in OG5_127233
Toxoplasma gondii	adenosylhomocysteinase, putative	Get druggable targets OG5_127233	All targets in OG5_127233
Trichomonas vaginalis	adenosylhomocysteinase, putative	Get druggable targets OG5_127233	All targets in OG5_127233
Trypanosoma brucei	S-adenosylhomocysteine hydrolase, putative	Get druggable targets OG5_127233	All targets in OG5_127233
Leishmania donovani	S-adenosylhomocysteine hydrolase	Get druggable targets OG5_127233	All targets in OG5_127233
Cryptosporidium hominis	adenosylhomocysteinase	Get druggable targets OG5_127233	All targets in OG5_127233
Mycobacterium tuberculosis	Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase)	Get druggable targets OG5_127233	All targets in OG5_127233
Trypanosoma congolense	S-adenosylhomocysteine hydrolase, putative	Get druggable targets OG5_127233	All targets in OG5_127233
Neospora caninum	hypothetical protein	Get druggable targets OG5_127233	All targets in OG5_127233
Plasmodium vivax	adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative	Get druggable targets OG5_127233	All targets in OG5_127233
Schistosoma japonicum	ko:K01251 adenosylhomocysteinase [EC3.3.1.1], putative	Get druggable targets OG5_127233	All targets in OG5_127233
Mycobacterium leprae	putative S-adenosyl-L-homocysteine hydrolase SahH	Get druggable targets OG5_127233	All targets in OG5_127233
Trichomonas vaginalis	adenosylhomocysteinase, putative	Get druggable targets OG5_127233	All targets in OG5_127233
Toxoplasma gondii	S-Adenosyl homocysteine hydrolase	Get druggable targets OG5_127233	All targets in OG5_127233
Echinococcus multilocularis	adenosylhomocysteinase	Get druggable targets OG5_127233	All targets in OG5_127233
Leishmania mexicana	S-adenosylhomocysteine hydrolase	Get druggable targets OG5_127233	All targets in OG5_127233
Brugia malayi	Adenosylhomocysteinase	Get druggable targets OG5_127233	All targets in OG5_127233
Leishmania major	S-adenosylhomocysteine hydrolase	Get druggable targets OG5_127233	All targets in OG5_127233
Trypanosoma brucei gambiense	S-adenosylhomocysteine hydrolase, putative	Get druggable targets OG5_127233	All targets in OG5_127233
Candida albicans	Putative S-adenosyl-L-homocysteine hydrolase	Get druggable targets OG5_127233	All targets in OG5_127233
Cryptosporidium parvum	S-adenosylhomocysteinase	Get druggable targets OG5_127233	All targets in OG5_127233
Leishmania braziliensis	S-adenosylhomocysteine hydrolase	Get druggable targets OG5_127233	All targets in OG5_127233
Plasmodium yoelii	adenosylhomocysteinase	Get druggable targets OG5_127233	All targets in OG5_127233
Plasmodium knowlesi	adenosylhomocysteinase, putative	Get druggable targets OG5_127233	All targets in OG5_127233
Leishmania braziliensis	S-adenosylhomocysteine hydrolase	Get druggable targets OG5_127233	All targets in OG5_127233
Schistosoma mansoni	adenosylhomocysteinase	Get druggable targets OG5_127233	All targets in OG5_127233
Theileria parva	S-adenosyl-L-homocysteine hydrolase, putative	Get druggable targets OG5_127233	All targets in OG5_127233
Echinococcus granulosus	adenosylhomocysteinase	Get druggable targets OG5_127233	All targets in OG5_127233
Plasmodium berghei	adenosylhomocysteinase, putative	Get druggable targets OG5_127233	All targets in OG5_127233

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.1064	0.1064
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0053	0.2164	0.2597
Echinococcus granulosus	hypothetical protein	0.0035	0.1064	0.1064
Echinococcus granulosus	lamin	0.0029	0.0749	0.0749
Echinococcus granulosus	somatostatin receptor	0.0035	0.1064	0.1064
Brugia malayi	G protein-coupled receptor	0.0035	0.1064	0.1276
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.1064	0.1064
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1952	0.1952
Echinococcus multilocularis	neuropeptide receptor	0.0035	0.1064	0.1064
Echinococcus granulosus	lamin dm0	0.0029	0.0749	0.0749
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0035	0.1064	0.1064
Echinococcus multilocularis	neuropeptides capa receptor	0.0035	0.1064	0.1064
Echinococcus granulosus	neuropeptide Y receptor	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Echinococcus multilocularis	fmrfamide receptor	0.0035	0.1064	0.1064
Schistosoma mansoni	amine GPCR	0.0035	0.1064	0.1064
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0035	0.1064	0.1064
Loa Loa (eye worm)	adenosylhomocysteinase	0.0156	0.8333	1
Echinococcus multilocularis	g-protein coupled receptor	0.0035	0.1064	0.1064
Onchocerca volvulus		0.0035	0.1064	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0035	0.1064	0.1064
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.1952	0.2342
Schistosoma mansoni	amine GPCR	0.0035	0.1064	0.1064
Brugia malayi	ORL1-like opioid receptor	0.0035	0.1064	0.1276
Echinococcus granulosus	tm gpcr rhodopsin	0.0035	0.1064	0.1064
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0035	0.1064	0.1064
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0035	0.1064	0.1064
Echinococcus granulosus	sex peptide receptor	0.0035	0.1064	0.1064
Schistosoma mansoni	biogenic amine receptor	0.0035	0.1064	0.1064
Onchocerca volvulus		0.0035	0.1064	1
Schistosoma mansoni	lamin	0.0029	0.0749	0.0749
Echinococcus granulosus	7TM GPCR rhodopsin	0.0035	0.1064	0.1064
Echinococcus multilocularis	g protein coupled receptor	0.0035	0.1064	0.1064
Brugia malayi	Adenosylhomocysteinase	0.0156	0.8333	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0035	0.1064	0.1064
Onchocerca volvulus		0.0035	0.1064	1
Brugia malayi	hypothetical protein	0.0035	0.1064	0.1276
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.1064	0.1064
Schistosoma mansoni	hypothetical protein	0.0184	1	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Schistosoma mansoni	biogenic amine receptor	0.0035	0.1064	0.1064
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0035	0.1064	0.1064
Schistosoma mansoni	adenosylhomocysteinase	0.0156	0.8333	0.8333
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.2164	0.2597
Schistosoma mansoni	adenosylhomocysteinase	0.0097	0.4775	0.4775
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0035	0.1064	0.1276
Echinococcus multilocularis	g protein coupled receptor	0.0035	0.1064	0.1064
Schistosoma mansoni	neuropeptide F-like receptor	0.0035	0.1064	0.1064
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0035	0.1064	0.1064
Brugia malayi	Dopamine receptor protein 1	0.0035	0.1064	0.1276
Echinococcus multilocularis	adenosylhomocysteinase	0.0156	0.8333	0.8333
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Brugia malayi	putative neuropeptide receptor NPR1	0.0035	0.1064	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Mycobacterium tuberculosis	Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase)	0.0156	0.8333	0.5
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0717	0.0861
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0035	0.1064	0.1064
Schistosoma mansoni	opsin-like receptor	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.1064	0.1064
Onchocerca volvulus		0.0035	0.1064	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0035	0.1064	0.1064
Echinococcus multilocularis	g protein coupled receptor	0.0035	0.1064	0.1064
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.1064	0.1064
Onchocerca volvulus		0.0035	0.1064	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.1952	0.1952
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1952	0.1952
Echinococcus granulosus	biogenic amine 5HT receptor	0.0035	0.1064	0.1064
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0035	0.1064	0.1064
Brugia malayi	Melatonin receptor type 1A	0.0035	0.1064	0.1276
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0749	0.0899
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.2164	0.2597
Onchocerca volvulus		0.0035	0.1064	1
Onchocerca volvulus		0.0035	0.1064	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.1064	0.1064
Onchocerca volvulus		0.0035	0.1064	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Loa Loa (eye worm)	melatonin receptor type 1A	0.0035	0.1064	0.1276
Echinococcus granulosus	neuropeptide s receptor	0.0035	0.1064	0.1064
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.1064	0.1064
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0035	0.1064	0.1064
Echinococcus multilocularis	dro:myosuppressin receptor	0.0035	0.1064	0.1064
Schistosoma mansoni	opsin-like receptor	0.0035	0.1064	0.1064
Schistosoma mansoni	neuropeptide receptor	0.0035	0.1064	0.1064
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0035	0.1064	0.1064
Loa Loa (eye worm)	neuropeptide F receptor	0.0035	0.1064	0.1276
Schistosoma mansoni	neuropeptide F-like receptor	0.0035	0.1064	0.1064
Schistosoma mansoni	hypothetical protein	0.0184	1	1
Onchocerca volvulus		0.0035	0.1064	1
Schistosoma mansoni	neuropeptide receptor	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Echinococcus granulosus	neuropeptide receptor	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Loa Loa (eye worm)	TYRA-2 protein	0.0035	0.1064	0.1276
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0035	0.1064	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Echinococcus granulosus	g protein coupled receptor	0.0035	0.1064	0.1064
Trichomonas vaginalis	adenosylhomocysteinase, putative	0.0156	0.8333	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0035	0.1064	0.1276
Loa Loa (eye worm)	G-protein coupled receptor	0.0035	0.1064	0.1276
Echinococcus multilocularis	lamin dm0	0.0029	0.0749	0.0749
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0035	0.1064	0.1064
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.2164	0.2597
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0035	0.1064	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Schistosoma mansoni	growth hormone secretagogue receptor	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.1064	0.1064
Echinococcus multilocularis	neuropeptide receptor	0.0035	0.1064	0.1064
Schistosoma mansoni	hypothetical protein	0.0035	0.1064	0.1064
Echinococcus granulosus	neuropeptide receptor A26	0.0035	0.1064	0.1064
Echinococcus granulosus	g-protein coupled receptor	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Brugia malayi	hypothetical protein	0.0035	0.1064	0.1276
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.1952	0.1952
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.1162	0.1395
Echinococcus granulosus	g protein coupled receptor	0.0035	0.1064	0.1064
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.1064	0.1064
Echinococcus granulosus	dro:myosuppressin receptor	0.0035	0.1064	0.1064
Schistosoma mansoni	neuropeptide f receptor 76f	0.0035	0.1064	0.1064
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0035	0.1064	0.1064
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Plasmodium falciparum	adenosylhomocysteinase	0.0156	0.8333	0.5
Mycobacterium ulcerans	S-adenosyl-L-homocysteine hydrolase	0.0156	0.8333	0.5
Echinococcus granulosus	neuropeptide receptor	0.0035	0.1064	0.1064
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0035	0.1064	0.1064
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0035	0.1064	0.1064
Echinococcus multilocularis	neuropeptides capa receptor	0.0035	0.1064	0.1064
Brugia malayi	neuropeptide F receptor	0.0035	0.1064	0.1276
Trypanosoma brucei	S-adenosylhomocysteine hydrolase, putative	0.0156	0.8333	0.5
Brugia malayi	Serotonin receptor	0.0035	0.1064	0.1276
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.1064	0.1064
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0035	0.1064	0.1064
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0035	0.1064	0.1276
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0035	0.1064	0.1064
Schistosoma mansoni	opsin-like receptor	0.0035	0.1064	0.1064
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0035	0.1064	0.1276
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0035	0.1064	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Schistosoma mansoni	adenosylhomocysteinase	0.0097	0.4775	0.4775
Schistosoma mansoni	histamine h1 receptor	0.0035	0.1064	0.1064
Echinococcus multilocularis	neuropeptide Y receptor	0.0035	0.1064	0.1064
Onchocerca volvulus		0.0035	0.1064	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0035	0.1064	0.1276
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0035	0.1064	0.1064
Brugia malayi	hypothetical protein	0.0035	0.1064	0.1276
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0035	0.1064	0.1276
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0035	0.1064	0.1276
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Echinococcus granulosus	fmrfamide receptor	0.0035	0.1064	0.1064
Schistosoma mansoni	hypothetical protein	0.0035	0.1064	0.1064
Toxoplasma gondii	adenosylhomocysteinase, putative	0.0156	0.8333	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.1064	0.1064
Brugia malayi	hypothetical protein	0.0035	0.1064	0.1276
Brugia malayi	hypothetical protein	0.0035	0.1064	0.1276
Echinococcus multilocularis	neuropeptide Y receptor	0.0035	0.1064	0.1064
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Brugia malayi	intermediate filament protein	0.0029	0.0749	0.0899
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0749	0.0899
Brugia malayi	GnHR receptor homolog	0.0035	0.1064	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Onchocerca volvulus		0.0035	0.1064	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0035	0.1064	0.1276
Brugia malayi	hypothetical protein	0.0035	0.1064	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.1064	0.1064
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0035	0.1064	0.1064
Echinococcus multilocularis	serotonin receptor	0.0035	0.1064	0.1064
Brugia malayi	hypothetical protein	0.0035	0.1064	0.1276
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.1952	0.2342
Schistosoma mansoni	amine GPCR	0.0035	0.1064	0.1064
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.1064	0.1064
Echinococcus granulosus	biogenic amine 5HT receptor	0.0035	0.1064	0.1064
Echinococcus multilocularis	serotonin receptor	0.0035	0.1064	0.1064
Brugia malayi	larval opioid receptor	0.0035	0.1064	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Onchocerca volvulus		0.0035	0.1064	1
Brugia malayi	hypothetical protein	0.0035	0.1064	0.1276
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.1952	0.1952
Onchocerca volvulus		0.0035	0.1064	1
Echinococcus multilocularis	lamin	0.0029	0.0749	0.0749
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.1064	0.1064
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.1064	0.1064
Schistosoma mansoni	adenosylhomocysteinase	0.0097	0.4775	0.4775
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Brugia malayi	G-protein coupled receptor	0.0035	0.1064	0.1276
Echinococcus multilocularis	somatostatin receptor	0.0035	0.1064	0.1064
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0749	0.0899
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0035	0.1064	0.1064
Echinococcus granulosus	neuropeptides capa receptor	0.0035	0.1064	0.1064
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.1064	0.1064
Echinococcus granulosus	neuropeptide Y receptor	0.0035	0.1064	0.1064
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.1952	0.1952
Schistosoma mansoni	biogenic amine receptor	0.0035	0.1064	0.1064
Schistosoma mansoni	hypothetical protein	0.0035	0.1064	0.1064
Schistosoma mansoni	lamin	0.0029	0.0749	0.0749
Brugia malayi	G protein-coupled receptor F59B2.13	0.0035	0.1064	0.1276
Toxoplasma gondii	S-Adenosyl homocysteine hydrolase	0.0156	0.8333	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.1064	0.1064
Schistosoma mansoni	myosin xvIII	0.0035	0.1064	0.1064
Schistosoma mansoni	hypothetical protein	0.0036	0.1162	0.1162
Trichomonas vaginalis	adenosylhomocysteinase, putative	0.0156	0.8333	1
Trypanosoma cruzi	S-adenosylhomocysteine hydrolase, putative	0.0156	0.8333	0.5
Brugia malayi	RE15519p	0.0035	0.1064	0.1276
Onchocerca volvulus		0.0035	0.1064	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0035	0.1064	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Echinococcus granulosus	neuropeptide FF receptor 2	0.0035	0.1064	0.1064
Schistosoma mansoni	adenoreceptor	0.0035	0.1064	0.1064
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.1064	0.1064
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0035	0.1064	0.1064
Leishmania major	S-adenosylhomocysteine hydrolase	0.0156	0.8333	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1162	0.1395
Echinococcus granulosus	neuropeptides capa receptor	0.0035	0.1064	0.1064
Echinococcus granulosus	serotonin receptor	0.0035	0.1064	0.1064
Echinococcus multilocularis	G protein coupled receptor 139	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Echinococcus multilocularis	sex peptide receptor	0.0035	0.1064	0.1064
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0035	0.1064	0.1064
Brugia malayi	neuropeptide F receptor	0.0035	0.1064	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Brugia malayi	Dopamine receptor	0.0035	0.1064	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Plasmodium vivax	adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative	0.0156	0.8333	0.5
Echinococcus granulosus	allatostatin A receptor	0.0035	0.1064	0.1064
Schistosoma mansoni	amine GPCR	0.0035	0.1064	0.1064
Brugia malayi	follicle stimulating hormone receptor	0.0035	0.1064	0.1276
Mycobacterium leprae	putative S-adenosyl-L-homocysteine hydrolase SahH	0.0156	0.8333	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Echinococcus multilocularis	neuropeptide s receptor	0.0035	0.1064	0.1064
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0035	0.1064	0.1064
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0035	0.1064	0.1064
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0035	0.1064	0.1064
Loa Loa (eye worm)	neuropeptide F receptor	0.0035	0.1064	0.1276
Schistosoma mansoni	amine GPCR	0.0035	0.1064	0.1064
Echinococcus multilocularis	musashi	0.0029	0.0749	0.0749
Echinococcus granulosus	g protein coupled receptor	0.0035	0.1064	0.1064
Echinococcus multilocularis	allatostatin A receptor	0.0035	0.1064	0.1064
Echinococcus multilocularis	orexin receptor type 2	0.0035	0.1064	0.1064
Brugia malayi	sulfakinin receptor protein	0.0035	0.1064	0.1276
Onchocerca volvulus		0.0035	0.1064	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0035	0.1064	0.1064
Brugia malayi	G-protein coupled receptor	0.0035	0.1064	0.1276
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Echinococcus multilocularis	neuropeptide receptor A26	0.0035	0.1064	0.1064
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0035	0.1064	0.1064
Onchocerca volvulus		0.0035	0.1064	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Schistosoma mansoni	neuropeptide receptor	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0035	0.1064	0.1064
Echinococcus granulosus	G protein coupled receptor 139	0.0035	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Brugia malayi	putative neuropeptide receptor	0.0035	0.1064	0.1276
Brugia malayi	AKH receptor	0.0035	0.1064	0.1276
Loa Loa (eye worm)	G-protein coupled receptor	0.0035	0.1064	0.1276
Echinococcus multilocularis	geminin	0.0184	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Echinococcus multilocularis	fmrfamide receptor	0.0035	0.1064	0.1064
Brugia malayi	hypothetical protein	0.0035	0.1064	0.1276
Schistosoma mansoni	neuropeptide receptor	0.0035	0.1064	0.1064
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0749	0.0899
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276
Echinococcus granulosus	orexin receptor type 2	0.0035	0.1064	0.1064
Trypanosoma cruzi	S-adenosylhomocysteine hydrolase, putative	0.0156	0.8333	0.5
Brugia malayi	hypothetical protein	0.0035	0.1064	0.1276
Schistosoma mansoni	adenosylhomocysteinase	0.0097	0.4775	0.4775
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0035	0.1064	0.1276
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0749	0.0749
Brugia malayi	Dopamine receptor protein 2	0.0035	0.1064	0.1276
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0035	0.1064	0.1064
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0035	0.1064	0.1064
Schistosoma mansoni	hypothetical protein	0.0035	0.1064	0.1064
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0035	0.1064	0.1064
Brugia malayi	Serotonin receptor	0.0035	0.1064	0.1276
Echinococcus granulosus	adenosylhomocysteinase	0.0156	0.8333	0.8333
Onchocerca volvulus		0.0035	0.1064	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0035	0.1064	0.1064
Entamoeba histolytica	adenosylhomocysteinase, putative	0.0156	0.8333	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.1064	0.1064
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0035	0.1064	0.1064
Echinococcus granulosus	intermediate filament protein	0.0029	0.0749	0.0749
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1952	0.1952
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1064	0.1276

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 49 %	Effect of the compound on the S-adenosylhomocysteine hydrolase activity	ChEMBL.	9748360
EC50 (functional)	= 6 uM	concentration required to inhibit vaccinia virus-induced cytopathicity by 50% in E6SM cells	ChEMBL.	9748360
EC50 (functional)	= 6 uM	concentration required to inhibit VSV-induced cytopathicity by 50% in E6SM cells	ChEMBL.	9748360
EC50 (functional)	= 45 uM	concentration required to inhibit VSV-induced cytopathicity by 50% in HeLa cells	ChEMBL.	9748360
EC50 (functional)	> 120 uM	concentration required to inhibit HSV-1(KOS)-induced cytopathicity by 50% in E6SM cells	ChEMBL.	9748360
EC50 (functional)	> 120 uM	concentration required to inhibit HSV-2(G)-induced cytopathicity by 50% in E6SM cells	ChEMBL.	9748360
EC50 (functional)	> 120 uM	concentration required to inhibit HSV-1/TK (B2006) or VMW1837-induced cytopathicity by 50% in E6SM cells	ChEMBL.	9748360
EC50 (functional)	= 210 uM	concentration required to inhibit RSV-induced cytopathicity by 50% in HeLa cells	ChEMBL.	9748360
EC50 (functional)	> 300 uM	concentration required to inhibit Coxsackie virus B4-induced cytopathicity by 50% in HeLa cells	ChEMBL.	9748360
Inhibition (binding)	= 56 %	Inhibition of S-adenosylhomocysteine hydrolase at 100 microM concentration was determined from S-adenosylhomocysteine hydrolase activity remaining	ChEMBL.	9748360
Inhibition (binding)	= 62.9 %	Inhibition of S-adenosylhomocysteine hydrolase at 10 microM concentration was determined from enzyme activity remaining	ChEMBL.	9748360
Inhibition (binding)	= 73.2 %	Inhibition of S-adenosylhomocysteine hydrolase at 1 microM concentration was determined from enzyme activity remaining	ChEMBL.	9748360
Inhibition (binding)	= 91 %	Inhibition of S-adenosylhomocysteine hydrolase at 0.1 microM concentration was determined from enzyme activity remaining	ChEMBL.	9748360
k2 (binding)	= 0.49 min-1	Kinetic constant of the compound calculated from the pseudo-first-order rate constant(k app) for S-adenosylhomocysteine hydrolase inactivation	ChEMBL.	9748360
Ki (binding)	= 3.8 uM	Kinetic constant of the compound calculated from the pseudo-first-order rate constant(k app) for S-adenosylhomocysteine hydrolase inactivation	ChEMBL.	9748360
MIC (functional)	> 300 uM	Minimum inhibitory concentration(MIC) required to elicit a microscopically visible alteration of cell morphology in E6SM cells	ChEMBL.	9748360
MIC (functional)	> 300 uM	Minimum inhibitory concentration(MIC) required to elicit a microscopically visible alteration of cell morphology in HeLa cells	ChEMBL.	9748360
Release (functional)	= 28 %	Enzyme-mediated release of Adenine(Ade) from the compound	ChEMBL.	9748360
Release (functional)	= 70 %	Enzyme-mediated release of halide ions from the compound	ChEMBL.	9748360
Total coenzyme (functional)	= 49 %	NADH content of the enzyme (percentage of total coenzyme) from the compound	ChEMBL.	9748360

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	9748360

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL608943

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1126090