Detailed information for compound 112628

Basic information

Technical information
  • TDR Targets ID: 112628
  • Name: 2-[(1R,3R)-3-(6-aminopurin-9-yl)cyclopentyl]- N-hydroxyacetamide
  • MW: 276.294 | Formula: C12H16N6O2
  • H donors: 3 H acceptors: 5 LogP: -0.47 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)C[C@@H]1CC[C@H](C1)n1cnc2c1ncnc2N
  • InChi: 1S/C12H16N6O2/c13-11-10-12(15-5-14-11)18(6-16-10)8-2-1-7(3-8)4-9(19)17-20/h5-8,20H,1-4H2,(H,17,19)(H2,13,14,15)/t7-,8-/m1/s1
  • InChiKey: NITZEITXMRNCEG-HTQZYQBOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(1R,3R)-3-(6-aminopurin-9-yl)cyclopentyl]ethanehydroxamic acid
  • 2-[(1R,3R)-3-(6-aminopurin-9-yl)cyclopentyl]-N-hydroxy-ethanamide
  • 2-[(1R,3R)-3-adenin-9-ylcyclopentyl]ethanehydroxamic acid
  • 2-[(1R,3R)-3-(6-amino-9-purinyl)cyclopentyl]ethanehydroxamic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenylate cyclase 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_126919 All targets in OG5_126919
Onchocerca volvulus Adenylate cyclase type 3 homolog Get druggable targets OG5_126919 All targets in OG5_126919
Loa Loa (eye worm) adenylyl cyclase 3 Get druggable targets OG5_126919 All targets in OG5_126919
Onchocerca volvulus Get druggable targets OG5_126919 All targets in OG5_126919
Echinococcus multilocularis adenylate cyclase 9 Get druggable targets OG5_126919 All targets in OG5_126919
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126919 All targets in OG5_126919
Onchocerca volvulus Adenylate cyclase type 2 homolog Get druggable targets OG5_126919 All targets in OG5_126919
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126919 All targets in OG5_126919
Brugia malayi Adenylyl cyclase protein Get druggable targets OG5_126919 All targets in OG5_126919
Echinococcus granulosus adenylate cyclase 9 Get druggable targets OG5_126919 All targets in OG5_126919
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0575 0.0566 0.0734
Schistosoma mansoni par domain protein 0.002 0.0007 0.0009
Leishmania major regulatory subunit of protein kinase a-like protein 0.0015 0.0002 0.0001
Schistosoma mansoni neuropeptide receptor 0.0575 0.0566 0.0734
Schistosoma mansoni cpg binding protein 0.0033 0.0021 0.0027
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Brugia malayi Hepatic leukemia factor 0.002 0.0007 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.0575 0.0566 0.0735
Schistosoma mansoni lamin 0.0026 0.0014 0.0017
Echinococcus multilocularis serotonin receptor 0.0575 0.0566 0.0735
Echinococcus multilocularis RUN 0.0023 0.001 0.0014
Echinococcus granulosus 7tm_1 domain containing protein 0.0575 0.0566 0.0735
Onchocerca volvulus 0.0575 0.0566 0.0734
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0011 0.0484
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0575 0.0566 0.0734
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.001 0.0009
Onchocerca volvulus 0.003 0.0017 0.0022
Brugia malayi Serotonin receptor 0.0575 0.0566 0.0734
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0015 0.0019
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0015 0.0019
Echinococcus granulosus g-protein coupled receptor 0.0575 0.0566 0.0735
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0015 0.0002 0.0003
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0015 0.0002 0.0003
Toxoplasma gondii NAC domain-containing protein 0.0041 0.0028 0.0027
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0015 0.0019
Loa Loa (eye worm) thymidylate synthase 0.7663 0.771 1
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0062 0.008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0575 0.0566 0.0734
Schistosoma mansoni lamin 0.0026 0.0014 0.0017
Treponema pallidum cyclic nucleotide binding protein 0.0015 0.0002 0.5
Brugia malayi CHE-14 protein 0.0042 0.0029 0.0038
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0015 0.0002 0.0002
Mycobacterium ulcerans regulatory protein 0.0015 0.0002 0.0002
Echinococcus multilocularis serotonin receptor 0.0575 0.0566 0.0735
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0017 0.0022
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0005 0.0003
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.001 0.0012
Echinococcus multilocularis fmrfamide receptor 0.0575 0.0566 0.0735
Brugia malayi hypothetical protein 0.0575 0.0566 0.0734
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0006
Loa Loa (eye worm) cytochrome P450 0.0014 0.0001 0.0001
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.001 0.0012
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0027 0.0015 0.0014
Echinococcus multilocularis neuropeptide Y receptor 0.0575 0.0566 0.0735
Echinococcus multilocularis transcription factor btf3 0.0041 0.0028 0.0037
Brugia malayi bZIP transcription factor family protein 0.002 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0009
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0015 0.0019
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0015 0.0002 0.0001
Onchocerca volvulus 0.0575 0.0566 0.0734
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0015 0.0002 0.0003
Plasmodium vivax basic transcription factor 3b, putative 0.0041 0.0028 0.0026
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0015 0.0002 0.0001
Echinococcus multilocularis expressed conserved protein 0.0015 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0477 0.0468 0.0606
Brugia malayi Doublecortin family protein 0.0023 0.001 0.0013
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0015 0.0002 0.0001
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0015 0.0019
Schistosoma mansoni multidrug resistance protein 0.0027 0.0015 0.0019
Echinococcus multilocularis lamin dm0 0.0026 0.0014 0.0018
Leishmania major protein kinase A regulatory subunit, putative 0.0015 0.0002 0.0001
Entamoeba histolytica transcription factor BTF3, putative 0.0041 0.0028 0.2722
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0085 0.011
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0005 0.0006
Schistosoma mansoni hypothetical protein 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Schistosoma mansoni hypothetical protein 0.004 0.0028 0.0036
Echinococcus granulosus somatostatin receptor 0.0575 0.0566 0.0735
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0027 0.0015 0.0014
Echinococcus granulosus protocadherin 11 0.002 0.0007 0.0009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0575 0.0566 0.0734
Brugia malayi dihydrofolate reductase family protein 0.4336 0.4357 0.5651
Echinococcus granulosus ccaat enhancer binding protein delta 0.002 0.0007 0.0009
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0015 0.0002 0.0003
Echinococcus multilocularis somatostatin receptor 0.0575 0.0566 0.0735
Mycobacterium ulcerans hypothetical protein 0.0015 0.0002 0.0002
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.9935 1 1
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0027 0.0015 0.0014
Brugia malayi hypothetical protein 0.0575 0.0566 0.0734
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Schistosoma mansoni transcription factor btf3 0.0041 0.0028 0.0036
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.001 0.0008
Entamoeba histolytica ATP-binding cassette protein, putative 0.0027 0.0015 0.1007
Entamoeba histolytica multidrug resistance protein, putative 0.0027 0.0015 0.1007
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0062 0.008
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.0015 0.0019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0004 0.0004
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0021 0.0027
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0033 0.002 0.0026
Mycobacterium ulcerans thymidine phosphorylase 0.6232 0.6268 0.8129
Brugia malayi RNA binding protein 0.0074 0.0062 0.008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0085 0.0111
Brugia malayi Cyclic-nucleotide gated cation channel 0.0022 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0003
Treponema pallidum catabolite gene activator (Crp) 0.0015 0.0002 0.5
Onchocerca volvulus 0.0068 0.0055 0.0071
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Loa Loa (eye worm) melatonin receptor type 1A 0.0575 0.0566 0.0735
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0022 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0018
Onchocerca volvulus 0.0263 0.0252 0.0327
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0015 0.0002 0.0003
Echinococcus granulosus cGMP dependent protein kinase 1 0.0015 0.0002 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0015 0.0019
Trypanosoma brucei p-glycoprotein 0.0027 0.0015 0.0014
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0011 0.001
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.08 0.0794 0.103
Echinococcus multilocularis rhodopsin orphan GPCR 0.0575 0.0566 0.0735
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.001 0.0014
Onchocerca volvulus 0.0575 0.0566 0.0734
Echinococcus granulosus tumor protein p63 0.0334 0.0323 0.042
Echinococcus granulosus microtubule associated protein 2 0.1486 0.1484 0.1925
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0085 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0062 0.008
Echinococcus granulosus serotonin receptor 0.0575 0.0566 0.0735
Giardia lamblia MRP-like ABC transporter 0.0027 0.0015 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0009
Onchocerca volvulus 0.0015 0.0002 0.0003
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0029 0.0038
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0127 0.0165
Echinococcus multilocularis expressed conserved protein 0.0091 0.0079 0.0103
Brugia malayi Cell death specification protein 2 0.002 0.0007 0.0009
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.0015 0.0019
Brugia malayi larval opioid receptor 0.0575 0.0566 0.0734
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Echinococcus granulosus multidrug resistance associated protein 7 0.0027 0.0015 0.0019
Schistosoma mansoni amine GPCR 0.0575 0.0566 0.0734
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0112 0.0101 0.013
Brugia malayi ecdysteroid receptor 0.0027 0.0015 0.0019
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0027 0.0015 0.0014
Leishmania major cyclic nucleotide-binding protein-like protein 0.0015 0.0002 0.0001
Echinococcus multilocularis orexin receptor type 2 0.0575 0.0566 0.0735
Loa Loa (eye worm) hypothetical protein 0.0051 0.0039 0.005
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0015 0.0019
Schistosoma mansoni alpha-1 adrenergic receptor 0.0575 0.0566 0.0734
Loa Loa (eye worm) CYP4Cod1 0.0022 0.001 0.0013
Echinococcus multilocularis 0.0014 0.0001 0.0001
Echinococcus multilocularis neuropeptides capa receptor 0.0575 0.0566 0.0735
Echinococcus granulosus lamin 0.0026 0.0014 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0015 0.0019
Echinococcus granulosus alpha 1A adrenergic receptor 0.0575 0.0566 0.0735
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0015 0.0002 0.0003
Schistosoma mansoni adenoreceptor 0.0575 0.0566 0.0734
Echinococcus multilocularis fmrfamide receptor 0.0575 0.0566 0.0735
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0575 0.0566 0.0735
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.001 0.0011
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0015 0.002
Brugia malayi hypothetical protein 0.0575 0.0566 0.0734
Echinococcus multilocularis thymidylate synthase 0.7663 0.771 1
Echinococcus multilocularis thymidine phosphorylase 0.6232 0.6268 0.813
Schistosoma mansoni multidrug resistance protein 0.0027 0.0015 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0017 0.0022
Loa Loa (eye worm) hypothetical protein 0.0098 0.0086 0.0111
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0014
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0575 0.0566 0.0735
Loa Loa (eye worm) hypothetical protein 0.0022 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0019
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0015 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.001 0.0014
Echinococcus multilocularis neuropeptide Y receptor 0.0575 0.0566 0.0735
Schistosoma mansoni biogenic amine (5HT) receptor 0.0575 0.0566 0.0734
Schistosoma mansoni hypothetical protein 0.062 0.0612 0.0794
Plasmodium falciparum basic transcription factor 3b, putative 0.0041 0.0028 0.0026
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0014 0.0017
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0575 0.0566 0.0735
Leishmania major hypothetical protein, conserved 0.0015 0.0002 0.0001
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.6232 0.6268 0.8129
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.001 0.0013
Leishmania major hypothetical protein, conserved 0.0015 0.0002 0.0001
Echinococcus granulosus dnaJ subfamily B 0.0477 0.0468 0.0607
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0015 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0097 0.0085 0.0111
Echinococcus multilocularis transcriptional factor nfil3:e4bp4 0.002 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0002
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.001 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0575 0.0566 0.0734
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0028 0.0076
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0022 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Onchocerca volvulus 0.002 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0003
Brugia malayi Pre-SET motif family protein 0.0202 0.0191 0.0247
Echinococcus multilocularis rhodopsin orphan GPCR 0.0575 0.0566 0.0735
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0015 0.0019
Loa Loa (eye worm) RNA binding protein 0.0074 0.0062 0.008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0017
Brugia malayi hypothetical protein 0.002 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0015 0.0019
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0575 0.0566 0.0734
Brugia malayi neuropeptide F receptor 0.0575 0.0566 0.0734
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Onchocerca volvulus 0.023 0.0219 0.0283
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Trypanosoma cruzi hypothetical protein 0.0021 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0049 0.0037 0.0047
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0015 0.0019
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0575 0.0566 0.0734
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0575 0.0566 0.0734
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0575 0.0566 0.0735
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0014
Echinococcus granulosus patatin phospholipase domain containing protein 0.0015 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.004 0.0028 0.0036
Onchocerca volvulus 0.0575 0.0566 0.0734
Schistosoma mansoni multidrug resistance protein 0.0027 0.0015 0.0019
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Brugia malayi hypothetical protein 0.0575 0.0566 0.0734
Schistosoma mansoni cpg binding protein 0.0035 0.0023 0.0029
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0033 0.002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Echinococcus granulosus translocator protein 0.0263 0.0252 0.0327
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.001 0.0008
Echinococcus multilocularis g-protein coupled receptor 0.0575 0.0566 0.0735
Trypanosoma brucei cAMP response protein 1, putative 0.0015 0.0002 0.0001
Onchocerca volvulus 0.0575 0.0566 0.0734
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.002 0.0007 0.0009
Schistosoma mansoni growth hormone secretagogue receptor 0.0575 0.0566 0.0734
Leishmania major protein kinase, putative 0.0015 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Echinococcus granulosus X box binding protein 1 0.062 0.0612 0.0794
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0071 0.0058 0.0076
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0011 0.0484
Brugia malayi Pre-SET motif family protein 0.003 0.0017 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0015 0.0019
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0015 0.0002 0.0003
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.001 0.0014
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.001 0.0014
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0575 0.0566 0.0735
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0062 0.008
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0196 0.0184 0.0239
Mycobacterium ulcerans tryptophan-rich sensory protein 0.0263 0.0252 0.0326
Trypanosoma cruzi transcription factor btf3, putative 0.0041 0.0028 0.0027
Onchocerca volvulus 0.0575 0.0566 0.0734
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0014 0.0018
Leishmania major ABC-thiol transporter 0.0027 0.0015 0.0014
Echinococcus multilocularis neuropeptide receptor 0.0575 0.0566 0.0735
Schistosoma mansoni biogenic amine (5HT) receptor 0.0575 0.0566 0.0734
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0015 0.0002 0.0003
Schistosoma mansoni amine GPCR 0.0575 0.0566 0.0734
Brugia malayi Dopamine receptor protein 2 0.0575 0.0566 0.0734
Echinococcus multilocularis cyclic AMP responsive element binding protein 0.002 0.0007 0.0009
Brugia malayi hypothetical protein 0.0106 0.0094 0.0122
Echinococcus granulosus protocadherin 11 0.002 0.0007 0.0009
Brugia malayi Cytochrome P450 family protein 0.0022 0.001 0.0012
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0015 0.0002 0.0003
Brugia malayi Dihydrofolate reductase 0.4336 0.4357 0.5651
Echinococcus multilocularis g protein coupled receptor 0.0575 0.0566 0.0735
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0015 0.0002 0.0003
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0011 0.0013
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0029 0.0038
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Giardia lamblia Multidrug resistance-associated protein 1 0.0027 0.0015 1
Echinococcus multilocularis G protein coupled receptor 139 0.0575 0.0566 0.0735
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0019
Schistosoma mansoni voltage-gated potassium channel 0.0123 0.0111 0.0144
Schistosoma mansoni neuropeptide F-like receptor 0.0575 0.0566 0.0734
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0014
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0002 0.0002
Echinococcus granulosus hypothetical protein 0.0575 0.0566 0.0735
Brugia malayi intermediate filament protein 0.0026 0.0014 0.0017
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.001 0.0013
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0575 0.0566 0.0734
Echinococcus multilocularis rhodopsin orphan GPCR 0.0575 0.0566 0.0735
Schistosoma mansoni opsin-like receptor 0.0575 0.0566 0.0734
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0575 0.0566 0.0734
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Onchocerca volvulus 0.0023 0.0011 0.0014
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0011 0.0013
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0015 0.0002 0.0003
Brugia malayi hypothetical protein 0.0575 0.0566 0.0734
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.7663 0.771 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0017 0.0022
Echinococcus multilocularis g protein coupled receptor 0.0575 0.0566 0.0735
Brugia malayi hypothetical protein 0.0014 0.0002 0.0002
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0017 0.0022
Brugia malayi hypothetical protein 0.0575 0.0566 0.0734
Trypanosoma cruzi transcription factor btf3, putative 0.0041 0.0028 0.0027
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0575 0.0566 0.0734
Brugia malayi multidrug resistance related protein 1 0.0027 0.0015 0.0019
Onchocerca volvulus 0.0071 0.0058 0.0075
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0575 0.0566 0.0734
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0011 0.0013
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0022 0.001 0.0013
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0027 0.0015 0.0014
Echinococcus granulosus thymidine phosphorylase 0.6232 0.6268 0.813
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0575 0.0566 0.0735
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.001 0.0012
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0015 0.0002 0.0003
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0112 0.0101 0.0131
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0001 0.0002
Trypanosoma cruzi cAMP response protein 1 0.0015 0.0002 0.0001
Trypanosoma brucei multidrug resistance protein E 0.0027 0.0015 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0017 0.0022
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.3645 0.3661 0.366
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0014
Echinococcus granulosus biogenic amine 5HT receptor 0.0575 0.0566 0.0735
Echinococcus granulosus cGMP dependent protein kinase 1 0.0015 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0575 0.0566 0.0734
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0022 0.001 0.0013
Loa Loa (eye worm) neuropeptide F receptor 0.0575 0.0566 0.0735
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0028 0.0076
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.9935 1 1
Brugia malayi neuropeptide F receptor 0.0575 0.0566 0.0734
Echinococcus granulosus allatostatin A receptor 0.0575 0.0566 0.0735
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.0193 0.0181 0.0235
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0575 0.0566 0.0735
Echinococcus multilocularis rhodopsin orphan GPCR 0.0575 0.0566 0.0735
Brugia malayi TspO/MBR family protein 0.0263 0.0252 0.0327
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0015 0.0002 0.0003
Echinococcus granulosus lamin dm0 0.0026 0.0014 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0004 0.0004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0575 0.0566 0.0735
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0015 0.0002 0.0001
Brugia malayi G-protein coupled receptor 0.0575 0.0566 0.0734
Echinococcus multilocularis translocator protein 0.0263 0.0252 0.0327
Echinococcus multilocularis neuropeptide receptor A26 0.0575 0.0566 0.0735
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0006
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0575 0.0566 0.0734
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0575 0.0566 0.0734
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0002 0.0003
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0022 0.001 0.0013
Echinococcus granulosus biogenic amine 5HT receptor 0.0575 0.0566 0.0735
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0015 0.0019
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0575 0.0566 0.0734
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0019
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.1759 0.176 0.2282
Brugia malayi Dopamine receptor 0.0575 0.0566 0.0734
Onchocerca volvulus 0.0575 0.0566 0.0734
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.4336 0.4357 0.5651
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0029 0.0078
Brugia malayi Serotonin receptor 0.0575 0.0566 0.0734
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0019
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0575 0.0566 0.0734
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.001 0.0009
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0575 0.0566 0.0735
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0575 0.0566 0.0735
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0029 0.0038
Echinococcus multilocularis adenylate cyclase 9 0.0071 0.0058 0.0076
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0011 0.0013
Schistosoma mansoni amine GPCR 0.0575 0.0566 0.0734
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0017 0.0022
Schistosoma mansoni opsin-like receptor 0.0575 0.0566 0.0734
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0575 0.0566 0.0734
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.002 0.0007 0.0009
Echinococcus granulosus neuropeptide receptor 0.0575 0.0566 0.0735
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.0002 0.0002
Brugia malayi cytochrome P450 0.0014 0.0001 0.0001
Treponema pallidum catabolite gene activator 0.0015 0.0002 0.5
Echinococcus granulosus cpg binding protein 0.0035 0.0023 0.003
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0575 0.0566 0.0734
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0015 0.0019
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Trypanosoma brucei transcription factor BTF3, putative 0.0041 0.0028 0.0027
Onchocerca volvulus 0.0023 0.001 0.0013
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.9935 1 1
Schistosoma mansoni amine GPCR 0.0575 0.0566 0.0734
Loa Loa (eye worm) adenylyl cyclase 3 0.0167 0.0155 0.0202
Brugia malayi nuclear hormone receptor 0.0027 0.0015 0.0019
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0015 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0575 0.0566 0.0734
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0015 0.0002 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0015 0.0019
Loa Loa (eye worm) ICD-1 protein 0.0041 0.0028 0.0037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0015 0.0019
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0575 0.0566 0.0734
Echinococcus multilocularis g protein coupled receptor 0.0575 0.0566 0.0735
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0575 0.0566 0.0735
Mycobacterium ulcerans thymidylate synthase 0.7663 0.771 1
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0005 0.0003
Schistosoma mansoni biogenic amine receptor 0.0575 0.0566 0.0734
Brugia malayi hypothetical protein 0.0575 0.0566 0.0734
Mycobacterium ulcerans hypothetical protein 0.0015 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0015 0.0002 0.0003
Loa Loa (eye worm) G-protein coupled receptor 0.0575 0.0566 0.0735
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.7663 0.771 1
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0015 0.0002 0.0003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0015 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0575 0.0566 0.0735
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0015 0.0019
Echinococcus granulosus dihydrofolate reductase 0.4336 0.4357 0.5651
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0015 0.0002 0.0003
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0027 0.0015 0.0014
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.7663 0.771 1
Echinococcus multilocularis protocadherin 11 0.002 0.0007 0.0009
Treponema pallidum cyclic nucleotide binding protein 0.0015 0.0002 0.5
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0575 0.0566 0.0734
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0005 0.0005
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.001 0.0012
Echinococcus granulosus neuropeptide receptor 0.0575 0.0566 0.0735
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0015 0.0019
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0015 0.0002 0.0003
Trypanosoma brucei cytochrome P450, putative 0.0022 0.001 0.0009
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0015 0.0002 0.0004
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0009
Brugia malayi Cytochrome P450 family protein 0.0032 0.002 0.0025
Brugia malayi CXXC zinc finger family protein 0.0033 0.0021 0.0027
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.001 0.0014
Echinococcus granulosus tar DNA binding protein 0.0074 0.0062 0.008
Mycobacterium ulcerans transmembrane transport protein 0.0015 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.005 0.0038 0.0048
Onchocerca volvulus 0.0026 0.0014 0.0017
Echinococcus granulosus g protein coupled receptor 0.0575 0.0566 0.0735
Trichomonas vaginalis set domain proteins, putative 0.023 0.0219 0.0595
Mycobacterium ulcerans hypothetical protein 0.0015 0.0002 0.0002
Schistosoma mansoni amine GPCR 0.0575 0.0566 0.0734
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0022 0.001 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0015 0.0019
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0027 0.0015 0.0014
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0015 0.0002 0.0003
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.0033 0.002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.002 0.0026
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.002 0.0007 0.0009
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0002 0.0002
Brugia malayi G protein-coupled receptor 0.0575 0.0566 0.0734
Brugia malayi AKH receptor 0.0575 0.0566 0.0734
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0002
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0575 0.0566 0.0734
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.001 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0062 0.008
Trypanosoma cruzi Flagellar Member 6 0.0015 0.0002 0.0001
Onchocerca volvulus 0.0575 0.0566 0.0734
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Onchocerca volvulus 0.0575 0.0566 0.0734
Echinococcus multilocularis neuropeptide FF receptor 2 0.0575 0.0566 0.0735
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0015 0.0002 0.0003
Echinococcus granulosus voltage gated potassium channel 0.0033 0.002 0.0026
Brugia malayi ORL1-like opioid receptor 0.0575 0.0566 0.0734
Echinococcus multilocularis tumor protein p63 0.0334 0.0323 0.042
Echinococcus granulosus neuropeptide Y receptor 0.0575 0.0566 0.0735
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0002 0.0003
Brugia malayi MH2 domain containing protein 0.0139 0.0128 0.0165
Schistosoma mansoni hypothetical protein 0.0575 0.0566 0.0734
Schistosoma mansoni neuropeptide F-like receptor 0.0575 0.0566 0.0734
Echinococcus multilocularis adenylate cyclase type IX 0.0099 0.0087 0.0113
Entamoeba histolytica hypothetical protein 0.0027 0.0015 0.1007
Echinococcus granulosus thymidylate synthase 0.7663 0.771 1
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.001 0.0013
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0027 0.0015 0.0014
Brugia malayi N-terminal motif family protein 0.0015 0.0002 0.0003
Schistosoma mansoni peripheral-type benzodiazepine receptor 0.0263 0.0252 0.0327
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0015 0.0019
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.0128 0.0165
Schistosoma mansoni biogenic amine receptor 0.0575 0.0566 0.0734
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0001 0.0001
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0015 0.0002 0.0003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0575 0.0566 0.0735
Onchocerca volvulus 0.0049 0.0037 0.0047
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0112 0.0101 0.0131
Brugia malayi steroid hormone receptor 0.0027 0.0015 0.0019
Chlamydia trachomatis dihydrofolate reductase 0.4336 0.4357 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0575 0.0566 0.0735
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.0191 0.0247
Leishmania major cytochrome p450-like protein 0.0022 0.001 0.0009
Echinococcus multilocularis microtubule associated protein 2 0.1486 0.1484 0.1925
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.0015 0.0019
Echinococcus multilocularis protocadherin 11 0.002 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.0528 0.052 0.0674
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0011 0.0014
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0002 0.0002
Echinococcus granulosus tm gpcr rhodopsin 0.0575 0.0566 0.0735
Onchocerca volvulus 0.0026 0.0014 0.0017
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0575 0.0566 0.0735
Schistosoma mansoni hypothetical protein 0.0023 0.001 0.0013
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0019
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0022 0.001 0.0013
Echinococcus multilocularis voltage gated potassium channel 0.0033 0.002 0.0026
Echinococcus granulosus tachykinin peptides receptor 99D 0.0575 0.0566 0.0735
Onchocerca volvulus 0.7663 0.771 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Onchocerca volvulus 0.0575 0.0566 0.0734
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0015 0.0002 0.0003
Schistosoma mansoni intermediate filament proteins 0.0026 0.0014 0.0017
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0062 0.008
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.0015 0.0019
Mycobacterium tuberculosis Conserved protein 0.0015 0.0002 0.0002
Echinococcus multilocularis sex peptide receptor 0.0575 0.0566 0.0735
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0015 0.0002 0.0003
Echinococcus multilocularis dnaJ subfamily B 0.0477 0.0468 0.0607
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0019
Schistosoma mansoni biogenic amine receptor 0.0575 0.0566 0.0734
Echinococcus multilocularis dro:myosuppressin receptor 0.0575 0.0566 0.0735
Echinococcus multilocularis ccaat enhancer binding protein delta ccaat enhancer binding protein beta 0.002 0.0007 0.0009
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0015 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0575 0.0566 0.0735
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0028 0.0076
Brugia malayi nuclear receptor RXR 0.0014 0.0002 0.0002
Echinococcus granulosus multidrug resistance associated protein 1 0.0027 0.0015 0.0019
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0001 0.0001
Loa Loa (eye worm) TYRA-2 protein 0.0575 0.0566 0.0735
Echinococcus granulosus transcriptional factor nfil3:e4bp4 0.002 0.0007 0.0009
Schistosoma mansoni 60S ribosomal protein L21 0.0018 0.0005 0.0006
Brugia malayi hypothetical protein 0.0023 0.001 0.0013
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0575 0.0566 0.0734
Loa Loa (eye worm) hypothetical protein 0.0263 0.0252 0.0327
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0014
Leishmania major protein kinase, putative 0.0015 0.0002 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0011 0.0014
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0015 0.0002 0.0001
Echinococcus granulosus sex peptide receptor 0.0575 0.0566 0.0735
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0002 0.0004
Onchocerca volvulus 0.0015 0.0002 0.0003
Schistosoma mansoni cytochrome P450 0.0014 0.0001 0.0001
Onchocerca volvulus 0.0575 0.0566 0.0734
Brugia malayi hypothetical protein 0.0023 0.001 0.0013
Onchocerca volvulus 0.0575 0.0566 0.0734
Schistosoma mansoni hypothetical protein 0.0575 0.0566 0.0734
Echinococcus granulosus neuropeptide Y receptor 0.0575 0.0566 0.0735
Schistosoma mansoni hypothetical protein 0.004 0.0028 0.0036
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0112 0.0101 0.0131
Onchocerca volvulus 0.0263 0.0252 0.0327
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.001 0.0013
Echinococcus multilocularis allatostatin A receptor 0.0575 0.0566 0.0735
Loa Loa (eye worm) bZIP transcription factor family protein 0.002 0.0007 0.0009
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0575 0.0566 0.0735
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Schistosoma mansoni rab6-interacting 0.0023 0.001 0.0013
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0017 0.0016
Echinococcus granulosus fmrfamide receptor 0.0575 0.0566 0.0735
Echinococcus granulosus tm gpcr rhodopsin 0.0575 0.0566 0.0735
Echinococcus multilocularis neuropeptides capa receptor 0.0575 0.0566 0.0735
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0037 0.0047
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0062 0.008
Schistosoma mansoni rab6-interacting 0.0023 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0263 0.0252 0.0327
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0015 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0002
Brugia malayi Cytochrome P450 family protein 0.0022 0.001 0.0012
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0005 0.0006
Schistosoma mansoni neuropeptide f receptor 76f 0.0575 0.0566 0.0734
Loa Loa (eye worm) G-protein coupled receptor 0.0575 0.0566 0.0735
Brugia malayi Egg laying defective protein 4 0.0015 0.0002 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0575 0.0566 0.0735
Mycobacterium ulcerans hypothetical protein 0.0023 0.0011 0.0013
Brugia malayi nuclear receptor NHR-88 0.0027 0.0015 0.0019
Echinococcus multilocularis multidrug resistance associated protein 7 0.0027 0.0015 0.0019
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0575 0.0566 0.0735
Echinococcus granulosus neuropeptide FF receptor 2 0.0575 0.0566 0.0735
Echinococcus multilocularis X box binding protein 1 0.062 0.0612 0.0794
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0011 0.0014
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.9935 1 1
Onchocerca volvulus 0.0575 0.0566 0.0734
Echinococcus multilocularis protein patched 0.0042 0.0029 0.0038
Brugia malayi hypothetical protein 0.0014 0.0002 0.0002
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0015 0.0019
Echinococcus granulosus geminin 0.0528 0.052 0.0674
Schistosoma mansoni myosin xvIII 0.0575 0.0566 0.0734
Brugia malayi TAR-binding protein 0.0074 0.0062 0.008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0004 0.0004
Schistosoma mansoni transcriptional factor nfil3/e4bp4 0.002 0.0007 0.0009
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0015 0.0002 0.0004
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.001 0.0013
Brugia malayi hypothetical protein 0.0575 0.0566 0.0734
Onchocerca volvulus 0.002 0.0007 0.0009
Echinococcus multilocularis lamin 0.0026 0.0014 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Schistosoma mansoni multidrug resistance protein 0.0027 0.0015 0.0019
Brugia malayi GnHR receptor homolog 0.0575 0.0566 0.0734
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0015 0.0019
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0014 0.0018
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.001 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0575 0.0566 0.0735
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.002 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Entamoeba histolytica ATP-binding cassette protein, putative 0.0027 0.0015 0.1007
Giardia lamblia Multidrug resistance-associated protein 1 0.0027 0.0015 1
Onchocerca volvulus 0.0575 0.0566 0.0734
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0062 0.008
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.002 0.0026
Echinococcus multilocularis dihydrofolate reductase 0.4336 0.4357 0.5651
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0575 0.0566 0.0735
Giardia lamblia ABC transporter, putative 0.0027 0.0015 1
Echinococcus granulosus expressed conserved protein 0.0091 0.0079 0.0103
Echinococcus granulosus peptide allatostatin:somatostatin 0.0575 0.0566 0.0735
Echinococcus multilocularis G-protein coupled receptor, putative 0.0575 0.0566 0.0735
Mycobacterium ulcerans hypothetical protein 0.0015 0.0002 0.0002
Trypanosoma cruzi protein kinase A regulatory subunit 0.0015 0.0002 0.0001
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0575 0.0566 0.0735
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.001 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.3645 0.3661 1
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0015 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0002
Schistosoma mansoni polycystin 1-related 0.0023 0.001 0.0013
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0105 0.0093 0.0252
Brugia malayi Melatonin receptor type 1A 0.0575 0.0566 0.0734
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.0575 0.0566 0.0735
Leishmania major hypothetical protein, unknown function 0.0015 0.0002 0.0001
Brugia malayi hypothetical protein 0.0575 0.0566 0.0734
Schistosoma mansoni neuropeptide receptor 0.0575 0.0566 0.0734
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0015 0.0019
Echinococcus granulosus multidrug resistance associated protein 4 0.0021 0.0009 0.0011
Echinococcus multilocularis protein dispatched 1 0.0048 0.0035 0.0046
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.0575 0.0566 0.0735
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0004 0.0004
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0019
Brugia malayi RE15519p 0.0575 0.0566 0.0734
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0015 0.0002 0.0001
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.001 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0015 0.0019
Schistosoma mansoni neuropeptide receptor 0.0575 0.0566 0.0734
Schistosoma mansoni histamine h1 receptor 0.0575 0.0566 0.0734
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0027 0.0015 0.0014
Loa Loa (eye worm) multidrug resistance-associated protein 0.0021 0.0009 0.0011
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0127 0.0165
Echinococcus multilocularis cpg binding protein 0.0035 0.0023 0.003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0015 0.0019
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0575 0.0566 0.0735
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0015 0.0002 0.0002
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0033 0.002 0.0026
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.0002 0.0002
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0071 0.0058 0.0075
Onchocerca volvulus Neuropeptide F receptor homolog 0.0575 0.0566 0.0734
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0695 0.0688 0.0892
Echinococcus granulosus neuropeptide receptor A26 0.0575 0.0566 0.0735
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.1759 0.176 0.2282
Brugia malayi hypothetical protein 0.002 0.0007 0.0009
Onchocerca volvulus 0.0023 0.001 0.0013
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0052 0.0051
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0015 0.0019
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.9935 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0011 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0015 0.0019
Schistosoma mansoni lipoxygenase 0.0023 0.001 0.0013
Echinococcus multilocularis multidrug resistance associated protein 4 0.0021 0.0009 0.0011
Entamoeba histolytica ATP-binding cassette protein, putative 0.0027 0.0015 0.1007
Brugia malayi hypothetical protein 0.3645 0.3661 0.4748
Schistosoma mansoni patched 1 0.0042 0.0029 0.0038
Mycobacterium leprae Conserved hypothetical protein 0.0015 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Schistosoma mansoni thyrotroph embryonic factor related 0.002 0.0007 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0015 0.0019
Brugia malayi sulfakinin receptor protein 0.0575 0.0566 0.0734
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0006
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0015 0.0002 0.0003
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0062 0.008
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0011 0.0013
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0575 0.0566 0.0735
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0009
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0011 0.0484
Echinococcus granulosus adenylate cyclase type IX 0.0099 0.0087 0.0113
Schistosoma mansoni hypothetical protein 0.0575 0.0566 0.0734
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0015 0.0019
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0015 0.0019
Brugia malayi Cell death specification protein 2 0.002 0.0007 0.0009
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0085 0.0111
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Schistosoma mansoni cpg binding protein 0.0035 0.0023 0.0029
Loa Loa (eye worm) neuropeptide F receptor 0.0575 0.0566 0.0735
Brugia malayi thymidylate synthase 0.7663 0.771 1
Brugia malayi hypothetical protein 0.002 0.0007 0.0009
Echinococcus multilocularis neuropeptide receptor 0.0575 0.0566 0.0735
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0015 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0015 0.0019
Echinococcus granulosus transcription factor btf3 0.0041 0.0028 0.0037
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.0128 0.0165
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0015 0.0019
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0027 0.0015 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0575 0.0566 0.0734
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0015 0.0019
Giardia lamblia Multidrug resistance-associated protein 1 0.0027 0.0015 0.9824
Loa Loa (eye worm) hypothetical protein 0.0042 0.0029 0.0038
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0015 0.0019
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0015 0.0019
Schistosoma mansoni dihydrofolate reductase 0.4336 0.4357 0.5651
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0575 0.0566 0.0734
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0029 0.0038
Echinococcus multilocularis musashi 0.0026 0.0014 0.0018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0015 0.0019
Schistosoma mansoni coup transcription factor 0.0027 0.0015 0.0019
Trypanosoma cruzi cAMP binding protein, putative 0.0015 0.0002 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0575 0.0566 0.0734
Echinococcus granulosus adenylate cyclase 9 0.0071 0.0058 0.0076
Schistosoma mansoni neuropeptide receptor 0.0575 0.0566 0.0734
Loa Loa (eye worm) doublecortin family protein 0.0023 0.001 0.0014
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.001 0.0013
Onchocerca volvulus 0.002 0.0007 0.0009
Echinococcus granulosus cGMP dependent protein kinase 0.0015 0.0002 0.0003
Schistosoma mansoni loxhd1 0.0023 0.001 0.0013
Leishmania major hypothetical protein, conserved 0.0015 0.0002 0.0001
Brugia malayi G-protein coupled receptor 0.0575 0.0566 0.0734
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0015 0.0002 0.0001
Onchocerca volvulus 0.0575 0.0566 0.0734
Trypanosoma cruzi cAMP response protein 1, putative 0.0015 0.0002 0.0001
Brugia malayi follicle stimulating hormone receptor 0.0575 0.0566 0.0734
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0015 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0575 0.0566 0.0735
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0015 0.0019
Giardia lamblia Hypothetical protein 0.002 0.0007 0.3808
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0015 0.0019
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0015 0.0002 0.0003
Loa Loa (eye worm) dihydrofolate reductase 0.4336 0.4357 0.5651
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0575 0.0566 0.0735
Brugia malayi Cell death specification protein 2 0.002 0.0007 0.0009
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0011 0.0013
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0011 0.0013
Leishmania major basic transcription factor 3a, putative 0.0041 0.0028 0.0027
Schistosoma mansoni hypothetical protein 0.004 0.0028 0.0036
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0019
Onchocerca volvulus 0.0027 0.0015 0.0019
Brugia malayi Adenylyl cyclase protein 0.0071 0.0058 0.0075
Brugia malayi putative neuropeptide receptor NPR1 0.0575 0.0566 0.0734
Loa Loa (eye worm) AGC/PKG protein kinase 0.0015 0.0002 0.0003
Trypanosoma brucei Flagellar Member 6 0.0015 0.0002 0.0001
Entamoeba histolytica ABC transporter, putative 0.0027 0.0015 0.1007
Echinococcus granulosus RUN 0.0023 0.001 0.0014
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.4336 0.4357 0.5651
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0009
Echinococcus multilocularis multidrug resistance associated protein 1 0.0027 0.0015 0.0019
Echinococcus granulosus g protein coupled receptor 0.0575 0.0566 0.0735
Echinococcus granulosus orexin receptor type 2 0.0575 0.0566 0.0735
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0015 0.0019
Brugia malayi Cytochrome P450 family protein 0.0014 0.0001 0.0001
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0015 0.0002 0.0001
Trypanosoma cruzi multidrug resistance protein E, putative 0.0027 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0263 0.0252 0.0327
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0575 0.0566 0.0734
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0009
Entamoeba histolytica ATP-binding cassette protein, putative 0.0027 0.0015 0.1007
Brugia malayi ABC transporter transmembrane region family protein 0.0027 0.0015 0.0019
Onchocerca volvulus 0.002 0.0007 0.0009
Trypanosoma brucei protein kinase A regulatory subunit 0.0015 0.0002 0.0001
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0575 0.0566 0.0735
Brugia malayi hypothetical protein 0.0575 0.0566 0.0734
Brugia malayi Tachykinin-like peptides receptor 99D 0.0575 0.0566 0.0734
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0015 0.0002 0.0001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0017 0.0022
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0015 0.0003 0.0002
Echinococcus multilocularis geminin 0.0528 0.052 0.0674
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0015 0.0019
Echinococcus granulosus g protein coupled receptor 0.0575 0.0566 0.0735
Mycobacterium ulcerans transcriptional regulatory protein 0.0015 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.001 0.0025
Echinococcus granulosus intermediate filament protein 0.0026 0.0014 0.0018
Echinococcus granulosus neuropeptide s receptor 0.0575 0.0566 0.0735
Echinococcus granulosus neuropeptides capa receptor 0.0575 0.0566 0.0735
Mycobacterium tuberculosis Hypothetical protein 0.3645 0.3661 0.4748
Schistosoma mansoni hypothetical protein 0.0528 0.052 0.0674
Trypanosoma brucei cAMP binding protein, putative 0.0015 0.0002 0.0001
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0105 0.0093 0.0252
Echinococcus multilocularis rhodopsin orphan GPCR 0.0575 0.0566 0.0735
Echinococcus granulosus dro:myosuppressin receptor 0.0575 0.0566 0.0735
Echinococcus granulosus 7TM GPCR rhodopsin 0.0575 0.0566 0.0735
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.1759 0.176 0.2282
Schistosoma mansoni microtubule-associated protein tau 0.1486 0.1484 0.1925
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0087 0.0112
Brugia malayi Dopamine receptor protein 1 0.0575 0.0566 0.0734
Schistosoma mansoni voltage-gated potassium channel 0.0123 0.0111 0.0144
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0017 0.0022
Loa Loa (eye worm) cell death specification protein 2 0.002 0.0007 0.0009
Leishmania major pentamidine resistance protein 1 0.0027 0.0015 0.0014
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0575 0.0566 0.0735
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.006 0.0077
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0006
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0575 0.0566 0.0735
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0575 0.0566 0.0734
Echinococcus multilocularis neuropeptide s receptor 0.0575 0.0566 0.0735
Echinococcus multilocularis rhodopsin orphan GPCR 0.0575 0.0566 0.0735
Echinococcus granulosus neuropeptides capa receptor 0.0575 0.0566 0.0735
Onchocerca volvulus 0.0263 0.0252 0.0327
Entamoeba histolytica hypothetical protein 0.0041 0.0028 0.2722
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0011 0.0013
Onchocerca volvulus 0.0263 0.0252 0.0327
Brugia malayi putative neuropeptide receptor 0.0575 0.0566 0.0734
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0015 0.0002 0.0002
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0575 0.0566 0.0735
Onchocerca volvulus 0.0575 0.0566 0.0734
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0002 0.0001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0005 0.0005
Brugia malayi beta-NAC-like protein 0.0041 0.0028 0.0036
Onchocerca volvulus 0.0033 0.0021 0.0027
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0015 0.0002 0.0003
Onchocerca volvulus 0.0575 0.0566 0.0734
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0011 0.0013
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0011 0.001
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.4336 0.4357 0.5651
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0575 0.0566 0.0735
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0015 0.0002 0.0001
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0575 0.0566 0.0735
Echinococcus granulosus G protein coupled receptor 139 0.0575 0.0566 0.0735
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0015 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0263 0.0252 0.0327
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0015 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0575 0.0566 0.0735
Schistosoma mansoni opsin-like receptor 0.0575 0.0566 0.0734
Brugia malayi G protein-coupled receptor F59B2.13 0.0575 0.0566 0.0734
Plasmodium vivax SET domain protein, putative 0.003 0.0017 0.0015
Leishmania major p-glycoprotein e 0.0027 0.0015 0.0014
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0011 0.001

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.6 uM Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells. ChEMBL. 12747789
IC50 (binding) = 0.6 uM Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells. ChEMBL. 12747789

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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