Detailed information for compound 1126179

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 513.626 | Formula: C28H39N3O6
  • H donors: 5 H acceptors: 5 LogP: 2.68 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCc1cc(ccc1O)[C@H](CNCCCCCCOCCCCc1ccc(cc1)N1C(=O)CNC1=O)O
  • InChi: 1S/C28H39N3O6/c32-20-23-17-22(10-13-25(23)33)26(34)18-29-14-4-1-2-5-15-37-16-6-3-7-21-8-11-24(12-9-21)31-27(35)19-30-28(31)36/h8-13,17,26,29,32-34H,1-7,14-16,18-20H2,(H,30,36)/t26-/m0/s1
  • InChiKey: PDSNPKNFICYVBX-SANMLTNESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0234 0.0533
Loa Loa (eye worm) beta-lactamase 0.004 0.0119 0.0119
Brugia malayi ecdysone receptor 0.0037 0.0109 0.0084
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.019 0.0381
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0127 0.0102
Echinococcus multilocularis musashi 0.003 0.0081 0.0116
Trichomonas vaginalis pyruvate kinase, putative 0.0078 0.0271 0.0169
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0131 0.0768
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0081 0.0056
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.019 0.0608
Loa Loa (eye worm) nuclear hormone receptor 0.0037 0.0109 0.0109
Onchocerca volvulus 0.0032 0.0089 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1344 0.5344 0.5295
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0109 0.0028
Echinococcus granulosus pyruvate kinase 0.004 0.012 0.0407
Brugia malayi pyruvate kinase, muscle isozyme 0.0016 0.0026 0.0001
Onchocerca volvulus 0.004 0.0119 0.0038
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0657 0.259 0.2501
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0037 0.0109 0.0155
Giardia lamblia Kinase, PLK 0.0112 0.0407 0.0291
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0079 0.0275 0.0251
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1764 0.7026 1
Schistosoma mansoni transcription factor btf3 0.0073 0.0254 0.0604
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0079 0.0275 0.0251
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0119 0.0131
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1344 0.5344 0.5295
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0079 0.0275 0.0935
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0246 0.0129
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0079 0.0275 0.0275
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.2506 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0117 0.043 0.1462
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.019 0.0088
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0109 0.0369
Brugia malayi intermediate filament protein 0.003 0.0081 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0107 0.0004
Echinococcus granulosus pyruvate kinase 0.004 0.012 0.0407
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0407 0.0306
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0182 0.0079
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1344 0.5344 0.5295
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0109 0.0096
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0037 0.0109 0.0109
Onchocerca volvulus Serine\/threonine kinase homolog 0.0112 0.0407 0.0328
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0081 0.0081
Echinococcus granulosus tumor protein p63 0.0251 0.0967 0.3284
Echinococcus granulosus ecdysone induced protein 78C 0.0079 0.0275 0.0935
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0246 0.0576
Brugia malayi beta-NAC-like protein 0.0073 0.0254 0.023
Plasmodium vivax pyruvate kinase 2, putative 0.004 0.012 0.0063
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0079 0.0275 0.0275
Onchocerca volvulus Bile acid receptor homolog 0.0079 0.0275 0.0196
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0043 0.0131 0.0446
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0079 0.0275 0.0251
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0079 0.0275 0.0275
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.019 0.0608
Echinococcus multilocularis nuclear receptor nhr 48 0.0037 0.0109 0.0155
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0079 0.0275 0.0392
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0079 0.0275 0.0275
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0109 0.0369
Echinococcus multilocularis pyruvate kinase 0.0061 0.0206 0.0292
Onchocerca volvulus Huntingtin homolog 0.0138 0.0514 0.0436
Brugia malayi Pyruvate kinase, muscle isozyme 0.0078 0.0271 0.0247
Entamoeba histolytica hypothetical protein 0.0117 0.043 0.033
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0079 0.0275 0.0196
Toxoplasma gondii pyruvate kinase PyKII 0.004 0.012 0.4314
Brugia malayi serine/threonine-protein kinase plk-2 0.0112 0.0407 0.0383
Schistosoma mansoni hypothetical protein 0.0394 0.1539 0.5093
Entamoeba histolytica protein tyrosine phosphatase, putative 0.2506 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0042 0.0127 0.018
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0043 0.0131 1
Loa Loa (eye worm) DR-78 0.0037 0.0109 0.0109
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.019 0.6972
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0112 0.0407 0.0407
Schistosoma mansoni thyroid hormone receptor 0.0079 0.0275 0.0678
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Schistosoma mansoni nuclear receptor 0.0037 0.0109 0.0096
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.019 0.019
Echinococcus multilocularis geminin 0.0394 0.1539 0.219
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0407 0.0306
Trypanosoma cruzi transcription factor btf3, putative 0.0073 0.0254 0.0817
Brugia malayi beta-lactamase family protein 0.004 0.0119 0.0094
Loa Loa (eye worm) hypothetical protein 0.0079 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0119 0.0131
Plasmodium falciparum pyruvate kinase 0.0078 0.0271 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0119 0.0119
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0246 0.0129
Loa Loa (eye worm) hypothetical protein 0.004 0.0119 0.0119
Entamoeba histolytica protein tyrosine phosphatase, putative 0.2506 1 1
Brugia malayi nuclear receptor NHR-88 0.0037 0.0109 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0079 0.0275 0.0275
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0037 0.0107 0.0082
Chlamydia trachomatis pyruvate kinase 0.0078 0.0271 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0079 0.0275 0.0935
Brugia malayi Nuclear hormone receptor-like 1 0.0079 0.0275 0.0251
Brugia malayi photoreceptor-specific nuclear receptor 0.0079 0.0275 0.0251
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0117 0.043 0.0612
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0127 0.0158
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Onchocerca volvulus 0.004 0.0119 0.0038
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.019 0.0088
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0036 0.0104 0.0324
Leishmania major basic transcription factor 3a, putative 0.0073 0.0254 0.0817
Schistosoma mansoni hypothetical protein 0.0394 0.1539 0.5093
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.2506 1 1
Echinococcus granulosus pyruvate kinase 0.0078 0.0271 0.0921
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1344 0.5344 0.5295
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.2506 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0246 0.0188
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0119 0.0403
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0043 0.0131 0.0187
Echinococcus granulosus pyruvate kinase 0.0078 0.0271 0.0921
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0407 0.1138
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Schistosoma mansoni hypothetical protein 0.0117 0.043 0.1219
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0079 0.0275 0.0935
Toxoplasma gondii ABC1 family protein 0.004 0.0119 0.4279
Brugia malayi Pyruvate kinase, M2 isozyme 0.0078 0.0271 0.0247
Loa Loa (eye worm) hypothetical protein 0.004 0.0119 0.0119
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1344 0.5344 0.5295
Echinococcus granulosus intermediate filament protein 0.003 0.0081 0.0276
Echinococcus granulosus dnaJ subfamily B 0.0459 0.1797 0.6106
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0081
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0079 0.0275 0.0678
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0043 0.0131 0.0415
Entamoeba histolytica hypothetical protein 0.0117 0.043 0.033
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.019 0.0088
Brugia malayi steroid hormone receptor 0.0079 0.0275 0.0251
Echinococcus granulosus expressed protein 0.0037 0.0107 0.0364
Echinococcus granulosus pyruvate kinase 0.004 0.012 0.0407
Brugia malayi hypothetical protein 0.0037 0.0109 0.0084
Brugia malayi MAP kinase sur-1 0.0057 0.019 0.0166
Schistosoma mansoni nuclear hormone receptor 0.0079 0.0275 0.0678
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0254 0.0152
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1344 0.5344 0.5295
Leishmania major hypothetical protein, conserved 0.0773 0.3055 1
Entamoeba histolytica transcription factor BTF3, putative 0.0073 0.0254 0.0152
Schistosoma mansoni rotamase 0.0037 0.0107 0.0091
Entamoeba histolytica hypothetical protein 0.0073 0.0254 0.0152
Toxoplasma gondii pyruvate kinase PyK1 0.0078 0.0271 1
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0127 0.0102
Brugia malayi hypothetical protein 0.0042 0.0127 0.0102
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0043 0.0131 0.0019
Brugia malayi nuclear hormone receptor 0.0037 0.0109 0.0084
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0119 0.0015
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0127
Onchocerca volvulus 0.0037 0.0109 0.0028
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.019 0.0647
Onchocerca volvulus Pyruvate kinase homolog 0.0078 0.0271 0.0191
Schistosoma mansoni hypothetical protein 0.0459 0.1797 0.5996
Giardia lamblia Pyruvate kinase 0.0078 0.0271 0.0153
Schistosoma mansoni cellular tumor antigen P53 0.0037 0.0107 0.0091
Schistosoma mansoni zinc finger protein 0.0037 0.0109 0.0096
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.019 0.0271
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0657 0.259 0.3642
Echinococcus multilocularis FTZ F1 alpha 0.0079 0.0275 0.0392
Leishmania major hypothetical protein, conserved 0.004 0.0119 0.0373
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0109 0.0155
Brugia malayi pyruvate kinase 0.0016 0.0026 0.0001
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0104 0.0324
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0079 0.0275 0.0275
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.019 0.0647
Echinococcus multilocularis tumor protein p63 0.0251 0.0967 0.1376
Brugia malayi nuclear receptor NHR-88 0.0079 0.0275 0.0251
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0119 0.0015
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Brugia malayi nuclear hormone receptor family member odr-7 0.0037 0.0109 0.0084
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.019 0.0271
Loa Loa (eye worm) hypothetical protein 0.0079 0.0275 0.0275
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0119 0.0094
Brugia malayi nuclear hormone receptor family member nhr-6 0.0037 0.0109 0.0084
Loa Loa (eye worm) hypothetical protein 0.0079 0.0275 0.0275
Trypanosoma cruzi polo-like protein kinase, putative 0.0112 0.0407 0.1319
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0119 0.0015
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0246 0.035
Entamoeba histolytica hypothetical protein 0.0117 0.043 0.033
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0043 0.0131 0.0131
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0079 0.0275 0.0392
Echinococcus granulosus nuclear receptor nhr 48 0.0037 0.0109 0.0369
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0079 0.0275 0.0251
Toxoplasma gondii NAC domain-containing protein 0.0073 0.0254 0.9366
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0079 0.0275 0.0392
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0079 0.0275 0.0251
Onchocerca volvulus 0.0037 0.0107 0.0026
Loa Loa (eye worm) hypothetical protein 0.0037 0.0107 0.0107
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.019 0.0608
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0109 0.0096
Brugia malayi nuclear hormone receptor 0.0079 0.0275 0.0251
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.0974 0.126
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0131 0.0028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0109 0.0155
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0246 0.0129
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.019 0.0088
Loa Loa (eye worm) hypothetical protein 0.0138 0.0514 0.0514
Schistosoma mansoni nuclear receptor 0.0037 0.0109 0.0096
Schistosoma mansoni nuclear receptor nhr-48 0.0037 0.0109 0.0096
Brugia malayi hypothetical protein 0.0042 0.0127 0.0102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1344 0.5344 0.5295
Echinococcus multilocularis expressed protein 0.0037 0.0107 0.0153
Mycobacterium leprae Probable pyruvate kinase PykA 0.0078 0.0271 0.0616
Loa Loa (eye worm) pyruvate kinase 0.0078 0.0271 0.0271
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.2506 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0407 0.0306
Toxoplasma gondii peptidylprolyl isomerase 0.0036 0.0104 0.3718
Schistosoma mansoni transcription factor LCR-F1 0.0117 0.043 0.1219
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0246 0.0836
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Echinococcus granulosus lamin dm0 0.003 0.0081 0.0276
Trypanosoma brucei pyruvate kinase 1 0.0078 0.0271 0.0873
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0079 0.0275 0.0678
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0131 0.0825
Brugia malayi nuclear receptor RXR 0.0037 0.0109 0.0084
Echinococcus multilocularis ecdysone induced protein 78C 0.0079 0.0275 0.0392
Brugia malayi hypothetical protein 0.0138 0.0514 0.049
Loa Loa (eye worm) hypothetical protein 0.004 0.0119 0.0119
Trypanosoma cruzi pyruvate kinase 2, putative 0.0078 0.0271 0.0873
Brugia malayi nuclear receptor NHR-67 0.0037 0.0109 0.0084
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0246 0.0791
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.2506 1 1
Giardia lamblia Fructose-bisphosphate aldolase 0.1344 0.5344 0.5288
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0104 0.0324
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0042 0.0127 0.0127
Entamoeba histolytica hypothetical protein 0.0117 0.043 0.033
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0042 0.0127 0.043
Echinococcus multilocularis lamin 0.003 0.0081 0.0116
Echinococcus granulosus FTZ F1 alpha 0.0079 0.0275 0.0935
Echinococcus multilocularis pyruvate kinase 0.0078 0.0271 0.0386
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0246 0.9061
Echinococcus multilocularis cpg binding protein 0.0034 0.0096 0.0137
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1344 0.5344 0.5295
Loa Loa (eye worm) hypothetical protein 0.0079 0.0275 0.0275
Onchocerca volvulus Pyruvate kinase homolog 0.0078 0.0271 0.0191
Loa Loa (eye worm) steroid hormone receptor 0.0079 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0079 0.0275 0.0392
Entamoeba histolytica pyruvate kinase, putative 0.0054 0.0177 0.0074
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0037 0.0109 0.0369
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0112 0.0407 0.0579
Onchocerca volvulus 0.0037 0.0109 0.0028
Mycobacterium ulcerans pyruvate kinase 0.0078 0.0271 0.0154
Plasmodium vivax pyruvate kinase, putative 0.0078 0.0271 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.004 0.0119 0.0119
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0131 0.0028
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0079 0.0275 0.0251
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0112 0.0407 0.1383
Schistosoma mansoni pyruvate kinase 0.0078 0.0271 0.0663
Schistosoma mansoni ap endonuclease 0.0043 0.0131 0.0175
Trypanosoma brucei transcription factor BTF3, putative 0.0073 0.0254 0.0817
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0019 0.0026
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0079 0.0275 0.0392
Loa Loa (eye worm) hypothetical protein 0.0079 0.0275 0.0275
Schistosoma mansoni thyroid hormone receptor 0.0079 0.0275 0.0678
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0037 0.0109 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0119 0.0373
Schistosoma mansoni RAR-like nuclear receptor 0.0079 0.0275 0.0678
Loa Loa (eye worm) pyruvate kinase 0.0016 0.0026 0.0026
Trypanosoma brucei protein kinase, putative 0.0057 0.019 0.0608
Echinococcus multilocularis microtubule associated protein 2 0.0745 0.2944 0.419
Schistosoma mansoni ap endonuclease 0.0043 0.0131 0.0175
Echinococcus multilocularis dnaJ subfamily B 0.0459 0.1797 0.2558
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0079 0.0275 0.0935
Echinococcus granulosus thyroid hormone receptor alpha 0.0037 0.0109 0.0369
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.2506 1 1
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.019 0.0072
Brugia malayi beta-lactamase 0.004 0.0119 0.0094
Schistosoma mansoni retinoic acid receptor RXR 0.0079 0.0275 0.0678
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0037 0.0107 0.0107
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.019 0.0608
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0025 0.0025
Brugia malayi nuclear receptor RXR 0.0042 0.0127 0.0102
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0079 0.0275 0.0678
Trypanosoma cruzi polo-like protein kinase, putative 0.0112 0.0407 0.1319
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Echinococcus granulosus geminin 0.0394 0.1539 0.5228
Schistosoma mansoni steroid hormone receptor ad4bp 0.0079 0.0275 0.0678
Brugia malayi exodeoxyribonuclease III family protein 0.0043 0.0131 0.0107
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0043 0.0131 0.0012
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0119 0.0119
Echinococcus granulosus lamin 0.003 0.0081 0.0276
Onchocerca volvulus Huntingtin homolog 0.0138 0.0514 0.0436
Brugia malayi hypothetical protein 0.0037 0.0109 0.0084
Loa Loa (eye worm) nuclear receptor NHR-67 0.0037 0.0109 0.0109
Brugia malayi tailless protein 0.0037 0.0109 0.0084
Trypanosoma cruzi hypothetical protein, conserved 0.0773 0.3055 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0079 0.0275 0.0935
Schistosoma mansoni cpg binding protein 0.0034 0.0096 0.0053
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0773 0.3055 0.2982
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0119 0.0373
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0109 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0079 0.0275 0.0251
Brugia malayi ecdysteroid receptor 0.0079 0.0275 0.0251
Onchocerca volvulus 0.0079 0.0275 0.0196
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0127
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0079 0.0275 0.0935
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0407 0.0306
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0042 0.0127 0.0158
Brugia malayi hypothetical protein 0.0117 0.043 0.0406
Trypanosoma brucei polo-like protein kinase 0.0112 0.0407 0.1319
Brugia malayi conserved hypotetical protein 0.0037 0.0109 0.0084
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0037 0.0109 0.0096
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0127
Onchocerca volvulus Protein ultraspiracle homolog 0.0079 0.0275 0.0196
Echinococcus granulosus microtubule associated protein 2 0.0745 0.2944 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0657 0.259 1
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0182 0.0079
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0019 0.0063
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.019 0.0608
Loa Loa (eye worm) hypothetical protein 0.0079 0.0275 0.0275
Leishmania major pyruvate kinase 0.0078 0.0271 0.0873
Trichomonas vaginalis rotamase, putative 0.0037 0.0107 0.0004
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0112 0.0407 0.1319
Trypanosoma cruzi pyruvate kinase 2, putative 0.0078 0.0271 0.0873
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0079 0.0275 0.0251
Echinococcus multilocularis pyruvate kinase 0.0078 0.0271 0.0386
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.2506 1 1
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0109 0.0084
Echinococcus multilocularis lamin dm0 0.003 0.0081 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0079 0.0275 0.0275
Echinococcus multilocularis pyruvate kinase 0.004 0.012 0.017
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0078 0.0271 0.0224
Loa Loa (eye worm) hypothetical protein 0.0078 0.0271 0.0271
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0089 0.0089
Leishmania major pyruvate kinase 0.0078 0.0271 0.0873
Echinococcus multilocularis transcription factor btf3 0.0073 0.0254 0.0362
Loa Loa (eye worm) hypothetical protein 0.0079 0.0275 0.0275
Plasmodium vivax basic transcription factor 3b, putative 0.0073 0.0254 0.8892
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.2506 1 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0112 0.0407 0.0306
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.019 0.0608
Echinococcus granulosus transcription factor btf3 0.0073 0.0254 0.0863
Loa Loa (eye worm) hypothetical protein 0.0138 0.0514 0.0514
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0119 0.0169
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.1734 0.6905 1
Brugia malayi CXXC zinc finger family protein 0.0032 0.0089 0.0064
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0119 0.0015
Plasmodium falciparum basic transcription factor 3b, putative 0.0073 0.0254 0.8885
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0407 0.0306
Loa Loa (eye worm) ICD-1 protein 0.0073 0.0254 0.0254
Schistosoma mansoni pyruvate kinase 0.0078 0.0271 0.0663
Onchocerca volvulus 0.2506 1 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0773 0.3055 0.2982
Trichomonas vaginalis pyruvate kinase, putative 0.0078 0.0271 0.0169
Schistosoma mansoni kinase 0.0057 0.0188 0.0374
Treponema pallidum fructose-bisphosphate aldolase 0.1344 0.5344 1
Schistosoma mansoni cpg binding protein 0.0032 0.0089 0.0027
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0043 0.0131 0.0028
Loa Loa (eye worm) pyruvate kinase 0.0078 0.0271 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0079 0.0275 0.0251
Echinococcus multilocularis pyruvate kinase 0.004 0.012 0.017
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0079 0.0275 0.0678
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0079 0.0275 0.0275
Schistosoma mansoni coup transcription factor 0.0079 0.0275 0.0678
Brugia malayi orphan nuclear receptor NR2E1 0.0037 0.0109 0.0084
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0109 0.0155
Brugia malayi beta-lactamase family protein 0.004 0.0119 0.0094
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0205 0.7501
Loa Loa (eye worm) hypothetical protein 0.0054 0.0177 0.0177
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0119 0.0373
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0023 0.0054 0.0029
Echinococcus granulosus cpg binding protein 0.0034 0.0096 0.0328
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0254 0.0152
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1344 0.5344 0.5295
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0079 0.0275 0.0678
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0079 0.0275 0.0251
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0773 0.3055 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0079 0.0275 0.0392
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1344 0.5344 0.5295
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0043 0.0131 0.0013
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0037 0.0109 0.0084
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0246 0.0576
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0043 0.0131 0.0415
Echinococcus multilocularis thyroid hormone receptor alpha 0.0079 0.0275 0.0392
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.2506 1 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0054 0.0177 0.0177
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0109 0.0084
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0037 0.0109 0.0096
Loa Loa (eye worm) intermediate filament protein 0.003 0.0081 0.0081
Brugia malayi Steroid receptor seven-up type 2 0.0079 0.0275 0.0251
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0043 0.0131 0.0415
Loa Loa (eye worm) hypothetical protein 0.004 0.0119 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0254 0.0152
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0079 0.0275 0.0935
Trichomonas vaginalis esterase, putative 0.004 0.0119 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0079 0.0275 0.0251
Echinococcus multilocularis pyruvate kinase 0.004 0.012 0.017
Trypanosoma brucei pyruvate kinase 1, putative 0.0078 0.0271 0.0873
Schistosoma mansoni microtubule-associated protein tau 0.0745 0.2944 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0079 0.0275 0.0251
Onchocerca volvulus Pyruvate kinase homolog 0.0078 0.0271 0.0191
Trypanosoma cruzi hypothetical protein, conserved 0.0773 0.3055 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0036 0.0104 0.0324
Trypanosoma cruzi transcription factor btf3, putative 0.0073 0.0254 0.0817
Toxoplasma gondii exonuclease III APE 0.0043 0.0131 0.4751
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0119 0.0015
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0127
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.019 0.0608
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0109 0.0369
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0407 0.0306
Schistosoma mansoni pyruvate kinase 0.004 0.012 0.0134
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0407 0.0306
Schistosoma mansoni cpg binding protein 0.0034 0.0096 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0079 0.0275 0.0251
Onchocerca volvulus 0.004 0.0119 0.0038
Loa Loa (eye worm) pyruvate kinase 0.0078 0.0271 0.0271
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0079 0.0275 0.0678
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0043 0.0131 0.0415

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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