Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Latrophilin receptor protein 2 | 0.0097 | 0.165 | 0.1619 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0121 | 1 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0059 | 0.0054 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0045 | 0.0567 | 0.0532 |
Schistosoma mansoni | bromodomain containing protein | 0.0061 | 0.0911 | 0.2217 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0083 | 0.1365 | 0.1365 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0001 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0034 | 0.0353 | 0.0799 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0097 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0499 | 0.0499 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0137 | 0.2475 | 0.3477 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0097 | 0.165 | 0.165 |
Echinococcus multilocularis | lamin dm0 | 0.0083 | 0.1365 | 0.1893 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.106 | 0.106 |
Echinococcus granulosus | GPCR family 2 | 0.0097 | 0.165 | 0.23 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0001 | 0.0001 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0121 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.0412 | 0.0376 |
Echinococcus granulosus | smad | 0.0034 | 0.0353 | 0.0449 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0502 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0121 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0121 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0476 | 0.0476 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0083 | 0.1365 | 0.1332 |
Echinococcus multilocularis | smad | 0.0034 | 0.0353 | 0.0449 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0097 | 0.165 | 0.23 |
Brugia malayi | MH2 domain containing protein | 0.0034 | 0.0353 | 0.0316 |
Schistosoma mansoni | intermediate filament proteins | 0.0083 | 0.1365 | 0.337 |
Schistosoma mansoni | lamin | 0.0083 | 0.1365 | 0.337 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0121 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0121 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0365 | 0.0466 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0137 | 0.2475 | 0.3477 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0461 | 0.0461 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0097 | 0.165 | 0.23 |
Brugia malayi | intermediate filament protein | 0.0083 | 0.1365 | 0.1332 |
Echinococcus multilocularis | musashi | 0.0083 | 0.1365 | 0.1893 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0034 | 0.0353 | 0.0353 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0001 | 0.5 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0034 | 0.0353 | 0.0353 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0502 | 1 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0121 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0121 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0121 | 0.0121 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0121 | 1 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0034 | 0.0353 | 0.0799 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0121 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0121 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0121 | 0.5 |
Echinococcus granulosus | lamin | 0.0083 | 0.1365 | 0.1893 |
Onchocerca volvulus | 0.0052 | 0.073 | 0.4899 | |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.5978 | 0.5978 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0121 | 0.5 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0121 | 0.0121 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0121 | 0.5 |
Schistosoma mansoni | smad | 0.0034 | 0.0353 | 0.0799 |
Echinococcus multilocularis | lamin | 0.0083 | 0.1365 | 0.1893 |
Schistosoma mansoni | lamin | 0.0083 | 0.1365 | 0.337 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.073 | 0.073 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0121 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0034 | 0.0353 | 0.0799 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1333 | 0.1333 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0034 | 0.0353 | 0.0449 |
Brugia malayi | MH1 domain containing protein | 0.0034 | 0.0353 | 0.0316 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0034 | 0.0353 | 0.0449 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0097 | 0.165 | 0.1619 |
Brugia malayi | MH2 domain containing protein | 0.0034 | 0.0353 | 0.0316 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.165 | 0.4095 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0121 | 0.0121 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0045 | 0.0567 | 0.0567 |
Echinococcus granulosus | intermediate filament protein | 0.0083 | 0.1365 | 0.1893 |
Echinococcus multilocularis | GPCR, family 2 | 0.0097 | 0.165 | 0.23 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0445 | 0.0445 |
Schistosoma mansoni | thyroid hormone receptor | 0.0148 | 0.2702 | 0.6767 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0001 | 0.0001 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0034 | 0.0353 | 0.0449 |
Brugia malayi | PHD-finger family protein | 0.0024 | 0.0145 | 0.0108 |
Onchocerca volvulus | 0.0083 | 0.1365 | 1 | |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.1145 | 0.1112 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.0839 | 0.1143 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0097 | 0.0085 |
Loa Loa (eye worm) | intermediate filament protein | 0.0083 | 0.1365 | 0.1365 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0307 | 0.5978 | 0.5963 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.0839 | 0.1143 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1365 | 0.1365 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0052 | 0.073 | 0.1758 |
Schistosoma mansoni | thyroid hormone receptor | 0.0148 | 0.2702 | 0.6767 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0037 | 0.0037 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0097 | 0.0151 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0148 | 0.2702 | 0.3801 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0413 | 0.0413 |
Schistosoma mansoni | hypothetical protein | 0.0137 | 0.2475 | 0.6191 |
Schistosoma mansoni | Smad4 | 0.0034 | 0.0353 | 0.0799 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.004 | 0.0476 | 0.0625 |
Onchocerca volvulus | 0.0083 | 0.1365 | 1 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.021 | 0.3975 | 0.3952 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.165 | 0.165 |
Echinococcus granulosus | Smad4 | 0.0034 | 0.0353 | 0.0449 |
Echinococcus multilocularis | tumor protein p63 | 0.0359 | 0.7046 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0121 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0445 | 0.0445 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.165 | 0.4095 |
Loa Loa (eye worm) | nuclear factor I | 0.0019 | 0.0037 | 0.0037 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.165 | 0.4095 |
Echinococcus granulosus | lamin dm0 | 0.0083 | 0.1365 | 0.1893 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0059 | 0.0059 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0097 | 0.165 | 0.23 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.165 | 0.4095 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0365 | 0.0466 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0121 | 0.0084 |
Loa Loa (eye worm) | Smad1 | 0.0034 | 0.0353 | 0.0353 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0121 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0097 | 0.165 | 0.23 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0001 | 0.0001 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0121 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0034 | 0.0353 | 0.0316 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0121 | 0.0084 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0307 | 0.5978 | 0.5963 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0307 | 0.5978 | 0.5978 |
Echinococcus granulosus | tumor protein p63 | 0.0359 | 0.7046 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.3975 | 0.3975 |
Echinococcus multilocularis | Smad4 | 0.0034 | 0.0353 | 0.0449 |
Schistosoma mansoni | smad1 5 8 and | 0.0034 | 0.0353 | 0.0799 |
Schistosoma mansoni | hypothetical protein | 0.021 | 0.3975 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.004 | 0.0476 | 0.0625 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0121 | 0.5 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0034 | 0.0353 | 0.0449 |
Brugia malayi | Smad1 | 0.0034 | 0.0353 | 0.0316 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.