Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | inositol monophosphatase 1 | 0.0044 | 0.5824 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 0.0902 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 0.0902 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0044 | 0.5824 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0044 | 0.5824 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 0.0902 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.0902 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 0.0902 |
Giardia lamblia | Hypothetical protein | 0.0005 | 0.0066 | 0.5 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.5824 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0044 | 0.5824 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0044 | 0.5824 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.4678 | 0.4643 |
Schistosoma mansoni | inositol monophosphatase | 0.0044 | 0.5824 | 0.5796 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0034 | 0.4393 | 0.7515 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.4393 | 0.4356 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.0634 | 0.0987 |
Echinococcus granulosus | cpg binding protein | 0.0036 | 0.4678 | 0.801 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.0902 |
Brugia malayi | CXXC zinc finger family protein | 0.0034 | 0.4393 | 0.7515 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0634 | 0.0572 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.092 | 0.1482 |
Chlamydia trachomatis | 3'(2'),5'-bisphosphate nucleotidase CysQ | 0.0005 | 0.0066 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.5824 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.5824 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0525 | 0.0902 |
Loa Loa (eye worm) | inositol-1 | 0.0044 | 0.5824 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0525 | 0.0902 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0939 | 0.1517 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.0902 |
Loa Loa (eye worm) | histone methyltransferase | 0.0011 | 0.0939 | 0.1517 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 0.0902 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0005 | 0.0066 | 0.0113 |
Trichomonas vaginalis | diphosphonucleoside phosphohydrolase, putative | 0.0005 | 0.0066 | 0.0113 |
Onchocerca volvulus | 0.0034 | 0.4393 | 1 | |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0039 | 0.515 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.4678 | 0.4643 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0634 | 0.0987 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.0902 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0044 | 0.5824 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 0.0902 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0044 | 0.5824 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.5824 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.0902 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0939 | 0.1517 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.0902 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0039 | 0.515 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0044 | 0.5824 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0044 | 0.5824 | 0.5796 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.0902 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0005 | 0.0066 | 0.0113 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0005 | 0.0066 | 0.0113 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0065 | 0.8867 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0525 | 0.0902 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0109 | 0.0044 |
Brugia malayi | Inositol-1 | 0.0044 | 0.5824 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0044 | 0.5824 | 0.6542 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.0902 |
Echinococcus multilocularis | cpg binding protein | 0.0036 | 0.4678 | 0.801 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.0902 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0634 | 0.0987 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.0634 | 0.0987 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 616 uM | Inhibition of Pseudomonas aeruginosa LasB by fluorimetric assay in buffer of pH 7.2 | ChEMBL. | 19773163 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.