Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA binding protein | 0.0192 | 0.6163 | 0.9406 |
Schistosoma mansoni | tar DNA-binding protein | 0.0192 | 0.6163 | 0.6163 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0192 | 0.6163 | 0.9406 |
Brugia malayi | Pre-SET motif family protein | 0.0203 | 0.6552 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0192 | 0.6163 | 0.6163 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0048 | 0.0728 | 0.0957 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0653 | 0.0653 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0117 | 0.3309 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0066 | 0.1402 | 0.2141 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.0641 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0653 | 0.106 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0287 | 0.0287 |
Schistosoma mansoni | tar DNA-binding protein | 0.0192 | 0.6163 | 0.6163 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0055 | 0.0981 | 0.1592 |
Onchocerca volvulus | 0.0048 | 0.0728 | 0.0957 | |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.0641 | 0.104 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0066 | 0.1402 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.0641 | 0.104 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.0641 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0038 | 0.035 | 0.0568 |
Trichomonas vaginalis | set domain proteins, putative | 0.0231 | 0.7609 | 0.5 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0055 | 0.0981 | 0.0981 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0066 | 0.1402 | 0.2141 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0117 | 0.3309 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 0.1402 | 0.2276 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0653 | 0.0997 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0191 | 0.6096 | 0.9892 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0117 | 0.3309 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0653 | 0.0997 |
Echinococcus granulosus | tar DNA binding protein | 0.0192 | 0.6163 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.0641 | 0.5 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0038 | 0.035 | 0.0568 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.0641 | 0.0978 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.1402 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0105 | 0.2867 | 0.8342 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 0.1402 | 0.2276 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0728 | 0.1112 |
Onchocerca volvulus | 0.0231 | 0.7609 | 1 | |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0728 | 0.0728 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0981 | 0.1497 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0653 | 0.106 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0287 | 0.0438 |
Schistosoma mansoni | tar DNA-binding protein | 0.0192 | 0.6163 | 0.6163 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.0641 | 0.0978 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0728 | 0.1112 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0055 | 0.0981 | 0.1592 |
Echinococcus multilocularis | tar DNA binding protein | 0.0192 | 0.6163 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0105 | 0.2867 | 0.8342 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0287 | 0.0466 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0203 | 0.6552 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0287 | 0.0287 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0055 | 0.0981 | 0.1497 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0048 | 0.0728 | 0.1182 |
Loa Loa (eye worm) | MBCTL1 | 0.0055 | 0.0981 | 0.1497 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0066 | 0.1402 | 1 |
Brugia malayi | glutathione reductase | 0.0046 | 0.0641 | 0.0978 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.0641 | 0.0978 |
Schistosoma mansoni | tar DNA-binding protein | 0.0192 | 0.6163 | 0.6163 |
Loa Loa (eye worm) | RNA binding protein | 0.0192 | 0.6163 | 0.9406 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0653 | 0.0653 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0105 | 0.2867 | 0.8342 |
Loa Loa (eye worm) | TAR-binding protein | 0.0192 | 0.6163 | 0.9406 |
Brugia malayi | TAR-binding protein | 0.0192 | 0.6163 | 0.9406 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0653 | 0.106 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0048 | 0.0728 | 0.1182 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0055 | 0.0981 | 0.1592 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0105 | 0.2867 | 0.8342 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0105 | 0.2867 | 0.8342 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0728 | 0.0728 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0191 | 0.6096 | 0.9892 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0653 | 0.106 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0066 | 0.1402 | 0.1402 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0048 | 0.0728 | 0.0728 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0048 | 0.0728 | 0.1182 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0048 | 0.0728 | 0.1112 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.0641 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0105 | 0.2867 | 0.8342 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.0641 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0287 | 0.0466 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0048 | 0.0728 | 0.1182 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0117 | 0.3309 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0728 | 0.1112 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0055 | 0.0981 | 0.1592 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.1402 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0192 | 0.6163 | 0.9406 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.1402 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 40 uM | Cytotoxicity against human HepG2 cells by MTT assay | ChEMBL. | 19863101 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.