Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0712 | 0.076 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0043 | 0.0525 | 0.0478 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.02 | 0.4709 | 0.6122 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0286 | 0.7019 | 0.8944 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.016 | 0.0019 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0043 | 0.0525 | 0.0031 |
Brugia malayi | follicle stimulating hormone receptor | 0.0272 | 0.664 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0078 | 0.1448 | 0.2334 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0284 | 0.6943 | 0.884 |
Trichomonas vaginalis | heat shock protein, putative | 0.0091 | 0.1805 | 0.2909 |
Echinococcus multilocularis | expressed protein | 0.0053 | 0.0797 | 0.0875 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0124 | 0.2693 | 0.3332 |
Leishmania major | heat shock protein 83-1 | 0.0106 | 0.2192 | 0.2712 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0043 | 0.0525 | 0.065 |
Plasmodium falciparum | endoplasmin, putative | 0.0079 | 0.1482 | 0.1478 |
Schistosoma mansoni | lipoxygenase | 0.0062 | 0.102 | 0.0887 |
Trypanosoma brucei | heat shock protein, putative | 0.0106 | 0.2192 | 0.2579 |
Giardia lamblia | Grp94/Hsp90 | 0.0091 | 0.1805 | 0.7678 |
Schistosoma mansoni | lamin | 0.0029 | 0.016 | 0.0014 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.1308 | 0.118 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0286 | 0.7019 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0106 | 0.2192 | 0.2712 |
Plasmodium falciparum | thioredoxin reductase | 0.0124 | 0.2693 | 0.2817 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0712 | 0.0575 |
Loa Loa (eye worm) | heat shock protein 75 | 0.0064 | 0.1095 | 0.1274 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0064 | 0.1084 | 0.1445 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0043 | 0.0525 | 0.0031 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0326 | 0.8083 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0315 | 0.7788 | 1 |
Echinococcus multilocularis | musashi | 0.0029 | 0.016 | 0.0019 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0106 | 0.2192 | 1 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0106 | 0.2192 | 0.2264 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0043 | 0.0525 | 0.0031 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0315 | 0.7788 | 1 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.0064 | 0.1095 | 0.1548 |
Echinococcus granulosus | heat shock protein 90 | 0.0083 | 0.159 | 0.1938 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0505 | 0.0482 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0043 | 0.0525 | 0.0478 |
Schistosoma mansoni | heat shock protein | 0.0106 | 0.2192 | 0.2077 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0043 | 0.0525 | 0.065 |
Trypanosoma brucei | heat shock protein, putative | 0.0106 | 0.2192 | 0.2579 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.4261 | 0.4176 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0046 | 0.06 | 0.0572 |
Trypanosoma brucei | heat shock protein, putative | 0.0106 | 0.2192 | 0.2579 |
Trypanosoma brucei | trypanothione reductase | 0.0124 | 0.2693 | 0.3209 |
Mycobacterium tuberculosis | Probable reductase | 0.0284 | 0.6943 | 0.884 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0106 | 0.2192 | 0.2712 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0049 | 0.0687 | 0.085 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.02 | 0.4709 | 0.6454 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.016 | 0.0019 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0064 | 0.1084 | 0.1341 |
Onchocerca volvulus | 0.0042 | 0.0505 | 0.0571 | |
Loa Loa (eye worm) | thioredoxin reductase | 0.0124 | 0.2693 | 0.3418 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0032 | 0.0236 | 0.0121 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0505 | 0.0813 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0043 | 0.0525 | 0.065 |
Leishmania major | DNA topoisomerase ii | 0.0058 | 0.0929 | 0.1149 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0056 | 0.0868 | 0.1073 |
Echinococcus multilocularis | snurportin 1 | 0.0308 | 0.7599 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0124 | 0.2693 | 0.2817 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0078 | 0.1448 | 0.6606 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.02 | 0.4709 | 0.5047 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0078 | 0.1448 | 0.1441 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0058 | 0.0929 | 0.1149 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0505 | 0.0813 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0236 | 0.0092 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0032 | 0.0236 | 0.0121 |
Leishmania major | heat shock protein 83-1 | 0.0106 | 0.2192 | 0.2712 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0172 | 0.3962 | 0.4747 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.02 | 0.4709 | 0.5772 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0326 | 0.8083 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.016 | 0.0019 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0712 | 0.076 |
Echinococcus granulosus | snurportin 1 | 0.0308 | 0.7599 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0505 | 0.0482 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0505 | 0.0364 |
Schistosoma mansoni | hypothetical protein | 0.0308 | 0.7599 | 0.7563 |
Loa Loa (eye worm) | glutathione reductase | 0.0124 | 0.2693 | 0.3418 |
Leishmania major | heat shock protein 83-1 | 0.0106 | 0.2192 | 0.2712 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0286 | 0.7019 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0106 | 0.2192 | 0.2579 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0046 | 0.06 | 0.0742 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0315 | 0.7788 | 1 |
Toxoplasma gondii | Hsp90 domain-containing protein | 0.0368 | 0.9187 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0284 | 0.6943 | 0.884 |
Trypanosoma brucei | heat shock protein, putative | 0.0106 | 0.2192 | 0.2579 |
Schistosoma mansoni | DNA topoisomerase II | 0.0078 | 0.1448 | 0.1322 |
Plasmodium falciparum | glutathione reductase | 0.0043 | 0.0525 | 0.042 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0286 | 0.7019 | 0.7602 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0043 | 0.0525 | 0.0478 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0286 | 0.7019 | 1 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0043 | 0.0525 | 0.042 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0043 | 0.0525 | 0.042 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0106 | 0.2192 | 0.2579 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0078 | 0.1448 | 0.2131 |
Trichomonas vaginalis | esterase, putative | 0.0042 | 0.0505 | 0.0813 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0.0505 | 0.0482 |
Plasmodium vivax | heat shock protein 86, putative | 0.0106 | 0.2192 | 0.2264 |
Echinococcus multilocularis | heat shock protein 90 | 0.0106 | 0.2192 | 0.2746 |
Schistosoma mansoni | endoplasmin | 0.0106 | 0.2192 | 0.2077 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0106 | 0.2192 | 0.2746 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0505 | 0.0553 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0106 | 0.2192 | 0.2579 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.02 | 0.4709 | 0.6122 |
Trichomonas vaginalis | heat shock protein, putative | 0.0079 | 0.1482 | 0.2389 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0064 | 0.1084 | 0.1259 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0505 | 0.0482 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0058 | 0.0929 | 0.1149 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0505 | 0.0813 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0505 | 0.0397 |
Loa Loa (eye worm) | RNA binding protein | 0.0072 | 0.1308 | 0.156 |
Onchocerca volvulus | 0.0042 | 0.0505 | 0.0571 | |
Trypanosoma brucei | DNA topoisomerase ii | 0.0171 | 0.3951 | 0.4794 |
Leishmania major | heat shock protein 83-1 | 0.0106 | 0.2192 | 0.2712 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0315 | 0.7788 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0043 | 0.0525 | 0.065 |
Echinococcus multilocularis | lamin | 0.0029 | 0.016 | 0.0019 |
Treponema pallidum | heat shock protein 90 | 0.0091 | 0.1805 | 0.1971 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0505 | 0.0624 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0106 | 0.2192 | 0.2712 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.1308 | 0.118 |
Echinococcus granulosus | endoplasmin | 0.0091 | 0.1805 | 0.2227 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0193 | 0.4516 | 0.6146 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0505 | 0.0624 |
Toxoplasma gondii | TIM10 family protein, putative | 0.0053 | 0.0797 | 0.0721 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0043 | 0.0525 | 0.065 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0091 | 0.1805 | 0.1996 |
Echinococcus granulosus | heat shock protein 90 | 0.0106 | 0.2192 | 0.2746 |
Leishmania major | heat shock protein 83-1 | 0.0106 | 0.2192 | 0.2712 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0225 | 0.5376 | 0.7017 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.016 | 0.0022 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.016 | 0.0019 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0078 | 0.1448 | 0.2006 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0236 | 0.0092 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0091 | 0.1805 | 0.2233 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0043 | 0.0525 | 0.065 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0032 | 0.0236 | 0.0121 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0272 | 0.664 | 0.8714 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0091 | 0.1805 | 0.1971 |
Echinococcus multilocularis | heat shock protein 75 kDa, mitochondrial | 0.0064 | 0.1095 | 0.1274 |
Onchocerca volvulus | 0.0032 | 0.0236 | 0.0126 | |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0.0505 | 0.0482 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0236 | 0.0092 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.016 | 0.0014 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0078 | 0.1448 | 0.1748 |
Leishmania major | heat shock protein 83-1 | 0.0106 | 0.2192 | 0.2712 |
Leishmania major | heat shock protein 83-1 | 0.0106 | 0.2192 | 0.2712 |
Trypanosoma brucei | heat shock protein, putative | 0.0106 | 0.2192 | 0.2579 |
Toxoplasma gondii | thioredoxin reductase | 0.0124 | 0.2693 | 0.2817 |
Onchocerca volvulus | 0.0042 | 0.0505 | 0.0571 | |
Plasmodium vivax | heat shock protein, putative | 0.0368 | 0.9187 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0064 | 0.1084 | 0.0889 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.02 | 0.4709 | 0.6454 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0058 | 0.0929 | 0.0986 |
Leishmania major | heat shock protein 83-1 | 0.0106 | 0.2192 | 0.2712 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.1308 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0236 | 0.0122 |
Entamoeba histolytica | 90 kDa heat shock protein, putative | 0.0064 | 0.1095 | 0.4996 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0505 | 0.0482 |
Plasmodium vivax | glutathione reductase, putative | 0.0124 | 0.2693 | 0.2817 |
Trypanosoma brucei | heat shock protein, putative | 0.0106 | 0.2192 | 0.2579 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0032 | 0.0236 | 0.0092 |
Echinococcus multilocularis | tar DNA binding protein | 0.0072 | 0.1308 | 0.156 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.02 | 0.4709 | 0.4631 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0043 | 0.0525 | 0.0846 |
Loa Loa (eye worm) | endoplasmin | 0.0106 | 0.2192 | 0.2746 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0043 | 0.0525 | 0.0028 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0091 | 0.1805 | 0.1786 |
Trichomonas vaginalis | endoplasmin, putative | 0.0079 | 0.1482 | 0.2389 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0126 | 0.2737 | 0.3477 |
Leishmania major | heat shock protein 83-1 | 0.0106 | 0.2192 | 0.2712 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.016 | 0.0019 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0286 | 0.7019 | 0.7602 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0043 | 0.0525 | 0.0478 |
Leishmania major | heat shock protein 83-1 | 0.0106 | 0.2192 | 0.2712 |
Plasmodium falciparum | heat shock protein 90 | 0.0106 | 0.2192 | 0.2264 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0043 | 0.0525 | 0.0385 |
Schistosoma mansoni | heat shock protein | 0.0064 | 0.1095 | 0.0964 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0043 | 0.0525 | 0.065 |
Giardia lamblia | DNA topoisomerase II | 0.0055 | 0.0846 | 0.1926 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0505 | 0.0813 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0062 | 0.102 | 0.1173 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.016 | 0.0019 |
Echinococcus granulosus | lamin | 0.0029 | 0.016 | 0.0019 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0078 | 0.1448 | 0.2131 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0062 | 0.102 | 0.1173 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0929 | 0.1051 |
Plasmodium vivax | heat shock protein 90, putative | 0.0064 | 0.1095 | 0.105 |
Leishmania major | heat shock protein 83-1 | 0.0106 | 0.2192 | 0.2712 |
Leishmania major | heat shock protein 83-1 | 0.0106 | 0.2192 | 0.2712 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0064 | 0.1084 | 0.0952 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0106 | 0.2192 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0043 | 0.0525 | 0.0846 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0043 | 0.0525 | 0.042 |
Plasmodium falciparum | mitochondrial import inner membrane translocase subunit TIM10, putative | 0.0053 | 0.0797 | 0.0721 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0326 | 0.8083 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0326 | 0.8083 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0078 | 0.1448 | 0.2006 |
Brugia malayi | RNA binding protein | 0.0072 | 0.1308 | 0.179 |
Plasmodium falciparum | heat shock protein 90, putative | 0.0056 | 0.088 | 0.0813 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0043 | 0.0525 | 0.0584 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0126 | 0.2737 | 0.3477 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0.0236 | 0.01 |
Plasmodium falciparum | thioredoxin reductase | 0.0043 | 0.0525 | 0.042 |
Brugia malayi | Thioredoxin reductase | 0.0124 | 0.2693 | 0.3922 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0046 | 0.06 | 0.0742 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0505 | 0.0482 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0124 | 0.2693 | 0.3005 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.1308 | 0.118 |
Trypanosoma brucei | heat shock protein, putative | 0.0106 | 0.2192 | 0.2579 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0072 | 0.1308 | 0.179 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0286 | 0.7019 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0171 | 0.3951 | 0.4209 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0284 | 0.6943 | 0.884 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0712 | 0.076 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0078 | 0.1448 | 0.1441 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.1308 | 0.118 |
Brugia malayi | Probable DNA topoisomerase II | 0.0078 | 0.1448 | 0.2006 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0712 | 0.076 |
Leishmania major | heat shock protein 83-1 | 0.0106 | 0.2192 | 0.2712 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0083 | 0.159 | 0.1967 |
Plasmodium vivax | endoplasmin, putative | 0.0106 | 0.2192 | 0.2264 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0064 | 0.1084 | 0.1259 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0078 | 0.1448 | 0.2131 |
Echinococcus granulosus | geminin | 0.0183 | 0.4261 | 0.5521 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0043 | 0.0525 | 0.065 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0712 | 0.076 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0043 | 0.0525 | 0.0509 |
Brugia malayi | Pre-SET motif family protein | 0.0032 | 0.0236 | 0.0139 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0078 | 0.1448 | 0.1748 |
Mycobacterium ulcerans | hypothetical protein | 0.0172 | 0.3962 | 0.5307 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0042 | 0.0505 | 0.0452 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0043 | 0.0525 | 0.042 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.02 | 0.4709 | 0.5826 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0171 | 0.3951 | 0.4888 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0043 | 0.0525 | 0.065 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0106 | 0.2192 | 0.2579 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0106 | 0.2192 | 0.2712 |
Schistosoma mansoni | mitochondrial import inner membrane translocase subunit tim10 | 0.0053 | 0.0797 | 0.0661 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0083 | 0.159 | 0.1967 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0043 | 0.0525 | 0.0509 |
Trichomonas vaginalis | set domain proteins, putative | 0.0256 | 0.6205 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0154 | 0.3496 | 0.4221 |
Brugia malayi | RNA, U transporter 1 | 0.0082 | 0.1566 | 0.2187 |
Leishmania major | trypanothione reductase | 0.0124 | 0.2693 | 0.3332 |
Brugia malayi | TAR-binding protein | 0.0072 | 0.1308 | 0.179 |
Brugia malayi | glutathione reductase | 0.0124 | 0.2693 | 0.3922 |
Trichomonas vaginalis | heat shock protein, putative | 0.0091 | 0.1805 | 0.2909 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.02 | 0.4709 | 0.6454 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0043 | 0.0525 | 0.065 |
Brugia malayi | Pre-SET motif family protein | 0.0225 | 0.5376 | 0.8053 |
Trichomonas vaginalis | heat shock protein, putative | 0.0083 | 0.159 | 0.2563 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0124 | 0.2693 | 0.2817 |
Leishmania major | heat shock protein 83-1 | 0.0106 | 0.2192 | 0.2712 |
Trypanosoma cruzi | heat shock protein, putative | 0.0064 | 0.1095 | 0.1355 |
Plasmodium falciparum | heat shock protein 90, putative | 0.0368 | 0.9187 | 1 |
Brugia malayi | Endoplasmin precursor | 0.0106 | 0.2192 | 0.3151 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0083 | 0.159 | 0.1938 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit TIM10 | 0.0053 | 0.0797 | 0.1004 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0031 | 0.0204 | 0.0079 |
Leishmania major | heat shock protein 83-1 | 0.0106 | 0.2192 | 0.2712 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0043 | 0.0525 | 0.065 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0106 | 0.2192 | 1 |
Plasmodium vivax | mitochondrial import inner membrane translocase subunit TIM10, putative | 0.0053 | 0.0797 | 0.0721 |
Loa Loa (eye worm) | TAR-binding protein | 0.0072 | 0.1308 | 0.156 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.006 | 0.0969 | 0.1105 |
Echinococcus granulosus | tar DNA binding protein | 0.0072 | 0.1308 | 0.156 |
Trypanosoma brucei | heat shock protein 84, putative | 0.0064 | 0.1095 | 0.1196 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0505 | 0.0482 |
Leishmania major | heat shock protein, putative | 0.0064 | 0.1095 | 0.1355 |
Toxoplasma gondii | hypothetical protein | 0.0053 | 0.078 | 0.0701 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0106 | 0.2192 | 0.2712 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0078 | 0.1448 | 0.1748 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0032 | 0.022 | 0.0114 |
Leishmania major | hypothetical protein, conserved | 0.0042 | 0.0505 | 0.0624 |
Trichomonas vaginalis | heat shock protein, putative | 0.0056 | 0.088 | 0.1419 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.027 | 0.6591 | 0.8356 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0505 | 0.0553 |
Leishmania major | heat shock protein 83-1 | 0.0106 | 0.2192 | 0.2712 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0106 | 0.2192 | 0.2264 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0505 | 0.0482 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0171 | 0.3951 | 0.4888 |
Echinococcus granulosus | heat shock protein 75 kDa mitochondrial | 0.0064 | 0.1095 | 0.1274 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0043 | 0.0525 | 0.065 |
Brugia malayi | heat shock protein 90 | 0.0106 | 0.2192 | 0.3151 |
Toxoplasma gondii | ABC1 family protein | 0.0042 | 0.0505 | 0.0397 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0712 | 0.0575 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0284 | 0.6943 | 0.884 |
Echinococcus granulosus | heat shock protein | 0.0106 | 0.2192 | 0.2746 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0064 | 0.1084 | 0.0889 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0171 | 0.3951 | 0.4888 |
Echinococcus multilocularis | geminin | 0.0183 | 0.4261 | 0.5521 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.016 | 0.0022 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.0091 | 0.1805 | 0.1786 |
Echinococcus multilocularis | heat shock protein | 0.0106 | 0.2192 | 0.2746 |
Schistosoma mansoni | endoplasmin | 0.0106 | 0.2192 | 0.2077 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0094 | 0.1878 | 0.1886 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0064 | 0.1084 | 0.0796 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0154 | 0.3496 | 0.4326 |
Toxoplasma gondii | heat shock protein 75, putative | 0.0064 | 0.1095 | 0.105 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0308 | 0.7599 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0046 | 0.06 | 0.0742 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0505 | 0.0553 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0929 | 0.1051 |
Echinococcus granulosus | expressed protein | 0.0053 | 0.0797 | 0.0875 |
Onchocerca volvulus | 0.0256 | 0.6205 | 1 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0712 | 0.0575 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0083 | 0.159 | 0.6389 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0078 | 0.1448 | 0.1441 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.4261 | 0.4176 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0043 | 0.0525 | 0.065 |
Echinococcus multilocularis | heat shock protein 90 | 0.0083 | 0.159 | 0.1938 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0505 | 0.0813 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0505 | 0.0553 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0284 | 0.6943 | 0.884 |
Loa Loa (eye worm) | transport to inner mitochondrial membrane family member | 0.0053 | 0.0797 | 0.0875 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0043 | 0.0525 | 0.042 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0058 | 0.0929 | 0.0986 |
Schistosoma mansoni | lamin | 0.0029 | 0.016 | 0.0014 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0032 | 0.0236 | 0.01 |
Brugia malayi | Hsp90 protein | 0.0064 | 0.1095 | 0.1462 |
Schistosoma mansoni | heat shock protein | 0.0106 | 0.2192 | 0.2077 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0154 | 0.3496 | 0.4326 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0106 | 0.2192 | 0.2712 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0712 | 0.0872 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0072 | 0.1308 | 0.156 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0043 | 0.0525 | 0.042 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0505 | 0.0364 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0284 | 0.6943 | 0.884 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0032 | 0.022 | 0.0114 |
Echinococcus multilocularis | endoplasmin | 0.0091 | 0.1805 | 0.2227 |
Toxoplasma gondii | mitochondrial import inner membrane translocase subunit TIM10, putative | 0.0053 | 0.0797 | 0.0721 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0505 | 0.0482 |
Trichomonas vaginalis | heat shock protein, putative | 0.0106 | 0.2192 | 0.3533 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.02 | 0.4709 | 0.4631 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 44.75 % | Inhibition of T-type calcium channel alpha1G expressed in human HEK293 cells assessed as inhibition of KCl-induced decrease in calcium level at 10 uM after 60 mins by FDSS6000 assay | ChEMBL. | 20382529 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.