TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 432.505 | Formula: C27H26F2N2O
H donors: 1 H acceptors: 0 LogP: 5.68 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Fc1cccc(c1)C1NC(c2cccc(c2)F)C2/C(=N\OCc3ccccc3)/C1CCC2
InChi: 1S/C27H26F2N2O/c28-21-11-4-9-19(15-21)25-23-13-6-14-24(26(30-25)20-10-5-12-22(29)16-20)27(23)31-32-17-18-7-2-1-3-8-18/h1-5,7-12,15-16,23-26,30H,6,13-14,17H2
InChiKey: RARMFLMCRQIWII-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nAChR subunit	0.0036	0.0525	0.057
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0078	0.1526	0.1455
Loa Loa (eye worm)	hypothetical protein	0.0203	0.4482	0.437
Trypanosoma brucei	glucosidase, putative	0.0035	0.0506	0.1953
Echinococcus multilocularis	epidermal growth factor receptor	0.0175	0.3814	0.3687
Loa Loa (eye worm)	fatty acid synthase	0.0024	0.0244	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0133	0.2819	0.2672
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0506	0.0622
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0525	0.0331
Onchocerca volvulus		0.0078	0.1526	0.2703
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0137	0.293	0.4797
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.002	0.0146	0.0301
Schistosoma mansoni	hypothetical protein	0.0033	0.0463	0.0461
Schistosoma mansoni	nAChR subunit	0.0078	0.1526	0.233
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0669	0.0478
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0026	0.0288	0.2165
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0463	0.0267
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0034	0.0478	0.0487
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.1128	0.1053
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0175	0.3814	0.3687
Trichomonas vaginalis	set domain proteins, putative	0.0229	0.5103	1
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1128	0.163
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1526	0.1352
Echinococcus multilocularis	muscleblind protein 1	0.0435	1	1
Brugia malayi	Cation transporter family protein	0.0203	0.4482	0.4436
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0078	0.1526	0.1352
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0078	0.1526	0.1455
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0137	0.293	0.2785
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0036	0.0525	0.0331
Onchocerca volvulus		0.0036	0.0525	0.0662
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0036	0.0525	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1526	0.1352
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.0478	0.1672
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0525	0.0331
Brugia malayi	Pre-SET motif family protein	0.0201	0.4444	0.4397
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0062	0.1135	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0463	0.0267
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0062	0.1135	0.2345
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0463	0.0267
Trichomonas vaginalis	D-aminoacylase, putative	0.0034	0.0478	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0525	0.0331
Schistosoma mansoni	nAChR subunit	0.0078	0.1526	0.233
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1128	0.163
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0203	0.4482	0.437
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0137	0.293	0.287
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0669	0.0478
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0024	0.0234	0.0483
Schistosoma mansoni	tyrosine kinase	0.0082	0.1616	0.2488
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0525	0.0331
Schistosoma mansoni	hypothetical protein	0.0033	0.0463	0.0461
Mycobacterium tuberculosis	Conserved protein	0.0034	0.0478	0.0987
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1526	0.1352
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0463	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1526	0.1352
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0026	0.0288	0.1868
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0022	0.0201	0.0414
Brugia malayi	beta-lactamase family protein	0.0034	0.0478	0.0398
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0078	0.1526	0.1352
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0649	0.0457
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0159	0.3442	0.3308
Echinococcus multilocularis	geminin	0.0182	0.3992	0.3869
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0353	0.0156
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0463	0.0267
Mycobacterium ulcerans	polyketide synthase Pks13	0.0037	0.0541	0.3884
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0478	0.0283
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0078	0.1526	0.1352
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0069	0.1306	1
Schistosoma mansoni	tyrosine kinase	0.0175	0.3814	0.6351
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1526	0.1352
Echinococcus granulosus	beta LACTamase domain containing family member	0.0034	0.0478	0.0283
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0042	0.0669	0.0823
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0036	0.0525	0.0445
Mycobacterium tuberculosis	Probable hydrolase	0.0034	0.0478	0.0987
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0078	0.1526	0.1352
Loa Loa (eye worm)	ACC-1 protein	0.0078	0.1526	0.1352
Loa Loa (eye worm)	RNA binding protein	0.0061	0.1128	0.0946
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0037	0.0541	0.1117
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0026	0.0288	0.0595
Schistosoma mansoni	hypothetical protein	0.0033	0.0463	0.0461
Mycobacterium ulcerans	hypothetical protein	0.0034	0.0478	0.3382
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0137	0.293	0.2785
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0669	0.0478
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0311	0.5
Brugia malayi	hypothetical protein	0.0036	0.0525	0.0445
Brugia malayi	Cation transporter family protein	0.0078	0.1526	0.1455
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0078	0.1526	0.1455
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0506	0.0622
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0037	0.0541	0.1117
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1526	0.1352
Echinococcus granulosus	insulin receptor	0.0082	0.1616	0.1445
Loa Loa (eye worm)	hypothetical protein	0.0133	0.2819	0.2672
Trichomonas vaginalis	penicillin-binding protein, putative	0.0034	0.0478	0.0565
Onchocerca volvulus		0.0034	0.0478	0.0565
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0463	0.0267
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.0478	0.1672
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0478	0.0283
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.002	0.0155	0.0929
Brugia malayi	excitatory GABA receptor EXP-1A	0.0078	0.1526	0.1455
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1128	0.163
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0218	0.484	1
Schistosoma mansoni	nAChR subunit	0.0078	0.1526	0.233
Echinococcus granulosus	neutral alpha glucosidase AB	0.0035	0.0506	0.0311
Echinococcus granulosus	nAChR subunit	0.0078	0.1526	0.1352
Onchocerca volvulus		0.0203	0.4482	0.8733
Trichomonas vaginalis	esterase, putative	0.0034	0.0478	0.0565
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0022	0.0201	0.0414
Mycobacterium ulcerans	beta-lactamase	0.0034	0.0478	0.3382
Loa Loa (eye worm)	beta-lactamase	0.0034	0.0478	0.0283
Echinococcus multilocularis	acetylcholinesterase	0.0133	0.2819	0.2672
Echinococcus granulosus	epidermal growth factor receptor	0.0175	0.3814	0.3687
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0025	0.0252	0.183
Onchocerca volvulus		0.0203	0.4482	0.8733
Mycobacterium leprae	Polyketide synthase Pks13	0.0037	0.0541	0.4501
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0463	0.0383
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0026	0.0288	0.1868
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0034	0.0478	0.0487
Trypanosoma brucei	hypothetical protein, conserved	0.0034	0.0478	0.1672
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0669	0.0478
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0024	0.0234	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0478	0.0283
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0042	0.0669	0.0823
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0023	0.0214	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0525	0.0331
Brugia malayi	hypothetical protein	0.0036	0.0525	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1526	0.1352
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0078	0.1526	0.233
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1128	0.163
Schistosoma mansoni	inositol monophosphatase	0.0069	0.1306	0.1944
Echinococcus multilocularis	carboxylesterase 5A	0.0133	0.2819	0.2672
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0311	0.0113
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0159	0.3442	0.3387
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0023	0.0214	0.0441
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.2516	0.2363
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0463	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0478	0.0283
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0353	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0203	0.4482	0.437
Onchocerca volvulus		0.0036	0.0525	0.0662
Mycobacterium tuberculosis	Probable thioesterase TesA	0.002	0.0155	0.0319
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0353	0.2432
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0025	0.0252	0.017
Plasmodium vivax	SET domain protein, putative	0.0029	0.0353	0.2516
Brugia malayi	Protein kinase domain containing protein	0.0082	0.1616	0.1546
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0047	0.0774	0.0697
Echinococcus multilocularis	muscleblind protein	0.0435	1	1
Schistosoma mansoni	alpha-glucosidase	0.0137	0.2917	0.4775
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0042	0.0669	0.0591
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.2516	0.2363
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0035	0.0506	0.0311
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.002	0.0138	0.0668
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0078	0.1526	0.1352
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0018	0.0087	0.0181
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0069	0.1306	0.5
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0137	0.293	0.2785
Schistosoma mansoni	alpha-glucosidase	0.0137	0.2917	0.4775
Echinococcus multilocularis	nAChR subunit	0.0042	0.0669	0.0478
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0078	0.1526	0.233
Mycobacterium tuberculosis	Probable lipase LipE	0.0034	0.0478	0.0987
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0078	0.1526	0.1455
Echinococcus granulosus	glycine receptor subunit beta	0.0078	0.1526	0.1352
Brugia malayi	hypothetical protein	0.0027	0.0311	0.023
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0669	0.0478
Schistosoma mansoni	nAChR subunit	0.0078	0.1526	0.233
Schistosoma mansoni	hypothetical protein	0.0033	0.0463	0.0461
Schistosoma mansoni	tyrosine kinase	0.0082	0.1616	0.2488
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0035	0.0506	0.3643
Toxoplasma gondii	type I fatty acid synthase, putative	0.0017	0.0084	0.0292
Schistosoma mansoni	neurotransmitter gated ion channel	0.0036	0.0525	0.057
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1526	0.1352
Mycobacterium ulcerans	lipase LipD	0.0034	0.0478	0.3382
Echinococcus granulosus	tar DNA binding protein	0.0061	0.1128	0.0946
Toxoplasma gondii	ABC1 family protein	0.0034	0.0478	0.342
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0078	0.1526	0.1352
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0078	0.1526	0.1352
Schistosoma mansoni	tyrosine kinase	0.0262	0.5889	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0034	0.0478	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1526	0.1352
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0506	0.1953
Loa Loa (eye worm)	inositol-1	0.0069	0.1306	0.1128
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0078	0.1526	0.1455
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0035	0.0506	0.0622
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.002	0.0138	0.0668
Trichomonas vaginalis	inositol monophosphatase, putative	0.0069	0.1306	0.2255
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0034	0.0478	0.0987
Mycobacterium ulcerans	polyketide synthase	0.0026	0.0288	0.1868
Schistosoma mansoni	neurotransmitter gated ion channel	0.0042	0.0669	0.0823
Schistosoma mansoni	nAChR subunit	0.0036	0.0525	0.057
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0353	0.0268
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0353	0.0268
Schistosoma mansoni	tyrosine kinase	0.0173	0.3788	0.6307
Brugia malayi	Carboxylesterase family protein	0.0133	0.2819	0.2759
Echinococcus granulosus	nAChR subunit	0.0042	0.0669	0.0478
Echinococcus multilocularis		0.0132	0.2792	0.2645
Schistosoma mansoni	nAChR subunit	0.0078	0.1526	0.233
Schistosoma mansoni	tyrosine kinase	0.0173	0.3788	0.6307
Echinococcus granulosus	epidermal growth factor receptor	0.0262	0.5889	0.5805
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0525	0.0331
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0036	0.0525	0.0445
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0022	0.0201	0.0414
Echinococcus granulosus	inositol monophosphatase 1	0.0069	0.1306	0.1128
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0025	0.0252	0.1579
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0078	0.1526	0.233
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0069	0.1306	1
Schistosoma mansoni	alpha glucosidase	0.0035	0.0506	0.0536
Echinococcus multilocularis	inositol monophosphatase 1	0.0069	0.1306	0.1128
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0078	0.1526	0.1455
Loa Loa (eye worm)	hypothetical protein	0.0435	1	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.1385	0.1312
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0034	0.0478	0.0283
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0353	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1526	0.1352
Loa Loa (eye worm)	acetylcholinesterase 1	0.0133	0.2819	0.2672
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0069	0.1306	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1526	0.1352
Mycobacterium ulcerans	polyketide synthase	0.0025	0.0252	0.1579
Mycobacterium leprae	Probable lipase LipE	0.0034	0.0478	0.3919
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0036	0.0525	0.0331
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0034	0.0478	0.0283
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0106	0.2179	0.2019
Brugia malayi	hypothetical protein	0.0036	0.0525	0.0445
Brugia malayi	Carboxylesterase family protein	0.0022	0.0201	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0669	0.0478
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0078	0.1526	0.233
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0201	0.4444	0.433
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0078	0.1526	0.1352
Schistosoma mansoni	hypothetical protein	0.0182	0.3992	0.6664
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0078	0.1526	0.1352
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0078	0.1526	0.1455
Mycobacterium tuberculosis	Conserved protein	0.0034	0.0478	0.0987
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0203	0.4482	0.437
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0034	0.0478	0.0987
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0106	0.2179	0.2114
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0137	0.293	0.2785
Loa Loa (eye worm)	hypothetical protein	0.0106	0.2179	0.2019
Schistosoma mansoni	acetylcholine receptor-related	0.0036	0.0525	0.057
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0078	0.1526	0.1455
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0036	0.0525	0.0445
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0035	0.0506	0.0622
Trichomonas vaginalis	D-aminoacylase, putative	0.0034	0.0478	0.0565
Echinococcus granulosus	glycine receptor subunit beta	0.0078	0.1526	0.1352
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0082	0.1616	0.1445
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0078	0.1526	0.1352
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0036	0.0525	0.0331
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0078	0.1526	0.1352
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1526	0.1352
Onchocerca volvulus		0.0229	0.5103	1
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0203	0.4482	0.437
Brugia malayi	TAR-binding protein	0.0061	0.1128	0.1053
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0133	0.2819	0.4603
Onchocerca volvulus		0.0078	0.1526	0.2703
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0025	0.0252	0.183
Mycobacterium ulcerans	thioesterase	0.002	0.0155	0.0802
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0042	0.0669	0.0591
Onchocerca volvulus		0.0203	0.4482	0.8733
Onchocerca volvulus		0.0078	0.1526	0.2703
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.1128	0.0946
Echinococcus granulosus	lysosomal alpha glucosidase	0.0159	0.3442	0.3308
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.1128	0.0946
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0078	0.1526	0.1455
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0042	0.0669	0.0591
Echinococcus multilocularis	acetylcholinesterase	0.0133	0.2819	0.2672
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0262	0.5889	0.5805
Onchocerca volvulus		0.0034	0.0478	0.0565
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0025	0.0252	0.1579
Brugia malayi	Inositol-1	0.0069	0.1306	0.1233
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0203	0.4482	0.7527
Mycobacterium tuberculosis	Probable esterase LipL	0.0034	0.0478	0.0987
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0036	0.0525	0.0331
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0506	0.0622
Brugia malayi	Cation transporter family protein	0.0078	0.1526	0.1455
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0078	0.1526	0.1455
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0506	0.0622
Schistosoma mansoni	inositol monophosphatase	0.0069	0.1306	0.1944
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0478	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1526	0.1352
Mycobacterium ulcerans	esterase/lipase LipP	0.0034	0.0478	0.3382
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0525	0.0331
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0203	0.4482	0.4436
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0214	0.0131
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0353	0.0156
Echinococcus granulosus	muscleblind protein	0.0435	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1128	0.163
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0078	0.1526	0.1352
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0525	0.0331
Plasmodium vivax	hypothetical protein, conserved	0.0034	0.0478	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0525	0.0331
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0203	0.4482	0.437
Brugia malayi	RNA binding protein	0.0061	0.1128	0.1053
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0506	0.0622
Brugia malayi	Carboxylesterase family protein	0.0022	0.0201	0.0118
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0025	0.0252	0.1579
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0078	0.1526	0.1455
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0203	0.4482	0.437
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1526	0.1352
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0078	0.1526	0.1352
Brugia malayi	beta-lactamase family protein	0.0034	0.0478	0.0398
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0506	0.1953
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0669	0.0478
Loa Loa (eye worm)	acetylcholine receptor protein	0.0036	0.0525	0.0331
Brugia malayi	beta-lactamase	0.0034	0.0478	0.0398
Schistosoma mansoni	hypothetical protein	0.0072	0.1385	0.2082
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0036	0.0525	0.0331
Loa Loa (eye worm)	LGC-31 protein	0.0078	0.1526	0.1352
Echinococcus granulosus	carboxylesterase 5A	0.0133	0.2819	0.2672
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0025	0.0252	0.052
Loa Loa (eye worm)	carboxylesterase	0.0133	0.2819	0.2672
Brugia malayi	Pre-SET motif family protein	0.0029	0.0353	0.0272
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0035	0.0506	0.0622
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0078	0.1526	0.1352
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0036	0.0525	0.0445
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0026	0.0288	0.0595
Onchocerca volvulus	Putative nachr subunit	0.0203	0.4482	0.8733
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0069	0.1306	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0069	0.1306	1
Onchocerca volvulus		0.0036	0.0525	0.0662
Entamoeba histolytica	hypothetical protein	0.0042	0.0669	0.2039
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0034	0.0478	0.3382
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0069	0.1306	0.2255
Schistosoma mansoni	hypothetical protein	0.0182	0.3992	0.6664
Schistosoma mansoni	nAChR subunit	0.0078	0.1526	0.233
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0078	0.1526	0.1455
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0025	0.0252	0.1579
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0525	0.0331
Trichomonas vaginalis	D-aminoacylase, putative	0.0034	0.0478	0.0565
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0106	0.2179	0.2114
Echinococcus multilocularis	epidermal growth factor receptor	0.0262	0.5889	0.5805
Brugia malayi	Carboxylesterase family protein	0.0133	0.2819	0.2759
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0069	0.1306	1
Onchocerca volvulus		0.0042	0.0669	0.0955
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.002	0.0138	0.0774
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0026	0.0288	0.2165
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0137	0.293	0.4797
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0463	0.0267
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0203	0.4482	0.437
Brugia malayi	hypothetical protein	0.0036	0.0525	0.0445
Echinococcus multilocularis	glycine receptor subunit beta	0.0078	0.1526	0.1352
Mycobacterium leprae	conserved hypothetical protein	0.0034	0.0478	0.3919
Onchocerca volvulus		0.0043	0.0684	0.0986
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0078	0.1526	0.1352
Loa Loa (eye worm)	hypothetical protein	0.0167	0.3626	0.3495
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0036	0.0525	0.0445
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0034	0.0478	0.0987
Echinococcus granulosus	GPCR family 2	0.0033	0.0463	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0669	0.0478
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0137	0.293	0.4797
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0078	0.1526	0.1352
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0069	0.1306	0.2255
Loa Loa (eye worm)	hypothetical protein	0.0203	0.4482	0.437
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0078	0.1526	0.1352
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0525	0.0331
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0328	0.013
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0078	0.1526	0.1455
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0353	0.0156
Schistosoma mansoni	neurotransmitter gated ion channel	0.0036	0.0525	0.057
Brugia malayi	Carboxylesterase family protein	0.0022	0.0201	0.0118
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0082	0.1616	0.1445
Echinococcus multilocularis	nAChR subunit	0.0078	0.1526	0.1352
Onchocerca volvulus		0.0042	0.0669	0.0955
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0025	0.0252	0.052
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0026	0.0288	0.2165
Brugia malayi	Furin-like cysteine rich region family protein	0.0262	0.5889	0.5855
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0203	0.4482	0.7527
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0137	0.293	0.2785
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0036	0.0525	0.0331
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0035	0.0506	0.0426
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1526	0.1352
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0078	0.1526	0.1455
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0159	0.3442	0.3308
Onchocerca volvulus	Fatty acid synthase homolog	0.0044	0.072	0.106
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0478	0.0283
Mycobacterium ulcerans	carboxylesterase, LipT	0.0022	0.0201	0.1169
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0042	0.0669	0.0591
Echinococcus granulosus	geminin	0.0182	0.3992	0.3869
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0078	0.1526	0.1352
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0035	0.0506	0.0622
Onchocerca volvulus		0.0029	0.0353	0.0311
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0078	0.1526	0.1455
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0036	0.0525	0.0445
Schistosoma mansoni	tyrosine kinase	0.0175	0.3814	0.6351
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0525	0.0331
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.1128	0.0946
Echinococcus multilocularis	insulin receptor	0.0082	0.1616	0.1445
Loa Loa (eye worm)	ACC-1 protein	0.0078	0.1526	0.1352
Mycobacterium tuberculosis	Conserved protein	0.0034	0.0478	0.0987
Echinococcus multilocularis	glycine receptor subunit beta	0.0078	0.1526	0.1352
Brugia malayi	hypothetical protein	0.0022	0.0201	0.0118
Brugia malayi	MH2 domain containing protein	0.012	0.2516	0.2453
Toxoplasma gondii	type I fatty acid synthase, putative	0.0026	0.0288	0.1916
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0078	0.1526	0.1352
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0069	0.1306	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1385	0.1208
Echinococcus granulosus	acetylcholinesterase	0.0133	0.2819	0.2672
Onchocerca volvulus		0.0034	0.0478	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0525	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1526	0.1352
Leishmania major	alpha glucosidase II subunit, putative	0.0035	0.0506	0.1953
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0026	0.0288	0.0595
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0159	0.3442	0.3308
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0034	0.0478	0.0398
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0035	0.0506	0.0311
Onchocerca volvulus		0.0023	0.0214	0.0026
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0203	0.4482	0.437
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0025	0.0252	0.052
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0078	0.1526	0.1352
Leishmania major	hypothetical protein, conserved	0.0034	0.0478	0.1672
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0353	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0525	0.0331
Echinococcus granulosus	acetylcholinesterase	0.0133	0.2819	0.2672
Schistosoma mansoni	tyrosine kinase	0.0173	0.3788	0.6307
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0311	0.21
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0036	0.0525	0.057
Schistosoma mansoni	nAChR subunit	0.0078	0.1526	0.233
Onchocerca volvulus		0.0092	0.1851	0.3366
Brugia malayi	hypothetical protein	0.0036	0.0525	0.0445
Loa Loa (eye worm)	TK/INSR protein kinase	0.0082	0.1616	0.1445
Mycobacterium tuberculosis	Probable lipase LipD	0.0034	0.0478	0.0987
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0311	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0525	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0435	1	1
Loa Loa (eye worm)	GABA receptor subunit	0.0042	0.0669	0.0478
Brugia malayi	Carboxylesterase family protein	0.0022	0.0201	0.0118
Mycobacterium ulcerans	thioesterase TesA	0.002	0.0155	0.0802

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 25 ug ml-1	Antibacterial activity against Escherichia coli by twofold serial dilution method	ChEMBL.	19879756
MIC (functional)	= 50 ug ml-1	Antifungal activity against Candida albicans by twofold serial dilution method	ChEMBL.	19879756

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1080357

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1128127