Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aurora kinase B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | aurora kinase B | 303 aa | 299 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Bromodomain containing protein | 0.0043 | 0.15 | 0.1162 |
Brugia malayi | serine/threonine kinase 12 | 0.0068 | 0.3123 | 0.3157 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0068 | 0.3123 | 0.3123 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0068 | 0.3123 | 0.5 |
Echinococcus multilocularis | geminin | 0.0176 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.1926 | 0.1926 |
Leishmania major | protein kinase, putative | 0.0068 | 0.3123 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.1926 | 0.1926 |
Entamoeba histolytica | protein kinase , putative | 0.0068 | 0.3123 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0049 | 0.1926 | 0.2217 |
Trichomonas vaginalis | AGC family protein kinase | 0.0068 | 0.3123 | 0.5 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0068 | 0.3123 | 0.3157 |
Toxoplasma gondii | aurora kinase | 0.0068 | 0.3123 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.3011 | 0.3011 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0156 | 0.8689 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.5559 | 0.5559 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0388 | 0.0388 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.0178 | 0.0178 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.3011 | 0.3011 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.1333 | 0.1333 |
Trichomonas vaginalis | AGC family protein kinase | 0.0068 | 0.3123 | 0.5 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0068 | 0.3123 | 0.3157 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.0178 | 0.0178 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1672 | 0.1924 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.1333 | 0.1333 |
Giardia lamblia | Aurora kinase | 0.0068 | 0.3123 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.5559 | 0.6398 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0049 | 0.1926 | 0.1686 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1505 | 0.1732 |
Echinococcus granulosus | GPCR family 2 | 0.0049 | 0.1926 | 0.1926 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0049 | 0.1926 | 0.1686 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0068 | 0.3123 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1926 | 0.2217 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0068 | 0.3123 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.3789 | 0.4361 |
Trypanosoma brucei | aurora B kinase | 0.0068 | 0.3123 | 0.5 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0068 | 0.3123 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0068 | 0.3123 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0156 | 0.8689 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0068 | 0.3123 | 0.3594 |
Trichomonas vaginalis | AGC family protein kinase | 0.0068 | 0.3123 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.1926 | 0.1926 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0253 | 0.0291 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1807 | 0.208 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0068 | 0.3123 | 0.3123 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0106 | 0.5559 | 0.6152 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0253 | 0.0253 |
Loa Loa (eye worm) | bromodomain containing protein | 0.002 | 0.0043 | 0.005 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0388 | 0.0388 |
Echinococcus granulosus | aurora kinase A | 0.0068 | 0.3123 | 0.3123 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0068 | 0.3123 | 0.3123 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0068 | 0.3123 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.3263 | 0.3263 |
Echinococcus multilocularis | GPCR, family 2 | 0.0049 | 0.1926 | 0.1926 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0068 | 0.3123 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.1926 | 0.1926 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.1926 | 0.1926 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.1926 | 0.1926 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.8689 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.0178 | 0.0178 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.1926 | 0.1926 |
Loa Loa (eye worm) | AUR protein kinase | 0.0068 | 0.3123 | 0.3594 |
Loa Loa (eye worm) | AUR protein kinase | 0.0068 | 0.3123 | 0.3594 |
Brugia malayi | Bromodomain containing protein | 0.0083 | 0.4091 | 0.4347 |
Trichomonas vaginalis | AGC family protein kinase | 0.0068 | 0.3123 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0156 | 0.8689 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0068 | 0.3123 | 0.5 |
Echinococcus multilocularis | aurora kinase A | 0.0068 | 0.3123 | 0.3123 |
Schistosoma mansoni | protein kinase | 0.0068 | 0.3123 | 0.3123 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0388 | 0.0388 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.1926 | 0.1926 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0068 | 0.3123 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 8500 nM | Antiproliferative activity against human HCT116 cells by BrdU incorporation assay | ChEMBL. | 19646866 |
IC50 (binding) | Inhibition of Aurora A after 60 mins | ChEMBL. | 19646866 | |
IC50 (binding) | = 580 nM | Inhibition of Aurora B after 60 mins | ChEMBL. | 19646866 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 19646866 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.