TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 365.489 | Formula: C22H23NO2S
H donors: 1 H acceptors: 0 LogP: 5.21 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: C1CC[C@H](NC1)COc1ccc(cc1)Oc1ccc(cc1)c1cscc1
InChi: 1S/C22H23NO2S/c1-2-13-23-19(3-1)15-24-20-8-10-22(11-9-20)25-21-6-4-17(5-7-21)18-12-14-26-16-18/h4-12,14,16,19,23H,1-3,13,15H2/t19-/m0/s1
InChiKey: GLLLFAXFNZDBAF-IBGZPJMESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	leukotriene A4 hydrolase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative	Get druggable targets OG5_129538	All targets in OG5_129538
Echinococcus multilocularis	leukotriene A 4 hydrolase	Get druggable targets OG5_129538	All targets in OG5_129538
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	Get druggable targets OG5_129538	All targets in OG5_129538
Echinococcus granulosus	leukotriene A 4 hydrolase	Get druggable targets OG5_129538	All targets in OG5_129538
Loa Loa (eye worm)	leukotriene A4 hydrolase	Get druggable targets OG5_129538	All targets in OG5_129538
Candida albicans	leukotriene A4 hydrolase/leucyl aminopeptidase	Get druggable targets OG5_129538	All targets in OG5_129538
Candida albicans	leukotriene A4 hydrolase/leucyl aminopeptidase	Get druggable targets OG5_129538	All targets in OG5_129538

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	leukotriene A4 hydrolase	611 aa	508 aa	22.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TATA binding protein associated factor	0.0015	0.0087	0.0089
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0023	0.0243	0.0268
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0032	0.0412	0.0461
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0279	0.5097	0.8293
Schistosoma mansoni	nuclear receptor nhr-48	0.0011	0.0009	0.0014
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0015	0.0087	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0031	0.04	0.0447
Toxoplasma gondii	thioredoxin reductase	0.0051	0.078	0.6826
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0032	0.0412	0.0461
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0317	0.5825	0.5789
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0012	0.0033	0.0028
Onchocerca volvulus		0.0178	0.3189	0.3183
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0317	0.5825	0.5789
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0018	0.0143	0.0233
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0018	0.0143	0.0154
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0015	0.0087	0.0141
Brugia malayi	Cation transporter family protein	0.0032	0.0412	0.0461
Brugia malayi	excitatory GABA receptor EXP-1A	0.0032	0.0412	0.0461
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0032	0.0412	0.0671
Plasmodium vivax	glutathione reductase, putative	0.0051	0.078	0.6826
Echinococcus granulosus	snurportin 1	0.0334	0.6146	1
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0236	0.0383
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.04	0.4515
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0068	0.1102	0.1793
Schistosoma mansoni	hypothetical protein	0.0039	0.0547	0.089
Schistosoma mansoni	nAChR subunit	0.0032	0.0412	0.0671
Echinococcus granulosus	cpg binding protein	0.0033	0.0431	0.0701
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0018	0.0143	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0086	0.0088
Brugia malayi	nuclear receptor RXR	0.0012	0.0033	0.0028
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0023	0.0236	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0086	0.0088
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0236	0.0259
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0032	0.0412	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0412	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0033	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0412	0.0461
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0155	0.2746	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.013	0.2275	0.3447
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0086	0.0088
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.0236	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0412	0.0461
Brugia malayi	Steroid receptor seven-up type 2	0.0023	0.0236	0.0259
Toxoplasma gondii	NADPH-glutathione reductase	0.0018	0.0143	0.0555
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0748	0.1217
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0017	0.0132	0.0216
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0023	0.0236	0.0383
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0032	0.0412	0.0671
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0236	0.0259
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0748	0.1217
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0748	0.0844
Trypanosoma brucei	trypanothione reductase	0.0051	0.078	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0236	0.0259
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0023	0.0236	0.0259
Brugia malayi	hypothetical protein	0.0178	0.3189	0.3632
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0017	0.0132	0.0141
Echinococcus granulosus	nAChR subunit	0.0032	0.0412	0.0671
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0032	0.0412	0.0671
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0032	0.0412	0.0461
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0032	0.0412	0.0671
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0236	0.0259
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0032	0.0412	0.0671
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0015	0.0087	0.0141
Onchocerca volvulus		0.0032	0.0412	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0086	0.0088
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0033	0.0028
Brugia malayi	F/Y-rich N-terminus family protein	0.0012	0.0034	0.0029
Echinococcus multilocularis	cpg binding protein	0.0033	0.0431	0.0701
Brugia malayi	hypothetical protein	0.0015	0.0086	0.0088
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0032	0.0412	0.0461
Schistosoma mansoni	nAChR subunit	0.0032	0.0412	0.0671
Brugia malayi	glutathione reductase	0.0051	0.078	0.0881
Brugia malayi	Pre-SET motif family protein	0.0472	0.8764	1
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0032	0.0412	0.0671
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0032	0.0412	0.0461
Trichomonas vaginalis	mercuric reductase, putative	0.0018	0.0143	0.0057
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0143	0.0814
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0023	0.0236	0.0259
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0023	0.0243	0.1537
Onchocerca volvulus		0.0032	0.0412	0.0404
Brugia malayi	hypothetical protein	0.0012	0.0033	0.0028
Schistosoma mansoni	hypothetical protein	0.018	0.3219	0.5238
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0236	0.0259
Onchocerca volvulus		0.0032	0.0412	0.0404
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0015	0.0086	0.0139
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0011	0.0009	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0412	0.0461
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0032	0.0412	0.0461
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0011	0.0009	0.0014
Mycobacterium tuberculosis	Probable oxidoreductase	0.013	0.2275	0.819
Schistosoma mansoni	nAChR subunit	0.0032	0.0412	0.0671
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0012	0.0036	0.0059
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0023	0.0236	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0033	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0033	0.0028
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0018	0.0143	0.0212
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0032	0.0412	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0412	0.0461
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0015	0.0086	0.0139
Plasmodium falciparum	glutathione reductase	0.0051	0.078	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0023	0.0236	0.0383
Leishmania major	trypanothione reductase	0.0051	0.078	1
Onchocerca volvulus		0.0015	0.0087	0.0078
Schistosoma mansoni	nAChR subunit	0.0032	0.0412	0.0671
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0412	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0086	0.0088
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0011	0.0009	0.0014
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0032	0.0412	0.0671
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0155	0.2746	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0236	0.0259
Schistosoma mansoni	neurotransmitter gated ion channel	0.0015	0.0086	0.0139
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0033	0.0054
Brugia malayi	hypothetical protein	0.0015	0.0086	0.0088
Schistosoma mansoni	zinc finger protein	0.0011	0.0009	0.0014
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0279	0.5097	0.5811
Plasmodium falciparum	importin beta, putative	0.0031	0.04	0.4515
Schistosoma mansoni	RAR-like nuclear receptor	0.0023	0.0236	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0236	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0132	0.0141
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0023	0.0236	0.0259
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0032	0.0412	0.0671
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0032	0.0412	0.0461
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0018	0.0143	0.0814
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0032	0.0412	0.0671
Brugia malayi	hypothetical protein	0.0012	0.0033	0.0028
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0023	0.0236	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0412	0.0461
Loa Loa (eye worm)	histone methyltransferase	0.0012	0.0036	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0236	0.0259
Echinococcus granulosus	ecdysone induced protein 78C	0.0023	0.0236	0.0383
Trichomonas vaginalis	set domain proteins, putative	0.0537	1	1
Loa Loa (eye worm)	LGC-31 protein	0.0032	0.0412	0.0461
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0023	0.0236	0.0383
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0397	0.0444
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0018	0.0143	0.0555
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0023	0.0243	0.2252
Brugia malayi	Peptidase family M1 containing protein	0.0015	0.0087	0.0089
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0015	0.0087	0.0141
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0317	0.5825	0.5789
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0143	0.0814
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0023	0.0236	0.0259
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0023	0.0243	0.0268
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0011	0.0009	0.0014
Plasmodium vivax	SET domain protein, putative	0.0068	0.1102	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0334	0.6146	0.7009
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0011	0.0009	0.0014
Echinococcus granulosus	aminopeptidase N	0.0015	0.0087	0.0141
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0279	0.5097	0.8293
Onchocerca volvulus		0.0015	0.0086	0.0077
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0018	0.0143	0.0814
Echinococcus multilocularis	importin subunit beta 1	0.0031	0.04	0.065
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0412	0.0461
Brugia malayi	Pre-SET motif family protein	0.0068	0.1102	0.1249
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0023	0.0236	0.0259
Echinococcus multilocularis	glycine receptor subunit beta	0.0032	0.0412	0.0671
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0032	0.0412	0.0461
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0015	0.0086	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0236	0.0259
Onchocerca volvulus		0.0015	0.0087	0.0078
Onchocerca volvulus		0.0032	0.0412	0.0404
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0317	0.5825	0.5789
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0032	0.0412	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0033	0.0028
Loa Loa (eye worm)	ACC-1 protein	0.0032	0.0412	0.0461
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0032	0.0412	0.0461
Entamoeba histolytica	hypothetical protein	0.0025	0.0287	0.0349
Onchocerca volvulus		0.0015	0.0086	0.0077
Brugia malayi	steroid hormone receptor	0.0023	0.0236	0.0259
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0013	0.0054	0.0052
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0547	0.089
Schistosoma mansoni	acetylcholine receptor-related	0.0015	0.0086	0.0139
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0017	0.0132	0.0141
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0032	0.0412	0.0671
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0132	0.0141
Schistosoma mansoni	coup transcription factor	0.0023	0.0236	0.0383
Echinococcus multilocularis	geminin	0.018	0.3219	0.5238
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0068	0.1102	0.1793
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0023	0.0236	0.0383
Entamoeba histolytica	hypothetical protein	0.0017	0.0132	0.0079
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0069	0.1108	0.1802
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0032	0.0412	0.0671
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0132	0.0141
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0023	0.0236	0.0383
Echinococcus granulosus	thyroid hormone receptor alpha	0.0011	0.0009	0.0014
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0287	0.0202
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0748	0.1217
Leishmania major	GTP-binding protein, putative	0.0023	0.0243	0.2252
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0018	0.0143	0.0814
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0015	0.0087	0.0141
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0032	0.0412	0.0671
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0062	0.0974	0.8737
Onchocerca volvulus		0.0015	0.0086	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0086	0.0088
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0287	0.2894
Onchocerca volvulus	Putative nachr subunit	0.0032	0.0412	0.0404
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0317	0.5825	0.5789
Echinococcus granulosus	thioredoxin glutathione reductase	0.0051	0.078	0.1269
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0748	0.1217
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0023	0.0243	0.0395
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0023	0.0236	0.0259
Schistosoma mansoni	cpg binding protein	0.0033	0.0431	0.0701
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0051	0.078	0.1269
Mycobacterium tuberculosis	Probable reductase	0.0117	0.2027	0.7238
Onchocerca volvulus		0.0015	0.0087	0.0078
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0015	0.0087	0.0141
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0015	0.0087	0.0141
Schistosoma mansoni	hypothetical protein	0.0334	0.6146	1
Entamoeba histolytica	Ran family GTPase	0.0023	0.0243	0.0272
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0015	0.0087	0.0141
Entamoeba histolytica	hypothetical protein	0.0039	0.0547	0.0801
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0143	0.0814
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0023	0.0236	0.0259
Trichomonas vaginalis	glutathione reductase, putative	0.0018	0.0143	0.0057
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0086	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0178	0.3189	0.3632
Echinococcus multilocularis	aminopeptidase N	0.0015	0.0087	0.0141
Schistosoma mansoni	nAChR subunit	0.0032	0.0412	0.0671
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0236	0.0259
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0015	0.0087	0.0141
Echinococcus granulosus	histone lysine methyltransferase setb	0.0068	0.1102	0.1793
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0018	0.0143	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0009	0.0014
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0023	0.0243	0.0395
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0015	0.0086	0.0088
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0032	0.0412	0.0461
Brugia malayi	TATA binding protein associated factor	0.0015	0.0087	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0412	0.0461
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0748	0.1217
Brugia malayi	Peptidase family M1 containing protein	0.0015	0.0087	0.0089
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0032	0.0412	0.0461
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0023	0.0236	0.0383
Echinococcus granulosus	nuclear receptor nhr 48	0.0011	0.0009	0.0014
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0236	0.0259
Plasmodium falciparum	thioredoxin reductase	0.0051	0.078	1
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0018	0.0143	0.0814
Brugia malayi	Cation transporter family protein	0.0032	0.0412	0.0461
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0011	0.0009	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0033	0.0028
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0117	0.2027	0.7238
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0412	0.0461
Trichomonas vaginalis	ran, putative	0.0023	0.0243	0.0157
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0086	0.0088
Brugia malayi	nuclear hormone receptor	0.0023	0.0236	0.0259
Schistosoma mansoni	cpg binding protein	0.0033	0.0431	0.0701
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0015	0.0086	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0236	0.0259
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.013	0.2275	0.819
Echinococcus granulosus	glycine receptor subunit beta	0.0032	0.0412	0.0671
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0086	0.0088
Entamoeba histolytica	hypothetical protein	0.0039	0.0547	0.0801
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0032	0.0412	0.0461
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0018	0.0143	0.0814
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0023	0.0236	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0086	0.0088
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0397	0.0444
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0015	0.0086	0.0139
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.04	0.4515
Schistosoma mansoni	hypothetical protein	0.018	0.3219	0.5238
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0018	0.0143	0.0814
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0023	0.0236	0.0383
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0032	0.0412	0.0671
Onchocerca volvulus		0.0017	0.0132	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0412	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0132	0.0141
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0018	0.0143	0.0212
Echinococcus granulosus	nAChR subunit	0.0017	0.0132	0.0216
Schistosoma mansoni	nAChR subunit	0.0015	0.0086	0.0139
Onchocerca volvulus	Protein ultraspiracle homolog	0.0023	0.0236	0.0227
Entamoeba histolytica	hypothetical protein	0.0039	0.0547	0.0801
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0068	0.1102	0.1793
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0023	0.0243	0.1537
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0017	0.0132	0.0141
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0236	0.0383
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0032	0.0412	0.0461
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0011	0.0009	0.0014
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0236	0.0383
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0023	0.0236	0.0383
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0032	0.0412	0.0461
Echinococcus multilocularis	nAChR subunit	0.0017	0.0132	0.0216
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0032	0.0412	0.0671
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0155	0.2746	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0117	0.2027	0.7238
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0032	0.0412	0.0461
Onchocerca volvulus		0.0031	0.0397	0.0389
Treponema pallidum	fructose-bisphosphate aldolase	0.0317	0.5825	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0317	0.5825	1
Echinococcus multilocularis	snurportin 1	0.0334	0.6146	1
Schistosoma mansoni	cpg binding protein	0.0031	0.0397	0.0647
Schistosoma mansoni	neurotransmitter gated ion channel	0.0017	0.0132	0.0216
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0018	0.0143	0.0212
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0243	0.2252
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0086	0.0088
Brugia malayi	Peptidase family M1 containing protein	0.0015	0.0087	0.0089
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0236	0.0383
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0065	0.1042	0.1695
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0033	0.0028
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0032	0.0412	0.0671
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0412	0.0461
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0015	0.0087	0.0141
Mycobacterium tuberculosis	Probable dehydrogenase	0.0117	0.2027	0.7238
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0236	0.0259
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0023	0.0236	0.0259
Brugia malayi	Cation transporter family protein	0.0032	0.0412	0.0461
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0317	0.5825	0.5789
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0132	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0086	0.0088
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0068	0.1102	0.1793
Echinococcus granulosus	glycine receptor subunit beta	0.0032	0.0412	0.0671
Schistosoma mansoni	ran	0.0023	0.0243	0.0395
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0023	0.0243	0.0175
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0032	0.0412	0.0671
Loa Loa (eye worm)	thioredoxin reductase	0.0051	0.078	0.0881
Plasmodium falciparum	thioredoxin reductase	0.0018	0.0143	0.0814
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0547	0.089
Brugia malayi	Thioredoxin reductase	0.0051	0.078	0.0881
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0018	0.0143	0.0555
Onchocerca volvulus	Bile acid receptor homolog	0.0023	0.0236	0.0227
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0032	0.0412	0.0671
Schistosoma mansoni	ran	0.0023	0.0243	0.0395
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0023	0.0236	0.0383
Schistosoma mansoni	nuclear receptor	0.0011	0.0009	0.0014
Onchocerca volvulus		0.0017	0.0132	0.0124
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0018	0.0143	0.0814
Trypanosoma cruzi	trypanothione reductase, putative	0.0018	0.0143	0.0814
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0023	0.0236	0.0383
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0015	0.0087	0.0141
Loa Loa (eye worm)	GABA receptor subunit	0.0017	0.0132	0.0141
Brugia malayi	Importin beta-1 subunit	0.0031	0.04	0.0447
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0032	0.0412	0.0671
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0412	0.0461
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0015	0.0086	0.0088
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0032	0.0412	0.0671
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0015	0.0086	0.0139
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0236	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0412	0.0461
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0012	0.0033	0.0054
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0287	0.2894
Trypanosoma cruzi	trypanothione reductase, putative	0.0051	0.078	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0143	0.0814
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0023	0.0236	0.0259
Onchocerca volvulus		0.0032	0.0412	0.0404
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0117	0.2027	0.7238
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0032	0.0412	0.0461
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0018	0.0143	0.0814
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0236	0.0383
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0009	0.0014
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0243	0.2252
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0068	0.1102	0.1793
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0412	0.0461
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0018	0.0143	0.0814
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0015	0.0087	0.0141
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0032	0.0412	0.0671
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0015	0.0086	0.0088
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0032	0.0412	0.0671
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0018	0.0143	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0132	0.0141
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0017	0.0132	0.0216
Onchocerca volvulus		0.0023	0.0236	0.0227
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.013	0.2275	0.819
Echinococcus multilocularis	nuclear receptor nhr 48	0.0011	0.0009	0.0014
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0012	0.0033	0.0054
Brugia malayi	hypothetical protein	0.0015	0.0086	0.0088
Schistosoma mansoni	nAChR subunit	0.0015	0.0086	0.0139
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0015	0.0087	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0087	0.0089
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0015	0.0087	0.0141
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0023	0.0236	0.0259
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0472	0.8764	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0068	0.1102	0.1793
Schistosoma mansoni	nuclear receptor	0.0011	0.0009	0.0014
Schistosoma mansoni	importin beta-1	0.0031	0.04	0.065
Brugia malayi	hypothetical protein	0.0039	0.0547	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0086	0.0088
Loa Loa (eye worm)	glutathione reductase	0.0051	0.078	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1102	0.1249
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0015	0.0087	0.0141
Toxoplasma gondii	HEAT repeat-containing protein	0.0031	0.04	0.3082
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0032	0.0412	0.0671
Echinococcus multilocularis	glycine receptor subunit beta	0.0032	0.0412	0.0671
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0023	0.0243	0.2252
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0317	0.5825	0.5789
Brugia malayi	hypothetical protein	0.0015	0.0087	0.0089
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0018	0.0143	0.0233
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0748	0.1217
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0017	0.0132	0.0141
Brugia malayi	hypothetical protein	0.0015	0.0086	0.0088
Plasmodium falciparum	glutathione reductase	0.0018	0.0143	0.0814
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0023	0.0236	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0132	0.0141
Echinococcus granulosus	geminin	0.018	0.3219	0.5238
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0086	0.0088
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0023	0.0236	0.0259
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0018	0.0143	0.0814
Echinococcus multilocularis	nAChR subunit	0.0032	0.0412	0.0671
Schistosoma mansoni	retinoic acid receptor RXR	0.0023	0.0236	0.0383
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0015	0.0086	0.0139
Echinococcus granulosus	FTZ F1 alpha	0.0023	0.0236	0.0383
Loa Loa (eye worm)	acetylcholine receptor protein	0.0015	0.0086	0.0088
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0287	0.0202
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0018	0.0143	0.5
Echinococcus multilocularis	FTZ F1 alpha	0.0023	0.0236	0.0383
Schistosoma mansoni	nAChR subunit	0.0032	0.0412	0.0671
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0009	0.0014
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0012	0.0036	0.0059
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0279	0.5097	0.8293
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0412	0.0461
Schistosoma mansoni	nAChR subunit	0.0032	0.0412	0.0671
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0015	0.0087	0.0089
Giardia lamblia	Fructose-bisphosphate aldolase	0.0317	0.5825	1
Echinococcus granulosus	importin subunit beta 1	0.0031	0.04	0.065
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0009	0.0014
Brugia malayi	hypothetical protein	0.0128	0.2238	0.2547
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0018	0.0143	0.0555
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0051	0.078	0.2445
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0087	0.0089
Brugia malayi	photoreceptor-specific nuclear receptor	0.0023	0.0236	0.0259
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0236	0.0259
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0748	0.0844
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0412	0.0461
Brugia malayi	hypothetical protein	0.0015	0.0087	0.0089
Brugia malayi	hypothetical protein	0.0015	0.0086	0.0088
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0117	0.2027	0.7238
Plasmodium vivax	thioredoxin reductase, putative	0.0051	0.078	0.6826
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0023	0.0236	0.0383
Loa Loa (eye worm)	steroid hormone receptor	0.0023	0.0236	0.0259
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0015	0.0087	0.0141
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0236	0.0383
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0023	0.0236	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0086	0.0088
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0023	0.0236	0.0383
Brugia malayi	RNA, U transporter 1	0.0089	0.1495	0.1697
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0317	0.5825	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0317	0.5825	0.5789
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0132	0.0141
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0547	0.089
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0018	0.0143	0.5
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0032	0.0412	0.0671
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0032	0.0412	0.0671
Plasmodium vivax	importin-beta 2, putative	0.0031	0.04	0.3082
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0012	0.0033	0.0054
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0011	0.0009	0.0014
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0143	0.0814
Loa Loa (eye worm)	aminopeptidase N	0.0015	0.0087	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0086	0.0088
Onchocerca volvulus		0.0032	0.0412	0.0404
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0143	0.0814
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0023	0.0236	0.0259
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0023	0.0236	0.0383
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0032	0.0412	0.0671
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0032	0.0412	0.0671
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0032	0.0412	0.0461
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0015	0.0086	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0412	0.0461
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0287	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0412	0.0461
Brugia malayi	ecdysteroid receptor	0.0023	0.0236	0.0259
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0032	0.0412	0.0461
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0018	0.0143	0.0233
Loa Loa (eye worm)	ACC-1 protein	0.0032	0.0412	0.0461
Schistosoma mansoni	neurotransmitter gated ion channel	0.0015	0.0086	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0236	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0087	0.0089
Brugia malayi	nuclear receptor NHR-88	0.0023	0.0236	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0132	0.0141
Entamoeba histolytica	hypothetical protein	0.0039	0.0547	0.0801
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0032	0.0412	0.0671
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0086	0.0088
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0013	0.0054	0.0052
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0748	0.1217
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0023	0.0236	0.0383
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0011	0.0009	0.0014
Onchocerca volvulus		0.0068	0.1102	0.1094
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0086	0.0088
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0032	0.0412	0.0461
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0068	0.1102	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.001 uM	Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISA	ChEMBL.	20371179
IC50 (binding)	= 0.093 uM	Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MS	ChEMBL.	20371179

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1098531

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1127041