Detailed information for compound 1128989

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 441.465 | Formula: C24H18F3NO2S
  • H donors: 0 H acceptors: 3 LogP: 5.93 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCS(=O)(=O)c1cccc(c1)c1cccc(c1)c1ccnc2c1cccc2C(F)(F)F
  • InChi: 1S/C24H18F3NO2S/c1-2-31(29,30)19-9-4-7-17(15-19)16-6-3-8-18(14-16)20-12-13-28-23-21(20)10-5-11-22(23)24(25,26)27/h3-15H,2H2,1H3
  • InChiKey: VJEBBKVWKHODQJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear receptor subfamily 1, group H, member 2 Starlite/ChEMBL References
Homo sapiens nuclear receptor subfamily 1, group H, member 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Bile acid receptor homolog Get druggable targets OG5_134445 All targets in OG5_134445
Brugia malayi ecdysteroid receptor Get druggable targets OG5_134445 All targets in OG5_134445
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_134445 All targets in OG5_134445
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor nuclear receptor subfamily 1, group H, member 3 387 aa 321 aa 28.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0 0.5
Onchocerca volvulus Bile acid receptor homolog 0.0207 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0 0.5
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0 0.5
Schistosoma mansoni nuclear hormone receptor 0.0022 0 0.5
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0 0.5
Schistosoma mansoni thyroid hormone receptor 0.0022 0 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0 0.5
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0 0.5
Schistosoma mansoni coup transcription factor 0.0022 0 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0 0.5
Echinococcus granulosus FTZ F1 alpha 0.0022 0 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0 0.5
Schistosoma mansoni thyroid hormone receptor 0.0022 0 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0022 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0207 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0 0.5

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 30 % Agonist activity at human recombinant LXRbeta ligand binding domain in HuH7 cells by Gal4 transactivation assay relative to T0901317 ChEMBL. 20382019
Activity (functional) = 74 % Upregulation of SREB1c mRNA level in human HuH7 cells relative to T0901317 ChEMBL. 20382019
Activity (functional) = 80 % Upregulation of ABCA1 mRNA level in mouse J774 cells relative to T0901317 ChEMBL. 20382019
Activity (functional) = 80 % Increase in triglyceride level in human HepG2 cells relative to T0901317 ChEMBL. 20382019
EC50 (functional) = 156 nM Upregulation of ABCA1 mRNA level in mouse J774 cells ChEMBL. 20382019
EC50 (functional) = 156 nM Increase in triglyceride level in human HepG2 cells ChEMBL. 20382019
EC50 (functional) = 521 nM Upregulation of SREB1c mRNA level in human HuH7 cells ChEMBL. 20382019
EC50 (binding) = 1080 nM Agonist activity at human recombinant LXRbeta ligand binding domain in HuH7 cells by Gal4 transactivation assay ChEMBL. 20382019
IC50 (binding) = 33 nM Displacement of [3H]T0901317 from LXRbeta ligand binding domain ChEMBL. 20382019
IC50 (binding) = 362 nM Displacement of [3H]T0901317 from LXRalpha ligand binding domain ChEMBL. 20382019

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 20382019
Mus musculus ChEMBL23 20382019

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.