Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.2667 | 0.5651 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.2667 | 0.2628 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.2667 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0032 | 0.4678 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.2667 | 0.6023 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.4393 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.2667 | 0.6023 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.2667 | 0.2628 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.2667 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0109 | 0.0056 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.1916 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.2667 | 1 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4393 | 0.4363 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.2667 | 1 |
Trichomonas vaginalis | sphingomyelinase C 2 precursor, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | type IV inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Onchocerca volvulus | 0.003 | 0.4393 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0058 | 0.8867 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.2667 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0634 | 0.0584 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.2667 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | ocrl type II inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.2667 | 0.2966 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.2667 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | type II inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0634 | 0.1257 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.1916 |
Echinococcus granulosus | cpg binding protein | 0.0032 | 0.4678 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.2667 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.2667 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0939 | 0.2042 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.4678 | 0.465 |
Trichomonas vaginalis | skeletal muscle/kidney enriched inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0634 | 0.1257 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.0634 | 0.1257 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.2667 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.2667 | 1 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.0634 | 0.1257 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.4678 | 0.465 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.2667 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.2667 | 0.5651 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.2667 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.092 | 0.1996 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | Phospholipase C precursor, putative | 0.0004 | 0.0053 | 0.0199 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.4393 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.2667 | 1 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0053 | 0.0199 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 42 % | Antagonist activity at rabbit Cav1.2 expressed in HEK293 cells assessed as inhibition of voltage pulse-induced calcium current at 500 nM by FLIPR calcium 4 assay | ChEMBL. | 20382537 |
Inhibition (functional) | = 43 % | Antagonist activity at rat Cav1.3 expressed in HEK293 cells assessed as inhibition of voltage pulse-induced calcium current at 500 nM by FLIPR calcium 4 assay | ChEMBL. | 20382537 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.