Detailed information for compound 1127187

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 318.518 | Formula: C16H34N2O2S
  • H donors: 2 H acceptors: 2 LogP: 4.68 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCNS(=O)(=O)CCNC1CCCCC1
  • InChi: 1S/C16H34N2O2S/c1-2-3-4-5-6-10-13-18-21(19,20)15-14-17-16-11-8-7-9-12-16/h16-18H,2-15H2,1H3
  • InChiKey: FUHQFQIVRKULQT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0016 0.0058 0.0379
Brugia malayi Inositol-1 0.0036 0.0275 0.0353
Schistosoma mansoni gliotactin 0.0116 0.1143 0.1553
Loa Loa (eye worm) hypothetical protein 0.0106 0.1031 0.1383
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0015 0.0021
Echinococcus granulosus GPCR family 2 0.0047 0.0392 0.0532
Mycobacterium ulcerans lipase LipD 0.0106 0.1031 0.2
Schistosoma mansoni histamine h1 receptor 0.0013 0.0015 0.0021
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0446 0.0586
Trichomonas vaginalis esterase, putative 0.0106 0.1031 0.0979
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0013 0.0015 0.0021
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.1494 0.2029
Echinococcus granulosus p2X purinoceptor 4 0.007 0.0646 0.0877
Loa Loa (eye worm) beta-lactamase 0.0106 0.1031 0.1383
Schistosoma mansoni hypothetical protein 0.0013 0.0015 0.0021
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0015 0.0021
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.027 0.0367
Schistosoma mansoni neuroligin 3 (S09 family) 0.0116 0.1143 0.1553
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0058 0.0379
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0929 1 1
Echinococcus granulosus fmrfamide receptor 0.0013 0.0015 0.0021
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0083 0.0413
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.0628
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0015 0.0021
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0116 0.1143 0.1553
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0149 0.1079
Loa Loa (eye worm) inositol-1 0.0036 0.0275 0.0353
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0563 0.5365
Loa Loa (eye worm) fibroinase 0.0016 0.0058 0.0058
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0258 0.2055
Loa Loa (eye worm) hypothetical protein 0.0053 0.046 0.0606
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0058 0.0079
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0013 0.0015 0.0021
Echinococcus granulosus cpg binding protein 0.0033 0.0242 0.0329
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0083 0.0025
Schistosoma mansoni hypothetical protein 0.0047 0.0392 0.0532
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0015 0.0021
Echinococcus granulosus dna polymerase eta 0.0019 0.0083 0.0113
Trichomonas vaginalis ran, putative 0.0026 0.0158 0.01
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0013 0.0015 0.0021
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0083 0.0025
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0015 0.0021
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0015 0.0021
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0061 0.0083
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0258 0.2356
Brugia malayi Carboxylesterase family protein 0.0116 0.1143 0.1535
Loa Loa (eye worm) hypothetical protein 0.0053 0.046 0.0606
Echinococcus multilocularis acetylcholinesterase 0.0686 0.7361 1
Mycobacterium tuberculosis Conserved protein 0.0106 0.1031 0.1324
Echinococcus multilocularis orexin receptor type 2 0.0013 0.0015 0.0021
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0053 0.046 0.0625
Loa Loa (eye worm) hypothetical protein 0.0116 0.1143 0.1535
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0013 0.0015 0.0021
Giardia lamblia Fructose-bisphosphate aldolase 0.0929 1 1
Echinococcus multilocularis cysteine protease 0.0016 0.0058 0.0079
Echinococcus multilocularis cysteine protease 0.0016 0.0058 0.0079
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0058 0.0158
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0139 0.0188
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0015 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0015 0.0021
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0083 0.0413
Schistosoma mansoni alpha-1 adrenergic receptor 0.0013 0.0015 0.0021
Schistosoma mansoni ran 0.0026 0.0158 0.0215
Loa Loa (eye worm) hypothetical protein 0.0116 0.1143 0.1535
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0686 0.7361 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0139 0.0188
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0255 0.266 0.36
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.0628
Schistosoma mansoni BC026374 protein (S09 family) 0.0116 0.1143 0.1553
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0013 0.0015 0.0021
Schistosoma mansoni hypothetical protein 0.0013 0.0015 0.0021
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0013 0.0015 0.0021
Onchocerca volvulus 0.0028 0.0184 0.1495
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0392 0.0512
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0414 0.4388 0.5952
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0563 0.5258
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0158 0.0215
Schistosoma mansoni biogenic amine receptor 0.0013 0.0015 0.0021
Leishmania major hypothetical protein, conserved 0.0025 0.0149 0.1079
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0454 0.4823 1
Schistosoma mansoni cpg binding protein 0.003 0.0203 0.0276
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0184 0.023
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.0628
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0106 0.1031 0.1383
Plasmodium falciparum importin beta, putative 0.0035 0.0258 0.8031
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0149 0.1079
Schistosoma mansoni zinc finger protein 0.0015 0.0043 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0015 0.0021
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0158 0.1167
Echinococcus multilocularis sex peptide receptor 0.0013 0.0015 0.0021
Echinococcus multilocularis BC026374 protein (S09 family) 0.0116 0.1143 0.1553
Echinococcus granulosus BC026374 protein S09 family 0.0116 0.1143 0.1553
Echinococcus granulosus somatostatin receptor 0.0013 0.0015 0.0021
Onchocerca volvulus Deterin homolog 0.0053 0.046 0.3945
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0007
Onchocerca volvulus 0.0116 0.1143 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0083 0.0113
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0307 1
Leishmania major cathepsin L-like protease 0.0016 0.0058 0.0158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0563 0.5365
Mycobacterium tuberculosis Probable lipase LipD 0.0106 0.1031 0.1324
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.1031 0.0979
Schistosoma mansoni amine GPCR 0.0013 0.0015 0.0021
Brugia malayi hypothetical protein 0.0016 0.0053 0.0052
Brugia malayi beta-lactamase family protein 0.0106 0.1031 0.1383
Schistosoma mansoni ran 0.0026 0.0158 0.0215
Onchocerca volvulus 0.0016 0.0058 0.0379
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0015 0.0021
Loa Loa (eye worm) carboxylesterase 0.0686 0.7361 1
Echinococcus multilocularis carboxylesterase 5A 0.0686 0.7361 1
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0053 0.046 0.0606
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0875 0.1188
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0038 0.029 0.0373
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0116 0.1143 0.1553
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0013 0.0015 0.0021
Echinococcus granulosus beta LACTamase domain containing family member 0.0106 0.1031 0.1401
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0058 0.0379
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0015 0.0021
Echinococcus multilocularis acetylcholinesterase 0.0686 0.7361 1
Echinococcus multilocularis p2X purinoceptor 4 0.007 0.0646 0.0877
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0015 0.0021
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0083 0.0413
Echinococcus multilocularis snurportin 1 0.0372 0.393 0.5339
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0083 0.0413
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0277 0.2367
Mycobacterium tuberculosis Carboxylesterase LipT 0.0116 0.1143 0.148
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0158 0.1026
Echinococcus multilocularis cpg binding protein 0.0033 0.0242 0.0329
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0372 0.322
Schistosoma mansoni intermediate filament proteins 0.0028 0.0184 0.025
Echinococcus granulosus hypothetical protein 0.0013 0.0015 0.0021
Echinococcus multilocularis zinc finger protein 0.0025 0.0146 0.0198
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0015 0.0021
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0277 0.027
Echinococcus granulosus allatostatin A receptor 0.0013 0.0015 0.0021
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0277 0.0376
Echinococcus multilocularis musashi 0.0028 0.0184 0.025
Brugia malayi Carboxylesterase family protein 0.0116 0.1143 0.1535
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0015 0.0021
Schistosoma mansoni inositol monophosphatase 0.0036 0.0275 0.0373
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0083 0.0093
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0015 0.0021
Onchocerca volvulus 0.0116 0.1143 1
Echinococcus granulosus inhibitor of apoptosis protein 0.0053 0.046 0.0625
Schistosoma mansoni hypothetical protein 0.0102 0.0987 0.1341
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0116 0.1143 0.1553
Loa Loa (eye worm) carboxylesterase 0.0116 0.1143 0.1535
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0013 0.0015 0.0021
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0258 0.0351
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0013 0.0015 0.0021
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0392 0.0532
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0068 0.0093
Onchocerca volvulus 0.0052 0.0446 0.3819
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0372 0.322
Trichomonas vaginalis spcc417.12 protein, putative 0.0116 0.1143 0.1091
Brugia malayi PHD-finger family protein 0.003 0.0203 0.0255
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0058
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0061 0.0083
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0116 0.1143 0.148
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0277 0.0195
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.393 0.533
Trypanosoma brucei unspecified product 0.0019 0.0083 0.0628
Onchocerca volvulus 0.0116 0.1143 1
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0277 0.022
Mycobacterium ulcerans carboxylesterase, LipT 0.0116 0.1143 0.2236
Schistosoma mansoni amine GPCR 0.0013 0.0015 0.0021
Loa Loa (eye worm) ctsf protein 0.0016 0.0058 0.0058
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0015 0.0021
Schistosoma mansoni ap endonuclease 0.0037 0.0277 0.0376
Leishmania major DNA polymerase kappa, putative 0.0019 0.0083 0.0413
Echinococcus granulosus intermediate filament protein 0.0028 0.0184 0.025
Schistosoma mansoni lamin 0.0028 0.0184 0.025
Echinococcus granulosus zinc finger protein 0.0025 0.0146 0.0198
Echinococcus granulosus g-protein coupled receptor 0.0013 0.0015 0.0021
Mycobacterium ulcerans esterase/lipase LipP 0.0106 0.1031 0.2
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0277 0.8773
Brugia malayi hypothetical protein 0.0255 0.266 0.36
Mycobacterium ulcerans beta-lactamase 0.0106 0.1031 0.2
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0053 0.046 0.0625
Leishmania major cathepsin L-like protease 0.0016 0.0058 0.0158
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0015 0.0021
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0392 0.0532
Echinococcus multilocularis geminin 0.0669 0.7176 0.9748
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0158 0.0194
Echinococcus granulosus tachykinin peptides receptor 99D 0.0013 0.0015 0.0021
Leishmania major cathepsin L-like protease 0.0063 0.0563 0.5258
Echinococcus multilocularis neuropeptide FF receptor 2 0.0013 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0116 0.1143 0.1535
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0083 0.0628
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0015 0.0021
Echinococcus multilocularis inhibitor of apoptosis protein 0.0053 0.046 0.0625
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0015 0.0021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0875 0.1188
Brugia malayi hypothetical protein 0.0116 0.1143 0.1535
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0158 0.0075
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.15 0.2021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0106 0.1031 0.1401
Brugia malayi Bromodomain containing protein 0.0079 0.074 0.0986
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0275 0.2347
Onchocerca volvulus 0.0053 0.046 0.3945
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0058 0.0079
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0929 1 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0275 0.2347
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0083 0.0093
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0116 0.1143 0.1091
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0275 0.0218
Echinococcus granulosus cathepsin l1 0.0016 0.0058 0.0079
Schistosoma mansoni hypothetical protein 0.0053 0.046 0.0625
Loa Loa (eye worm) hypothetical protein 0.0116 0.1143 0.1535
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0058 0.0079
Echinococcus granulosus acetylcholinesterase 0.0686 0.7361 1
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.1031 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0015 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.0628
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0158 0.1366
Brugia malayi Bromodomain containing protein 0.0041 0.0328 0.0425
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0258 0.2356
Echinococcus multilocularis beta LACTamase domain containing family member 0.0106 0.1031 0.1401
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.1031 0.0979
Echinococcus granulosus neuropeptide s receptor 0.0509 0.5427 0.7372
Schistosoma mansoni neuropeptide receptor 0.0013 0.0015 0.0021
Onchocerca volvulus 0.0016 0.0058 0.0379
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0013 0.0015 0.0021
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0277 0.022
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0184 0.023
Loa Loa (eye worm) hypothetical protein 0.0028 0.0184 0.023
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0307 0.0226
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0015 0.0021
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0106 0.1031 0.2
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0929 1 1
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0053 0.046 0.0606
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0083 0.0113
Mycobacterium tuberculosis Conserved protein 0.0106 0.1031 0.1324
Echinococcus granulosus importin subunit beta 1 0.0035 0.0258 0.0351
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0277 0.0408
Onchocerca volvulus 0.0028 0.0184 0.1495
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0567 0.077
Schistosoma mansoni inositol monophosphatase 0.0036 0.0275 0.0373
Brugia malayi follicle stimulating hormone receptor 0.0458 0.4873 0.6612
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0042 0.0037
Schistosoma mansoni bromodomain containing protein 0.0067 0.0614 0.0834
Loa Loa (eye worm) hypothetical protein 0.0106 0.1031 0.1383
Echinococcus granulosus serotonin receptor 0.0013 0.0015 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0563 0.5365
Schistosoma mansoni biogenic amine receptor 0.0013 0.0015 0.0021
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0015 0.0021
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0277 0.0356
Schistosoma mansoni hypothetical protein 0.0669 0.7176 0.9748
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.0628
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0392 0.0512
Entamoeba histolytica hypothetical protein 0.0036 0.027 0.0213
Schistosoma mansoni hypothetical protein 0.002 0.01 0.0135
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0083 0.0628
Onchocerca volvulus 0.0116 0.1143 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0106 0.1031 0.1324
Brugia malayi Cathepsin L-like precursor 0.0016 0.0058 0.0058
Mycobacterium tuberculosis Conserved protein 0.0106 0.1031 0.1324
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0015 0.0021
Plasmodium vivax hypothetical protein, conserved 0.0106 0.1031 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.1143 0.1535
Echinococcus multilocularis para nitrobenzyl esterase 0.0116 0.1143 0.1553
Entamoeba histolytica hypothetical protein 0.0036 0.027 0.0213
Echinococcus granulosus neuroligin 0.0116 0.1143 0.1553
Echinococcus granulosus 7tm_1 domain containing protein 0.0013 0.0015 0.0021
Echinococcus granulosus g protein coupled receptor 0.0013 0.0015 0.0021
Schistosoma mansoni hypothetical protein 0.0047 0.0392 0.0532
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0072
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0013 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.007 0.0636 0.0845
Echinococcus multilocularis G protein coupled receptor 139 0.0013 0.0015 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0015 0.0021
Echinococcus multilocularis lamin 0.0028 0.0184 0.025
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0929 1 1
Echinococcus multilocularis p2X purinoceptor 4 0.007 0.0646 0.0877
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0093
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0116 0.1143 0.148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0563 0.5365
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0275 0.2224
Schistosoma mansoni neuropeptide f receptor 76f 0.0013 0.0015 0.0021
Schistosoma mansoni DNA polymerase eta 0.0019 0.0083 0.0113
Treponema pallidum fructose-bisphosphate aldolase 0.0929 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0116 0.1143 0.1553
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0563 0.5365
Loa Loa (eye worm) hypothetical protein 0.0149 0.15 0.2021
Echinococcus granulosus carboxylesterase 5A 0.0686 0.7361 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0563 0.5365
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0875 0.1188
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0116 0.1143 0.1553
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0929 1 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0058 0.0058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0875 0.1188
Echinococcus granulosus acetylcholinesterase 0.0686 0.7361 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0015 0.0021
Schistosoma mansoni hypothetical protein 0.0013 0.0015 0.0021
Brugia malayi Cathepsin L-like precursor 0.0016 0.0058 0.0058
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0875 0.117
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0058 0.0379
Loa Loa (eye worm) hypothetical protein 0.0116 0.1143 0.1535
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0149 0.0936
Schistosoma mansoni amine GPCR 0.0013 0.0015 0.0021
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0277 0.2367
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0058 0.0079
Loa Loa (eye worm) hypothetical protein 0.0106 0.1031 0.1383
Echinococcus granulosus lamin 0.0028 0.0184 0.025
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0106 0.1031 0.1383
Echinococcus granulosus g protein coupled receptor 0.0013 0.0015 0.0021
Leishmania major DNA polymerase eta, putative 0.0019 0.0083 0.0413
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.145 0.1953
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0058 0.0079
Schistosoma mansoni opsin-like receptor 0.0013 0.0015 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0015 0.0021
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0015 0.0021
Loa Loa (eye worm) cysteine protease 0.0016 0.0058 0.0058
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.266 0.3614
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0275 0.0218
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0275 0.0218
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0277 0.2367
Echinococcus multilocularis GPCR, family 2 0.0047 0.0392 0.0532
Echinococcus granulosus para nitrobenzyl esterase 0.0116 0.1143 0.1553
Brugia malayi Carboxylesterase family protein 0.0116 0.1143 0.1535
Schistosoma mansoni hypothetical protein 0.0372 0.393 0.5339
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0392 0.0532
Loa Loa (eye worm) hypothetical protein 0.0025 0.0149 0.0182
Loa Loa (eye worm) hypothetical protein 0.0106 0.1031 0.1383
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0203 0.0256
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0563 0.5258
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0061 0.0083
Schistosoma mansoni opsin-like receptor 0.0013 0.0015 0.0021
Echinococcus granulosus lamin dm0 0.0028 0.0184 0.025
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0026 0.0035
Onchocerca volvulus 0.0116 0.1143 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0929 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.0013 0.0015 0.0021
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0158 0.1026
Brugia malayi RNA, U transporter 1 0.0099 0.0958 0.1283
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0875 0.117
Schistosoma mansoni lamin 0.0028 0.0184 0.025
Schistosoma mansoni hypothetical protein 0.0052 0.0446 0.0606
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0875 0.1188
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0275 0.2347
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0277 0.2539
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0186 0.0129
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0372 0.0505
Brugia malayi Carboxylesterase family protein 0.0686 0.7361 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0013 0.0015 0.0021
Leishmania major GTP-binding protein, putative 0.0026 0.0158 0.1167
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.0628
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0015 0.0021
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0264 0.0358
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0454 0.4823 1
Schistosoma mansoni hypothetical protein 0.0015 0.0043 0.0058
Leishmania major importin beta-1 subunit, putative 0.0028 0.0186 0.1455
Loa Loa (eye worm) acetylcholinesterase 1 0.0686 0.7361 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0068 0.0093
Mycobacterium tuberculosis Probable lipase LipE 0.0106 0.1031 0.1324
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0015 0.0021
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0058 0.0079
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0015 0.0021
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0015 0.0021
Brugia malayi Importin beta-1 subunit 0.0035 0.0258 0.0331
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0106 0.1031 0.1383
Echinococcus granulosus g protein coupled receptor 0.0013 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0047 0.0392 0.0512
Brugia malayi MH2 domain containing protein 0.0144 0.145 0.1953
Trypanosoma brucei ISWI complex protein 0.0015 0.0043 0.0225
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0139 0.0188
Schistosoma mansoni cpg binding protein 0.0033 0.0242 0.0329
Loa Loa (eye worm) hypothetical protein 0.0044 0.0354 0.0461
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0083 0.0413
Leishmania major cathepsin L-like protease 0.0063 0.0563 0.5258
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0015 0.0021
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0013 0.0015 0.0021
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0106 0.1031 0.1324
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0053 0.046 0.0625
Echinococcus granulosus peptide allatostatin:somatostatin 0.0013 0.0015 0.0021
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0275 0.0373
Echinococcus multilocularis dro:myosuppressin receptor 0.0013 0.0015 0.0021
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0015 0.0021
Brugia malayi intermediate filament protein 0.0028 0.0184 0.023
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0013 0.0015 0.0021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0875 0.1188
Loa Loa (eye worm) hypothetical protein 0.0047 0.0393 0.0514
Mycobacterium ulcerans hypothetical protein 0.0106 0.1031 0.2
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0068 0.0093
Mycobacterium leprae Probable lipase LipE 0.0106 0.1031 0.1739
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.266 0.3614
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0392 0.0532
Echinococcus multilocularis allatostatin A receptor 0.0013 0.0015 0.0021
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0158 0.1167
Loa Loa (eye worm) carboxylesterase 0.0116 0.1143 0.1535
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0372 0.322
Plasmodium vivax importin-beta 2, putative 0.0035 0.0258 0.2055
Brugia malayi CXXC zinc finger family protein 0.003 0.0203 0.0256
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.1031 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0106 0.1031 0.1324
Onchocerca volvulus 0.0016 0.0058 0.0379
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0015 0.0021
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0186 0.0129
Schistosoma mansoni adenoreceptor 0.0013 0.0015 0.0021
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0149 0.1279
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0083 0.0628
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0372 0.0315
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0013 0.0015 0.0021
Schistosoma mansoni amine GPCR 0.0013 0.0015 0.0021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0106 0.1031 0.1401
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.145 0.1953
Entamoeba histolytica hypothetical protein 0.0036 0.027 0.0213
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0233 0.0209
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0015 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.0628
Schistosoma mansoni hypothetical protein 0.0047 0.0392 0.0532
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0929 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0875 0.1188
Echinococcus granulosus snurportin 1 0.0372 0.393 0.5339
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0503 0.4658
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0015 0.0021
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0264 0.0358
Brugia malayi hypothetical protein 0.0025 0.0149 0.0182
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.1494 0.2013
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0013 0.0015 0.0021
Echinococcus granulosus orexin receptor type 2 0.0013 0.0015 0.0021
Brugia malayi hypothetical protein 0.0036 0.027 0.0346
Echinococcus granulosus neuropeptide receptor 0.0013 0.0015 0.0021
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0015 0.0021
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0275 0.0373
Echinococcus granulosus neuropeptide receptor 0.0013 0.0015 0.0021
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0149 0.3657
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0416 0.3778
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0007
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0015 0.0021
Loa Loa (eye worm) acetyltransferase 0.0148 0.1494 0.2013
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0987 0.1323
Leishmania major hypothetical protein, conserved 0.0106 0.1031 1
Schistosoma mansoni zinc finger protein 0.0025 0.0146 0.0198
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0015 0.0021
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0676 0.7244 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0558 0.5135
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0058 0.0058
Echinococcus multilocularis serotonin receptor 0.0013 0.0015 0.0021
Echinococcus multilocularis neuropeptide s receptor 0.0509 0.5427 0.7372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0563 0.5365
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0563 0.5365
Schistosoma mansoni P2X receptor subunit 0.007 0.0646 0.0877
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0042 0.0037
Entamoeba histolytica hypothetical protein 0.0036 0.027 0.0213
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0158 0.4008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0014
Leishmania major cathepsin L-like protease 0.0016 0.0058 0.0158
Echinococcus granulosus p2X purinoceptor 4 0.007 0.0646 0.0877
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0015 0.0021
Schistosoma mansoni P2X receptor subunit 0.007 0.0646 0.0877
Echinococcus multilocularis dna polymerase eta 0.0019 0.0083 0.0113
Schistosoma mansoni ap endonuclease 0.0037 0.0277 0.0376
Brugia malayi beta-lactamase 0.0106 0.1031 0.1383
Echinococcus multilocularis serotonin receptor 0.0013 0.0015 0.0021
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0576 0.0782
Onchocerca volvulus 0.0016 0.0058 0.0379
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0277 0.022
Schistosoma mansoni neuropeptide receptor 0.0013 0.0015 0.0021
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0068 0.0093
Loa Loa (eye worm) hypothetical protein 0.0028 0.0178 0.0222
Toxoplasma gondii ABC1 family protein 0.0106 0.1031 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0015 0.0021
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0458 0.4873 0.6612
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0277 0.0356
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.1031 0.0979
Loa Loa (eye worm) hypothetical protein 0.0414 0.4388 0.5952
Loa Loa (eye worm) PHD-finger family protein 0.002 0.01 0.0115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0929 1 1
Schistosoma mansoni myosin xvIII 0.0013 0.0015 0.0021
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0083 0.0025
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0015 0.0021
Schistosoma mansoni growth hormone secretagogue receptor 0.0013 0.0015 0.0021
Schistosoma mansoni opsin-like receptor 0.0013 0.0015 0.0021
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0013 0.0015 0.0021
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0275 0.2519
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0058 0.0158
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.15 0.2021
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0083 0.0093
Echinococcus multilocularis neuropeptide receptor A26 0.0509 0.5427 0.7372
Echinococcus multilocularis somatostatin receptor 0.0013 0.0015 0.0021
Entamoeba histolytica Ran family GTPase 0.0026 0.0158 0.01
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.15 0.2021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0015 0.0021
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0149 0.3657
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0275 0.0404
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0149 0.0936
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0015 0.0021
Schistosoma mansoni biogenic amine receptor 0.0013 0.0015 0.0021
Schistosoma mansoni P2X receptor subunit 0.007 0.0646 0.0877
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0929 1 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.1424 0.1934
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0061 0.0083
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0083 0.0413
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0015 0.0021
Toxoplasma gondii exonuclease III APE 0.0037 0.0277 0.2245
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0186 0.1455
Loa Loa (eye worm) hypothetical protein 0.0686 0.7361 1
Echinococcus multilocularis g-protein coupled receptor 0.0013 0.0015 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0015 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.0628
Echinococcus granulosus G protein coupled receptor 139 0.0013 0.0015 0.0021
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.1494 0.2029
Schistosoma mansoni neuropeptide receptor 0.0013 0.0015 0.0021
Schistosoma mansoni neuropeptide receptor 0.0013 0.0015 0.0021
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0013 0.0015 0.0021
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0015 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0015 0.0021
Echinococcus granulosus neuropeptide FF receptor 2 0.0013 0.0015 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.0628
Echinococcus granulosus p2X purinoceptor 4 0.007 0.0646 0.0877
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0563 0.5365
Echinococcus granulosus sex peptide receptor 0.0013 0.0015 0.0021
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0015 0.0021
Trichomonas vaginalis penicillin-binding protein, putative 0.0106 0.1031 0.0979
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0307 0.0251
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0083 0.0113
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.027 0.0367
Schistosoma mansoni survival motor neuron protein 0.0052 0.0446 0.0606
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0026 0.0035
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0015 0.0021
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0083 0.0113
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0058 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.0628
Loa Loa (eye worm) hypothetical protein 0.0686 0.7361 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0563 0.5365
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0015 0.0021
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0013 0.0015 0.0021
Trichomonas vaginalis penicillin-binding protein, putative 0.0106 0.1031 0.0979
Echinococcus granulosus alpha 1A adrenergic receptor 0.0013 0.0015 0.0021
Brugia malayi Carboxylesterase family protein 0.0686 0.7361 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0015 0.0021
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0277 0.2245
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0083 0.0628
Schistosoma mansoni hypothetical protein 0.0013 0.0015 0.0021
Onchocerca volvulus 0.0016 0.0058 0.0379
Mycobacterium leprae conserved hypothetical protein 0.0106 0.1031 0.1739
Leishmania major cathepsin L-like protease 0.0016 0.0058 0.0158
Trypanosoma brucei hypothetical protein, conserved 0.0106 0.1031 1
Leishmania major cathepsin L-like protease 0.0016 0.0058 0.0158
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0563 0.5258
Onchocerca volvulus 0.003 0.0203 0.1666
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0013 0.0015 0.0021
Schistosoma mansoni importin beta-1 0.0035 0.0258 0.0351
Echinococcus multilocularis neuroligin 0.0116 0.1143 0.1553
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0015 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0015 0.0021
Brugia malayi Cathepsin L-like precursor 0.0016 0.0058 0.0058
Echinococcus multilocularis p2X purinoceptor 4 0.007 0.0646 0.0877
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0015 0.0021
Schistosoma mansoni cpg binding protein 0.0033 0.0242 0.0329
Brugia malayi Cathepsin L-like precursor 0.0016 0.0058 0.0058
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0277 0.0376
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0158 0.0194
Schistosoma mansoni hypothetical protein 0.0669 0.7176 0.9748
Loa Loa (eye worm) hypothetical protein 0.0035 0.0258 0.0331
Mycobacterium tuberculosis Probable hydrolase 0.0106 0.1031 0.1324
Echinococcus granulosus 7TM GPCR rhodopsin 0.0013 0.0015 0.0021
Mycobacterium tuberculosis Probable esterase LipL 0.0106 0.1031 0.1324
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.027 0.0367
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0186 0.0129
Brugia malayi Carboxylesterase family protein 0.0116 0.1143 0.1535
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0275 0.0218
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0158 0.0215
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0454 0.4823 0.6619
Echinococcus granulosus neuropeptide receptor A26 0.0509 0.5427 0.7372
Onchocerca volvulus 0.0106 0.1031 0.9011
Brugia malayi beta-lactamase family protein 0.0106 0.1031 0.1383
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0372 0.0315
Schistosoma mansoni acetylcholinesterase 0.0116 0.1143 0.1553
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0576 0.0782
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0107 0.0125
Loa Loa (eye worm) hypothetical protein 0.0106 0.1031 0.1383
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0058 0.0079
Brugia malayi Cathepsin L-like precursor 0.0016 0.0058 0.0058
Schistosoma mansoni P2X receptor subunit 0.007 0.0646 0.0877
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0563 0.5258
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0563 0.5365
Schistosoma mansoni hypothetical protein 0.0047 0.0392 0.0532
Onchocerca volvulus 0.0106 0.1031 0.9011
Schistosoma mansoni inhibitor of apoptosis protein 0.0053 0.046 0.0625
Schistosoma mansoni amine GPCR 0.0013 0.0015 0.0021
Echinococcus multilocularis lamin dm0 0.0028 0.0184 0.025
Entamoeba histolytica hypothetical protein 0.0028 0.0186 0.0129
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0083 0.0113
Leishmania major cathepsin L-like protease 0.0063 0.0563 0.5258
Echinococcus granulosus geminin 0.0669 0.7176 0.9748
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0015 0.0021
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0392 0.0512
Onchocerca volvulus 0.0016 0.0058 0.0379
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0083 0.0113
Loa Loa (eye worm) hypothetical protein 0.0102 0.0987 0.1323
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0277 1
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0015 0.0021
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0036 0.027 0.0367
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0058 0.0079
Onchocerca volvulus 0.0106 0.1031 0.9011
Loa Loa (eye worm) hypothetical protein 0.0116 0.1143 0.1535
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0184 0.023

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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