Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sphingosine-1-phosphate receptor 3 | Starlite/ChEMBL | References |
Homo sapiens | sphingosine-1-phosphate receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0031 | 0.3896 | 0.4775 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0044 | 0.8159 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0044 | 0.8159 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.8159 | 0.8159 |
Echinococcus granulosus | dna polymerase eta | 0.0044 | 0.8159 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0031 | 0.3896 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0044 | 0.8159 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0044 | 0.8159 | 0.8159 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.488 | 0.488 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.488 | 0.5982 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.488 | 0.488 |
Leishmania major | DNA polymerase eta, putative | 0.0031 | 0.3896 | 0.4775 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0044 | 0.8159 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0044 | 0.8159 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 103 nM | Agonist activity at human recombinant S1P1 receptor expressed in CHO cells by GTPgammaS binding assay | ChEMBL. | 20446681 |
EC50 (binding) | = 114 nM | Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assay | ChEMBL. | 20446681 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.